| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 81 | 바이오 칩 | KR1020110109183 | 2011-10-25 | KR1020130044863A | 2013-05-03 | 양정승; 구보성 |
| PURPOSE: A biochip is provided to precisely combine a first substrate and a second substrate. CONSTITUTION: A biochip comprises a first substrate(100) and a second substrate. The first substrate comprises a first lateral side(102) and a first groove(110). The second substrate has a first coupling column which is inserted into the first groove, and second coupling columns which contact the second lateral side(104) which faces the first lateral side. The first coupling column has a cone, a pyramid, a truncated cone, or a truncated corn shape. The second coupling columns have a cone, a pyramid, a truncated cone, or a truncated corn shape. The cross section of the first groove becomes narrower in a thickness direction of the first substrate. | ||||||
| 82 | 정십자형 자기비드 감지 어레이 소자 | KR1020080131572 | 2008-12-22 | KR101181697B1 | 2012-09-19 | 서정대; 정상돈; 정명애 |
| 고감도이며 고밀도의 자기바이오센서로 사용할 수 있는 다양한 형태의 구조를 갖는 정십자형 자기비드 감지 어레이 소자를 제시한다. 제시된 정십자형 자기비드 감지 어레이 소자는 인가전류방향에 수직으로 교차되는 수직방향의 출력전압을 측정할 수 있으므로, 기존의 인가전류방향에 평행한 방향의 출력전압을 측정하는 자기비드 감지소자에 비하여 고감도의 자기장변화를 측정할 수 있다. 그로 인해, 신호잡음비가 높은 자기비드 자기장 감지소자가 가능하다. 또한, 정십자형 자기비드 감지 어레이 소자는 수직방향의 전압을 측정하기 때문에 자기장을 외부에서 인가함이 없이 인가전류에 의해 발생하는 인가전류 유도자기장에 의하여 자기비드를 자화시킬 수 있다. 이 자화필드는 수직전압에 민감하게 영향을 주기 때문에 외부인가 자기장이 불필요한 간편한 자기바이오센서를 구현할 수 있게 된다. 그에 따라, 본 발명의 정십자형 자기비드 감지 어레이 소자를 이용하여 고밀도 및 고감도의 자기바이오센서의 제조가 가능하다. | ||||||
| 83 | Cell chip | KR20100132859 | 2010-12-22 | KR20120071216A | 2012-07-02 | SONG SUK HO; KU BO SUNG; JEONG SE HOON; LEE MOO YEAL; LEE DONG WOO |
| PURPOSE: A three dimensional cell chip is provided to resolve the problem of interactive contamination and to enhance the accuracy of tests. CONSTITUTION: A cell chip(10) comprises: an upper substrate(100) having a plurality of bio-matrices(120) separated by a spacer(110); a first hydrophobic coating layer(130) formed on the upper substrate; and a lower substrate(200) which are coupled to the upper substrate and a plurality of wells(210) containing fluid(F). The spacer is formed at the lower side of the upper substrate. The first hydrophobic coating layer covers the entire lower portion of the coating layer. The cell chip further comprises a hydrophilic coating layer formed at the inner wall of the wells. | ||||||
| 84 | 마이크로어레이 패키지 장치 및 이를 제조하는 방법 | KR1020100025874 | 2010-03-23 | KR1020110106684A | 2011-09-29 | 이우창; 심저영; 이묘용; 남궁각; 정원석 |
| 마이크로어레이 패키지 장치 및 이를 제조하는 방법이 개시된다. 구조적인 안정성 및 신뢰성 있는 실험 결과를 도출할 수 있는 마이크로어레이 패키지 장치를 이용하여 효율적으로 마이크로어레이 분석 반응을 수행할 수 있다.
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| 85 | 정십자형 자기비드 감지 어레이 소자 | KR1020080131572 | 2008-12-22 | KR1020100072998A | 2010-07-01 | 서정대; 정상돈; 정명애 |
| PURPOSE: A magnetic bead sensing array device of cross form which is useful as a magnetic biosensor is provided to measure output voltage of vertical direction and to manufacture magnetic biosensor of high density and high sensitivity. CONSTITUTION: A magnetic bead sensing array device of cross form comprises: a substrate(1); plural magnetic resistance devices(20) of cross form which is formed using thin film for detecting bio molecules; an electrode pad(26a, 26b, 26c) which is connected with plural magnetic devices and is formed on the substrate; a bio molecule fixing layer(33) for fixing bio molecules; a protection layer(30) formed on the upper portion of the magnetic resistance device and electrode pad; and a magnetic bead container layer(34) which surrounds the bio molecule fixing layer. The magnetic bead container layer is formed using photosensitive thin film. | ||||||
| 86 | DIAGNOSTIC AND TREATMENT METHODS USING A LIGAND LIBRARY | EP12760047.6 | 2012-03-23 | EP2689053B1 | 2018-11-14 | MOOLA, Muralidhar, Reddy; SCHILKE, Jessica |
| The present invention is useful in screening for biomarkers associated with any other disease or condition. Such diseases and conditions range from the neurological diseases, autoimmune diseases and cancers identified above as well as any other disease or condition that has a biomarker such as an antibody or other characterizing protein or biomolecule associated with the disease or progression of the disease. The large ligand libraries of the invention can be used directly in biological fluid, under the appropriate experimental conditions and according to the processes recited herein, to screen for such markers and without the need to use fewer support members (e.g. about 100,000 or less) or without the need to transfer such peptoids or ligands to a microarray before screening the biological fluid. In addition, the ligand libraries may also be used to screen for cell based receptors that specifically relate to a particular cell surface marker. | ||||||
| 87 | BIOCHIP PILLAR STRUCTURE | EP16873410.1 | 2016-12-12 | EP3388150A1 | 2018-10-17 | LEE, Don Jung; SONG, Ho Jeong; LEE, Dong Woo |
Technology for a biochip pillar structure is disclosed. According to an embodiment of the present disclosure, the biochip pillar structure includes: a pillar structure including a plate-shaped first substrate portion, and pillar portions protruding from a surface of the first substrate portion; and a well structure including a plate-shaped second substrate portion, and well portions formed in a surface of the second substrate portion and having a predetermined depth to respectively receive the pillar portions of the pillar structure, wherein the well portions have a diameter within a range of 800 µm to 1500 µm, and the pillar portions configured to be inserted into the well portions have a diameter of which the ratio to the diameter of the well portions ranges from 0.3 to 0.58, thereby providing a high-density biochip and preventing bubbling in an aqueous liquid contained in the well portions when the pillar portions are inserted. |
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| 88 | METHODS FOR SAMPLING FROM NON-ATMOSPHERIC VESSELS IN A PARALLEL REACTOR SYSTEM | EP13771285.7 | 2013-09-18 | EP2992335B1 | 2018-04-18 | LAMBERT, Stephen; VARNI, John F.; HSIAO, Gregor |
| Methods for sampling reactor contents in parallel reactor systems are disclosed. The methods may be used to sample reactor contents in non-atmospheric (e.g., pressurized) reaction vessels. | ||||||
| 89 | PORTABLE NUCLEIC ACID ANALYSIS SYSTEM AND HIGH-PERFORMANCE MICROFLUIDIC ELECTROACTIVE POLYMER ACTUATORS | EP15780486 | 2015-04-14 | EP3132069A4 | 2018-03-21 | HUBER DAVID E |
| Devices, systems and methods for the parallel detection of a set of distinct nucleic acid sequences use multiple sequence amplification and simultaneous hybridization readout. An automated nucleic acid analysis system comprises in microfluidic connection sample lysis, purification, PCR and detection modules configured to detect in parallel distinct nucleic acid sequences via multiple sequence amplification and simultaneous microarray hybridization readout. High performance microfluidic electroactive polymer (μEAP) actuators comprising a dead-end fluid chamber in which the floor of the chamber is an electrode covered with an EAP layer of dielectric elastomer are configured for particle sorting. | ||||||
| 90 | ANALYSIS METHOD AND READING DEVICE FOR MICROARRAY | EP11857286 | 2011-12-26 | EP2669662A4 | 2017-12-27 | OZAKI KUMIE; SASAMOTO HIROMICHI; NAGINO KUNIHISA |
| In order to provide a microarray analysis method that can perform alignment processing appropriately in an analysis of a DNA chip on which no positive control is arranged or an analysis of a chip on which a sample contains a small amount of DNAs, the microarray analysis method in which a microarray obtained by arranging probes on a substrate surface having an irregular shape is irradiated with excitation light and fluorescence amounts of the probes excited by the excitation light are obtained as numerical data includes a step (a) of measuring the fluorescence amounts of the probes to acquire fluorescence image data, a step (b) of receiving reflected light and/or scattered light from the substrate surface to acquire the irregular shape of the substrate surface of the microarray as alignment image data based on the light receiving intensities of the light, and a step (c) of determining positions of the probes on the fluorescence image data based on the alignment image data. | ||||||
| 91 | AUTOMATED SAMPLE HANDLING INSTRUMENTATION, SYSTEMS, PROCESSES, AND METHODS | EP17170265.7 | 2012-09-10 | EP3225972A1 | 2017-10-04 | OPALSKY, David; SILBERT, Rolf; ROSATI, Robert J.; BUSE, David Aaron; TAMMER, Olev |
There is disclosed a method for automatically processing patient sample material within a sample processing station (107), said method comprising: (a) providing to the sample processing station (107), a sample container (102, 210, 211) containing a volume of patient sample material, the sample container including a sample container barcode on a surface thereof, the sample container barcode containing patient-identifying information; (b) with a barcode reader (204), reading the sample container barcode on the sample container in the sample processing station; (c) providing a tubular reaction vessel (101) to a printer module configured to print a barcode directly onto a surface of the tubular reaction vessel; (d) printing a barcode on the surface of the reaction vessel with the printer module, the barcode printed onto the reaction vessel being associated with the sample container barcode read in step (b); and (e) automatically moving the reaction vessel from the printer module to the sample processing station.
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| 92 | Biomarker discovery in complex biological fluid using bead or particle based libraries | EP12761160.6 | 2012-03-22 | EP2688911B1 | 2017-08-02 | MOOLA, Muralidhar, Reddy; SCHILKE, Jessica |
| 93 | METHODS FOR SAMPLING FROM NON-ATMOSPHERIC VESSELS IN A PARALLEL REACTOR SYSTEM | EP13771285.7 | 2013-09-18 | EP2992335A1 | 2016-03-09 | LAMBERT, Stephen; VARNI, John F.; HSIAO, Gregor |
| Methods for sampling reactor contents in parallel reactor systems are disclosed. The methods may be used to sample reactor contents in non-atmospheric (e.g., pressurized) reaction vessels. | ||||||
| 94 | COATED SUBSTRATES FOR HIGH ENERGY CAPTURE PHASE BINDING AND METHODS OF PRODUCTION AND USE THEREOF | EP12860149 | 2012-12-20 | EP2795500A4 | 2015-12-30 | PUGIA MICHAEL J; SINGH PRATAP |
| A substrate, which is useful for performing biological, chemical and diagnostic assays, and a method for preparing the substrate are provided. The substrate has an upper surface with a coating disposed thereon. The coating comprises a charged polymer, a non-ionic polyether, and a silicate compound. The substrate can increase capture phase binding and reduce non-specific binding of biomolecules for a biological microarray. | ||||||
| 95 | HIGH THROUGHPUT SCREENING OF ION CHANNELS | EP11766586.9 | 2011-04-05 | EP2556371B1 | 2015-08-05 | OSIPCHUK, Yuri, Vladimirovich; WASSON, James, Richard; VERDONK, Edward, D. |
| 96 | METHODS FOR SCREENING AND ARRAYING MICRORGANISMS SUCH AS VIRUSES USING SUBTRACTIVE CONTACT PRINTING BACKGROUND | EP09786626.3 | 2009-07-16 | EP2329270B1 | 2015-04-08 | COYER, Sean R.; DELAMARCHE, Emmanuel; SOLIS, Daniel, J. |
| 97 | FLUORESCENCE SCANNING HEAD WITH MULTIBAND DETECTION | EP12776158 | 2012-04-30 | EP2702394A4 | 2014-11-12 | MCCOLLUM TOM |
| In a scanning system for the detection and discrimination of a plurality of targets in each of a plurality of samples, one or more multiband fluorescence detection channels each of which contains a single multiband emission filter and a single detector replaces multiple detection components in scanning heads of the prior art. In certain embodiments, a single multi-emitter light source is used as well, to illuminate each sample with excitation light at a variety of distinct wavelengths in succession. | ||||||
| 98 | PROGRAMMABLE ARRAYS | EP12787975.7 | 2012-10-24 | EP2771102A2 | 2014-09-03 | WIKTOR, Peter; LABAER, Joshua; KAHN, Peter; TAKULAPALLI, Bharath; QIU, Ji; BRUNNER, Al; MAGEE, Mitch |
| Biomolecule arrays on a substrate are described which contain a plurality of biomolecules, such as coding nucleic acids and/or isolated polypeptides, at a plurality of discrete, isolated, locations. The arrays can be used, for example, in high throughput genomics and proteomics for specific uses including, but not limited molecular diagnostics for early detection, diagnosis, treatment, prognosis, monitoring clinical response, and protein crystallography. | ||||||
| 99 | THERMAL PHASE SEPARATION SIMULATOR | EP12716729.4 | 2012-02-17 | EP2675542A1 | 2013-12-25 | HART, Paul, R.; NUEBLING, Lee, E.; CLEARY, Robert, R.; LITTLE, Virgil, T.; BEETGE, Jan, H. |
| A thermal phase separation simulator and method for testing chemicals is disclosed. The simulator comprises a circular block heater carousel mounted for rotation on a stage. The carousel includes a circular array of test wells for receiving a plurality of test bottles, a plurality of heating elements and thermocouples disposed between the wells. Each well has an illumination port and a vertical slit to the outside to allow visual observation or imaging of a vertical swatch of the bottle. An illumination source aligns with the illumination port of each well in response to rotation of the carousel. The method includes adding a mixed phase fluid to a plurality of bottles, adding a chemical agent to each bottle, and simulating a thermal phase separation. Images of the fluid in each bottle are captured and analyzed to determine the performance of the one or more chemical agents. | ||||||
| 100 | HIGH THROUGHPUT SCREENING OF ION CHANNELS | EP11766586.9 | 2011-04-05 | EP2556371A2 | 2013-02-13 | OSIPCHUK, Yuri, Vladimirovich; WASSON, James, Richard; VERDONK, Edward, D. |
| Multi-well plates having contoured well designs allow multi-stage high throughput parallel assaying of ion channels or ion transporters. A well of a multi- well plate has a bottom region that is sized and shaped to simultaneous accommodate a sensing electrode and a pipette for delivering, e.g., test compounds, wash fluid, and optionally ligands. Such multi-well plates may be coupled with an instrument having a pipette head and an electrode plate. Such arrangement facilitates fluidic contact between cells and fluids provided via a pipette. It also facilitates washing of wells with buffers or other wash solutions to allow serial exposure of test cells to various reagents or other stimuli. Generally, the design allows control and test experiments to be performed on the same cell (or cells) in a single well. | ||||||
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