ASSAYS FOR S1OO INHIBITORS |
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| 申请号 | PCT/US2006031330 | 申请日 | 2006-08-10 | 公开(公告)号 | WO2008054354A3 | 公开(公告)日 | 2008-09-12 |
| 申请人 | EINSTEIN COLL MED; BRESNICK ANNE REBA; GARRETT SARAH CLAIRE; | 发明人 | BRESNICK ANNE REBA; GARRETT SARAH CLAIRE; | ||||
| 摘要 | Provided are methods of determining whether a compound is an inhibitor of an S1OO protein. The methods utilize a biosensor that comprises the S1OO protein that has a covalently bound fluorescent dye at an amino acid residue of the S1OO protein that becomes less exposed to the aqueous solution upon activation of the S1OO protein, where the fluorescent dye has decreased fluorescence when exposed to the aqueous solution than when protected from exposure to the aqueous solution. Also provided are methods of treating a subject having metastatic cancer. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
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