子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 新的生物标记及其在诊断、治疗孤独症中的用途 | CN201180060249.6 | 2011-12-13 | CN103328501B | 2015-09-16 | 纳吉·莫门尼; 本特·L·佩尔松 |
| 一种新的生物标记，其为具有序列SSKITHRIHWESASLLR*的肽，其中用星号标示的C端精氨酸侧链缺少通常在侧链中存在的NH2-C＝NH部分。本发明公开了所述生物标记在诊断神经疾病和/或神经精神疾病(特别是孤独症)中的用途，以及用于确定所述新的生物标记和针对所述新的生物标记的抗体的浓度的方法。孤独症的治疗，包括向受试者使用补体因子I抑制剂。 | ||||||
| 2 | 新的生物标记及其在诊断、治疗孤独症中的用途 | CN201180060249.6 | 2011-12-13 | CN103328501A | 2013-09-25 | 纳吉·莫门尼; 本特·L·佩尔松 |
| 一种新的生物标记，其为具有序列SSKITHRIHWESASLLR*的肽，其中用星号标示的C端精氨酸侧链缺少通常在侧链中存在的NH2-C＝NH部分。本发明公开了所述生物标记在诊断神经疾病和/或神经精神疾病(特别是孤独症)中的用途，以及用于确定所述新的生物标记和针对所述新的生物标记的抗体的浓度的方法。孤独症的治疗，包括向受试者使用补体因子I抑制剂。 | ||||||
| 3 | 自閉症の診断、治療におけるバイオマーカーおよびその使用 | JP2013544428 | 2011-12-13 | JP5960717B2 | 2016-08-02 | モメニ ナギ; ペルッソン ベント エル. |
| 4 | Diagnosis of autism, biomarkers and their use in the treatment | JP2013544428 | 2011-12-13 | JP2014506244A | 2014-03-13 | ナギ モメニ; ベント エル． ペルッソン |
| 本発明は、新規バイオマーカーである配列SSKITHRIHWESASLLR *を有するペプチドを提供し、式中、アステリスクで示されるC末端のアルギニンの側鎖が、通常は側鎖に存在するNH2-C=NH分子を欠く。 神経疾患および／または神経精神疾患（特に自閉症）の診断における本バイオマーカーの有用性が開示され、この新規バイオマーカーおよびこの新規バイオマーカーに対して向けられる抗体の濃度を測定するための方法も開示される。 補体因子I阻害剤を対象に投与する工程を含む自閉症の治療も提供される。 | ||||||
| 5 | Expanded radix for polymeric tags | US14921977 | 2015-10-23 | US09909121B2 | 2018-03-06 | Michael P. Weiner |
| A method having steps of (a) providing nucleic acids having a tag sequence (N1)n(N2)n . . . (Nx)n, wherein N1, N2 and Nx are nucleotides that complement different nucleotides, respectively, wherein n is an integer that can differ for N1, N2 and Nx; (b) detecting the nucleic acids individually and under conditions to distinguish signal intensities for (N1)n sequences having different values for n, (N2)n sequences having different values for n and. (Nx)n sequences having different values for n; and (c) distinguishing the tags based on the signal intensities. | ||||||
| 6 | Biomarker and uses thereof in diagnosis, treatment of autism | US13994671 | 2011-12-13 | US09347956B2 | 2016-05-24 | Naghi Momeni; Bengt L. Persson |
| A new biomarker, a peptide having sequence SSKITHRIHWESASLLR*, wherein the side chain of the C-terminal arginine denoted with the asterisk is lacking the NH2- C═NH moiety normally present in the side chain. Usefulness of the biomarker in the diagnosis of neurological and/or neuropsychiatric disorders (in particular autism) is disclosed, as well as are methods for determining the concentration of the new biomarker and antibodies directed to the new biomarker. Treatment of autism, comprising administering a complement factor I inhibitor to the subject. | ||||||
| 7 | EXPANDED RADIX FOR POLYMERIC TAGS | US14921977 | 2015-10-23 | US20160083718A1 | 2016-03-24 | Michael P. Weiner |
| A method having steps of (a) providing nucleic acids having a tag sequence (N1)n(N2)n . . . (Nx)n, wherein N1, N2 and Nx are nucleotides that complement different nucleotides, respectively, wherein n is an integer that can differ for N1, N2 and Nx; (b) detecting the nucleic acids individually and under conditions to distinguish signal intensities for (N1)n sequences having different values for n, (N2)n sequences having different values for n and. (Nx)n sequences having different values for n; and (c) distinguishing the tags based on the signal intensities. | ||||||
| 8 | cDNA library for nucleic acid sequencing | US12956802 | 2010-11-30 | US09023769B2 | 2015-05-05 | Radoje Drmanac; Fredrik Dahl; Evan Hurowitz; Fredrie Dahl |
| The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs. The invention also includes methods of detecting and identifying sequences using various sequencing applications, including sequencing by ligation methods. | ||||||
| 9 | NOVEL BIOMARKER AND USES THEREOF IN DIAGNOSIS, TREATMENT OF AUTISM | US13994671 | 2011-12-13 | US20130267441A1 | 2013-10-10 | Naghi Momeni; Bent L. Persson |
| A new biomarker, a peptide having sequence SSKITHRIHWESASLLR*, wherein the side chain of the C-terminal arginine denoted with the asterisk is lacking the NH2-C═NH moiety normally present in the side chain. Usefulness of the biomarker in the diagnosis of neurological and/or neuropsychiatric disorders (in particular autism) is disclosed, as well as are methods for determining the concentration of the new biomarker and antibodies directed to the new biomarker. Treatment of autism, comprising administering a complement factor I inhibitor to the subject. | ||||||
| 10 | Nucleic Acid Sequencing and Process | US12956802 | 2010-11-30 | US20110281736A1 | 2011-11-17 | Radoje DRMANAC; Fredrik DAHL; Evan HUROWITZ; Fredrie DAHL |
| The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs. The invention also includes methods of detecting and identifying sequences using various sequencing applications, including sequencing by ligation methods. | ||||||
| 11 | 診断治療融合的な応用のための方法及びキット | JP2017529322 | 2015-12-02 | JP2018500892A | 2018-01-18 | イアン・ダン; マシュー・ローラー |
| 本発明の開示は、テンプレート化されたアセンブリ反応体を同定し、濃縮し、及び評価するための方法及びキットを対象とする。いくつかの実施形態は、テンプレート化アセンブリ反応体を合成すること、そのテンプレート化アセンブリ反応体を標的核酸に相補的形成をさせること、テンプレート化アセンブリ反応を実施すること、及びそのテンプレート化アセンブリ反応体に相補的形成をした標的核酸を同定することによって、テンプレート化アセンブリ標的を同定する方法を開示する。テンプレート化アセンブリ反応体のライブラリー、テンプレート化アセンブリ標的を同定するキット、及び化学的に連結反応したオリゴヌクレオチドの空間的誘発(CLOSE)産物のライブラリーから濃縮された、一対のテンプレート化アセンブリ標的をまた、開示する。【選択図】なし | ||||||
| 12 | Methods to detect and quantify RNA | US13397572 | 2012-02-15 | US09677130B2 | 2017-06-13 | Kai Wang; Shile Zhang; David Galas |
| Improved methods to quantitate RNA in biological or other analytical samples employ extended RNAs containing adaptors at the 5′ end and polyA sequences coupled to a tag at the 3′ end. The invention method is particularly useful in quantitating microRNAs as primers can be used that need not complement the non-conserved 3′ ends of these molecules. | ||||||
| 13 | Improved Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds | US15307616 | 2015-04-27 | US20170058305A1 | 2017-03-02 | Peter James Facchini |
| Novel methods that may be used for the manufacture of plant alkaloid compounds and novel polynucleotide compounds are provided. The plant alkaloid compounds are useful as medicinal compounds. | ||||||
| 14 | Analysis of DNA | US14888137 | 2014-05-01 | US20160068901A1 | 2016-03-10 | Allen E. Eckhardt; Michael G. Pollack; David S. Cohen |
| The invention provides pyrosequencing-based methods of analyzing and synthesizing DNA, including methods of DNA error correction, determining DNA size distribution, screening for nucleotide repeat disorders such as fragile X syndrome, determining size distribution and bias in a DNA library, and determining pyrosequencing read length. The methods include on-bench protocols as well as droplet-based protocols that may be conducted on a droplet actuator. | ||||||
| 15 | Expanded radix for polymeric tags | US14359558 | 2012-11-19 | US09200274B2 | 2015-12-01 | Michael P. Weiner |
| A method having steps of (a) providing nucleic acids having a tag sequence (N1)n(N2)n . . . (Nx)n, wherein N1, N2 and Nx are nucleotides that complement different nucleotides, respectively, wherein n is an integer that can differ for N1, N2 and Nx; (b) detecting the nucleic acids individually and under conditions to distinguish signal intensities for (N1)n sequences having different values for n, (N2)n sequences having different values for n and. (Nx)n sequences having different values for n; and (c) distinguishing the tags based on the signal intensities. | ||||||
| 16 | EXPANDED RADIX FOR POLYMERIC TAGS | US14359558 | 2012-11-19 | US20140342921A1 | 2014-11-20 | Michael P. Weiner |
| A method having steps of (a) providing nucleic acids having a tag sequence (N1)n(N2)n . . . (Nx)n, wherein N1, N2 and Nx are nucleotides that complement different nucleotides, respectively, wherein n is an integer that can differ for N1, N2 and Nx; (b) detecting the nucleic acids individually and under conditions to distinguish signal intensities for (N1)n sequences having different values for n, (N2)n sequences having different values for n and. (Nx)n sequences having different values for n; and (c) distinguishing the tags based on the signal intensities. | ||||||
| 17 | Method for genetic testing of human embryos for chromosome abnormalities, segregating genetic disorders with or without a known mutation and mitochondrial disorders following in vitro fertilization (IVF), embryo culture and embryo biopsy | US11903587 | 2007-09-24 | US20080085836A1 | 2008-04-10 | William Kearns; Richard Leach |
| We describe a method for interrogating the content and primary structure of DNA by microarray analyses and to provide comprehensive genetic screening and diagnostics prior to embryo transfer within an IVF setting. We will accomplish this by the following claims: 1) an optimized embryo grading system, 2) a less invasive embryo biopsy with reduced cellular contamination, 3) an optimized DNA amplification protocol for single cells, 4) identify aneuploidy and structural chromosome abnormalities using microarrays, 5) identifying sub-telomeric chromosome rearrangements, 6) a modified DNA fingerprinting protocol, 7) determine imprinting and epigenetic changes in developing embryos, 8) performing genome-wide scans to clarify/diagnose multi-factorial genetic disease and to determine genotype/haplotype patterns that may predict future disease, 9) determining single gene disorders with or without a known DNA mutation, 10) determining mtDNA mutations and/or the combination of mtDNA and genomic (nuclear) DNA aberrations that cause genetic disease. | ||||||
| 18 | Library design in combinatorial chemistry by Monte Carlo methods | US09474965 | 1999-12-30 | US06640191B1 | 2003-10-28 | Michael W. Deem; Marco Falcioni |
| Methods for generating multiple rounds of combinatorial libraries, which use Monte Carlo methods to search the multi-dimensional composition and non-composition space of variables in combinatorial chemistry; the combinatorial libraries generated and screened by such Monte Carlo methods; and an apparatus for generating and screening such libraries robotically. The process involves preparing a first set of samples, then changing the composition and non-composition variables of the samples using Monte Carlo sampling methods, and accepting proposed new samples according to a detailed balance acceptance criterion. | ||||||
| 19 | METHODS FOR DETERMINING LYMPHOCYTE RECEPTOR CHAIN PAIRS | EP15796244 | 2015-05-22 | EP3146079A4 | 2017-10-11 | HANSEN CARL LARS GENGHIS; MEWIS GEORGIA ELIZABETH; HEYRIES KEVIN ALBERT; VANINSBERGHE MICHAEL ANDREW; DA COSTA DANIEL JAY; RICICOVA MARKETA |
| Provided herein are high-throughput sequencing methods to study the diversity and functionality of lymphocyte receptor chains and pairing of the same. Specifically, the methods provided herein are used to identify with confidence one or more lymphocyte receptor chain pairs in a sample, for example one or more functional chain pairs. | ||||||
| 20 | ANALYSIS OF DNA | EP14791467.5 | 2014-05-01 | EP2992083A1 | 2016-03-09 | ECKHARDT, Allen, E.; POLLACK, Michael, G.; COHEN, David, S. |
| The invention provides pyrosequencing-based methods of analyzing and synthesizing DNA, including methods of DNA error correction, determining DNA size distribution, screening for nucleotide repeat disorders such as fragile X syndrome, determining size distribution and bias in a DNA library, and determining pyrosequencing read length. The methods include on-bench protocols as well as droplet-based protocols that may be conducted on a droplet actuator. | ||||||
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