| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | PEPTIDE LIBRARIES FOR SCREENING AND OTHER APPLICATIONS | EP11820266 | 2011-08-29 | EP2609236A4 | 2016-04-20 | LEE SU SEONG; LIM JAEHONG; CHA JUNHOE; ANG YI LI; ZHENG YIRAN; TAN SYLVIA |
| 62 | IMPROVED METHOD FOR A HIGHLY SENSITIVE DETECTION AND QUANTIFICATION OF BIOMOLECULES USING SECONDARY ION MASS SPECTROMETRY (SIMS) | EP10754327.4 | 2010-09-15 | EP2478372A1 | 2012-07-25 | RIPOLL, Camille; NORRIS, Victor; LEGENT, Guillaume; DELAUNE, Anthony |
| The present invention relates to an improved method for detecting and quantifying the presence or absence of a number of biomolecules in a sample using the SIMS technique and arrays for use in said method. | ||||||
| 63 | ALTERNATIVE NUCLEIC ACID SEQUENCING METHODS | EP08798901.8 | 2008-08-28 | EP2201021A1 | 2010-06-30 | BORTNER, Scott R. |
| Embodiments are provided that provide for parallel sequencing of nucleic acid segments. In some embodiments, a single sequence is sequenced by at least two different sequencing techniques and the results compared, allowing for deficiencies or strengths of one technique to be complemented by the second technique. | ||||||
| 64 | AMINES THAT INHIBIT A MAMMALIAN ANANDAMIDE TRANSPORTER, AND METHODS OF USE THEREOF | EP03736639 | 2003-05-15 | EP1509489A4 | 2007-03-21 | AQUILA BRIAN A; HOPKINS SETH; LOCKSHIN CURTIS A; WANG FENGJIANG |
| 65 | Infrared spectroscopy and imaging of libraries | EP06004658.8 | 1997-10-07 | EP1669738A2 | 2006-06-14 | McFarland, Eric, W.; Archibald, William |
A method of characterizing materials comprising the steps of: providing a substrate; synthesizing an array of materials on said substrate; providing at least one reactant gas wherein said reactant gas is in contact with said array of materials; activating at least one of said materials on said array with a heating source; and periodically monitoring an infrared emission from said activated material with an infrared camera, wherein said infrared camera outputs a series of signals corresponding to an emission intensity varying with time of said activated material.
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| 66 | METHODS FOR LIGAND DISCOVERY | EP02723967 | 2002-04-24 | EP1446496A4 | 2005-03-30 | ERLANSON DANIEL A; BRAISTED ANDREW C; WELLS JAMES |
| The present invention provides novel methods for ligand discovery. The inventive methods rely on a process termed 'tethering' where potential ligands are covalently bonded or 'tethered' to a target and subsequently identified as exemplified by the figure. | ||||||
| 67 | A conduit system for mass spectrometers and methods for rapid screening of libraries of different materials | EP02018112.9 | 1997-10-08 | EP1280185A1 | 2003-01-29 | Weinberg, W. Henry; McFarland, Eric W.; Cong, Peijun; Guan, Shenheng |
A conduit system for an apparatus for screening materials is provided, wherein the conduit system comprises a sampling probe having an inner passage and an outer passage concentrically arranged around the inner passage. Moreover, a screening apparatus including the conduit system and a method of operating the apparatus are provided. |
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| 68 | MASS SPECTROMETERS AND METHODS FOR RAPID SCREENING OF LIBRARIES OF DIFFERENT MATERIALS | EP97910017.9 | 1997-10-08 | EP1019947B1 | 2002-08-14 | WEINBERG, W., Henry; MCFARLAND, Eric, W.; CONG, Peijun; GUAN, Shenheng |
| 69 | CHEMICAL CONSTRUCTS | EP00966100.0 | 2000-10-03 | EP1218319A1 | 2002-07-03 | CARR, Robin, Arthur, Ellis,Glaxo Wellcome plc; GEHANNE, Sylvie,Glaxo Wellcome SpA; PAIO, Alfredo,Glaxo Wellcome SpA; WILLIAMS, Geoffrey M.,Glaxo Wellcome Chem. Lab.; ZARAMELLA, Alessio,Glaxo Wellcome SpA; KAY, Corinne |
| A chemical construct for use in solid phase synthesis comprising a solid support Q having linked thereto via a connecting group Y a substrate R; the connecting group Y having first and second cleavage sites which are orthogonally and selectively cleavable; the second cleavage site being selectively cleavable to release the substrate; and the first cleavage site being located at a position between the second cleavage site and the solid support and being selectively cleavable to release a fragment Fru comprising the substrate and at least a portion of the connecting group Y, wherein the said portion contains a chromophore Cu which facilitates analysis of the fragment Fru by ultra violet, visible or fluorescence spectroscopy, the chromophore Cu having a principal log E¿max? value of at least 2.5 and wherein (i) the principal log Emax value is at least 1.5 times greater than the principal log Emax of the substrate R; or (ii) the chromophore C?u¿ has an absorption peak at a wavelength remote from absorptions due to the substrate R; and to methods of analysis of products of solid phase synthesis using the constructs. | ||||||
| 70 | CHEMICAL CONSTRUCTS | EP99947750.8 | 1999-10-05 | EP1119529A2 | 2001-08-01 | CARR, Robin, Arthur, EllisGlaxo Wellcome plc; GEHANNE, SylvieGlaxo Wellcome SpA; KAY, CorinneGlaxo Wellcome Chemistry Laboratory; McKEOWN, Stephen, CarlGlaxo Wellcome plc; MURRAY, Peter, JohnOSI Pharmaceuticals; PAIO, AlfredoGlaxo Wellcome SpA; SCICINSKI, JanGlaxo Wellcome Chemistry Laboratory; WATSON, Stephen, PaulGlaxo Wellcome plc; WILLIAMS, G.Glaxo Wellcome Chemistry Laboratory; ZARAMELLA, AlessioGlaxo Wellcome SpA |
| The invention provides a chemical construct for use in solid phase synthesis comprising a solid support Q having linked thereto via a connecting group Y a substrate R; the connecting group Y having first and second cleavage sites which are orthogonally and selectively cleavable; the second cleavage site being selectively cleavable to release the substrate; and the first cleavage site being located at a position between the second cleavage site and the solid support and being selectively cleavable to release a fragment Fr comprising the substrate and at least a portion of the connecting group Y; characterised in that cleavage at the first cleavage site forms or introduces on the chemical fragment Fr at the first cleavage site a moiety comprising a sensitising group G (such as an amino group) which sensitises the chemical fragment Fr to instrumental, e.g. mass spectroscopic, analysis. Also provided are methods of analysis employing the constructs, as well as intermediate constructs. | ||||||
| 71 | Verfahren zum Verifizieren der Synthese organischer Moleküle in der kombinatorischen Chemie | EP99119836.7 | 1999-10-07 | EP1000918A2 | 2000-05-17 | Schröder, Harald, Dr.; Neidig, Klaus-Peter, Dr. |
Ein Verfahren zum Verifizieren der Synthese von aus Substrukturen aufgebauten organischen Molekülen der kombinatorischen Chemie umfaßt folgende Schritte:
Damit wird eine schnelle, reproduzierbare und zuverlässige Verifizierung einer großen Anzahl von systhetisierten Produkten der kombinatorischen Chemie ermöglicht. |
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| 72 | INFRARED SPECTROSCOPY AND IMAGING OF LIBRARIES | EP97910844.0 | 1997-10-07 | EP0934515A1 | 1999-08-11 | McFARLAND, Eric, W.; ARCHIBALD, William |
| Methods and apparatus for screening diverse arrays of materials using infrared imaging techniques are provided. Typically, each of the individual materials on the array will be screened or interrogated for the same material characteristic. Once screened, the individual materials may be ranked or otherwise compared relative to each other with respect to the material characteristic under investigation. According to one aspect, infrared imaging techniques are used to identify the active sites within an array of compounds by monitoring the temperature change resulting from a reaction. This same technique can also be used to quantify the stability of each new material within an array of compounds. According to another aspect, identification and characterization of condensed phase products is achieved, wherein library elements are activated by a heat source serially, or in parallel. According to another aspect, a Fourier transform infrared spectrometer is used to rapidly characterize a large number of chemical reactions contained within a combinatorial library. | ||||||
| 73 | Screening method and systems utilizing mass spectral fragmentation patterns | US14405415 | 2013-06-05 | US09842198B2 | 2017-12-12 | Nathan Magarvey; Aubrey Bailey Morgan Wyatt; Chad William Johnston; Ashraf Ibrahim; Bin Ma; Lian Yang |
| The present application is directed to methods and systems for identifying small molecule compounds in mixtures using a library comprising calculated structures and corresponding calculated mass spectral fragmentation patterns of known and/or hypothetical small molecule compounds that may be in the mixture and screening of a mass spectrum of the mixture using the library to identify matching fragmentation patterns. If a mass spectral fragmentation pattern present in the mass spectrum of the mixture matches a calculated fragmentation pattern of one of the known or hypothetical compounds this confirms the identity of a compound in the mixture as the known or hypothetical compound. The method represents a platform method that can be used for a multitude of purposes related to the screening and identification of compounds in mixtures. Therefore the methods and systems of the present application represent an approach that is uniquely capable of navigating chemical space and providing a understanding of desired families and pharmacophores. | ||||||
| 74 | Methods for Modulating ATRX-Dependent Gene Repression | US15522171 | 2015-10-30 | US20170335317A1 | 2017-11-23 | Jeannie T. Lee; Kavitha Sarma |
| Methods and compositions for modulation of the activity of alpha thalassemia/mental retardation syndrome X-linked (ATRX), e.g., modulation of DNA-ATRX or RNA-ATRX interactions, and methods for identifying and using compounds that modulate DNA-ATRX or RNA-ATRX interactions, as well as the compounds themselves. | ||||||
| 75 | Methods for identifying ligands that target nucleic acid molecules and nucleic acid structural motifs | US11998466 | 2007-11-29 | US09719191B2 | 2017-08-01 | Matthew D. Disney; Jessica L. Childs-Disney |
| Disclosed are methods for identifying a nucleic acid (e.g., RNA, DNA, etc.) motif which interacts with a ligand. The method includes providing a plurality of ligands immobilized on a support, wherein each particular ligand is immobilized at a discrete location on the support; contacting the plurality of immobilized ligands with a nucleic acid motif library under conditions effective for one or more members of the nucleic acid motif library to bind with the immobilized ligands; and identifying members of the nucleic acid motif library that are bound to a particular immobilized ligand. Also disclosed are methods for selecting, from a plurality of candidate ligands, one or more ligands that have increased likelihood of binding to a nucleic acid molecule comprising a particular nucleic acid motif, as well as methods for identifying a nucleic acid which interacts with a ligand. | ||||||
| 76 | METHODS FOR OPTIMIZING OPTICAL MAPPING CONDITIONS | US13190934 | 2011-07-26 | US20130029877A1 | 2013-01-31 | Colin William Dykes; Trevor Wagner; Adam Michael Briska; Wenlong Jiang |
| The invention generally relates to methods and apparatuses for optimizing conditions for optical mapping. In certain embodiments, methods of the invention involve providing a substrate including a gradient of silanes in a first direction, introducing to the substrate, a gradient of enzyme activity in a second direction, contacting a plurality of enzymes and a plurality of nucleic acids to the substrate, and analyzing enzymatic activity and interaction of the nucleic acids with the substrate, thereby determining the optimal conditions for optical mapping of the nucleic acid. | ||||||
| 77 | Assays for S100 inhibitors | US11989901 | 2006-08-10 | US08236791B2 | 2012-08-07 | Anne Reba Bresnick; Sarah Claire Garrett |
| Provided are methods of determining whether a compound is an inhibitor of an S100 protein. The methods utilize a biosensor that comprises the S100 protein that has a covalently bound fluorescent dye at an amino acid residue of the S100 protein that becomes less exposed to the aqueous solution upon activation of the S100 protein, where the fluorescent dye has decreased fluorescence when exposed to the aqueous solution than when protected from exposure to the aqueous solution. Also provided are methods of treating a subject having metastatic cancer. | ||||||
| 78 | EFFICIENT METHOD FOR PARTIAL SEQUENCING OF PEPTIDE/PROTEIN USING ACID OR BASE LABILE XANTHATES | US12513031 | 2007-10-30 | US20100069252A1 | 2010-03-18 | Bakshy Akshaykirit Chibber |
| A method and system for sequencing polypeptides utilizing acid and base labile xanthates. | ||||||
| 79 | SYSTEM AND METHOD FOR SURFACE PLASMON RESONANCE BASED DETECTION OF MOLECULES | US12527961 | 2008-02-21 | US20100045995A1 | 2010-02-25 | Lidija Malic; Maryam Tabrizian; Teodor Veres; Bo Cui; Francois Normandin |
| A system and method for molecule detection uses a surface plasmon resonance (SPR) system with detection spots having fixed nanostructures. An SPR assembly may be combined with a digital microfluidic control system such as an electrowetting-on-dielectric (EWOD) chip. The microfluidic system individually directs sample droplets to different detection spots of the SPR assembly, thus allowing the SPR examination of different samples or sample reactions on the same surface. The nanostructures at the detection spots enhance the sensitivity of the SPR signals. | ||||||
| 80 | AMINES THAT INHIBIT A MAMMALIAN ANANDAMIDE TRANSPORTER, AND METHODS OF USE THEREOF | US12392981 | 2009-02-25 | US20090163593A1 | 2009-06-25 | Brian M. Aquila; Seth C. Hopkins; Curtis A. Lockshin; Fengjiang Wang |
| One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson's disease, spasticity, Tourette's syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, autoimmune diseases, allergy, arthritis, Crohn's disease, malignant gliomas, neurodegenerative diseases, Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, and stroke. Another aspect of the present invention relates to combinatorial libraries of amines, and methods for preparing the libraries. | ||||||
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