| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS | US15331452 | 2016-10-21 | US20170067047A1 | 2017-03-09 | Darren Roy Link; Laurent Boitard; Jeffrey Branciforte; Yves Charles; Gilbert Feke; John Q. Lu; David Marran; Ahmadali Tabatabai; Michael Weiner; Wolfgang Hinz; Jonathan M. Rothberg |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | ||||||
| 182 | NANO-SENSOR ARRAY | US15230048 | 2016-08-05 | US20160340721A1 | 2016-11-24 | Hesaam Esfandyarpour |
| In one embodiment, a method is provided for the manufacture of a nano-sensor array. A base having a sensing region is provided along with a plurality of nano-sensors. Each of the plurality of nano-sensors is formed by: forming a first nanoneedle along a surface of the base, forming a dielectric on the first nanoneedle, and forming a second nanoneedle on the dielectric layer. The first nanoneedle of each sensor has a first end adjacent to the sensing region of the base. The second nanoneedle is separated from the first nanoneedle by the dielectric and has a first end adjacent the first end of the first nanoneedle. The base is provided with a fluidic channel. The plurality of nano-sensors and the fluidic channel are configured and arranged with the first ends proximate the fluidic channel to facilitate sensing of targeted matter in the fluidic channel. | ||||||
| 183 | SYSTEM AND METHOD FOR SCREENING A LIBRARY OF SAMPLES | US15146319 | 2016-05-04 | US20160245837A1 | 2016-08-25 | Jeff Tza-Huei Wang; Tushar Dnyandeo Rane; Helena Claire Zec; Wen-Chy Chu |
| A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system. | ||||||
| 184 | MOLECULAR PROFILING OF TUMORS | US15099442 | 2016-04-14 | US20160232284A1 | 2016-08-11 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 185 | Microfluidic devices and methods of use in the formation and control of nanoreactors | US14226482 | 2014-03-26 | US09410151B2 | 2016-08-09 | Darren R. Link; Laurent Boitard; Jeffrey Branciforte; Yves Charles; Gilbert Feke; John Q. Lu; David Marran; Ahmadali Tabatabai; Michael Weiner; Wolfgang Hinz; Jonathan M. Rothberg |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | ||||||
| 186 | MOLECULAR PROFILING OF TUMORS | US15094520 | 2016-04-08 | US20160224747A1 | 2016-08-04 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 187 | MOLECULAR PROFILING OF TUMORS | US15094507 | 2016-04-08 | US20160224746A1 | 2016-08-04 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 188 | MOLECULAR PROFILING OF TUMORS | US15094486 | 2016-04-08 | US20160224745A1 | 2016-08-04 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 189 | MOLECULAR PROFILING OF TUMORS | US15094457 | 2016-04-08 | US20160224728A1 | 2016-08-04 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 190 | MOLECULAR PROFILING OF TUMORS | US15093668 | 2016-04-07 | US20160224726A1 | 2016-08-04 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 191 | MOLECULAR PROFILING OF TUMORS | US15093653 | 2016-04-07 | US20160224725A1 | 2016-08-04 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 192 | NANOFIBROUS PHOTOCLICKABLE HYDROGEL MICROARRAYS | US14991889 | 2016-01-08 | US20160202241A1 | 2016-07-14 | Michael Floren; Wei Tan; Sadhana Sharma; Stephanie Bryant |
| Nanofibrous hydrogel microarray systems that act as facile, high throughput platforms for in vitro drug discovery and investigation and screening of combinatorial effects of physical and biochemical cues on maturation and differentiation of mammalian cells. | ||||||
| 193 | Coated substrates for high energy capture phase binding and methods of production and use thereof | US14364850 | 2012-12-20 | US09366669B2 | 2016-06-14 | Michael J. Pugia; Pratap Singh |
| A substrate, which is useful for performing biological, chemical and diagnostic assays, and a method for preparing the substrate are provided. The substrate has an upper surface with a coating disposed thereon. The coating comprises a charged polymer, a non-ionic polyether, and a silicate compound. The substrate can increase capture phase binding and reduce non-specific binding of biomolecules for a biological microarray. | ||||||
| 194 | Automated sample handling instrumentation, systems, processes, and methods | US13608876 | 2012-09-10 | US09335336B2 | 2016-05-10 | Rolf Silbert; David Opalsky; David Aaron Buse; Robert J. Rosati; Olev Tammer |
| The present invention provides a processing station for automatically processing a biological sample, a system for automated real-time inventory control of consumables within a biological sample handling or assay instrument, a high throughput random access automated instrument for processing biological samples, an automated instrument for processing or analysis of a sample, and processes for automated mucoid detection and elimination. Methods of using the disclosed instruments, mucoid detection processes, and systems to process and/or analyze samples are also disclosed. | ||||||
| 195 | Microfluidic devices and methods of use in the formation and control of nanoreactors | US13759660 | 2013-02-05 | US09328344B2 | 2016-05-03 | Darren Link; Laurent Boitard; Jeffrey Branciforte; Yves Charles; Gilbert Feke; John Q. Lu; David Marran; Ahmadali Tabatabai; Michael Weiner; Wolfgang Hinz; Jonathan M. Rothberg |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds. | ||||||
| 196 | AUTOMATED SAMPLE HANDLING INSTRUMENTATION, SYSTEMS, PROCESSES, AND METHODS | US14858436 | 2015-09-18 | US20160077118A1 | 2016-03-17 | ROLF SILBERT; DAVID OPALSKY; DAVID Aaron BUSE; ROBERT J. ROSATI; OLEV TAMMER |
| The present invention provides a processing station for automatically processing a biological sample, a system for automated real-time inventory control of consumables within a biological sample handling or assay instrument, a high throughput random access automated instrument for processing biological samples, an automated instrument for processing or analysis of a sample, and processes for automated mucoid detection and elimination. Methods of using the disclosed instruments, mucoid detection processes, and systems to process and/or analyze samples are also disclosed. | ||||||
| 197 | GLYCAN-BASED DRUGS, THERAPIES AND BIOMARKERS | US14803725 | 2015-07-20 | US20160015729A1 | 2016-01-21 | Huiru WANG |
| The present disclosure discloses simple and efficient glycan- or carbohydrate-based processes or methods for the rapid identification of biological markers and therapeutic targets especially glycan-related targets of infectious diseases, cancers, autoimmune diseases, allergies, inflammation, toxicity, obesity and/or other disorders of humans, animals, plants and other organisms. Therefore, novel methods and products for the diagnosis, prevention, and treatment of such diseases obtainable based on these therapeutic targets can be developed. | ||||||
| 198 | COMPOSITIONS AND METHODS FOR CLASSIFYING THYROID NODULE DISEASE | US14727801 | 2015-06-01 | US20150329915A1 | 2015-11-19 | Elai Davicioni; Sam Michael Wiseman |
| A system for classifying thyroid nodule tissue as malignant or benign is provided that is based on the identification of sets of gene transcripts, which are characterized in that changes in expression of each gene transcript within a set of gene transcripts can be correlated to with either malignant or benign thyroid nodule disease. The thyroid classification system provides for sets of “thyroid classifying” target sequences and further provides for combinations of polynucleotide probes and primers derived there from. These combinations of polynucleotide probes can be provided in solution or as an array. The combination of probes and the arrays can be used for diagnosis. The invention further provides further methods of classifying thyroid nodule tissue. | ||||||
| 199 | Systems and methods for high-throughput detection of an analyte in a sample | US13679200 | 2012-11-16 | US09164100B2 | 2015-10-20 | Sebastian J. Osterfeld; Shan X. Wang |
| Provided are high-throughput detection systems. The systems include a magnetic sensor device, a magnetic field source and a reservoir plate that includes a plurality of fluid reservoirs. The magnetic sensor device includes a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end. Also provided are methods in which the subject high-throughput detection systems find use. | ||||||
| 200 | Molecular profiling of tumors | US14175781 | 2014-02-07 | US09092392B2 | 2015-07-28 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
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