| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | 구리를 촉매로 한 탄소-헤테로원자 결합 및 탄소-탄소결합 형성방법 | KR1020057001925 | 2003-07-31 | KR1020050032107A | 2005-04-06 | 부쉬왈드,스테판,엘.; 클라파스,아티스; 콩,훅,와이.; 스트레이터,에릭; 자논,쟈코포 |
| One aspect of the present invention relates to copper-catalyzed carbon- heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-sulfur bond between the sulfur atom of a thiol moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper(II)-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-carbon bond between the carbon atom of cyanide ion and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In another embodiment, the present invention relates to a copper-catalyzed method of transforming and aryl, heteroaryl, or vinyl iodide. Yet another embodiment of the present invention relates to a tandem method, which may be practiced in a single reaction vessel, wherein the first step of the method involves the copper-catalyzed formation of an aryl, heteroaryl, or vinyl iodide from the corresponding aryl, heteroaryl, or vinyl chloride or bromide; and the second step of the method involves the copper-catalyzed formation of an aryl, heteroaryl, or vinyl nitrile, amide or sulfide from the aryl, heteroaryl, or vinyl iodide formed in the first step. | ||||||
| 162 | 2-할로벤조산의 제조 방법 | KR1020027014334 | 2001-04-27 | KR1020030001450A | 2003-01-06 | 고다마히로끼; 가쯔히라다께시; 니시다다떼끼; 히노도모까즈; 쯔바따겐지 |
| 본 발명은 Pd 촉매의 존재 하에서, 화학식 Ⅱ의 벤조산을 할로겐화제와 반응시키는 것을 특징으로 하는, 화학식 Ⅰ의 2-할로벤조산의 제조 방법을 제공한다: (식 중, A는 -OH, -OM (M은 알칼리금속이다), -N(R 6 )R 7 (R 6 및 R 7 은 각각 H, C 1 -C 6 알킬, 임의 치환 페닐 등이다)이고; R은 H, C 1 -C 6 알킬, C 1 -C 6 알킬카르보닐, 카르복실, C 1 -C 12 알콕시카르보닐, 임의 치환 페닐카르보닐 등이고; n은 0 내지 4이고; X는 Cl, Br 또는 I이거나, 대안적으로 (R)n은 서로 인접한, 벤젠-구성 탄소 원자 상에 존재할 수 있고, C 3 -C 4 알킬렌- 또는 C 3 -C 4 알케닐렌-축합 고리를 형성할 수 있다). | ||||||
| 163 | 할로겐화제 및 수산기의 할로겐화 방법 | KR1019997009323 | 1998-12-10 | KR100317425B1 | 2001-12-22 | 스즈키다이스케; 기쿠치료; 야스이마사루 |
| 화학식 1로표시되는할로겐화제및 수산기의할로겐화방법. (화학식 1) (식중, R및 R는동일또는상이하며, 에틸, 프로필, 이소프로필, 부틸, 이소부틸또는알릴을표시한다. X는염소원자또는브롬원자를표시한다. Y는염소이온, 브롬이온, 디클로로포스페이트이온, 디브로모포스페이트이온, 클로로술포네이트이온, 브로모술포네이트이온, 클로로옥살레이트이온또는브로모옥살레이트이온을표시한다.) | ||||||
| 164 | 친전자성 방향족 화합물 치환 방법 | KR1020007003738 | 1998-10-08 | KR1020010030976A | 2001-04-16 | 어웬슨아릴; 이차크데이비드; 프리버그버그스타인미리암; 슈샨애셔; 크로이토루베르타; 베네쉬데이비드; 파자나임 |
| 본발명은방향족화합물, 원하는치환체의전구체및 할로겐화아연을함유하는수성시약을승온에서접촉시키는것을포함하여, 방향족화합물을친전자성치환시키는방법에관한것이다. | ||||||
| 165 | 할로겐-불소 교환 반응용 아미도포스포늄 염 함유 촉매 | KR1019997006623 | 1998-01-22 | KR1020000070390A | 2000-11-25 | 파세녹세르게이; 아펠볼프강; 피르만랄프; 베쎌토마스; 샤흐토마스; 슈베르트한스 |
| 본발명은하나이상의화합물 a)와화합물 b), c) 및/또는 d)중의하나이상과의혼합물로필수적으로이루어진방향족화합물의할로겐-불소교환반응을위한촉매에관한것이다. 화합물 (a)는화학식Ⅰ의아미도포스포늄염이고, 화합물 (b)는 4급암모늄염이고, 화합물 (c)는 4급포스포늄염이고, 화합물 (d)는화학식Ⅳ의크라운에테르또는폴리에테르이다. 화학식Ⅰ 화학식Ⅳ 상기식에서, A, A, A, A, A, A, A및 A은동일하거나상이하고, 각각탄소수 1 내지 12의직쇄또는측쇄알킬또는알케닐, 탄소수 4 내지 8의사이클로알킬, 탄소수 6 내지 12의아릴, 탄소수 7 내지 12의아르알킬이거나, AA, AA, AA및 AA은독립적으로동일하거나상이하고직접또는 O 또는 N-R를통해서로결합되어 3 내지 7원환을형성하고, A는탄소수 1 내지 4의알킬이고, B는 1가산 음이온또는동량의다가산 음이온이고, R및 R은동일하거나상이하고각각탄소수 1 내지 16, 바람직하게는 1 내지 8의직쇄또는측쇄알킬라디칼이고, x는 2 내지 6, 바람직하게는 2 또는 3의정수이고, r은 0 내지 20, 바람직하게는 1 내지 18, 특히 4 내지 14의수이다. | ||||||
| 166 | 방향족 염화물의 파라-이성체 제조용 촉매 | KR1019950044527 | 1995-11-24 | KR100188339B1 | 1999-06-01 | 박상언; 유중환; 이풍만 |
| 본 발명은 염소화 반응 수율과 파라선택성이 우수한 방향족 화합물의 액상 염소화 반응용 촉매를 얻기 위한 것으로 알칼리금속으로 이온교환된 제올라이트 L에 전이금속염, 희토류금속염 또는 이들 금속염의 혼합물과 알칼리금속 또는 알칼리토금속염화물을 고상반응법 또는 함침법에 의하여 담지시킨 방향족 화합물의 파라선택성 액상 염소화 반응용 촉매 및 이를 이용하여 방향족 염화물의 파라-이성체를 제조하는 방법에 관한 것이며 이러한 촉매에 의하여 기존의 제올라이트 L에 전이금속염, 희토류금속염, 알칼리금속염 또는 알칼리토금속염이 첨가된 촉매에 비하여 높은 염소화반응 수율과 파라선택성이 우수한 결과를 얻었다. | ||||||
| 167 | 플루오로벤젠 및 플루오로피리딘 화합물의 제조 방법 | KR1019870008670 | 1987-08-07 | KR1019950014596B1 | 1995-12-11 | 미카엘스코트호워쓰; 데이비드미카엘톰킨슨 |
| 내용 없음. | ||||||
| 168 | SUBSTITUTED PHENYLSULFUR TRIFLUORIDE AND OTHER LIKE FLUORINATING AGENTS | PCT/US2007074359 | 2007-07-25 | WO2008014345A3 | 2008-07-03 | UMEMOTO TERUO; SINGH RAJENDRA P |
| Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided. | ||||||
| 169 | CATALYST COMPOSITION AND METHOD FOR HALOGENATING AROMATIC COMPOUNDS | PCT/US2005020787 | 2005-06-13 | WO2006009661A3 | 2006-11-02 | GANESAN BALAKRISHNAN; NADKARNI PRADEEP JEEVAJI |
| A method for ring-halogenating an aromatic compound comprises contacting with chlorine or bromine, a mixture comprising the aromatic compound and a mixed copper salt of formula Cu(Y)X, where Y comprises a counterion derived from an organic acid, where the organic acid has a pKa relative to water of 0 or greater; and X comprises Cl, Br, I, or (SO4 2- | ||||||
| 170 | FLUORODENITROGENATION METHOD | PCT/FR2004003241 | 2004-12-15 | WO2005061417A3 | 2005-11-17 | SAINT-JALMES LAURENT; VIDAL THIERRY |
| The invention relates to a fluorodenitrogenation method which aims to eliminate nitrogen from carbon-nitrogen multiple bonds. The inventive method consists in subjecting a substrate bearing said carbon-nitrogen multiple bond to the action of a reagent comprising a compound that can form a precursor of nitrosonium (NO<+>) and comprising hydrofluoric acid or one of the acid complexes thereof. The invention also relates to the applications of said method for functionalisation into fluoromethyl or difluoromethyl groups. | ||||||
| 171 | FLUORIDATION OF ELECTRON RICH AROMATIC SYSTEMS | PCT/GB2004003621 | 2004-08-24 | WO2005021472A3 | 2005-04-21 | WIDDOWSON DAVID ARTHUR; CARROLL MICHAEL ANDREW; PIKE VICTOR WILLIAM |
| The present invention provides a process for the fluoridation of the electron rich aryl group (A) in a diaryliodium salt of formula (I). The process comprises contacting a compound of formula (I) with a source of fluoride, wherein in the diaryliodium salt (1), the ring (B) is more electronegative than the ring (A). | ||||||
| 172 | A METHOD FOR PREPARING ORGANIC FLUOROCOMPOUNDS | PCT/KR0300489 | 2003-03-13 | WO03076366A2 | 2003-09-18 | CHI DAE YOON; KIM DONG WOOK |
| The present invention relates to a method for preparing organic fluorocompounds, more particluraly to a method for preparing organic fluorocompounds by means of reaction of alkyl halide or alkyl sulfonate with fluoro salt in the presence of imidazolium salt as a solvent or mixture solvent of imidazolium salt and oragnic solvent. Such a method reduces the reaction time and improves the yield considerably by being accomplished under a mild reaction condition, such that the organic fluorocompounds can be prepared in an economic manner. | ||||||
| 173 | SYNTHESIS OF (DIBROMOCYCLOBUTA) AROMATIC COMPOUNDS | PCT/US0218251 | 2002-06-12 | WO02102810A2 | 2002-12-27 | STANGER AMNON |
| A method for the synthesis of cyclobuta aromatic compounds by cyclizing two ortho dibromoalkyl substituents is described. Using a mediator, such as nickel metal, and continuous removal of product from contact with the mediator, high product yields are achieved. A method for bromination of ortho alkyl substituents of aromatic compounds is also described. | ||||||
| 174 | PROCESS FOR PREPARING SUBSTITUTED ORGANIC COMPOUNDS AND METHOD OF USING A CATALYST FOR SUBSTITUTION REACTION | PCT/EP0114871 | 2001-12-17 | WO0249992A2 | 2002-06-27 | KUEHLEIN KLAUS; WASSERSCHEID PETER |
| Disclosed is a process for exchanging substituents, for example chlorine by fluorine, in organic compounds. The process encompasses the application of a compound of Formula (IV) as a catalyst, wherein the R's independently of one another are aliphatic, cycloaliphatic, aromatic or araliphatic groups, A |
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| 175 | PREPARATION OF SELECTIVELY FLUORINATED ORGANIC COMPOUNDS | PCT/GB0003976 | 2000-10-16 | WO0128959A8 | 2001-09-27 | CHAMBERS RICHARD DICKINSON; PARSONS MANDY; SANDFORD GRAHAM |
| The present invention provides a method of selectively fluorinating a carbon-hydrogen bond at an unactivated saturated sp<3> hybridised carbon atom of an organic compound, the method including reacting the organic compound with elemental fluorine gas, characterised in that the reaction is carried out in the presence of a basic compound. The method enables the selective transformation of carbon-hydrogen bonds to carbon-fluorine bonds in molecules where the hydrogen atom is attached to a fully saturated unactivated sp<3> hybridised carbon atom such as a tertiary carbon atom found in many saturated hydrocarbon compounds and steroid derivatives. Advantageously, the method may be carried out at or just below room temperature. | ||||||
| 176 | SYSTEMS AND METHODS FOR COMBINATORIAL ORGANIC SYNTHESIS OF ARRAYS OF REACTION | PCT/US9822193 | 1998-10-21 | WO9920395A9 | 1999-08-05 | BERNSTEIN DANIEL M; WRIGHT PETER; MILLER STEVE; KILCOIN CHRISTOPHER; WASSON JAMES; HUGHES JAN; BRENNAN-MARQUEZ THOMAS; KYRIE DOMINIC |
| The present system is useful for the synthesis of chemical compounds and can be used for solid state or liquid chemistries. In one embodiment, the system (10) includes a reagent delivery/vent unit (20) and a chemical processing unit (30) containing a plurality of reaction vessels (50). The reagent delivery/vent unit has a plurality of tubular structures (100) adapted to slidably engage cavities (104) in the chemical processing unit to form a circumferential seal about each of the tubular structures. The delivery/vent unit typically uses a fluid interface head containing the tubular structures to engage the chemical processing unit. The chemical processing unit preferably uses a cassette (110) to house all of the reaction vessels and defines the plurality of elongate cavities adapted to receive the tubular structures. | ||||||
| 177 | METHOD FOR PRODUCING AROMATIC BROMOMETHYL BIPHENYL COMPOUNDS | PCT/EP9808483 | 1998-12-28 | WO9933788A2 | 1999-07-08 | LEHMANN BERND |
| The invention relates to a method for producing aromatic bromomethyl biphenyl compounds of formula (II), wherein R is a carboxylic acid group, a cyanogen group, a carboxylic acid amide group, a carboxylic acid ester group or a tetrazolyl group which can be substituted, by reacting the corresponding methyl biphenyl compound with hydrogen bromide and hydrogen peroxide in the presence of a radical starter and/or light. The inventive method produces a greater yield of bromomethyl biphenyl compounds of formula (II) and with greater selectivity. Said method can also be used on a commercial scale and is characterised in that it is very environmentally friendly. | ||||||
| 178 | 플루오르화된 유기 화합물의 제조방법 | KR1020137030882 | 2012-05-29 | KR101649018B1 | 2016-08-17 | 뷔쟁느올리비에; 드쥬미샤엘 |
| 본발명은적어도하나의핵 배척이탈기 Nu를포함하는유기화합물 (I)로부터플루오르화된유기화합물 (II)을제조하는방법에관한것이다. 본방법은물의존재하에서유기화합물 (I) 및적어도하나의불화물음이온을제공하는적어도하나의염의반응; 및화합물 (I)의적어도하나의핵 배척이탈기 Nu를불소원자로대체하여, 플루오르화된유기화합물 (II)를얻는단계를포함한다. 본발명은또한상이한특정유기화합물, 특히플루오로-메틸피라졸화합물의제조에관한것이다. | ||||||
| 179 | 산화적 탈수소화 단위를 함유하는 콤플렉스 | KR1020157025058 | 2014-01-24 | KR1020150128720A | 2015-11-18 | 시만젠코브,바실리; 쿠스토브,레오니드모데스토비치; 쿠체로브,알렉세이빅토로비치; 피나시나,엘레나드미트리브나; 가오,지아오리앙; 포이,에드워드크리스토퍼; 에니스,클레어지닌 |
| 파라핀을올레핀으로산화적탈수소화(ODH)하기위한화학콤플렉스및 방법이개시된다. 이화학콤플렉스는증기분해기, C분리기및 아세틸렌을제거하는수소화단위를함유하며, 산화적탈수소화단위는 C분리기또는아세틸렌을제거하는수소화단위와통합된다. 산화적탈수소화공정은종래의증기분해기의후미분리공정들에통합되어역량을증가시키고(또는) 올레핀을생산하는저 에너지경로를제공하여비용을감소시킬수 있다. 산화적탈수소화공정은중합공정및 글리콜, 카르복시산및 에스테르의제조와같은화학플랜트의다수의공정들과통합될수 있다. | ||||||
| 180 | 3,5-디치환된-2,4,6-트리요오도 아로마틱 아민 화합물의 제조를 위한 요오드화 방법 | KR1020147014693 | 2011-10-31 | KR1020140100945A | 2014-08-18 | 후쯔치; 씽홍덩; 리레이 |
| 본 발명은 화학식 (II)의 3,5-디치환된-2,4,6-트리요오도 아로마틱 아민의 개선된 제조방법을 개시하며, 식 중 R
1 및 R
2 는 명세서에서 정의된다. 상기 화학식 (II)의 화합물은 이오파미돌, 이오헥솔 및 이오딕산올과 같은 비-이온성 조영제류의 합성을 위한 핵심 중간체이다. 상기 제조방법은 무-염소 요오드화 시약을 3,5-디치환된-2,4,6-트리요오도 아로마틱 아민과 반응시켜 화학식 (II)의 3,5-디치환된-2,4,6-트리요오도 아로마틱 아민을 얻는 것을 포함하며, 여기서 상기 요오드화 반응의 몰 수율은 89%에 도달될 수 있다.
|
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