| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | Hydroxide group protection agent, and hydroxide group protection method | JP2012252453 | 2012-11-16 | JP2013126976A | 2013-06-27 | KUNISHIMA MUNETAKA; FUJITA HIKARI; YAMADA KOHEI |
| PROBLEM TO BE SOLVED: To provide an inexpensive hydroxide group protection agent being stable and easily usable and exhibiting no carcinogenicity and lachrymatory properties, and to provide a hydroxide group protection method capable of protecting a hydroxide group under an acidic condition.SOLUTION: The hydroxide group protection agent is a nitrogen-containing electron-attracting heterocycle bonded with at least one protection group through an oxygen atom, a sulfur atom or a nitrogen atom. The heterocycle is, for example, a triazine ring, and the protection group is, for example, a benzyl group. The hydroxide group protection agent is specifically 2,4,6-tribenzyloxy-1,3,5-triazine, 2,4,6-tris(4-methoxybenzyloxy)-1,3,5-triazine and the like. 2,4,6-tris(t-butoxy)-1,3,5-triazine and the like are additionally usable. In hydroxide group protection, a hydroxide group protection agent is reacted with an object compound having a hydroxide group under an acidic condition. | ||||||
| 122 | ジベンゾフルベンの除去方法 | JP2010523889 | 2009-08-06 | JPWO2010016551A1 | 2012-01-26 | 祐二 西内; 皓俊 木村 |
| Fmoc基で保護されたアミノ酸化合物を窒素原子が少なくとも一つの水素原子を有するアミン化合物と反応させることにより脱保護して得られる、ジベンゾフルベンアミン付加体を含む反応混合物を、二酸化炭素と接触させ、ジベンゾフルベンアミン付加体の炭酸塩を除去することにより、ジベンゾフルベンアミン付加体を除去する。またはFmoc基で保護されたアミノ酸化合物の脱保護反応中または反応後の反応混合物に、窒素原子が少なくとも一つの水素原子を有するアミン化合物を混合してジベンゾフルベンアミン付加体を含む混合物を得、該混合物を二酸化炭素と接触させ、ジベンゾフルベンアミン付加体の炭酸塩を除去することにより、ジベンゾフルベンアミン付加体を除去する。 | ||||||
| 123 | Production method of cycloalkanedicarboxylic acid monoesters | JP2010266202 | 2010-11-30 | JP2011231098A | 2011-11-17 | OKAWA HARUKI |
| PROBLEM TO BE SOLVED: To provide a production method of cycloalkanedicarboxylic acid monoester with high yield.SOLUTION: The production method of cycloalkanedicarboxylic acid monoesters includes: a first step of blocking two carboxyl groups contained in a compound represented by general formula (1-A) with groups represented by Z to obtain a compound represented by general formula (2-A); and a second step of subjecting either one of the groups represented by Z contained in the compound represented by the formula (2-A) obtained in the first step to deblocking with an acid to obtain a compound represented by general formula (3-A). In the general formulas, m denotes an integer of 0 to 3, Z denotes a group eliminated with an acid, and p denotes 0 or 1. | ||||||
| 124 | Solvent-free synthesis of amphiphilic polymer material | JP2010529373 | 2008-10-15 | JP2011500908A | 2011-01-06 | コスグローブ，テレンス; ハサン，エロール; ペットマン，ロジャー |
| 本発明は、直鎖または分岐鎖炭素−炭素幹と、前記幹に結合した複数の側鎖とを含む両親媒性ポリマー材料を含む組成物の製造方法であって、前記方法において、アシル化基を含む幹前駆体を、少なくとも一つの末端に求核基を含む側鎖前駆体と混合して、反応混合物を形成し；前記幹前駆体、側鎖前駆体及び／または反応混合物を加熱し；前記反応混合物を攪拌し；及び前記求核基はアシル化基と反応して、両親媒性ポリマー材料を形成し、ここで前記側鎖はアシル結合を介して幹に結合し；前記反応混合物は有機溶媒を含まないことを特徴とする前記製造方法を提供する。
【選択図】なし |
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| 125 | (R) -1- production method of (aryloxy) propane-2-ol | JP2001578384 | 2001-04-20 | JP2003531184A | 2003-10-21 | ジェイ・フランシス・ラロウ |
| (57)【要約】 広範に使用される抗生物質レボフロキサシンの合成において有用な中間体である（Ｒ）−１−（２,３−ジフルオロ−６−ニトロフェノキシ）プロパン−２−オールを製造する方法が提供される。 （Ｒ）−１−（２,３−ジフルオロ−６−ニトロフェノキシ）−２−トリメチルシロキシプロパンを製造する方法もまた記載されている。 この方法は、光学的活性のあるＣｏ（サレン）触媒の存在で２,３−ジフルオロ−６−ニトロフェニルトリメチルシリルエーテルによる開環を含む。 反応体のトリメチルシリル基は、生成物のアリールオキシアルコールに転換され、これは第２級アルコールをその場で保護するのに役立つ。 単離に際してトリメチルシリル基が除去され、そして得られるレジオアイソマー混合物が精製されて所望の（Ｒ）−１−（２,３−ジフルオロ−６−ニトロフェノキシ）プロパン−２−オールが高純度および収率で得られる。 | ||||||
| 126 | New single functional method of phenolic hydroxy of specific sites in the polyphenol | JP35306991 | 1991-12-18 | JP3051538B2 | 2000-06-12 | ジャンルイ・ブレイエ; ダニエル・カルボ; フランソワ・オテロ |
| 127 | PROTECTING-GROUP INTRODUCING AGENT FOR HYDROXY GROUP AND/OR MERCAPTO GROUP | EP15848889 | 2015-09-30 | EP3205639A4 | 2018-03-21 | TORIKAI KOHEI |
| A novel agent for introducing a protecting group for a hydroxy group and/or a mercapto group that can be introduced and removed under mild conditions is provided. The agent for introducing a protecting group for a hydroxy group and/or mercapto group of a substrate compound having the hydroxy group and/or mercapto group is represented by the following formula (I), wherein A represents a ring structure having 1 to 5 rings in which two carbon atoms of an adjacent benzene ring are included, the ring structure comprises a substituted or unsubstituted five-membered ring or six-membered ring and optionally include a heterocycle; each of R 1 , R 2 , R 3 , and R 4 is independently a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms; and X is a halogen atom or OSO 2 R 5 (R 5 = an aryl group or an alkyl group) . | ||||||
| 128 | METHOD FOR PRODUCING 2-AMINO-SUBSTITUTED BENZALDEHYDE COMPOUND | EP15837423.1 | 2015-08-25 | EP3196189A1 | 2017-07-26 | KOBAYASHI, Shinichi |
The present invention provides a method for producing a benzaldehyde in which an amino group is bonded in the 2 position, a halogeno group or an alkoxy group is bonded in the 3 position, and a hydrogen atom, an alkyl group, a halogeno group, an alkoxy group, or a cyano group is bonded independently in each of the 4, 5, and 6 positions, the method including: preparing a benzaldehyde in which a halogeno group or an alkoxy group is bonded in the 3 position, a hydrogen atom is bonded in the 2 position, and a hydrogen atom, an alkyl group, a halogeno group, an alkoxy group, or a cyano group is bonded independently in each of the 4, 5, and 6 positions so that a lithiation reaction is most active at the 2 position; acetal-protecting a formyl group in the benzaldehyde; sequentially performing lithiation, azidation, and amination of the 2 position; and the performing acetal deportection. |
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| 129 | METHOD FOR PRODUCING DIPEPTIDE DERIVATIVE CONTAINING DISUBSTITUTED AMINO ACID RESIDUE | EP14841691 | 2014-08-20 | EP3042911A4 | 2017-04-26 | MATSUYAMA KEISUKE; KODAMA KAZUYA |
| 130 | METHOD FOR PRODUCING DIPEPTIDE DERIVATIVE CONTAINING DISUBSTITUTED AMINO ACID RESIDUE | EP14841691.0 | 2014-08-20 | EP3042911A1 | 2016-07-13 | MATSUYAMA Keisuke; KODAMA Kazuya |
A method for producing a dipeptide that has a protected N-terminal and is represented by formula (1) or a salt of the dipeptide, said method comprising condensing an α-monosubstituted amino acid that has a protected N-terminal and is represented by formula (2) or glycine or a salt thereof with a disubstituted amino acid that is represented by formula (3) or a salt thereof in the presence of a condensing agent [in each of the formulae, substituents are as defined in the description or the like].
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| 131 | PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE 4-HYDROXY-1,2,3,4 -TETRAHYDROQUINOLINES | EP06811176.4 | 2006-10-04 | EP1964925B1 | 2016-03-30 | OKAMOTO, Masaki c/o Mitsubishi Tanabe Pharma Corporation; SAKURAGI, Akira c/o Mitsubishi Tanabe Pharma Corporation; KISHIDA, Muneki c/o Mitsubishi Tanabe Pharma Corporation; MORI, Yoshikazu c/o Mitsubishi Tanabe Pharma Corporation |
| 132 | NOVEL CYCLIC DEPSIPEPTIDE DERIVATIVE AND PEST CONTROL AGENT COMPRISING SAME | EP13804000 | 2013-06-13 | EP2862872A4 | 2015-10-28 | MITOMI MASAAKI; SAKAI MASAYO; HORIKOSHI RYO; ONOZAKI YASUMICHI; NAKAMURA SATOSHI; OMURA SATOSHI; SUNAZUKA TOSHIAKI; HIROSE TOMOYASU; SHIOMI KAZURO; MASUMA ROKURO |
| An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them. | ||||||
| 133 | METHOD FOR PROTECTING HYDROXYL, AMINE OR THIOL FUNCTIONAL GROUPS WITH TETRAISOPROPYDISILANE AND THE CORRESPONDING PROTECTED COMPOUNDS | EP13727662.2 | 2013-04-23 | EP2841401A1 | 2015-03-04 | MARKIEWICZ, Wojciech, Tadeusz; CHMIELEWSKI, Marcin Krzysztof; MUSIAL, Sylwia Maria; MACIEJEWSKI, Hieronim Franciszek; HRECZYCHO, Grzegorz |
| A novel method of simultaneously protecting two functions which are same or different, namely hydroxyl, amine, or thiol ones, particularly in sugars, polyalcohols, nucleosides, nucleotides, peptides, and nucleic acids during an organic synthesis, and to novel compounds for implementing this method, as well as to the method of obtaining these compounds. Method of simultaneously protecting two hydroxyl, amine, or thiol functions according to the invention by carrying out a protecting reaction between a compound having at least two free hydroxyl, amine, or thiol groups, and the disilane of formula 1, where R stands for Cl or Br, or I, or a substituent of formula 2, where X1, X2, X3, X4 are the same or different. | ||||||
| 134 | PROCESS FOR PREPARATION OF CYCLOALKANEDICARBOXYLIC ACID MONOESTERS | EP10834588 | 2010-11-25 | EP2508504A4 | 2014-08-27 | OKAWA HARUKI |
| 135 | PROCESSES FOR REMOVING DIBENZOFULVENE | EP09805034.7 | 2009-08-06 | EP2322498B1 | 2014-04-16 | NISHIUCHI, Yuji; KIMURA, Terutoshi |
| 136 | PROCESSES FOR REMOVING DIBENZOFULVENE | EP09805034 | 2009-08-06 | EP2322498A4 | 2013-03-20 | NISHIUCHI YUJI; KIMURA TERUTOSHI |
| 137 | METHOD OF PRODUCING OPTICALLY ACTIVE AMINO ACID DERIVATIVE | EP09758313 | 2009-06-02 | EP2298729A4 | 2012-12-19 | YAMAMOTO SHOHEI; FUJII AKIO; MITSUDA MASARU |
| 138 | PROCESS FOR PREPARATION OF CYCLOALKANEDICARBOXYLIC ACID MONOESTERS | EP10834588.5 | 2010-11-25 | EP2508504A1 | 2012-10-10 | OKAWA, Haruki |
A process for preparation of cycloalkanedicarboxylic acid monoesters which is characterized by comprising: a first step of protecting two carboxyl groups (-COOH) of a compound represented by formula (1-A) with a group represented by Z to obtain a compound represented by formula (2-A), and a second step of deprotecting either of the groups represented by Z of the compound represented by formula (2-A) obtained in the first step with an acid to obtain a compound represented by formula (3-A).
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| 139 | METHOD OF PRODUCING OPTICALLY ACTIVE AMINO ACID DERIVATIVE | EP09758313.2 | 2009-06-02 | EP2298729A1 | 2011-03-23 | YAMAMOTO, Shohei; FUJII, Akio; MITSUDA, Masaru |
The present application relates to a method for producing an optically active α-amino acid derivative, comprising steps of reacting an α-haloester derivative represented by the general formula (1):
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| 140 | Norbornylsubstituierte Silane und deren Verwendung zum Schützen funktioneller Gruppen organischer Verbindungen | EP02021272.6 | 2002-09-19 | EP1298134B1 | 2003-09-17 | Heldmann, Dieter, Dr.; Schäfer, Oliver, Dr.; Stohrer, Jürgen, Dr. |
