| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | Methods for ligand discovery | US10121216 | 2002-04-10 | US20020155505A1 | 2002-10-24 | Jim Wells; Dan Erlanson; Andrew C. Braisted |
| The present invention provides novel methods for ligand discovery. The inventive methods rely on a process termed nulltetheringnull where potential ligands are covalently bonded or nulltetherednull to a target and subsequently identified. | ||||||
| 102 | Antisense inhibition of PTEN expression | US09577902 | 2000-05-24 | US06284538B1 | 2001-09-04 | Brett P. Monia; Lex M. Cowsert; Robert McKay |
| Antisense compounds, compositions and methods are provided for modulating the expression of PTEN. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTEN. Methods of using these compounds for modulation of PTEN expression and for treatment of diseases and conditions associated with expression of PTEN are provided. Such conditions include diabetes and hyperproliferative conditions. Methods for decreasing blood glucose levels, inhibiting PEPCK expression, decreasing blood insulin levels, decreasing insulin resistance, increasing insulin sensitivity, decreasing blood triglyceride levels or decreasing blood cholesterol levels in an animal using the compounds of the invention are also provided. The animal is preferably a human; also preferably the animal is a diabetic animal. | ||||||
| 103 | Optical systems and methods for rapid screening of libraries of different materials | US947085 | 1997-10-08 | US6034775A | 2000-03-07 | Eric W. McFarland; Earl Danielson; William Archibald |
| Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions. Optical or visible luminescence systems are also provided as well as their application to screening libraries of different materials. | ||||||
| 104 | Selection of aptamers based on geometry | US11959435 | 2007-12-18 | US09938641B2 | 2018-04-10 | Jason Andrew Appleton West; Brent Coleman Satterfield |
| Disclosed are methods for performing aptamer preselection based on unique geometry and the content of stems or loops of the aptamer, which methods are capable of providing suitable binders and also permit selection of aptamers performed essentially entirely on a chip or other device. Also disclosed are kits for aptamer selection. | ||||||
| 105 | OLIGONUCLEOTIDE PROBES AND USES THEREOF | US15557010 | 2016-03-09 | US20180066262A1 | 2018-03-08 | Valeriy DOMENYUK; Adam STARK; Nianqing XIAO; Zhenyu ZHONG; Mark MIGLARESE; David SPETZLER |
| Methods and compositions are provided for oligonucleotide probes and oligonucleotide probe libraries that recognize targets of interest. The targets include circulating biomarkers such as microvesicles, including those derived from various diseases. | ||||||
| 106 | Glycopeptide analyzer | US14553311 | 2014-11-25 | US09460903B2 | 2016-10-04 | Masaki Murase |
| The same sample S is analyzed using an ion-trap (IT) mass spectrometer section 11 in which ions are captured in an ion trap before mass spectrometry and a time-of-flight (TOF) mass spectrometer section 12 in which ions generated from the sample are directly subjected to mass spectrometry. A mass spectrum creator 21 creates an IT mass spectrum and a TOF mass spectrum from the measured results. A glycopeptide detector 23 detects fragment ion peaks related to neutral loss of sugars from the IT mass spectrum as well as peaks corresponding to intact molecular ions from the TOF mass spectrum, and furthermore, detects peaks common to the two spectra as glycopeptide ions. A quantitative analyzer 24 determines relative quantities of glycoforms of the glycopeptide based on the TOF mass spectrum. A structural analyzer 25 analyzes the structure of the glycopeptide using the result of an MSn analysis of the sample S. | ||||||
| 107 | SCREENING METHOD AND SYSTEMS UTILIZING MASS SPECTRAL FRAGMENTATION PATTERNS | US14405415 | 2013-06-05 | US20150148242A1 | 2015-05-28 | Nathan Magarvey; Aubrey Bailey Morgan Wyatt; Chad William Johnston; Ashraf Ibrahim; Bin Ma; Lian Yang |
| The present application is directed to methods and systems for identifying small molecule compounds in mixtures using a library comprising calculated structures and corresponding calculated mass spectral fragmentation patterns of known and/or hypothetical small molecule compounds that may be in the mixture and screening of a mass spectrum of the mixture using the library to identify matching fragmentation patterns. If a mass spectral fragmentation pattern present in the mass spectrum of the mixture matches a calculated fragmentation pattern of one of the known or hypothetical compounds this confirms the identity of a compound in the mixture as the known or hypothetical compound. The method represents a platform method that can be used for a multitude of purposes related to the screening and identification of compounds in mixtures. Therefore the methods and systems of the present application represent an approach that is uniquely capable of navigating chemical space and providing a understanding of desired families and pharmacophores. | ||||||
| 108 | GLYCOPEPTIDE ANALYZER | US14553311 | 2014-11-25 | US20150144783A1 | 2015-05-28 | Masaki MURASE |
| The same sample S is analyzed using an ion-trap (IT) mass spectrometer section 11 in which ions are captured in an ion trap before mass spectrometry and a time-of-flight (TOF) mass spectrometer section 12 in which ions generated from the sample are directly subjected to mass spectrometry. A mass spectrum creator 21 creates an IT mass spectrum and a TOF mass spectrum from the measured results. A glycopeptide detector 23 detects fragment ion peaks related to neutral loss of sugars from the IT mass spectrum as well as peaks corresponding to intact molecular ions from the TOF mass spectrum, and furthermore, detects peaks common to the two spectra as glycopeptide ions. A quantitative analyzer 24 determines relative quantities of glycoforms of the glycopeptide based on the TOF mass spectrum. A structural analyzer 25 analyzes the structure of the glycopeptide using the result of an MSn analysis of the sample S. | ||||||
| 109 | METHOD AND APPARATUS FOR PRODUCING SEQUENCE VERIFIED DNA | US14268832 | 2014-05-02 | US20150072873A1 | 2015-03-12 | Austen Heinz; Anselm Levskaya; John T. Mulligan |
| A method of retrieving a subset of polynucleotide molecules from a mixture of polynucleotide molecules includes receiving a mixture of nucleotide sequences comprising one or more polynucleotide molecules, synthesizing one or more identifier (ID) regions onto the one or more polynucleotide molecules, and sequencing members of the population of polynucleotide molecules to associate the sequence of one or more of the molecules (the “Polynucleotide Sequence”) with the sequence of the attached ID region (the “ID Sequence”). The method also includes generating a bead-bound library of one or more beads comprising subsets of identical polynucleotide molecules. Each bead is identified by the ID Sequence of the associated Polynucleotide Sequence. The method further includes sequencing the one or more ID regions of each bead to generate ID Sequence information for each bead, combining the Polynucleotide Sequence information, the one or more ID Sequences, and coordinates of each bead to identify the Polynucleotide Sequence on the bead, and retrieving the bead with its associated Polynucleotide Sequence from the flow cell based on the absolute coordinate position of the bead. | ||||||
| 110 | COMPOUNDS, REACTIONS, AND SCREENING METHODS | US13598470 | 2012-08-29 | US20130274144A1 | 2013-10-17 | John F. HARTWIG; Daniel W. ROBBINS; Seth J. HERZON |
| The invention provides a method comprising identifying a successful metal-mediated conjugation reaction by analyzing a test mixture for the presence of a conjugation product. The invention provides a two-dimensional approach to reaction discovery in which many catalysts for many catalytic reactions can be tested simultaneously to provide an efficient discovery platform. Reactants and products from the system can be identified using techniques such as gas chromatography, liquid chromatography, mass spectrometry, and combinations thereof. | ||||||
| 111 | System and method for surface plasmon resonance based detection of molecules | US12527961 | 2008-02-21 | US08345253B2 | 2013-01-01 | Lidija Malic; Maryam Tabrizian; Teodor Veres; Bo Cui; Francois Normandin |
| A system and method for molecule detection uses a surface plasmon resonance (SPR) system with detection spots having fixed nanostructures. An SPR assembly may be combined with a digital microfluidic control system such as an electrowetting-on-dielectric (EWOD) chip. The microfluidic system individually directs sample droplets to different detection spots of the SPR assembly, thus allowing the SPR examination of different samples or sample reactions on the same surface. The nanostructures at the detection spots enhance the sensitivity of the SPR signals. | ||||||
| 112 | METHOD FOR A HIGHLY SENSITIVE DETECTION AND QUANTIFICATION OF BIOMOLECULES USING SECONDARY ION MASS SPECTROMETRY (SIMS) | US13395238 | 2010-09-15 | US20120172249A1 | 2012-07-05 | Camille Ripoll; Victor Norris; Guillaume Legent; Anthony Delaune |
| The present invention relates to an improved method for detecting and quantifying the presence or absence of a number of biomolecules in a sample using the SIMS technique and arrays for use in said method. | ||||||
| 113 | METHOD AND SYSTEM FOR INDENTIFICATION OF MICROORGANISMS | US11757020 | 2007-06-01 | US20110224104A1 | 2011-09-15 | Evgenia Razumovski; Berk Oktem; Appavu K. Sundaram; Vsevolod S. Rakov; Sudeepta Shanbhag; Sergey Kurnosenko; Vladimir M. Doroshenko |
| A method and system for identification of microorganisms in a sample. The method includes processing the sample to produce at least one group of biomarker molecules from at least one microorganism in the sample, tandem mass-analyzing biomarker fragment ions from the at least one group of biomarker molecules to obtain a sample biomarker tandem mass spectrum of the biomarker, and identifying the microorganism in the sample based on a comparison of the sample biomarker tandem mass spectrum to an experimentally-derived reference tandem mass spectrum (stored in the reference library) from a known microorganism. The system includes a sample processing unit configured to process the sample and produce at least one group of biomarker molecules from at least one microorganism in the sample. The system includes a mass-analyzer for tandem mass analysis biomarker fragment ions. The system includes a processor configured to identify the microorganism in the sample based on a comparison of a sample biomarker tandem mass spectrum to an experimentally-derived reference tandem mass spectrum from a known microorganism. | ||||||
| 114 | Carbodithioate ligands for nanotechnology and biosensing applications | US11407751 | 2006-04-20 | US07803568B2 | 2010-09-28 | Alexander Wei; Yan Zhao |
| The present invention is directed to methods and products related to carbodithioate ligands bonded to surfaces. The invention is further directed to molecular and biomolecular sensing methods based on analyte recognition by carbodithioate ligands bonded to surfaces. | ||||||
| 115 | Assays for S100 inhibitors | US11989901 | 2006-08-10 | US20100216776A1 | 2010-08-26 | Anne Reba Bresnick; Sarah Claire Garrett |
| Provided are methods of determining whether a compound is an inhibitor of an S100 protein. The methods utilize a biosensor that comprises the S100 protein that has a covalently bound fluorescent dye at an amino acid residue of the S100 protein that becomes less exposed to the aqueous solution upon activation of the S100 protein, where the fluorescent dye has decreased fluorescence when exposed to the aqueous solution than when protected from exposure to the aqueous solution. Also provided are methods of treating a subject having metastatic cancer. | ||||||
| 116 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof | US12392981 | 2009-02-25 | US07671087B2 | 2010-03-02 | Brian M. Aquila; Seth C. Hopkins; Curtis A. Lockshin; Fengjiang Wang |
| One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson's disease, spasticity, Tourette's syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, autoimmune diseases, allergy, arthritis, Crohn's disease, malignant gliomas, neurodegenerative diseases, Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, and stroke. Another aspect of the present invention relates to combinatorial libraries of amines, and methods for preparing the libraries. | ||||||
| 117 | SUBSTRATE FOR PRODUCING ORGANIC NANOCRYSTALS | US12181084 | 2008-07-28 | US20100021744A1 | 2010-01-28 | Allan S. Myerson; In Sung Lee |
| Substrates for growing small crystals, the substrates having a first layer consisting of glass, polymer, and/or metal; a second layer having hydrophilic SAMs and hydrophobic SAMs, wherein the hydrophilic SAMs are located only on discrete islands on the first layer and the hydrophobic SAMs are located only on areas of the first layer free of hydrophilic SAMs. | ||||||
| 118 | GENERATION AND USE OF ISOTOPIC PATTERNS IN MASS SPECTRAL PHENOTYPIC COMPARISON OF ORGANISMS | US12244555 | 2008-10-02 | US20090124518A1 | 2009-05-14 | Christopher William Ward Beecher |
| A method for assaying phenotypic similarity or dissimilarity between organisms is disclosed in which a composite sample of admixed first and second samples is provided. The first, standard sample contains average concentrations of compounds of molecular mass less than about 1000 AMU present in the organism species. The second, assay sample contains compounds of having a similar molecular mass present in the organism whose phenotype is to be assayed. The constituents of both samples are (i) in a liquid medium and (ii) each compound of a sample has the same, first and second respective amounts of first and second stable isotopes of a first atom. The composite sample is mass spectroscopically analyzed for analytes, with the ratio of first to second isotope being determined for each analyte, along with a composite sample median ratio. The ratios for each analyte are compared to the median, with outlying ratios indicating dissimilarity. | ||||||
| 119 | SYSTEMS FOR OBSERVING REACTIONS USING INFRARED IMAGING | US12110710 | 2008-04-28 | US20090045341A1 | 2009-02-19 | Eric W. McFarland; William Archibald |
| A system for monitoring the heats of reaction of an array of materials has an infrared transparent substrate containing the materials. A reaction chamber encloses the substrate. At least one reactant gas is coupled to the reaction chamber through a valve. An infrared camera images the array of materials. The camera outputs signals corresponding to an infrared emission intensity of at least one activated material in the array. A system for characterizing chemical reactions has an infrared transparent substrate for containing an array of materials. A modulated infrared radiation source simultaneously irradiates the materials in the array with infrared radiation. An infrared camera has a focal plane array detecting infrared radiation. An optical element focuses the infrared radiation transmitted by the array of materials onto the focal plane array. A processor coupled to the camera transforms sequential intensity profiles of the detected infrared radiation into infrared spectra using Fourier analysis. | ||||||
| 120 | SELECTION OF APTAMERS BASED ON GEOMETRY | US11959435 | 2007-12-18 | US20080182759A1 | 2008-07-31 | Jason A. A. West; Brent Coleman Satterfield |
| Disclosed are methods for performing aptamer preselection based on unique geometry and the content of stems or loops of the aptamer, which methods are capable of providing suitable binders and also permit selection of aptamers performed essentially entirely on a chip or other device. Also disclosed are kits for aptamer selection. | ||||||
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