| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | A method of detecting changes in cell | JP2011540952 | 2009-12-14 | JP2012511909A | 2012-05-31 | カニンガム，ブライアン，ティー．; フェルナンデス，ラファエル; ラング，ランス; ワグナー，リック |
| 検出標識の使用なしに細胞における変化を検出するための方法が提供される。 一実施態様において、刺激に対する細胞の応答の検出は、１つまたは複数の細胞外マトリックスリガンドを比色共鳴反射バイオセンサーもしくは回折格子に基づいた導波路バイオセンサーの表面へ固定化する工程、およびその１つまたは複数の細胞外マトリックスリガンドに特異的な細胞表面受容体を有する細胞をバイオセンサーに加える工程を含む。 その後、細胞における変化が、バイオセンサーへの刺激の導入前と後に、バイオセンサーによって検出される。 | ||||||
| 22 | Manufacturing method of mass coded combinatorial library | JP2010206977 | 2010-09-15 | JP2011039067A | 2011-02-24 | NASH HUW M; BIRNBAUM SETH; WINTNER EDWARD A; KALGHATGI KRISHNA; SHIPPS GERALD; JINDAL SATISH |
| PROBLEM TO BE SOLVED: To provide a method for identifying any member of mass coded combinatorial library which is the ligand of the first biomolecule, not the second biomolecule ligand. SOLUTION: In this mass coded combinatorial library, a mass coded molecule library contains a set of chemical compounds including a general expression X(Y) n (where, X is Scaffold, Y is each of independent peripheral moiety, respectively, and n is an integer larger than 1). The mass coded combinatorial library includes selection of peripheral moiety precursor subset from peripheral moiety precursor set. This selected subset contains sufficiently many peripheral moiety precursors so that at least approx. 250 various combinations of n peripheral moieties originating in the peripheral moiety precursor may exist in the subset. COPYRIGHT: (C)2011,JPO&INPIT | ||||||
| 23 | Systems and methods for improving the fluorescence detection of target molecules in the test sample | JP2010515329 | 2008-07-09 | JP2010532868A | 2010-10-14 | ジェシー エム クロストラネック; トラヴィス レオン ジェニングス; ウォーレン チェ ウォー チャン |
| 試験サンプル中の標的分子の蛍光検出の向上のためのシステムおよび方法が、照射装置による使用を目的とする。 第１の蛍光体が、ＥＭＦの放射の吸収および第１のシグナルの発光のために提供される。 第２の蛍光体が、第１のシグナルの部分的吸収、および第１のシグナルから識別可能な第２のシグナルの発光のために提供される。 蛍光体は試験サンプルと組み合わせて、標的分子に、および互いに固定される。 第１の蛍光体が照射装置からＥＭＦの放射を受けた後、標的分子が試験サンプル中に存在する場合、第１のシグナルが第２のスペクトルシグナルと共に検出される。 | ||||||
| 24 | Detection of the target molecule in a sample | JP2009534001 | 2007-10-19 | JP2010507796A | 2010-03-11 | クルンデル，デルク，イェー．，ウェー．; スタペルト，ヘンドリク，エル．; ヘルペン，マールテン，エム．，イェー．，ウェー． ファン |
| The invention relates to detection the presence of a target molecule in a sample, wherein the sample is contacted with a substrate, the substrate subsequently being washed in a wash step. In particular, the invention relates to a method of detecting the presence of a target molecule in a sample, the method comprising: (a) contacting the sample (37) with a substrate having immobilized thereon probe molecules that specifically binds to the target molecule; (b) washing the substrate (38) in a wash step by a wash fluid in order to remove or dilute unbound target molecules; (c) detect the presence of resultant binding complexes (39) on the substrate to determine whether the target molecule is present in the sample. The wash fluid being substantially refractive index matched to the substrate. | ||||||
| 25 | Non-labeled assay implementation method using a colorimetric resonant reflectance optical biosensor | JP2006527132 | 2004-09-22 | JP2007506107A | 2007-03-15 | カニンガム，ブライアン，ティー; リ，ピーター; リン，ボー |
| 本発明は細胞相互作用を判定する組成物および方法を提供する；これらは常套の方法よりも迅速であり、必要とする試薬の使用も常套の方法よりも少ない。 | ||||||
| 26 | Screening using fluorescence anisotropy for the identification compounds with affinity to nucleic acid | JP53883798 | 1998-03-05 | JP2001514511A | 2001-09-11 | アレナス，ジャイム; クロード，シャロン; エー パクラ，アンドリュー; ライング，ランス; ダブリュ リリー，ジェイムズ |
| (57)【要約】 本発明は、生物活性化合物、特に、疾患の病原または生理機能の調節に含まれるＲＮＡ配列に結合するものをスクリーニングする方法を提供する。 この方法は、試験リガンドの存在下及び不存在下でのＲＮＡ標的の安定性及び／またはコンホメーションを評価し、標的ＲＮＡの安定性及び／またはコンホメーションにおいて測定可能な変化を生じた任意の試験リガンドをリガンドとして同定することを含む。 好ましい実施態様では、リガンドの標的ＲＮＡ安定性及び／またはコンホメーションに対する影響は、蛍光ラベルされたプローブの蛍光偏向を測定することにより評価される。 | ||||||
| 27 | SYSTEMS AND METHODS FOR ENHANCING FLUORESCENT DETECTION OF TARGET MOLECULES IN A TEST SAMPLE | EP08783190.5 | 2008-07-09 | EP2174115B1 | 2013-08-28 | CHAN, Warren Che Wor; JENNINGS, Travis, Leon; KLOSTRANEC, Jesse, M. |
| 28 | Strategies for high throughput identification and detection of polymorphisms | EP10075564.4 | 2006-06-23 | EP2302070B1 | 2012-08-22 | van der Poel, Henricus Johannes Adam; van Eijk, Michael Josephus Theresia |
| The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in an immune cell resulting in modulation of the immune response. The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more samples to yield two or more libraries, sequencing at least part of the libraries, aligning the identified sequences and determining any putative single nucleotide polymorphisms, confirming any putative single nucleotide polymorphism, generating detection probes for the confirmed single nucleotide polymorphisms, subjection a test sample to the same complexity reduction to provide a test library and screen the test library for the presence or absence of the single nucleotide polymorphisms using the detection probe. | ||||||
| 29 | METHODS OF DETECTION OF CHANGES IN CELLS | EP09835554 | 2009-12-14 | EP2376920A4 | 2012-06-27 | WAGNER RICK; FERNANDEZ RAFAEL; CUNNINGHAM BRIAN T; LAING LANCE |
| 30 | Strategies for high throughput identification and detection of polymorphisms | EP10184351.4 | 2006-06-23 | EP2292788A1 | 2011-03-09 | van Eijk, Michael Josephus Theresia; van der Poel, Henricus Johannes Adam |
The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more samples to yield two or more libraries, sequencing at least part of the libraries, aligning the identified sequences and determining any putative single nucleotide polymorphisms, confirming any putative single nucleotide polymorphism, generating detection probes for the confirmed single nucleotide polymorphisms, subjection a test sample to the same complexity reduction to provide a test library and screen the test library for the presence or absence of the single nucleotide polymorphisms using the detection probe. |
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| 31 | SYSTEMS AND METHODS FOR ENHANCING FLUORESCENT DETECTION OF TARGET MOLECULES IN A TEST SAMPLE | EP08783190 | 2008-07-09 | EP2174115A4 | 2010-12-29 | CHAN WARREN CHE WOR; JENNINGS TRAVIS LEON; KLOSTRANEC JESSE M |
| 32 | STRATEGIES FOR HIGH THROUGHPUT IDENTIFICATION AND DETECTION OF POLYMORPHISMS | EP06757808.8 | 2006-06-23 | EP1910562B1 | 2010-12-08 | VAN EIJK, Michael, Josephus, Theresia; VAN DER POEL, Henricus, Johannes, Adam |
| The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in an immune cell resulting in modulation of the immune response. The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more samples to yield two or more libraries, sequencing at least part of the libraries, aligning the identified sequences and determining any putative single nucleotide polymorphisms, confirming any putative single nucleotide polymorphism, generating detection probes for the confirmed single nucleotide polymorphisms, subjection a test sample to the same complexity reduction to provide a test library and screen the test library for the presence or absence of the single nucleotide polymorphisms using the detection probe. | ||||||
| 33 | Method for identifying a member of a mass-coded combinatorial library | EP10170678.6 | 1999-01-04 | EP2241541A1 | 2010-10-20 | Birnbaum, Seth, N.; Nash, Huw, M.; Wintner, Edward, A.; Kalghatgi, Krishna; Shipps, Gerald; Jindal, Satish |
The present invention relates to a method for identifying a member of a mass-coded molecular library which is a ligand for a biomolecule and binds to the biomolecule at the binding site of a known second ligand for the biomolecule, said mass-coded molecular library comprising compounds of the general formula XYn, wherein n is an. integer from 2 to about 6, X is a scaffold and each Y is, independently, a peripheral moiety, wherein said mass-coded molecular library is produced by reacting a scaffold precursor with a sufficient number of distinct peripheral moiety precursors such that there exist at least about 250 distinct combinations of n peripheral moieties derived from said peripheral moiety precursors. |
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| 34 | LIBRARIES OF OLIGOMERS LABELLED WITH DIFFERENT TAGS | EP99922334.0 | 1999-05-17 | EP1068216A2 | 2001-01-17 | SOUTHERN, Edwin Mellor; SHCHEPINOV, Mikhail Sergeevich; HOUSBY, John Nicholas; HAMILTON, Alan Lewis; ELDER, John Kenneth |
| A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different label, and combining the said lots of the support. The steps are repeated several times, preferably to build up oligomer molecules carrying labels which identify the nature and position of a monomer unit of the oligomer, and which are releasable from the support. Preferred labels, which are releasable from the compounds by cleavage to provide charged groups for analysis by mass spectrometry, are groups of the trityl (trimethylphenyl) family. Also claimed are libraries of these labels and their use in assays and nucleic acid analysis methods. | ||||||
| 35 | Strategies for high throughput identification and detection of polymorphisms | US15862956 | 2018-01-05 | US10095832B2 | 2018-10-09 | Michael Josephus Theresia Van Eijk; Henricus Johannes Adam Van Der Poel |
| The invention relates to a method for identifying one or more polymorphisms in nucleic acid samples, comprising: (a) performing a reproducible complexity reduction on a plurality of nucleic acid samples to provide a plurality of libraries of the nucleic acid samples comprising amplified fragments, wherein the reproducible complexity reduction comprises amplifying fragments of the nucleic acid samples using one or more primers to obtain the amplified fragments, and wherein the amplified fragments in each library comprise a unique identifier sequence to indicate origin of each library obtained by the reproducible complexity reduction; (b) combining the plurality of libraries to obtain a combined library and sequencing at least a portion of the combined library to obtain sequences; (c) aligning the sequences to obtain an alignment; and (d) identifying one or more polymorphisms in the plurality of nucleic acid samples. | ||||||
| 36 | Strategies for high throughput identification and detection of polymorphisms | US15729328 | 2017-10-10 | US09898577B2 | 2018-02-20 | Michael Josephus Theresia Van Eijk; Henricus Johannes Adam Van Der Poel |
| The invention relates to a method for identifying one or more polymorphisms in nucleic acid samples, comprising: (a) performing a reproducible complexity reduction on a plurality of nucleic acid samples to provide a plurality of libraries of the nucleic acid samples comprising amplified fragments, wherein the reproducible complexity reduction comprises amplifying fragments of the nucleic acid samples using one or more primers to obtain the amplified fragments, and wherein the amplified fragments in each library comprise a unique identifier sequence to indicate origin of each library obtained by the reproducible complexity reduction; (b) combining the plurality of libraries to obtain a combined library and sequencing at least a portion of the combined library to obtain sequences; (c) aligning the sequences to obtain an alignment; and (d) identifying one or more polymorphisms in the plurality of nucleic acid samples. | ||||||
| 37 | Strategies for high throughput identification and detection of polymorphisms | US15467241 | 2017-03-23 | US09898576B2 | 2018-02-20 | Michael Josephus Theresia Van Eijk; Henricus Johannes Adam Van Der Poel |
| The invention relates to a method for identifying one or more polymorphisms in nucleic acid samples, comprising: (a) performing a reproducible complexity reduction on a plurality of nucleic acid samples to provide a plurality of libraries of the nucleic acid samples comprising amplified fragments, wherein the reproducible complexity reduction comprises amplifying fragments of the nucleic acid samples using one or more primers to obtain the amplified fragments, and wherein the amplified fragments in each library comprise a unique identifier sequence to indicate origin of each library obtained by the reproducible complexity reduction; (b) combining the plurality of libraries to obtain a combined library and sequencing at least a portion of the combined library to obtain sequences; (c) aligning the sequences to obtain an alignment; and (d) identifying one or more polymorphisms in the plurality of nucleic acid samples. | ||||||
| 38 | Strategies for high throughput identification and detection of polymorphisms | US14885063 | 2015-10-16 | US09376716B2 | 2016-06-28 | Michael Josephus Theresia Van Eijk; Henricus Johannes Adam Van Der Poel |
| The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more samples to yield two or more libraries, sequencing at least part of the libraries, aligning the identified sequences and determining any putative single nucleotide polymorphisms, confirming any putative single nucleotide polymorphism, generating detection probes for the confirmed single nucleotide polymorphisms, subjection a test sample to the same complexity reduction to provide a test library and screen the test library for the presence or absence of the single nucleotide polymorphisms using the detection probe. | ||||||
| 39 | Strategies for high throughput identification and detection of polymorphisms | US13449611 | 2012-04-18 | US08685889B2 | 2014-04-01 | Michael Josephus Theresia van Eijk; Henricus Johannes Adam van der Poel |
| The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more samples to yield two or more libraries, sequencing at least part of the libraries, aligning the identified sequences and determining any putative single nucleotide polymorphisms, confirming any putative single nucleotide polymorphism, generating detection probes for the confirmed single nucleotide polymorphisms, subjection a test sample to the same complexity reduction to provide a test library and screen the test library for the presence or absence of the single nucleotide polymorphisms using the detection probe. | ||||||
| 40 | Methods for screening cells and antibodies | US13527072 | 2012-06-19 | US08551716B2 | 2013-10-08 | Christine C. Genick; Lance G. Laing; Peter Li; Timothy F. Smith; Lara Madison; Bo Lin |
| The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies. | ||||||
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