| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | SYSTEM SUITABLE FOR HIGH THROUGHPUT EXPERIMENTATION | EP02750927.2 | 2002-05-13 | EP1392428B1 | 2012-11-07 | VAN DEN BRINK, Peter, John; BRACHT, Maarten; HARJI, Bashir, Husein |
| 102 | SYSTEME POUR LA DETECTION DE COMPLEXES D'HYBRIDATION DE SONDES AVEC DES LIGANDS SPECIFIQUES | EP10723717.4 | 2010-04-21 | EP2422190A1 | 2012-02-29 | BONNET, Jacques, Jean, René; GUASCH, Cathy |
| The invention relates to a system for detecting hybridization complexes between (i) probes immobilized on a substrate and (ii) and ligand molecules specifically hybridizing with said probes, said system being described in detail in the description. | ||||||
| 103 | MICROFLUIDIC SELECTION OF LIBRARY ELEMENTS | EP09766300.9 | 2009-06-19 | EP2296814A1 | 2011-03-23 | DELAMARCHE, Emmanuel; LOVCHIK, Robert; SOLIS, Daniel J. |
| Disclosed herein is a system comprising a chip; a flow channel disposed in the chip; the flow channel being in communication with an entry port and an exit port; the flow channel being operative to permit the flow of a library from the entry port to the exit port; a substrate; the substrate being disposed upon the chip; the substrate being operative to act as an upper wall for the flow channel; and a receptor; the receptor being disposed on the substrate; the receptor being operative to interact with a component from the library. | ||||||
| 104 | HIGH PRESSURE PARALLEL FIXED BED REACTOR AND METHOD | EP07854450.9 | 2007-10-26 | EP2104755A2 | 2009-09-30 | BERGH, H., Sam; WELLS, Jason; WONG, Victor; GALLIPEO, John; VAN ERDEN, Lynn; VOLPE, Anthony, F.; MAAG, Jeffrey |
| The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of reactor vessels for containing individual library members, a fluid handling system that apportions a test fluid about equally between each of the vessels and a housing for enclosing the reactor vessels, the housing defining a pressure chamber, wherein the housing is configured to sustain a pressure substantially above atmospheric pressure. This allows for simultaneous screening of library members at high pressure by providing a small pressure differential on reactor components. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants. | ||||||
| 105 | AUTOMATED FISH ANALYSIS, CIRCULATING MICROFLUIDIC CHIP, AND METHOD FOR IMMOBILIZING CELLS TO A MICROFLUIDIC CHIP | EP07815835.9 | 2007-09-17 | EP2082035A1 | 2009-07-29 | PILARSKI, Linda; BACKHOUSE, Christopher; SIEBEN, Vincent, J.; DEBES-MARUN, Carina, S.; PILARSKI, Patrick, M.; KAIGALA, Govind, V. |
| The present invention provides for a method of implementing fluorescent in situ hybridization (FISH) or other cellular analysis processes using intact cells within a microfluidic, chip-based, apparatus. The invention further provides for a method of cellular immobilization within a microfluidic device. Also provided is a method for automated analysis of FISH or other cellular analysis using discrete colormetric probes. | ||||||
| 106 | NANOWIRE SENSOR, NANOWIRE SENSOR ARRAY AND METHOD OF FABRICATING THE SAME | EP06784252.6 | 2006-08-11 | EP2049436A1 | 2009-04-22 | AGARWAL, Ajay; SINGH, Navab; KUMAR, Rakesh; LAO, Ieng Kin; BALASUBRAMANIAN, Narayanan |
| A method of fabricating a sensor comprising a nanowire on a support substrate with a first semiconductor layer arranged on the support substrate is disclosed. The method comprises forming a fin structure from the first semiconductor layer, the fin structure comprising at least two supporting portions and a fin portion arranged there between; oxidizing at least the fin portion of the fin structure thereby forming the nanowire being surrounded by a first layer of oxide; and forming an insulating layer above the supporting portions; wherein the supporting portions and the first insulating layer form a microfluidic channel. A nanowire sensor is also disclosed. The nanowire sensor comprises a support substrate, a semiconducting fin structure arranged on the support substrate, the fin structure comprising at least two semiconducting supporting portions and a nanowire arranged there between; and a first insulating layer on a contact surface of the supporting portions; wherein the supporting portions and the first insulating layer form a microfluidic channel. | ||||||
| 107 | Infrared spectroscopy and imaging of libraries | EP06004658.8 | 1997-10-07 | EP1669738A3 | 2007-12-12 | McFarland, Eric, W.; Archibald, William |
A method of characterizing materials comprising the steps of: providing a substrate; synthesizing an array of materials on said substrate; providing at least one reactant gas wherein said reactant gas is in contact with said array of materials; activating at least one of said materials on said array with a heating source; and periodically monitoring an infrared emission from said activated material with an infrared camera, wherein said infrared camera outputs a series of signals corresponding to an emission intensity varying with time of said activated material.
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| 108 | A conduit system for mass spectrometers and methods for rapid screening of libraries of different materials | EP02018112.9 | 1997-10-08 | EP1280185B1 | 2004-09-22 | Weinberg, W. Henry; McFarland, Eric W.; Cong, Peijun; Guan, Shenheng |
| 109 | SYSTEM SUITABLE FOR HIGH THROUGHPUT EXPERIMENTATION | EP02750927.2 | 2002-05-13 | EP1392428A1 | 2004-03-03 | VAN DEN BRINK, Peter, John; BRACHT, Maarten; HARJI, Bashir, Husein |
| A system for performing experiments, in particular for high throughput experimentation. The system comprises a tubular vessel allowing a flow of fluid through said vessel and an assembly for housing said vessel. The assembly comprises a base block having a first channel formed therein for removably housing the vessel, said first channel having first and second channel openings allowing introduction and/or discharge a fluid into and from said first channel. The assembly also comprises a cover element having a bottom surface being releasably attachable to the first face of the base block. A first sealing element is provided between the first face of the base block and the bottom surface of the cover element, the first sealing element surrounding the first channel opening completely, and thereby sealing gastight around said first channel opening between the cover element and the base block. The system further comprises a second sealing element located in the first channel, said second sealing element sealing gastight against the inside of the first channel and the outside of the vessel. | ||||||
| 110 | Beads | EP01130123.1 | 2001-12-18 | EP1217376A1 | 2002-06-26 | Nakao, Motonato, Hitachi Software Eng. Co.,Ltd.; Yamamoto, Kenji, Hitachi Software Eng. Co.,Ltd.; Ito, Toshiaki, Hitachi Software Eng. Co.,Ltd. |
Provided is a technology for increasing types of color separation in accordance with density gradients by refining the mode of setting gradients in the event of two-dimensional or three-dimensional color separation. A conventional color separation is conducted in a manner that dots indicating densities are defined in intersecting points of lines parallel to the X axis and the Y axis, respectively, in the case of two-dimensional color separation. In the case of three-dimensional color separation, dots indicating densities are defined in intersecting points of lines parallel to the XY axis, the YZ axis and the ZX axis, respectively. The present invention does not define the dots in the intersecting points of those parallel lines. Instead, the dots are configured to be shifted. An analysis based on the shifted configuration of the dots enables more secured separation than an analysis based on the conventional color separation, and resultantly the number of the dots can be increased in comparison with the conventional color separation provided that such analyses take place under the same degrees of precision. |
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| 111 | OPTICAL PROBES AND ASSAYS | EP00932098.7 | 2000-05-05 | EP1175508A1 | 2002-01-30 | POLLOK, Brian, A.; HAMMAN, Brian, D.; RODEMS, Steven, M.; MAKINGS, Lewis, R. |
| This invention provides an optical probe useful as an optical probe or sensor of post translational type modifications, such as phosphorylation. The invention comprises a polypeptide moiety, which contains a recognition motif for a post translational type activity, and a protease site, which is coupled to a probe moiety. Modification of the polypeptide, by the post translational type activity, results in a modulation of the rate at which a protease cleaves the polypeptide which is sensed by a measurable change in at least one optical property of the optical probe upon cleavage. The present invention also includes a recombinant nucleic acid molecule that encodes an optical probe and a vector and host cell or library of cells that include the recombinant nucleic acid molecule. The optical probe can be used in methods to determine whether a sample, including a cell or a sample from an organism, contains a post-translational type modification activity. Such methods can also be used to determine whether a test chemical modulates the activity of a modifying activity, and thus can be used to identify therapeutic compositions. The identification of such therapeutic compositions can be automated using a system that includes an optical probe. | ||||||
| 112 | SYSTEMS AND METHODS FOR CHARACTERIZATION OF MATERIALS AND COMBINATORIAL LIBRARIES WITH MECHANICAL OSCILLATORS | EP97945564 | 1997-10-08 | EP1021711A4 | 2000-07-26 | MCFARLAND ERIC; MATSIEV LEONID |
| Methods and apparatus for screening diverse arrays of materialsa nd for imaging a library of materials are provided using ultrasonic imaging techniques. Systems include tranducer lens (109) or mechanical resonator for exiting an element of library deposited onto a substrate (103) such that acoustic waves are propagated through, and from, the library element (101). The acoustic waves propagated from the element are detected and processed to yield a visual image of the library element; such acoustic wave data is processed to obtain information about various properties of the library elements (e.g. elasticity, molecular weight, viscosity, specific weight, dielectric properties, conductivity, etc.) of individual liquid elements. Acoustic waves are generated in an imaging tank filled with coupling liquid (107), with the library of materials then placed in the tank while the surface of the coupling liquid is scanned with a laser beam. The physical structure of the liquid surface distubed by these acoustic waves is recorded. | ||||||
| 113 | SYSTEMS AND METHODS FOR CHARACTERIZATION OF MATERIALS AND COMBINATORIAL LIBRARIES WITH MECHANICAL OSCILLATORS | EP97945564.9 | 1997-10-08 | EP1021711A2 | 2000-07-26 | MCFARLAND, Eric; MATSIEV, Leonid |
| Methods and apparatus for screening diverse arrays of materialsa nd for imaging a library of materials are provided using ultrasonic imaging techniques. Systems include tranducer lens (109) or mechanical resonator for exiting an element of library deposited onto a substrate (103) such that acoustic waves are propagated through, and from, the library element (101). The acoustic waves propagated from the element are detected and processed to yield a visual image of the library element; such acoustic wave data is processed to obtain information about various properties of the library elements (e.g. elasticity, molecular weight, viscosity, specific weight, dielectric properties, conductivity, etc.) of individual liquid elements. Acoustic waves are generated in an imaging tank filled with coupling liquid (107), with the library of materials then placed in the tank while the surface of the coupling liquid is scanned with a laser beam. The physical structure of the liquid surface distubed by these acoustic waves is recorded. | ||||||
| 114 | MASS SPECTROMETERS AND METHODS FOR RAPID SCREENING OF LIBRARIES OF DIFFERENT MATERIALS | EP97910017.9 | 1997-10-08 | EP1019947A2 | 2000-07-19 | WEINBERG, W., Henry; MCFARLAND, Eric, W.; CONG, Peijun; GUAN, Shenheng |
| Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques are provided for rapidly characterizing compounds in combinatorial arrays of materials for discovering and/or optimizing new materials with specific desired properties. According to one aspect, a scanning mass spectrometer is used which includes an ionization chamber and a collector that outputs an electrical signal responsive to the quantity of gas ions contacting the collector surface. A conduit system selectively withdraws samples from the array of materials, passing the samples into the ionization chamber. In a specific embodiment, reactants are passed through the conduit system to the selected regions of interest on the substrate. Means are provided to selectively heat regions on the substrate. | ||||||
| 115 | METHOD OF IDENTIFYING DROPLETS IN A STACK AND AN ASSOCIATED SEQUENCER | EP16179518.2 | 2016-07-14 | EP3269444A1 | 2018-01-17 | FRAYLING, Cameron Alexander; ISAAC, Thomas Henry |
Disclosed is a method of identifying the contents of individual droplets in a droplet stream each droplet containing fluorophores in an initial non-fluorescing state characterised by the steps of introducing the droplets one-by-one into at least one open-ended tube to create a stack of droplets therein; activating the fluorophores within the droplets to cause them to fluoresce; releasing each droplet in the droplet stack in turn from the tube and detecting along the major axis of the tube fluorescence associated with each droplet as it emerges. Also disclosed is a method suitable for sequencing a biopolymer characterised by the steps of (1) progressively digesting the biopolymer into an ordered stream of its constituent monomers; (2) converting the stream of monomers into a corresponding stream of monomer-containing aqueous droplets each droplet additionally containing a probe capable of (a) capturing the monomer and (b) thereafter being digested to release an unqueched fluorophore characteristic of the captured monomer; (3) introducing the stream of droplets created in step (2) into an inlet end of at least one open-ended tube to create a stack of droplets therein and (4) releasing each droplet in turn from an outlet end of the tube(s) and detecting fluorophores in each droplet as each droplet emerges. The method may be used in a corresponding apparatus for sequencing a biopolymer such as a nucleic acid or protein
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| 116 | AFFINITY REAGENT AND CATALYST DISCOVERY THOUGH FIBER-OPTIC ARRAY SCANNING TECHNOLOGY | EP15847665 | 2015-09-16 | EP3180465A4 | 2017-08-30 | COLLINS NATHAN; MADRID PETER |
| Devices, systems and methods for affinity reagent and catalyst discovery employing a library on a bead HTS platform, each bead comprising affixed non-natural polymers of a distinct bioactive monomer with sequence pre-defined branching and folding in tertiary structures, and fiber-optic array scanning technology. | ||||||
| 117 | PORTABLE NUCLEIC ACID ANALYSIS SYSTEM AND HIGH-PERFORMANCE MICROFLUIDIC ELECTROACTIVE POLYMER ACTUATORS | EP15780486.5 | 2015-04-14 | EP3132069A1 | 2017-02-22 | HUBER, David E. |
| Devices, systems and methods for the parallel detection of a set of distinct nucleic acid sequences use multiple sequence amplification and simultaneous hybridization readout. An automated nucleic acid analysis system comprises in microfluidic connection sample lysis, purification, PCR and detection modules configured to detect in parallel distinct nucleic acid sequences via multiple sequence amplification and simultaneous microarray hybridization readout. High performance microfluidic electroactive polymer (μEAP) actuators comprising a dead-end fluid chamber in which the floor of the chamber is an electrode covered with an EAP layer of dielectric elastomer are configured for particle sorting. | ||||||
| 118 | APPARATUR UND VERFAHREN ZUR UNTERSUCHUNG VON DISKONTINUIERLICHEN PRODUKTFLUIDSTRÖMEN BEI DER UMSETZUNG VON EDUKTFLUIDSTRÖMEN AN FESTSTOFFKATALYSATOREN | EP14781876.9 | 2014-10-08 | EP3055057A2 | 2016-08-17 | LANGE DE OLIVEIRA, Armin; BREM, Nadine; SOORHOLTZ, Mario; LIEBERKNECHT, Johannes |
| The invention relates to an apparatus and method for studying solid catalysts and processes in which there are discontinuous product fluid flows. The claimed apparatus, which is preferably designed for studying a plurality of catalysts in parallel, has at least one reaction chamber, with one or more fluid mixing chambers downstream of each reaction chamber. The outlet pipe of the fluid mixing chamber or the outlet pipe of a sequence of fluid mixing chambers is operatively connected to a throttle element (11), the throttle element (11) being operatively connected to an analysis device and to an outlet pipe, and the outlet pipe comprising a control device. The claimed method is characterised by a cyclic operating mode in which there is a controlled supply of at least one product fluid into the at least one fluid mixing chamber, the product fluid flow is mixed in the mixing chamber, and the at least one mixed product fluid flow is passed to the outlet pipe and the analysis device. A cycle lasts from 0.2 to 7200 seconds and can include multiple phases with different compositions. The method can include a plurality of cycles. | ||||||
| 119 | METHODS FOR MANUFACTURING MOLECULAR ARRAYS | EP12843117 | 2012-10-26 | EP2771450A4 | 2016-04-20 | ROUTENBERG DAVID A |
| The methods of the present invention provide methods for manufacturing a master substrate and methods for manufacturing replica arrays from the master substrate. The methods may be used, for example, directly to manufacture or “print” peptide arrays from a DNA array; however, the methods are applicable to a wide range of manufacturing applications for use any time multiple copies of an array needs to be printed. | ||||||
| 120 | THERMAL PHASE SEPARATION SIMULATOR | EP12716729.4 | 2012-02-17 | EP2675542B1 | 2014-11-19 | Hart, Paul, R.; Nuebling, Lee, E.; Cleary, Robert, R.; Little, Virgil, T.; Beetge, Jan, H. |
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