| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 81 | 고밀도 다차원 어드레스가능한 어셈블리의 생성 | KR1020117005291 | 2009-08-06 | KR1020110052692A | 2011-05-18 | 수자라,빈센트; 벤트리,파울; 랩시스,트로이; 크리쉬나무르티,비스워나스 |
| 본 발명은 고밀도의 생성, 폴리머를 함유하는 핵염기의 기하학적으로 패터닝된 2차원과 3차원 어드레스가능한 어셈블리, 및 그것과 함께 융화되는 형상의 구성을 포함하는 구조의 분자 스케일 어셈블리를 위한 방법 및 장치에 관한 것이다. 본 발명은 규정된 형상으로 형성되고, 상보적 단일 가닥 폴리핵염기를 나타내는 상보적 마스터 형상으로부터 생성되는 공유 부착 생체고분자를 포함하는 생산 아이템을 제조하는 방법을 제공한다. 본 발명은 광감응성 고체 기판 매트릭스에서 일정하게 오목한 형상 포메이션을 생성해서 셀프 어셈블리된 생체고분자 패턴을 부착하는 금속 기상 증착을 행하는 단계를 포함하는 생산 아이템 제조 방법을 제공한다.
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| 82 | Microarray including layer comprising dna molecule and method for manufacturing the same | KR20080134972 | 2008-12-26 | KR20100076802A | 2010-07-06 | JUNG SUN OK |
| PURPOSE: A microarray for enhancing detection sensitivity in analyzing target materials without noise signal is provided. CONSTITUTION: A microarray comprises: a substrate(100); a spot area(300) having a probe which is able to bind with a target substance formed on the substrate; and a membrane(200) having DNA molecules having two or more nucleotides formed except for the spot area. The binding between probe and target substance is performed over 19°C. The DNA molecule has 2-6 nucleotides. The substrate is formed in flat, bead, or spherical form. A method for manufacturing the microarray comprises: a step of preparing the substrate; and a step of forming spot area having probe; a step of forming a membrane having DNA molecule. | ||||||
| 83 | 리버스-턴 유사체 및 이와 관련된 방법 | KR1020047005346 | 2002-10-11 | KR100910307B1 | 2009-08-03 | 칸마이클; 에구치마사카츠; 문성환; 정재욱; 이승찬; 정광원 |
| 생물학적으로 활성이 있는 펩티드와 단백질의 리버스-턴 영역의 2차 구조를 모방한 구조적으로 제한된 화합물이 밝혀져 있다. 이러한 리버스-턴 유사체는 진단제, 치료제로의 사용을 포함하는 넓은 범위의 분야에서 유용성이 있다. 본 발명의 리버스-턴 유사체를 포함하는 라이브러리 뿐만 아니라 생물학적으로 활성이 있는 구성원들(biologically active members)을 동정하기 위한 스크리닝 방법 또한 밝혀져 있다. 본 발명은 Wnt-신호 경로 변형에 의한 질병, 즉 암 특히 결장 직장암, 혈관 확장술과 관련된 재협착, 다낭신 질병, 혈관생성 변형 질병, 류머티스성 관절염, 또는 궤양성의 대장염의 억제 또는 치료를 위해 이러한 화합물을 사용하는 것과 관련이 있다.
리버스-턴 유사체, 결장 직장암, 재협착, 다낭신 질병, 혈관생성 변형 질병, 류머티스성 관절염, 궤양성의 대장염 |
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| 84 | 감광성 물질의 코팅을 이용한 폴리머 어레이의 제조 방법 | KR1020070099877 | 2007-10-04 | KR1020090034571A | 2009-04-08 | 유창은; 지성민 |
| A method for preparing a polymer array and a method for cutting a photolabile protecting group are provided to effectively manufacture a polymer array with less exposure energy by photolithography. A method for preparing a polymer array comprises the steps of: (i) reacting a monomer containing a photolabile protecting group on the surface of a substrate, and fixing the monomer on the substrate; (ii) coating the surface fixed with the monomer with the solution containing a photosensitive material and coating material; (iii) cutting the photolabile protecting group from the monomer by performing selectively electromagnetic irradiation to specific site on the surface of the substrate coated with the photosensitive material and coating material; (iv) exposing the monomer cut with the photolabile protecting group by electromagnetic irradiation of (iii) step; (v) reacting the monomer cut with the photolabile protecting group and the monomer containing the photolabile protecting group and connecting them; and (vi) repeating the (ii) ~ (v) step. | ||||||
| 85 | 마이크로 어레이용 마스크 세트, 이의 제조 방법, 및마스크 세트를 이용한 마이크로 어레이의 제조 방법 | KR1020070014896 | 2007-02-13 | KR100819006B1 | 2008-04-03 | 신재필; 최진숙; 유문현; 이종배 |
| A mask set is provided to have a controlled area of a transparent region. A system and a method for determining a mask layout are provided to control the area of the transparent region of the mask layout to have the same or larger area than minimum transparent region without changing sequences of a probe to be synthesized, thereby improving the pattern reliability of the mask set. A mask set comprises a plurality of masks for in situ synthesizing a probe of a microarray, wherein each of the mask includes a transparent region and a shielding region and the area of the transparent region regarding the total area of the transparent region and the shielding region is more than 5%. A system for determining a mask layout comprises: a pattern determining portion which provides the transparent region and the shielding region to a plurality of mask layouts for in situ synthesizing the probe of the microarray; a selection portion which selects one of the mask layouts; a comparison portion which compares the transparent region area of the selected mask layout with a minimum transparent area; and a pattern changing portion which exchanges the selected shielding region of the selected mask layout with the pattern changing portion of the transparent region of the non-selected mask layout when the transparent region of the selected mask layout is smaller than the minimum transparent region. A method for preparing the microarray comprises the steps of: (a) providing a substrate including a plurality of arrayed probe cells and the surface being protected by a photodegradable protecting group; and (b) in situ synthesizing the probe of the microarray using the mask set, wherein each the transparent region and the shielding region corresponds to the probe cell of the microarray. Further, an area of the probe cells is 100mum or more. | ||||||
| 86 | 마이크로어레이 및 다른 마이크로규모 장치들에 대한 고농도 스폿 침착을 위한 스폿 장치 및 방법 | KR1020077002867 | 2005-07-06 | KR1020070063498A | 2007-06-19 | 게일브루스; 창-옌데이비드; 미스즈카데이비드 |
| Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other substrate. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow of solution bearing the desired substance over the spot area until surface saturation is accomplished. The spotter uses microfluidic conduits and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate substrate. Each orifice is part of a fluid pathways that includes an inlet conduit and an outlet conduit. When the spotter contacts a substrate a seal is formed between the orifices and the substrate. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a substrate, since the spotter may be placed on a substrate for an extended period of time. | ||||||
| 87 | 스폿패턴 암호화 기능을 구비한 스포터 및 스폿패턴암호화에 대처한 검출 장치 | KR1020040045880 | 2004-06-19 | KR100663805B1 | 2007-01-03 | 이시바시토오류 |
| 프로브 고정기재상에 스폿되어 있는 복수의 프로브는 제3자에 의해 용이하게 프로브를 특정할 수 없도록 배치된다. 프로브 고정기재상에, 복수의 프로브를 스폿하는 경우, 제조되는 프로브 고정기재마다, 각 프로브가 스폿되는 위치를 변경함으로써, 각 스폿 어드레스에 배치되는 프로브 종류를 암호화한다. 본 발명은 스포터(spotter), 이 스포터에 이용되는 분주장치, 상기 스포터를 이용하여 제조되는 프로브 고정기재 및 각각의 프로브를 스폿하는 암호화된 위치를 해독하는 검출 장치를 제공한다. | ||||||
| 88 | 올리고뉴클레오티드의 제조방법 | KR1020057011278 | 2003-12-16 | KR1020050085745A | 2005-08-29 | 맥코맥폴 |
| A process for the synthesis of an oligonucleotide is provided in which an oligonucleotide is assembled on a swellable solid support using the phosphoramidite approach in the presence of an activator, wherein the activator is not tetrazole or a substituted tetrazole. Preferred activators are pyridinium, imidazolinium and benzimidazolinium salts; benzotriazole and derivatives thereof; and saccharin or a saccharin derivative. Preferred swellable solid supports comprise functionalised polystyrene, partially hydrolysed polyvinylacetate or poly(acrylamide). | ||||||
| 89 | 광자 및 전자 용품을 위한 친화성 자가-어셈블리 시스템 및 디바이스 | KR1019997005013 | 1997-11-26 | KR100507815B1 | 2005-08-10 | 헬러,마이클,제이.; 케이블,제프리,엠.; 에세너,사딕,씨. |
| 본 발명은 프로그래밍가능한 기능화 자가-어셈블리 핵산, 핵산 변성 구조물, 및 다른 선택적 친화성 또는 결합 잔기를 빌딩 블록으로 사용하는 기술에 관한 것이다. 본 발명은 제1 부품 디바이스를 제1 지지체 상에 조립하는 단계, 제1 지지체로부터 하나 이상의 제1 부품 디바이스를 방출시키는 단계, 제1 부품 디바이스를 제2 지지체 상에 전달하는 단계 및 제1 부품 디바이스를 제2 지지체 상에 부착하는 단계를 포함하는 마이크로 크기 및 나노 크기 디바이스의 조립 방법이다. 본 발명은 또한 구조물을 전계 중에 배향시키는 방법, 친화성 서열을 반응시키는 방법 및 광활성화에 의해 발색 구조물을 조립하는 방법을 제공한다. | ||||||
| 90 | 구조적으로 결정된 금속 구조체 및 그의 용도 | KR1020057007332 | 1996-06-06 | KR1020050062639A | 2005-06-23 | 샤르마슈브디. |
| A metallo-construct, which may be a peptide, is provided for use as a biological, therapeutic, diagnostic imaging, or radiotherapeutic agent, and for use in library or combinatorial chemistry methods. The construct has a conformationally constrained global secondary structure obtained upon complexing with a metal ion. The peptide constructs are of the general formula R1-X-R2, wherein X is a plurality of amino acids and includes a complexing backbone for complexing metal ions, so that substantially all of the valences of the metal ion are satisfied upon complexation of the metal ion with X, resulting in a specific regional secondary structure forming a part of the global secondary structure; and where R1 and R2 each include from 0 to about 20 amino acids, the amino acids being selected so that upon complexing the metal ion with X at least a portion of either R1 or R2 or both have a structure forming the balance of the conformationally constrained global secondary structure. All or a portion of the global secondary structure, which may be sychnologic or rhegnylogic, may form a ligand or mimic a known biological- function domain. The construct has substantially higher affinity for its target upon labeling with a metal ion. | ||||||
| 91 | 스폿패턴 암호화 기능을 구비한 스포터 및 스폿패턴암호화에 대처한 검출 장치 | KR1020040045880 | 2004-06-19 | KR1020040111194A | 2004-12-31 | 이시바시토오류 |
| PURPOSE: A spotter with spot pattern encryption function and a detection device for coping with spot pattern encryption are provided, thereby hardly translating the nucleotide sequence of a DNA probe in a DNA chip by a third party. CONSTITUTION: The spotter with spot pattern encryption function which is used for spotting a plurality of probes specifically binding to target materials in a plurality of spot regions on a substrate comprises a spotting unit which spots each probe according to the spot position pattern; and a spot position pattern encoding unit for encoding the spot position pattern according to the certain information in each probe fixing substrate to be formed. The spot position pattern encoding unit comprises a unit which preliminarily memorizes a plurality of spot position patterns applicable to the probe fixing substrate, and selects one spot position pattern from the spot position patterns according to the certain information in each probe fixing substrate; and the spot position pattern encoding unit has the spot position pattern changing function. | ||||||
| 92 | 기질결합된고리형유기화합물의조합라이브러리 | KR1019970709161 | 1996-05-23 | KR100445564B1 | 2004-11-16 | 데사이마노이씨.; 누스존엠.; 스피어케리엘.; 싱라진더; 레노위폴에이.; 브라운에드워드지.; 리히터루츠; 스코트바바라오. |
| The invention relates to libraries of cyclic organic compounds and method of producing and assaying such libraries. According to the invention, each cyclic organic compound is constructed from a starting material in the form of a solid surface derivatized with a starting resin. Compounds are reacted with the resin to add or to form a cyclic group. The reactions are preferable carried out using a split resin procedure so that different compounds can be reacted with a plurality of subamounts so as to increase the size of the library. For example, compounds are reacted with a solid support bound starting resin to obtain a compound which includes an aldehyde functional group wherein the aldehyde compound or compounds reacted with it have substituents which are varied such that a mixture of products is obtained. The invention further relates to methods of producing combinatorial libraries of cyclic organic compounds from substrate bound compounds by cleaving the compounds from the support after synthesizing is completed and to assaying libraries of such compounds. | ||||||
| 93 | 핵산 어레이의 복제방법 | KR1020030000381 | 2003-01-03 | KR1020040062847A | 2004-07-09 | 김영아; 임희균; 이영환; 임근배 |
| PURPOSE: A method for replicating nucleic acid array is provided, thereby significantly reducing the costs and time for replicating nucleic acid array although the kinds or length of probes on the nucleic acid array are increased because the total of the second polynucleotides which is in-situ synthesized by using one nucleic acid array as a template are transferred into a new substrate. CONSTITUTION: The method for replicating nucleic acid array comprises the steps of: (i) fixing each first polynucleotide(2) having a nucleotide sequence complementary with a second polynucleotide and each first nucleic acid probe with a primer binding site(1) on a first substrate(10) to prepare a template nucleic acid array; (ii) binding a primer to the primer binding site(1) of each first nucleic acid probe fixed on the surface of the template nucleic acid array; (iii) in-situ synthesizing the second polynucleotide by using the primer from the first polynucleotide(2) as a template; and (iv) transferring the numerous synthesized second polynucleotides and seconds nucleic acid probes with the primer into a second substrate, wherein the first and second substrates are patterned with a metal membrane pattern or surface-treated with functional groups such as aldehyde, streptavidin or thiol; and the primer is universal primer. | ||||||
| 94 | 리버스-턴 유사체 및 이와 관련된 방법 | KR1020047005346 | 2002-10-11 | KR1020040045504A | 2004-06-01 | 칸마이클; 에구치마사카츠; 문성환; 정재욱; 이승찬; 정광원 |
| PURPOSE: Reverse-turn mimetics and methods relating thereto are provided, can inhibit the expression of survivin, TCF/B-catenin transcription, and the expression of Wnt signaling, so that it can inhibit the growth of tumor cell in a mammalian subject. CONSTITUTION: The reverse-turn mimetics represented by formula (I) are provided, wherein A is -(CHR3)- or -(C=O); B is -(CHR4)- or -(C=O)-; D is -(CHR5)- or -(C=O)-; E is -(ZR6)- or -(C=O)-; G is -(XR7)n-, -(CHR7)-(NR8)-, -(C=O)-(XR9)- or -(C=O)-; W is -Y(C=O)-, -(C=O)NH-, -(SO2)- or nothing; Y is oxygen or sulfur; X and Z is independently nitrogen or CH; N is 0 or 1; and R1, R2, R3, R4, R5, R6, R7, R8 and R9 are the same or different and independently selected from an amino acid side chain moiety or derivative thereof, the remainder of the molecule, a linker and a solid support, and stereoisomers thereof. The methods for inhibiting the growth of tumor cell in a mammalian subject, for treating cancer in combination with other anti-neoplastic agents, for treating or preventing diseases such as restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease and ulcerative colitis, and for identifying a biologically active component, and a library of compounds using the reverse-turn mimetics of formula (I) are provided . | ||||||
| 95 | 천연물 유래 화합물 라이브러리의 제조방법 | KR1020000057197 | 2000-09-29 | KR1020010067256A | 2001-07-12 | 최호일; 장승구; 김선영; 김성규; 방정규 |
| PURPOSE: A method for preparing a natural substance-derived compound library is provided to use the compound purified by means of solid-phase to develop new medicines and/or pharmaceutically functional materials such as anticancer drugs. CONSTITUTION: The method for preparing the chemical library comprises a solid-phase synthesis manner comprising of adhering anchor compound of base material to a solid phase resin; blocking the obtained material to exclude specific functional groups such as alcohol, phenol, carbonyl, amine radicals of extract from natural substances; attaching the resultant extract to the solid phase resin bonded with the anchor compound to react together; washing and removing un-attached residual compounds and/or reactants; and cutting the bonded anchor compound from the solid phase resin. The obtained chemical library is useful for detecting or optimizing any physiological active materials including enzyme inhibitors or acceptors. | ||||||
| 96 | 화학합성을 위한 방법 및 장치 | KR1020007006441 | 1998-12-15 | KR1020010033080A | 2001-04-25 | 파머,데릭,아데예미; 프렌치,마틴,토마스 |
| 본발명은복수개의시약입력부(2)와고체지지체입력부(1)로이루어진화학합성장치를제공한다. 각입력부(1,2)는각 개폐밸브(3)을통해주 유체통로와연결되어있다. 장치는입력부(1,2)하류의개폐밸브(3)에의해유동적으로주 유체통로에연결되어있는반응실(4)을추가로포함한다. 반응실(4)는상기의고체지지체통과를막고조합하지않은분자의통과가가능하도록배열된장벽(5)하류의출구를추가적으로포함하고있다. 대표도1 도 1 칼리브란트조합화학/고-처리율스크리닝시스템도 2 | ||||||
| 97 | 끓는점이 높은 용매를 사용하여 올리고뉴클레오티드를합성하는 방법 | KR1020007005197 | 1998-11-10 | KR1020010032074A | 2001-04-16 | 브레넌토머스엠.; 프라우엔도르프알브레흐트더블유. |
| 본발명은개방환경의고체받참판표면상에서소단위체로이루어진분자의고체상을미소규모로화학적으로합성하는동안액체시약용액의증발을감소시키는방법에관한것으로서, 본발명은반응성화학성분으로기능화된적어도하나의결합사이트를포함하는개방고체받침판표면을설치하는단계, 및실질적으로조절되는미소량의액체시약용액을상기받침판표면상으로주입하고, 상기결합사이트와접촉시키는단계를포함하며, 상기액체시약용액은상기고체받침판상에서의합성동안반응상당히높은반응수율을유지하면서개방환경내시약용액의증발을상당히감소시키기는것을특징으로한다. | ||||||
| 98 | 고분자 광산발생제를 이용한 올리고펩티드 핵산 탐침의 제조방법 | KR1019990020899 | 1999-06-07 | KR1020010001577A | 2001-01-05 | 김민환; 김도윤; 문봉석; 박재찬 |
| PURPOSE: A method for synthesizing an oligopeptide nucleic acid probe on a solid matrix using a polymeric photoacid generator is provided which has highly simplified steps and which can effectively synthesize the heavy ionic oligopeptide nucleic acid probe compared with a conventional method such as a photoresist (PR) method and a photoacid patterned array (PPA) method used in the production of biochip. CONSTITUTION: The method for synthesizing the oligopeptide nucleic acid probe on the solid matrix using the polymeric photoacid generator comprises the steps of : (1) attaching a linker that is masked with a protecting group unstable to an acid, to the solid matrix treating surface thereof; (2) coating the solid matrix with the polymeric photoacid generator; (3) exposing the coated solid matrix to light and generating the acid to remove the protecting group unstable to the acid; (4) binding the solid matrix unmasking protecting group to each monomer of the peptide nucleic acid masked with a protecting group unstable to the acid; and (5) removing the residual polymeric photoacid generator in reaction and carrying out from step (2) to step (5) repeatedly to synthesize the desired length of the oligopeptide nucleic acid probe. | ||||||
| 99 | ポリペプチドの修飾 | JP2015562247 | 2014-03-14 | JP6437468B2 | 2018-12-12 | ステイス,キャサリン; ウォーカー,エドワード |
| 100 | 認識化合物付着モノリス、そのアレイ、およびその使用 | JP2016548235 | 2015-01-28 | JP2017503522A | 2017-02-02 | ペール ハーブリー，; マダン パイドゥンガット，; ロビン プリンス， |
| 本明細書において、リガンドに選択的に結合する認識化合物付着モノリス、そのようなモノリスの調製方法、そのアレイ、およびその使用が提供される。例えば、本明細書で提供されるモノリスは、そのカラムおよびアレイで使用することができる。 | ||||||
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