| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | METHODS FOR LIGAND DISCOVERY | PCT/US0213061 | 2002-04-24 | WO03046200A3 | 2003-07-24 | ERLANSON DANIEL A; BRAISTED ANDREW A; WELLS JAMES |
| The present invention provides novel methods for ligand discovery. The inventive methods rely on a process termed "tethering" where potential ligands are covalently bonded or "tethered" to a target and subsequently identified as exemplified by the figure. | ||||||
| 162 | MASS SPECTROMETERS AND METHODS FOR RAPID SCREENING OF LIBRARIES OF DIFFERENT MATERIALS | PCT/US9718147 | 1997-10-08 | WO9815969A2 | 1998-04-16 | WEINBERG W HENRY; MCFARLAND ERIC W; CONG PEIJUN; GUAN SHENHENG |
| Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques are provided for rapidly characterizing compounds in combinatorial arrays of materials for discovering and/or optimizing new materials with specific desired properties. According to one aspect, a scanning mass spectrometer is used which includes an ionization chamber and a collector that outputs an electrical signal responsive to the quantity of gas ions contacting the collector surface. A conduit system selectively withdraws samples from the array of materials, passing the samples into the ionization chamber. In a specific embodiment, reactants are passed through the conduit system to the selected regions of interest on the substrate. Means are provided to selectively heat regions on the substrate. | ||||||
| 163 | ASSAYS FOR S1OO INHIBITORS | PCT/US2006031330 | 2006-08-10 | WO2008054354A3 | 2008-09-12 | BRESNICK ANNE REBA; GARRETT SARAH CLAIRE |
| Provided are methods of determining whether a compound is an inhibitor of an S1OO protein. The methods utilize a biosensor that comprises the S1OO protein that has a covalently bound fluorescent dye at an amino acid residue of the S1OO protein that becomes less exposed to the aqueous solution upon activation of the S1OO protein, where the fluorescent dye has decreased fluorescence when exposed to the aqueous solution than when protected from exposure to the aqueous solution. Also provided are methods of treating a subject having metastatic cancer. | ||||||
| 164 | DISSOLUTION AND PRECIPITATION OF COCRYSTALS WITH IONIZABLE COMPONENTS | PCT/US2007021308 | 2007-10-04 | WO2008054609A2 | 2008-05-08 | RODRIGUEZ-HORNEDO NAIR |
| An approach to designing families of cocrystals with desired (tunable) pH dependent dissolution is developed. The solubility and dissolution rate of a family of cocrystals with the same API and a series of ligands that are weak acids or weak bases has been found to be determined and controlled by the acid or base dissociation constant of the ligand and the pH of the dissolution medium. In various aspects, pH dependent dissolution is imparted to a non-ionizable API or the dissolution of ionizable API's is modulated. | ||||||
| 165 | OPTICALLY ENCODED PARTICLES, SYSTEM AND HIGH-THROUGHPUT SCREENING | PCT/US2004043001 | 2004-12-21 | WO2005062866A3 | 2006-05-18 | SAILOR MICHAEL J; MEADE SHAWN O |
| The invention concerns a particle (10, 10a) having a code from a library of codes embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum. An assay detection method uses such a particle and detects a spectral shift in the presence of an analyte. Additional embodiments are disclosed including additional features. | ||||||
| 166 | RATIO-BASED OLIGONUCLEOTIDE PROBE SELECTION | PCT/US0223974 | 2002-07-29 | WO03012042A3 | 2003-10-16 | DORRIS DAVID; MAZUMDER ABHIJIT; SHIPPY RICHARD D |
| Disclosed herein are methods of selecting probes to targetf nucleic acid sequences, methods of making oligonucleotides arrays comprising such probes, and methods of using such arrays. Also, described herein are oligonucleotide arrays comprising probes selected by a method of the invention. | ||||||
| 167 | CHEMICAL CONSTRUCTS | PCT/GB9903286 | 1999-10-05 | WO0020357A3 | 2000-10-26 | CARR ROBIN ARTHUR ELLIS; GEHANNE SYLVIE; KAY CORINNE; MCKEOWN STEPHEN CARL; MURRAY PETER JOHN; PAIO ALFREDO; SCICINSKI JAN JOSEF; WATSON STEPHEN PAUL; WILLIAMS GEOFFREY MARTYN; ZARAMELLA ALESSIO |
| The invention provides a chemical construct for use in solid phase synthesis comprising a solid support Q having linked thereto via a connecting group Y a substrate R; the connecting group Y having first and second cleavage sites which are orthogonally and selectively cleavable; the second cleavage site being selectively cleavable to release the substrate; and the first cleavage site being located at a position between the second cleavage site and the solid support and being selectively cleavable to release a fragment Fr comprising the substrate and at least a portion of the connecting group Y; characterised in that cleavage at the first cleavage site forms or introduces on the chemical fragment Fr at the first cleavage site a moiety comprising a sensitising group G (such as an amino group) which sensitises the chemical fragment Fr to instrumental, e.g. mass spectroscopic, analysis. Also provided are methods of analysis employing the constructs, as well as intermediate constructs. | ||||||
| 168 | SYSTEMS AND METHODS FOR CHARACTERIZATION OF MATERIALS AND COMBINATORIAL LIBRARIES WITH MECHANICAL OSCILLATORS | PCT/US9718192 | 1997-10-08 | WO9815501A3 | 1998-06-25 | MCFARLAND ERIC; MATSIEV LEONID |
| A method of characterizing materials comprising the steps of: providing a substrate; synthesizing an array of materials on said substrate; providing at least one reactant gas wherein said reactant gas is in contact with said array of materials; activating at least one of said materials on said array with a heating source; and periodically monitoring an infrared emission from said activated material with an infrared camera, wherein said infrared camera outputs a series of signals corresponding to an emission intensity varying with time of said activated material. | ||||||
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