| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | Process for the preparation of a metal-organic compound comprising at least one imine ligand | US10566979 | 2004-08-03 | US07524906B2 | 2009-04-28 | Edwin IJpeij; Henricus Arts; Gerardus van Doremaele; Felix Beijer |
| The invention relates to a process for the preparation of a metal-organic compound, comprising at least one imine ligand, characterized in that an imine ligand according to formula 1, or the HA adduct thereof, wherein HA represents an acid, of which H represents its proton and A its conjugate base, is contacted with a metal-organic reagent of formula 2 in the presence of at least 1, respectively 2 equivalents of an inorganic or metal-organic base, wherein Y═N-R (formula 1), Y is selected from a substituted carbon, nitrogen or phosphorous atom, R represents a proton, a protic or an aprotic substituent, and the metal organic compound is: MV(L1)k(L2)l(L3)m(L4)nX (formula 2) wherein: M represents a group 4 or group 5 metal ion, V represents the valency of the metal ion, being 3, 4 or 5, L1, L2, L3, and L4 represent ligands on M and may be equal or different, X represents a group 17 halogen atom, and k, 1, m, n=0, 1, 2, 3, 4 with k+l+m+n+l=V. The invention further relates to a process for the preparation of a polyolefin by making a metal-organic compound according to the process of the invention, wherein the base is an olefin polymerisation compatible base, which metal-organic compound is activated anywhere in, or before a polymerisation reactor. | ||||||
| 102 | Process for the preparation of a metaloorganic compound comprising at least one imine ligand | US12230991 | 2008-09-09 | US20090018293A1 | 2009-01-15 | Edwin IJPEIJ; Arts Henricus; Gerardus van Doremaele; Beijer Felix |
| The invention relates to a process for the preparation of a metalorganic compound, comprising at least one imine ligand, characterized in that an imine ligand according to formula 1, or the HA adduct thereof, wherein HA represents an acid, of which H represents its proton and A its conjugate base, is contacted with a metal-organic reagent of formula 2 in the presence of at least 1, respectively 2 equivalents of an inorganic or metal-organic base, wherein Y═N—R (formula 1), Y is selected from a substituted carbon, nitrogen or phosphorous atom, R represents a proton, a protic or an aprotic substituent, and the metal organic compound is: Mv(L1)k(L2)I(L3)m(L4)nX (formula 2) wherein: M represents a group 4 or group 5 metal ion, V represents the valency of the metal ion, being 3, 4 or 5, L1, L2, L3, and L4 represent ligands on M and may be equal or different, X represents a group 17 halogen atom, and k, l, m, n=0, 1, 2, 3, 4 with k+l+m+n+1=V. The invention further relates to a process for the preparation of a polyolefin by making a metal-organic compound according to the process of the invention, wherein the base is an olefin polymerisation compatible base, which metal-organic compound is activated anywhere in, or before a polymerisation reactor. | ||||||
| 103 | Process for the Preparation of a Metal-Organic Compound Comprising at Least One Imine Ligand | US10567098 | 2004-08-03 | US20080045719A1 | 2008-02-21 | Edwin Ijpeij; Henricus Arts; Gerardus van Doremaele; Felix Beijer; Francis Van Der Burgt; Martin Alexander Zuideveld |
| The invention relates to a process for the preparation of a metal-organic compound, comprising at least one phosphinimine ligand, characterized in that the HA adduct of a phosphinimine ligand according to formula (1) is contacted with a metal-organic reagent of formula (2) in the presence of at least 2 equivalents of a base, wherein HA represents an acid, of which H represents its proton and A its conjugate base, with Y═N—H as formula (1), and Mv(L1)k(L2)1(L3)m(L4)nX as formula (2), and wherein Y is a substituted phosphorous atom, and M represents a group 4 or group 5 metal ion, V represents the valency of the metal ion, being 3, 4 or 5 L1, L2, L3, and L4 represent a ligand or a group 17 halogen atom on M and may be equal or different, k, l, m, n=0, 1, 2, 3, 4 with k+l+m+n+l=V, and X represents a group 17 halogen atom. The invention further relates to a process for the preparation of a polyolefin by making a metal-organic compound according to the process of the invention, wherein the base is an olefin polymerisation compatible base, which metal-organic compound is activated anywhere in, or before a polymerisation reactor. | ||||||
| 104 | Process For The Preparation Of A Metal-Organic Compound Comprising At Least One Imine Ligand | US10567156 | 2004-08-03 | US20070219376A1 | 2007-09-20 | Edwin Ijpeij; Henricus Arts; Gerardus Van Doremaele; Felix Beijer; Francis Van Der Burgt; Martin Zuideveld |
| The invention relates to a process for the preparation of a metal-organic compound, comprising at least one imine ligand, characterized in that an imine ligand according to formula I or the HA adduct thereof, wherein HA represents an acid, of which H represents its proton and A its conjugate base, is contacted with a metal-organic reagent of formula 2 In the presence of at least 1, respectively at least 2 equivalents of a base, with Y═N—R as formula 1, wherein Y is selected from a substituted carbon, nitrogen, or phosphorous atom and R represents a substituent, and with MV(L1)k(L2)l(L3)m(L4)nX as formula 2, wherein: M represents a group 4 or group 5 metal ion V represents the valency of the metal ion, being 3, 4 or 5 L1, L2, L3, and L4 represent a ligand or a group 17 halogen atom on M and may be equal or different X represents a group 17 halogen atom, k, l, m, n=0, 1, 2, 3, 4 with k+l+m+n+1=V. The invention further relates to a process for the preparation of a polyolefin in the presence of the compound prepared according to the process of the invention. | ||||||
| 105 | Process for the preparation of a polyolefin | US10566840 | 2004-08-03 | US20060252893A1 | 2006-11-09 | Edwin Ijpeij; Henricus Arts; Gerardus Van Doremaele; Felix Beijer; Francis Van der Burgt; Martin Zuideveld |
| The invention related to a process for the polymerization of at least one aliphatic or aromatic hydrocarbyl C2-20 mono- or multiolefin in the presence of a catalyst and a boron comprising co-catalyst, wherein the catalyst comprises a composition of a metal-organic reagent, a spectator ligand and optionally at least one equivalent of a hydrocarbylating agent. The invention further relates to a polymer obtainable by the process of the invention. | ||||||
| 106 | Preparation of polymerization catalysts | US09739176 | 2000-12-18 | US06518444B1 | 2003-02-11 | David H. McConville; Jaimes Sher |
| A method to synthesize a Group 15 containing metal polymerization catalyst is disclosed. The method includes an efficient high temperature synthesis of Group 15 containing ligands, especially arylamine ligands, for use in preparing polymerization catalysts and catalyst systems. | ||||||
| 107 | Lipoic acid derivatives and their use in treatment of disease | US09962372 | 2001-09-24 | US20020107234A1 | 2002-08-08 | Paul M. Bingham; Zuzana Zachar |
| This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poison the pyruvate dehydrogenase complex specifically in such cells. This invention also provides for methods of using therapeutically effective amounts of the lipoic acid derivatives for the treatment of cancer and other diseases. The lipoic acid derivatives described herein have a wide range of preventive and therapeutic applications. | ||||||
| 108 | Lipoic acid derivatives and their use in treatment of disease | US09427477 | 1999-10-26 | US06331559B1 | 2001-12-18 | Paul M. Bingham; Zuzana Zachar |
| This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poison the pyruvate dehydrogenase complex specifically in such cells. This invention also provides for methods of using therapeutically effective amounts of the lipoic acid derivatives for the treatment of cancer and other diseases. The lipoic acid derivatives described herein have a wide range of preventive and therapeutic applications. | ||||||
| 109 | II-bond aromatic vitamin chelates | US930747 | 1992-08-14 | US5292729A | 1994-03-08 | Harvey H. Ashmead |
| Vitamin and mineral absorption in warm-blooded animals is promoted by means of a class of vitamin chelates where at least one of the bonds between the metal ion and the vitamin ligand is formed between the ion and an electron rich .pi.-cloud of an aromatic ring of the water soluble vitamin. The chelate, containing a total of from one to three ligands, may contain from one up to three vitamin ligands which form a .pi.-bond with the mineral and, when present, one or two amino acid, dipeptide or tripeptide ligands. The mineral is selected from the group consisting of Fe, Cu, Zn, Mg, Mn and Ca. The water soluble vitamin ligand is preferably a residue of nicotinamide, nicotinic acid, pyridoxine, thiamine, riboflavin and folic acid. The amino acid may be any of the naturally occurring .alpha.-amino acids such as glycine. The .pi.-bond vitamin chelates are absorbed more readily from both the gastric and intestinal areas of the GI tract than vitamins or minerals administered separately or as mixtures. | ||||||
| 110 | Process for the preparation of substituted difluorobenzo-1,3-dioxoles | US987902 | 1992-12-04 | US5281718A | 1994-01-25 | Peter Ackermann; Hans-Ruedi Kanel; Bruno Schaub |
| The reaction of 2,2-difluorobenzo-1,3-dioxole with (a) an alkali metal or an alkali metal compound and then (b) a compound R.sup.1 -Z.sup.1 in which Z.sup.1 is a leaving group, or with an aldehyde produces compounds of formula I ##STR1## wherein R.sup.1 is --OH, --SH, --CHO, --CN, --COOH, --B(OH).sub.2, --COX, with X being Cl or Br, or is --COOR.sup.2, --SiR.sub.3.sup.2 or --B(OR.sup.2).sub.2, with R.sup.2 being a C.sub.1 -C.sub.12 alcohol moiety without the hydroxy group, wherein R.sup.1 is further --C.sub.n H.sub.2n COOR.sup.2, with n being an integer from 1 to 4, or linear or branched C.sub.1 -C.sub.12 hydroxyalkyl which is unsubstituted or is substituted by --F, --CN, C.sub.1 -C.sub.6 alkoxy, phenyl, fluorophenyl, C.sub.1 -C.sub.4 alkoxy-phenyl, C.sub.1 -C.sub.4 alkylthio-phenyl, C.sub.1 -C.sub.4 alkylphenyl, C.sub.1 -C.sub.4 fluoroalkyl-phenyl, nitrophenyl or by cyanophenyl, or wherein R.sup.1 is a benzyl alcohol which is unsubstituted or is substituted by F, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 fluoroalkyl, nitro or by cyano, or is C.sub.1 -C.sub.12 acyl, or wherein R.sup. 1 is a radical of formula II ##STR2## wherein R.sup.5 is --CN, --CF.sub.3, --COOR.sup.2, --CONH.sup.2, --CO--NHR.sup.2 or --CONR.sub.2.sup.2, R.sup.3 and R.sup.4 are a direct bond or each is H, or R.sup.3 is H and R.sup.4 independently has the meanings of R.sup.5, or R.sup.3 and R.sup.4 together are --CH.sub.2 --NR.sup.6 --CH.sub.2 --, --CH.sub.2 --NR.sup.6 --CO-- or --CO--NR.sup.6 --CO-- wherein R.sup.6 is the radical of a removable protecting group, or wherein further R.sup.1 is a radical of formula III ##STR3## Insecticides or fungicides can be prepared from the compounds of formula I. 3-(2,2-difluorobenzodioxol-4-yl)-4-cyanopyrrole can be prepared by reacting 4-metallo-2,2-difluorobenzodioxole (III) with an unsaturated nitrile and then with a sulfonylmethyl isocyanide in a one-pot process. The compounds III are novel intermediates. | ||||||
| 111 | Bismuth containing pharmaceutical compositions | US103225 | 1987-09-30 | US4851398A | 1989-07-25 | Emanuel Revici |
| The invention relates to a method for making a composition which comprises selecting at least one fatty acid or fatty ester compound having an allylic unsaturation of the type --CH.dbd.CH--CH.sub.2 --CH.dbd.CH-- or --CH.dbd.CH--CH.dbd.CH--CH.sub.2 --, adding to said compound a salt of an element having a rhombohedral crystal structure, such as Bi, Hg, As, B, Sb or Sm, to form a mixture, heating said mixture above about 260.degree. C. for a sufficient period of time to incorporate at least about 0.1% by weight of the element into the compound, cooling the mixture, and recovering the incorporated compound as the remaining fluid of the mixture. The invention also relates to the reaction products thus produced along with methods of administering these compositions to a subject to treat abnormal conditions caused mainly by a catabolic imbalance. | ||||||
| 112 | 有機金属錯体、有機エレクトロルミネッセンス素子及びその製造方法、表示装置並びに照明装置 | JP2016084427 | 2016-11-21 | JPWO2017119200A1 | 2018-11-01 | 服部 貴宗; 田畑 顕一; 植田 則子 |
| 本発明の課題は、良好な安定性と発光性とを兼ね備え、素子の発光効率や発光寿命を向上させることが可能な有機金属錯体、これを含有した有機エレクトロルミネッセンス素子及びその製造方法、表示装置並びに照明装置を提供することである。本発明の有機金属錯体は、元素周期表における8族〜11族の金属を中心金属(例;イリジウム等)として有し、架橋基によって互いに連結された2座の配位子が配位した構造を有する。配位子は、芳香族炭化水素環、芳香族複素環(例;2−フェニルイミダゾール等)によって構成され、金属−配位子間の配位結合に対するオルト位に、架橋基が連結した2価以上のヘテロ原子(例;酸素原子、窒素原子、硫黄原子等)が結合している。有機エレクトロルミネッセンス素子は、この有機金属錯体を有機層に含有し、ウェットプロセス方式で形成される。表示装置及び照明装置は、この有機エレクトロルミネッセンス素子を具備する。 | ||||||
| 113 | シリルホスフィン化合物の製造方法及びシリルホスフィン化合物 | JP2018524857 | 2017-09-19 | JP6401426B2 | 2018-10-10 | 田久保 洋介; 田村 健 |
| 114 | ポリオレフィンーポリスチレンブロック共重合体を含む有機亜鉛化合物及びその製造方法 | JP2017541971 | 2016-01-21 | JP6398015B2 | 2018-09-26 | イ、プン−ヨル; チョン、チョン−ヨプ; パク、クン−ホ |
| 115 | ルテニウム錯体の製造方法 | JP2016076564 | 2016-09-09 | JPWO2017056916A1 | 2018-07-19 | 中山 裕治 |
| 本発明は、ルテニウム二核錯体(2A)と化合物(3A)を第1級アルコール及び塩基の存在下で反応させることにより、ルテニウム錯体(1A)を効率的に製造する方法に関する。また、ルテニウム二核錯体(4A)に対して第1級アルコールと塩基を作用させることによっても、ルテニウム錯体(1A)を効率的に製造することが出来る。 【化1】 (式中、実線、三重線、破線、C、H、N、O、P、Ru、X、AH及びR1〜R12は明細書中に定義された意味を有する) |
||||||
| 116 | 金属錯化合物、これを含む金属ナノ構造体および触媒組成物 | JP2017536542 | 2016-02-16 | JP2018504489A | 2018-02-15 | ウォン・ジョン・クォン; スン・ホ・ユン; イェ・ジ・イ |
| 本発明は、多様な立体構造を有する金属ナノ構造体の形態で製造され、ポリアルキレンカーボネート樹脂などの製造において優れた活性を有する触媒などとして使用できる新規な金属錯化合物、これを含む金属ナノ構造体および触媒組成物などに関する。前記金属錯化合物は、シュウ酸が遷移金属に配位されて連結された形態の線状無機配位高分子鎖を複数含み、このような複数の高分子鎖が所定の中性リガンドを介して互いに連結されている構造を有するものである。 | ||||||
| 117 | 触媒の製造方法 | JP2016129025 | 2016-06-29 | JP2018002804A | 2018-01-11 | 喜来 直裕 |
| 【課題】フルオレン骨格を含む特定の構造の配位子を用いて、メタロセン化合物である触媒を、高純度且つ高収率で製造できる触媒の製造方法を提供すること。 【解決手段】フルオレン骨格を含む特定の構造の配位子に対して、特定量且つ特定の構造の有機リチウム化合物を反応させる工程(I)と、工程(I)の生成物に、それぞれ所定の構造のMg化合物、Zn化合物、及びAl化合物からなる群より選択される1種以上を反応させる工程(II)と、工程(II)の生成物に、ハロゲン原子等を有するTi化合物、Zr化合物、又はHf化合物を、配位子に対して1モル当量以上反応させる工程(III)と、を含む方法により触媒を製造する。 【選択図】なし |
||||||
| 118 | 新規なルテニウム錯体ならびにメタノールおよびジオールの製造方法 | JP2015537109 | 2013-03-22 | JP6190886B2 | 2017-08-30 | ディン,クイリン; ハン,ツァオビン |
| 119 | テッベ錯体の製造方法 | JP2016551949 | 2015-09-18 | JPWO2016052279A1 | 2017-07-27 | 真二 波多江; 修一 須永; 辻 智啓; 智啓 辻 |
| ビス(シクロペンタジエニル)チタニウムジクロリドとトリメチルアルミニウムとを、25℃における溶媒1gに対するテッベ錯体の溶解度が0.5mmol/g以下である溶媒の存在下で反応させることを特徴とする、高収率で、高純度及び高活性の、保存安定性に優れる、テッベ錯体の製造方法に関する。 | ||||||
| 120 | ルテニウム錯体及びその製造方法並びにその用途 | JP2016515217 | 2015-04-24 | JPWO2015163440A1 | 2017-04-20 | 理 小形; 秀樹 奈良; 裕治 中山 |
| 本発明は、製造及び取り扱いが容易で比較的安価に調達できる新規ルテニウム錯体及びその製造法と、該ルテニウム錯体を触媒としたアルコール類等の製造方法、該ルテニウム錯体を触媒としたカルボニル化合物の製造方法及び該ルテニウム錯体を触媒としたN−アルキルアミン化合物の製造方法を提供する。本発明は、次の一般式(1)RuX1X2(PNP)(NHC)m(Solv)n(1)(一般式(1)中、X1及びX2は各々独立して一価のアニオン性単座配位子を表す。PNPは三座アミノジホスフィン配位子を表し、NHCは含窒素複素環に由来するN−へテロ環状カルベンを表し、Solvは配位性溶媒を表す。mは1から3、nは0から2の整数を表し、1≦m+n≦3である。)で表されるルテニウム錯体及びその製造方法、並びにそれを含有してなる触媒及び当該触媒を用いる各種有機化合物の製造方法に関する。 | ||||||
QQ群二维码
意见反馈
意见反馈