| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | Method of enzymatic optical resolution of racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline | US12083014 | 2006-10-04 | US07972836B2 | 2011-07-05 | Masaki Okamoto; Akira Sakuragi; Muneki Kishida; Yoshikazu Mori |
| The present invention relates to a method for preparing an optically active 4-hydroxy-1,2,3,4-tetrahydroquinoline compound [I], which comprises the steps of: treating a racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline compound represented by general formula [I]: [wherein R1 represents a hydrogen atom or a protecting group for amino group.] with an enzyme having an ability of selectively or preferentially acylating one enantiomer of the racemic compound [I] in the presence of an acyl donor; and if necessary, subjecting the reaction product to solvolysis. | ||||||
| 62 | Method for Preparing Optically Active 4-Hydroxy-1,2,3,4-Tetrahydroquinoline Compound | US12083014 | 2006-10-04 | US20090269821A1 | 2009-10-29 | Masaki Okamoto; Akira Sakuragi; Muneki Kishida; Yoshikazu Mori |
| The present invention relates to a method for preparing an optically active 4-hydroxy-1,2,3,4-tetrahydroquinoline compound [I], which comprises the steps of:treating a racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline compound represented by general formula [I]: [wherein R1 represents a hydrogen atom or a protecting group for amino group.] with an enzyme having an ability of selectively or preferentially acylating one enantiomer of the racemic compound [I] in the presence of an acyl donor; and if necessary, subjecting the reaction product to solvolysis. | ||||||
| 63 | Fluorous tagging and scavenging reactants and methods of synthesis and use thereof | US11338378 | 2006-01-24 | US07576245B2 | 2009-08-18 | Wei Zhang; Zhiyong Luo |
| The present invention includes methods and compositions for increasing the fluorous nature of an organic compound by reacting it with at least one fluorous compound to produce a fluorous tagged organic compound. The increased fluorous nature of the fluorous tagged organic compound can then be utilized to separate the fluorous organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom. The resultant fluorous tagged organic compound can be subjected to subsequent chemical transformations, wherein the fluorous nature of the tagged compound is utilized to increase the ease of separation of the fluorous tagged organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom, after each chemical transformation. The chemical transformations result in a second fluorous tagged organic compound wherein the fluorous nature of the second fluorous tagged organic compound can then be reduced by removing the fluorous group therefrom, thereby producing a second organic compound that may be employed as a pharmaceutical compound or intermediate, or a combinatorial library component. | ||||||
| 64 | Norbornyl-substituted silanes and the use thereof | US10255515 | 2002-09-26 | US06881855B2 | 2005-04-19 | Dieter Heldmann; Oliver Schaefer; Juergen Stohrer |
| Silanes of the formula Ra1R4-a-xSiLx (I) where each R is identical or different and is a monovalent, optionally substituted hydrocarbon radical which is free of aliphatic carbon—carbon multiple bonds and has from 1 to 18 carbon atoms per radical, R1 is an optionally substituted 2-norbornyl radical, L is a leaving group, a is 1, 2 or 3 and x is 1 or 2, with the proviso that the sum of a+x≦4, are useful for protecting functional groups of organic compounds (2) which have at least one functional group having an active hydrogen atom, preferably as a hydroxyl group —OH, a thiol groups —SH, an amine group —NH— or —NH2, a carboxyl group —COOH, or an amide group —CONH— or —CONH2. | ||||||
| 65 | NOVEL CYCLIC DEPSIPEPTIDE DERIVATIVE AND PEST CONTROL AGENT COMPRISING SAME | EP13804000.1 | 2013-06-13 | EP2862872B1 | 2018-09-19 | MITOMI Masaaki; SAKAI Masayo; HORIKOSHI Ryo; ONOZAKI Yasumichi; NAKAMURA Satoshi; OMURA Satoshi; SUNAZUKA Toshiaki; HIROSE Tomoyasu; SHIOMI Kazuro; MASUMA Rokuro |
| An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them. | ||||||
| 66 | METHOD FOR PROTECTING HYDROXYL, AMINE OR THIOL FUNCTIONAL GROUPS WITH TETRAISOPROPYLDISILANE AND THE CORRESPONDING PROTECTED COMPOUNDS | EP13727662.2 | 2013-04-23 | EP2841401B1 | 2018-07-04 | MARKIEWICZ, Wojciech, Tadeusz; CHMIELEWSKI, Marcin Krzysztof; MUSIAL, Sylwia Maria; MACIEJEWSKI, Hieronim Franciszek; HRECZYCHO, Grzegorz |
| A novel method of simultaneously protecting two functions which are same or different, namely hydroxyl, amine, or thiol ones, particularly in sugars, polyalcohols, nucleosides, nucleotides, peptides, and nucleic acids during an organic synthesis, and to novel compounds for implementing this method, as well as to the method of obtaining these compounds. Method of simultaneously protecting two hydroxyl, amine, or thiol functions according to the invention by carrying out a protecting reaction between a compound having at least two free hydroxyl, amine, or thiol groups, and the disilane of formula 1, where R stands for Cl or Br, or I, or a substituent of formula 2, where X1, X2, X3, X4 are the same or different. | ||||||
| 67 | SUBSTITUTED BENZOTRIAZOLE PHENOLS | EP16739636.5 | 2016-06-30 | EP3319947A1 | 2018-05-16 | VOLP, Kelly A.; SCHULTZ, Nathan E.; LI, Fuming B. |
| Benzotriazole phenols with substituents either ortho to the phenol hydroxyl group and/or para to the phenol hydroxyl group can be prepared from the unsubstituted benzotriazole phenol by coupling reactions. The ortho substituent group can be a simple alkoxy or amino group, or the ortho substituent group can be a linking group, linking the benzotriazole phenol to another benzotriazole phenol group. | ||||||
| 68 | DEPROTECTION METHOD FOR PROTECTED HYDROXYL GROUP | EP12774758.2 | 2012-04-19 | EP2700628B1 | 2016-09-14 | ISHIBASHI, Yuichiro; MATSUMURA, Yasushi |
| To deprotect an alcoholic hydroxyl group protected by a t-butyldimethylsilyl group without influencing a functional group unstable to an acid. In the presence of a solvent, an alcohol having a hydroxyl group protected by a t-butyldimethylsilyl group is deprotected in the presence of an acid or an acid salt having a pKa of from 1.0 to 3.0 in water. | ||||||
| 69 | PROCESS FOR PREPARATION OF CYCLOALKANEDICARBOXYLIC ACID MONOESTERS | EP10834588.5 | 2010-11-25 | EP2508504B1 | 2016-04-13 | OKAWA, Haruki |
| 70 | PRODUCTION METHOD FOR COMPOUND COMPRISING AMINO GROUP AND/OR HYDROXYL GROUP | EP13755516 | 2013-03-04 | EP2821389A4 | 2015-04-22 | OHSHIMA TAKASHI; MORIMOTO HIROYUKI; SHIMIZU YUHEI |
| 71 | DEPROTECTION METHOD FOR PROTECTED HYDROXYL GROUP | EP12774758 | 2012-04-19 | EP2700628A4 | 2014-10-08 | ISHIBASHI YUICHIRO; MATSUMURA YASUSHI |
| To deprotect an alcoholic hydroxyl group protected by a t-butyldimethylsilyl group without influencing a functional group unstable to an acid. In the presence of a solvent, an alcohol having a hydroxyl group protected by a t-butyldimethylsilyl group is deprotected in the presence of an acid or an acid salt having a pKa of from 1.0 to 3.0 in water. | ||||||
| 72 | Process for the preparation of 2,3-dihydropyran | EP09171996.3 | 2009-10-01 | EP2305661A1 | 2011-04-06 | Künzle, Niklaus |
The present invention relates to a process for producing 2,3-dihydropyran (DHP), comprising contacting tetrahydrofurfuryl alcohol (THFA) entrained in a carrier gas with a catalyst comprising aluminium oxide (Al2O3), wherein the carrier gas is water vapour.
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| 73 | アルキルアミン誘導体の製造方法及びその製造中間体 | JP2017521942 | 2016-05-31 | JPWO2016194881A1 | 2018-03-22 | 岡戸 康太朗; 阿部 誠輝; 室野井 真; 小林 泰久; 丹羽 誠司; 松澤 俊博 |
| 以下の工程(a)、(b)を含む、式(I)で表されるウレア結合を有するアルキルアミン誘導体、又はその塩の製造方法:工程(a):【化38】工程(b):工程(a)で得られた反応物を、必要に応じて脱保護する工程により、CaSRアゴニスト作用を有する薬剤として有用性の高い化合物である、式(I)で示されるウレア結合を有するアルキルアミン誘導体の工業化に適した製造方法が提供される。 | ||||||
| 74 | 新規キサンテン保護剤 | JP2017557218 | 2017-07-24 | JP6283775B1 | 2018-02-21 | 矢野 真也; 森 利裕; 窪田 秀樹 |
| 官能基を保護した化合物を固体化又は不溶化させず、反応後の分離、精製を容易ならしめる保護基を開発することにある。 一般式(1) R9は炭素数1〜16の直鎖又は分岐鎖のアルキレン基を示し; XはO又はCONR19(ここでR19は水素原子又は炭素数1〜4のアルキル基を示す)を示し; Aは式(3)等 で表される基を示す) で表されるキサンテン化合物。 |
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| 75 | ベンジル化合物 | JP2017039276 | 2017-03-02 | JP6201076B1 | 2017-09-20 | 矢野 真也; 若杉 裕樹; 岩永 陽介 |
| 【課題】官能基を保護した化合物の有機溶媒への溶解性を向上させることで、反応後の分離、精製を固体化又は不溶化せずに容易ならしめる保護基を形成する化合物の提供。 【解決手段】式(1)で表されるベンジル化合物。 【選択図】なし |
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| 76 | ベンジル化合物 | JP2016574023 | 2016-08-25 | JPWO2017038650A1 | 2017-08-31 | 矢野 真也; 真也 矢野; 裕樹 若杉; 陽介 岩永 |
| 官能基を保護した化合物の有機溶媒への溶解性を向上させることで、反応後の分離、精製を固体化又は不溶化することなく容易ならしめる保護基を提供する。一般式(1)(式中、X1は−CH2OR14(ここでR14は水素原子、ハロゲノカルボニル基又は活性エステル型保護基を示す)、−CH2NHR15(ここで、R15は水素原子、炭素数1〜6の直鎖若しくは分岐鎖のアルキル基、又はアラルキル基を示す)、ハロゲノメチル基、アジ化メチル基、ホルミル基、又はオキシムを示し;R1、R2、R3、R4及びR5のうちの少なくとも1個は式(2)で表される基を示し、残余は水素原子、ハロゲン原子、炭素数1〜4のアルキル基又は炭素数1〜4のアルコキシ基を示し;R6は炭素数1〜16の直鎖又は分岐鎖のアルキレン基を示し;X2はO又はCONR16(ここでR16は水素原子又は炭素数1〜4のアルキル基を示す)を示し;Aは式(3)、(4)、(5)、(6)、(7)、(8)、(9)、(10)、(11)、(12)又は(13)で表される基を示す)で表されるベンジル化合物。 | ||||||
| 77 | ２−アミノ置換ベンズアルデヒド化合物を製造する方法 | JP2016546566 | 2015-08-25 | JPWO2016035609A1 | 2017-04-27 | 小林 真一; 真一 小林 |
| 本発明により、ハロゲノ基またはアルコキシ基が3位に結合し、水素原子が2位に結合し、且つリチオ化反応が2位にて最も活性となるように、水素原子、アルキル基、ハロゲノ基、アルコキシ基若しくはシアノ基が4位、5位および6位にそれぞれ独立に結合しているベンズアルデヒドを用意し、該ベンズアルデヒド中のホルミル基をアセタール保護し、 2位を、順次、リチオ化、アジ化、およびアミノ化し、次いで、アセタール脱保護することを含む、アミノ基が2位に結合し、ハロゲノ基またはアルコキシ基が3位に結合し且つ水素原子、アルキル基、ハロゲノ基、アルコキシ基若しくはシアノ基が4位、5位および6位にそれぞれ独立に結合しているベンズアルデヒドを製造する方法が提供される。 | ||||||
| 78 | ベンジル化合物 | JP2016574023 | 2016-08-25 | JP6116782B1 | 2017-04-19 | 矢野 真也; 若杉 裕樹; 岩永 陽介 |
| 官能基を保護した化合物の有機溶媒への溶解性を向上させることで、反応後の分離、精製を固体化又は不溶化することなく容易ならしめる保護基を提供する。 一般式(1) で表されるベンジル化合物。 |
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| 79 | 保護基が結合した水酸基の脱保護方法 | JP2013511035 | 2012-04-19 | JP6060898B2 | 2017-01-18 | 石橋 雄一郎; 松村 靖 |
| 80 | シクロアルカンジカルボン酸モノエステルの製造方法 | JP2010266202 | 2010-11-30 | JP5696452B2 | 2015-04-08 | 大川 春樹 |
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