子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | Purification of fluorinated alcohols | US10983201 | 2004-11-05 | US07138551B2 | 2006-11-21 | Alexander Borisovich Shtarov; Stephen James Getty; Axel Hans-Joachim Herzog |
| A process for reducing the level of perfluoroalkanoic acids, perfluoroalkanoic esters, and perfluoroalkyliodides in fluorinated alcohols comprising heating a fluorinated alcohol, or mixtures thereof, containing said acids, esters, or iodides to a temperature of at least 175° C. in the presence of water and a base additive is disclosed. | ||||||
| 62 | 1-Aryloxy-3-alkylamino-propan-2-ols | US398577 | 1982-07-15 | US4442120A | 1984-04-10 | Herbert Koppe; Werner Kummer; Helmut Stahle; Gojko Muacevic; Werner Traunecker |
| Compounds of the formula ##STR1## wherein R.sub.1 is cycloalkyl of 3 to 10 carbon atoms; phenyl; mono- or poly-substituted phenyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, lower alkinyloxy, lower cycloalkyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the phenyl ring; aryloxy-lower alkyl; (mono- or poly-substituted aryl)-oxy-lower alkyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, lower alkinyloxy, lower cycloalkyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the phenyl ring;R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or the ring-forming group (--CH.dbd.CH).sub.2 or --(CH.sub.2).sub.n --, where n is an integer from 3 to 5, attached to vicinal carbon atoms of the phenyl ring; andR.sub.3 is straight or branched alkyl of 1 to 10 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful for the treatment of tachycardia, hypertension and coronary diseases. | ||||||
| 63 | 1-Aryloxy-3-alkylamino-2-propanols and pharmaceutical compositions containing them | US420796 | 1982-09-21 | US4438143A | 1984-03-20 | Herbert Koppe; Werner Kummer; Helmut Stahle; Gojko Muacevic; Werner Traunecker |
| This invention relates to compounds of the formula ##STR1## wherein R.sub.1 represents a linear or branched alkyl of from 1 to 20 carbon atoms;R.sub.2 represents a hydrogen or halogen atom, a linear or branched alkyl or alkoxy of from 1 to 4 carbon atoms, or a divalent group --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.n --, in which n is an integer of from 3 to 5, with the free valences bonded in the o-position relative to one another; andR.sub.3 represents a linear or branched alkyl of from 3 to 10 carbon atoms, with the provisos that R.sub.3 is not tert.butyl when R.sub.1 is ethyl or propyl and R.sub.2 is a hydrogen atom and that R.sub.3 is not isopropyl when R.sub.1 is propyl and R.sub.2 is a hydrogen atom,or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of Formula I are useful for treatment and prophylaxis of diseases of the coronaries, for the treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia. | ||||||
| 64 | Catalytic hydrogenation of alpha,beta-unsaturated aldehydes to alpha,beta-unsaturated alcohols | US450134 | 1974-03-11 | US3953524A | 1976-04-27 | Kurt Steiner |
| Improved, selective hydrogenation of alpha, beta-unsaturated aldehydes to alpha,beta-unsaturated alcohols utilizing a platinum-cobalt catalyst. | ||||||
| 65 | Allylic terpenic alcohol production | US3763245D | 1969-04-30 | US3763245A | 1973-10-02 | SULLY B |
| C10 ALLYLIC TERPENIC HALIDES ARE CONVERTED TO THE CORRESPONDING C10 ALLYLIC TERPENIC ALCOHOLS BY DIRECT AQUEOUS HYDROLYSIS IN AN AQUEOUS HYDROTROPIC SOLUTION OF A BENZENE OR ALKYLBENZENE SULPHONATE SALT WHEREIN EACH OF ANY ALKYL GROUPS PRESENT DOES NOT CONTAIN MORE THAN 4 CARBON ATOMS, PREFERABLY SODIUM XYLENE SULPHONATE. BY-PRODUCT FORMATION MAY THEREBY BE MINIMISED.
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| 66 | Preparation of allylic terpenic alcohols | US3737467D | 1969-04-30 | US3737467A | 1973-06-05 | FORDHAM W; ANSARI H |
| C10 ALLYLIC TERPENIC HALIDES ARE SOLVOLYSED IN GOOD YIELD TO THE CORRESPONDING ALCOHOLS IN AONE-STEP PROCESS COMPRISING AQUEOUS SOLVOLYSIS IN THE PRESENCE OF A LIQUID ORGANIC COMPOUND, PREFERABLY ACETONE, IN WHICH THE TERPENIC HALIDE AND WATER BOTH SEPARATELY MIXABLE AND USING A CUPROUS HALIDE CATALYST. THE REACTION IS PREFERABLY CONDUCTED AT FROM -20*C. TO +30*C. AND AT A PH 7.5 TO 9.0.
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| 67 | Process for producing alcohols | US3697605D | 1968-04-19 | US3697605A | 1972-10-10 | WATANABE MASAMI; NAMIKAWA KEISHI; YASUDA KOTARO; TAKAGI MOTOYOSHI |
| A process for the reduction of esters of aromatic carboxylic acids with hydrogen in the presence of a copper-containing catalyst to the corresponding aromatic alchols is provided wherein the copper-containing catalyst is composed of copper oxide and oxides or carbonates or oxide-carbonate mixtures of one or more alkaline earth metals selected from the group consisting of magnesium, calcium, strontium and barium, the copper being present in an amount of 0.01 to 3 atoms per atom of alkali metal. Reduction is effected at a temperature above 80* C. and at a pressure higher than 60 kg./cm.2. If desired, chromium is added to the catalyst in an amount of at least about 0.01 atom per atom of copper contained in the catalyst.
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| 68 | Method of preparing mixed isomers of vitamin a | US3499044D | 1967-11-07 | US3499044A | 1970-03-03 | STUGIS WALTER C |
| 69 | Method for producing an optically active alcohol compound | JP24111997 | 1997-09-05 | JP4144814B2 | 2008-09-03 | ティ マイ ジャン カソリーヌ ファム; ドゥセ ヘンリ; 幸一 三上; 雅通 伊藤; 昇 佐用; 毅 大熊; 眞浩 寺田; 敏伸 是永; 良治 野依 |
| 70 | Surface active lewis acid catalyst | JP5307598 | 1998-03-05 | JPH11244705A | 1999-09-14 | KOBAYASHI OSAMU; OYAMADA HIDEKAZU |
| PROBLEM TO BE SOLVED: To execute an organic synthetic reaction in a water medium by a method wherein a surface active function is provided by allowing a hydrophobic atomic group and a hydrophilic atomic group are allowed to exist in a molecule to have a surface-active function, and a specific surface active Lewis acid catalyst having a Lewis acidity in a part of the hydrophilic atomic group is obtained. SOLUTION: A surface active Lewis acid catalyst represented by M<n+> (R<1> X<-> )k (R<2> X<-> )l (Y<-> )m is imparted with a surface-active function by allowing a hydrophobic atomic group and a hydrophilic atomic group to exist in a molecule, and a Lewis acidity is equipped to a part of the hydrophilic atomic group. Wherein, in the formula, (k+l+m)=n is provided, (n) indicates a number of 1 or over, (k), (l) and (m) each indicate a number of 0 to 3, M indicates a kind of a transition metal element, X indicates a conjugated salt group of an organic acid group, R<1> indicates a hydrocarbon group which may have a 8-30C functional group, R<2> indicates a hydrocarbon group which may have a 1-12C functional group, and Y respectively indicates an inorganic anion. | ||||||
| 71 | Water-insoluble solid coated alcohol and its production | JP4544096 | 1996-02-07 | JPH09208508A | 1997-08-12 | WATABE HIROTERU; TAKEBAYASHI TAKASHI; IWATA MASUO |
| PROBLEM TO BE SOLVED: To obtain a water insoluble solid coated polyhydric alcohol which is not hygroscopic and insoluble in water and is useful as an auxiliary agent for a flame retarder or as a flame-retardant foaming composition having fire retardant property. SOLUTION: This solid coated polyhydric alcohol is prepared by coating a solid polyhydric alcohol (for example, catechol) with a thermosetting resin, for example, an alkyd resin, or treating the solid polyhydric alcohol with a surface-treating agent such as a silane coupling agent or further coating the surface-treated polyhydric alcohol with a thermosetting resin at 20-100°C. At this time, 100 pts.wt. solid polyhydric alcohol is preferably coated with 1-30 pts.wt. of the thermosetting resin. COPYRIGHT: (C)1997,JPO | ||||||
| 72 | Production of 3,7,11,15,19,23,27-heptamethyl-6,10,14,18,22,26-octacosahexaen-1-ol | JP30846795 | 1995-10-31 | JPH09124525A | 1997-05-13 | ASANUMA GORO; TAMAI HIRONOBU; KANEHIRA KOICHI |
| PROBLEM TO BE SOLVED: To obtain the subject compound useful as a preventing and treating agent for immunological function insufficiency on an industrial scale in high yield at a low cost by a specific method including a 5C-extension reaction of an allyl alcohol compound. SOLUTION: A compound of the formula I (A is a hydroxyl-protecting group) is reacted with 2-methyl-3,3-dimethoxy-1-butene and the carbonyl group of the resultant compound is reduced to extend 5 carbon atoms. The 5C-extension reaction is repeated m-times. The product is halogenated to a compound of the formula II (X is a halogen; (m) is 1-4), the obtained compound is reacted with a compound of the formula III (R 1 is an alkyl or an aryl) and finally the reaction product is desulfonated and deprotected to obtain the objective compound of the formula IV. The reduction of the carbonyl group in the 5C extension reaction is carried out e.g. by Meerwein-Ponndorf reduction using a secondary alcohol and an aluminum alkoxide. The compound of the formula II is preferably produced from citronellol. COPYRIGHT: (C)1997,JPO | ||||||
| 73 | JPH0316932B2 - | JP19946182 | 1982-11-12 | JPH0316932B2 | 1991-03-06 | SHIONO MANZO; FUJITA YOSHIJI; SUZUKI SHIGEAKI; KANEHIRA KOICHI; OONISHI TAKASHI; NISHIDA TAKUJI |
| 74 | Production of alcohol | JP18487888 | 1988-07-25 | JPH0236135A | 1990-02-06 | YAMAMURO AKIRA; HATTORI YASUYUKI; FUKUOKA NORIAKI; TSUKADA KIYOSHI |
| PURPOSE: To obtain an alcohol by hydrogenating a carboxylic ester in the presence of a catalyst prepared by reduction of a compound metal oxide containing CuO, ZnO, MoO 3 and/or WO 3 or containing an alkaline (earth) metal oxide, iron family metal oxide, etc., other than the above-mentioned oxides. CONSTITUTION: A carboxylic ester is reacted with hydrogen under 50-300kg/cm 2 hydrogen pressure at 150-300°C in the presence of a catalyst prepared by reduction of a compound metal oxide represented by formula I (AO is MoO 3 and/or WO 3, a is 55-75wt.%; b is 25-45wt.%; c is 0.1-10wt.%) or formula II [BO is oxide of alkaline (earth) metal, iron family metal, etc.; a', b' and c' are respectively synonymous with a, b and c; d' is 0.1-8wt.%] to prepare an alcohol. The above-mentioned catalyst has durability against poisoning by trace impurities in the raw materials or heat deterioration in a high-activity state. The catalyst is prepared by the coprecipitation method, etc., where a precipitant is added to an aqueous mixture solution of respective metal salts. COPYRIGHT: (C)1990,JPO&Japio | ||||||
| 75 | JPS6332333B2 - | JP18236483 | 1983-09-29 | JPS6332333B2 | 1988-06-29 | OODERA JUNZO; SHIMIZU YASUMI; NAKADA TETSUYA |
| 76 | JPS6256139B2 - | JP21482682 | 1982-12-08 | JPS6256139B2 | 1987-11-24 | TSUKADA KYOSHI; MYAHATA YOJI; FUKUOKA NORIAKI |
| 77 | JPS6032612B2 - | JP12076875 | 1975-10-08 | JPS6032612B2 | 1985-07-29 | ICHIKAWA YATARO; YAMAJI TEIZO; SAWAKI TOORU |
| 78 | Preparation of optically active compound | JP11469982 | 1982-07-01 | JPS595131A | 1984-01-12 | TODA FUMIO; TANAKA KOUICHI |
| PURPOSE: To obtain the titled compound useful as an agricultural chemical, medicine or perfume or a starting raw material therefor, by forming a molecular clathrate complex from an optically active brucine and a cyanhydrin, and carrying out the optical resolution. CONSTITUTION: An optically active brucine expressed by formula II is brought into contact with a racemate of cyanhydrin or secondary alcohol expressed by formula I [Ar is (substituted) aromatic group; R is alkyl, halogen-substituted alkyl, halogen-substituted aryl or trialkylsilyl; Y is cyano or H] or in a molar amount of 1W2 times of that of the optically active brucine in an organic solvent at 0W50°C, usually room temperature for 1W40hr, mostly 6W12hr, to form a molecular clathrate complex, which is then dissolved in a water-insoluble solvent and then brought into contact with an acid and resolved optically to afford the aimed optically active compound expressed by formula I . l-Brucine naturally occurring in large amounts in seeds of a plant belonging to the genus Strychnos, etc. is advantageous to the brucine of formula II. COPYRIGHT: (C)1984,JPO&Japio | ||||||
| 79 | JPS5754489B2 - | JP14826874 | 1974-12-26 | JPS5754489B2 | 1982-11-18 | |
| 80 | Preparation of allyl alcohol | JP4634780 | 1980-04-08 | JPS56142224A | 1981-11-06 | TAMURA MITSUHISA; SUZUKAMO TAKEO; HIROSE KENICHI |
| PURPOSE: To obtain a di-substituted allyl alcohol mainly of the Z type useful as an intermediate for a medicine and an agricultural chemical, readily in one stage, high yield and selectivity, by the reaction of an organolithium compound with 3- methyl-3,4-epoxybutene-1, in the presence of an amine. CONSTITUTION: A compound expressed by formula (A) (R is alkyl, aralkyl or one of these containing a functional group in the organic part), e.g. n-butyllithium, is reacted with a 3-methyl-3,4-epoxy-buten-1-expressed by formula (B), in the presence of an amine, e.g. ammonia or N,N,N',N'-tetramethylethylenediamine, to give a di-substituted allyl alcohol mainly of the Z type expressed by formula (C). The aimed compound is obtained in high selectivity for the position and configuration in one step under mild conditions. USE: A perfume, i.e. α,β-santalol contained in a natural sandal-wood oil. COPYRIGHT: (C)1981,JPO&Japio | ||||||
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