| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | 바이오 칩 | KR1020110109183 | 2011-10-25 | KR1020130044863A | 2013-05-03 | 양정승; 구보성 |
| PURPOSE: A biochip is provided to precisely combine a first substrate and a second substrate. CONSTITUTION: A biochip comprises a first substrate(100) and a second substrate. The first substrate comprises a first lateral side(102) and a first groove(110). The second substrate has a first coupling column which is inserted into the first groove, and second coupling columns which contact the second lateral side(104) which faces the first lateral side. The first coupling column has a cone, a pyramid, a truncated cone, or a truncated corn shape. The second coupling columns have a cone, a pyramid, a truncated cone, or a truncated corn shape. The cross section of the first groove becomes narrower in a thickness direction of the first substrate. | ||||||
| 102 | COMBINATORIC ENCODING METHODS FOR MICROARRAYS | EP13742057.6 | 2013-07-19 | EP2839030B1 | 2016-09-14 | TRAU, Dieter |
| 103 | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays | EP12190906.3 | 1997-02-05 | EP2574617B1 | 2016-04-20 | Barany, Francis; Barany, George; Hammer, Robert P; Kempe, Maria; Blok, Herman; Zirvi, Monib |
| The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support. The ligation phase can be preceded by an amplification process. The present invention also relates to a kit for practicing this method, a method of forming arrays on solid supports, and the supports themselves. | ||||||
| 104 | WATER TREATMENT AND MONITORING | EP12798351.8 | 2012-11-29 | EP2785856A2 | 2014-10-08 | BRIDLE, Helen; BRADLEY, Mark; WU, Mei |
| The present invention relates to the provision of polymers that are selected to have either; surface properties that allow protozoa, in particular Cryptosporidium and Giardia, to bind to the polymer; or have surface properties that are repellent to the binding of these protozoa. Methods for identifying suitable polymers are provided. Products comprising, consisting of or coated with the polymers of the present invention are also provided, as well as methods of treating or monitoring water employing polymers of the present invention. | ||||||
| 105 | BIOMARKERS OF LUNG FUNCTION | EP11728575 | 2011-01-04 | EP2521916A4 | 2013-12-04 | FLORA JASON; ZEDLER BARBARA K; LEPPERT MARK; WEBB BRADLEY TODD; VAN DEN OORD EDWIN J C G; RANA GAURAV S J B; MCKINNEY WILLIE J; EDMISTON JEFFREY S; YORK TIMOTHY; MURELLE EDWARD LENN |
| Cigarette smoking is a primary determinant of chronic obstructive pulmonary disease (COPD), which is the fourth leading cause of morbidity and mortality in the United States. Unique proteins associated with COPD capable of differentiating subjects likely to experience rapid (RPD) or slow (SLW) decline in lung function have been identified using comprehensive high-throughput proteomic approaches. Thirty peptides, which mapped to 21 unique proteins, were linearly associated with annualized rates of lung function decline among smokers with COPD characterized as having rapid or slow decline and smokers without COPD. Using three different statistical approaches to assess the data, the RPD and SLW groups are differentiated by 55 peptides, which mapped to 33 unique proteins. A number of the identified peptides are proteolytic fragments of proteins that are involved in the complement and/or coagulation systems, have anti-protease activity, or metabolic functions. | ||||||
| 106 | Spatially addressable oligonucleotide arrays and method of making the same | EP07075987.3 | 1997-02-05 | EP1958955B1 | 2013-09-04 | Barany, George; Barany, Francis; Hammer, Robert P.; Kempe, Maria; Blok, Herman; Zirvi, Monib |
| The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support. The ligation phase can be preceded by an amplification process. The present invention also relates to a kit for practicing this method, a method of forming arrays on solid supports, and the supports themselves. | ||||||
| 107 | HIGH-DENSITY BIOCHEMICAL ARRAY CHIPS | EP11822596.0 | 2011-08-31 | EP2611954A1 | 2013-07-10 | STAKER, Bryan P. |
| An array chip useful for biochemical assays is provided wherein the chip includes a field region arranged with attachment sites according to a first pitch and at least one track region having a one-dimensional spot pattern arranged according to a second pitch that is less dense and is a non-integer multiple of the first pitch so that one-dimensional Moiré averaging may be applied in the track region, thereby to attain alignment of the chip to the optical instrumentation with a higher density of attachment sites. | ||||||
| 108 | A MICROARRAY SYSTEM AND A PROCESS FOR PRODUCING MICROARRAYS | EP07794246 | 2007-08-03 | EP2054711A4 | 2013-05-01 | TRAU DIETER; LIU WEN-TSO; NG KIAN KOK JOHNSON |
| A process for making a micro-array. The process comprises the step of depositing a population of microbeads on a substrate having at least one fiducial. The population being comprised of at least two sub-populations, preferably multiple sub-populations, each comprising a known active agent capable of specific binding with at least one target analyte. The said subpopulations are deposited sequentially and at discrete periods of each other. The process also comprises the step of making images of the substrate after deposition of each subpopulation. The images are then compared using the fiducial as a reference to thereby determine the location of each microbead and to identify the subpopulation, and its known active agent, based on differences between each image. Also disclosed in a system for using the microarray. | ||||||
| 109 | BIOMARKERS OF LUNG FUNCTION | EP11728575.9 | 2011-01-04 | EP2521916A1 | 2012-11-14 | FLORA, Jason; ZEDLER, Barbara, K.; LEPPERT, Mark; WEBB, Bradley, Todd; VAN DEN OORD, Edwin, J.C.G.; RANA, Gaurav S. J. B.; MCKINNEY, Willie J.; EDMISTON, Jeffrey S.; YORK, TImothy; MURELLE, Edward, Lenn |
| Cigarette smoking is a primary determinant of chronic obstructive pulmonary disease (COPD), which is the fourth leading cause of morbidity and mortality in the United States. Unique proteins associated with COPD capable of differentiating subjects likely to experience rapid (RPD) or slow (SLW) decline in lung function have been identified using comprehensive high-throughput proteomic approaches. Thirty peptides, which mapped to 21 unique proteins, were linearly associated with annualized rates of lung function decline among smokers with COPD characterized as having rapid or slow decline and smokers without COPD. Using three different statistical approaches to assess the data, the RPD and SLW groups are differentiated by 55 peptides, which mapped to 33 unique proteins. A number of the identified peptides are proteolytic fragments of proteins that are involved in the complement and/or coagulation systems, have anti-protease activity, or metabolic functions. | ||||||
| 110 | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays | EP10075551.1 | 1997-02-05 | EP2368897A1 | 2011-09-28 | Barany, Francis; Barany, George; Hammer, Robert P.; Kempe, Maria; Blok, Herman; Zirvi, Monib |
The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specifc portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotide at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support. The ligation phase can be preceded by an amplification process. The present invention also relates to a kit for practicing this method, a method of forming arrays on solid supports, and the supports themselves.
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| 111 | Detection of nucleic and acid sequence differences using the ligase detection reaction with addressable arrays | EP10075459.7 | 1997-02-05 | EP2332957A1 | 2011-06-15 | Barany, Francis; Barany, George; Hammer, Robert P.; Kempe, Maria; Blok, Herman; Zirvi, Monib |
The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support. The ligation phase can be preceded by an amplification process. The present invention also relates to a kit for practicing this method, a method of forming arrays on solid supports, and the supports themselves.
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| 112 | TAGGED LIGAND ARRAYS FOR IDENTIFYING LIGAND-TARGET INTERACTIONS | EP99909680.3 | 1999-02-26 | EP1071813A1 | 2001-01-31 | BURMER, Glenna, C. |
| The present invention relates generally to high throughput screening methods. More particularly, the present invention provides screening methods that can readily be used to identify simultaneously multiple proteins or compounds that interact with multiple ligands, using a tagged array of ligands. | ||||||
| 113 | DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING THE LIGASE DETECTION REACTION WITH ADDRESSABLE ARRAYS | EP97922283.0 | 1997-02-05 | EP0920440A2 | 1999-06-09 | BARANY, Francis; BARANY, George; HAMMER, Robert, P.; KEMPE, Maria; BLOK, Herman; ZIRVI, Monib |
| The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support. The ligation phase can be preceded by an amplification process. The present invention also relates to a kit for practicing this method, a method of forming arrays on solid supports, and the supports themselves. | ||||||
| 114 | METHOD OF ANALYZING BINDING INTERACTIONS | PCT/US2011001618 | 2011-09-20 | WO2012039756A2 | 2012-03-29 | DUBRIDGE ROBERT B |
| The invention is directed to methods for obtaining statistically significant information about how structural elements of proteins, e.g. position and identity of amino acid residues in binding domains, relate to functional properties of interest, such as binding affinity, specificity, and the like. In some embodiments, such information is collected by reacting under binding conditions a focused library of candidate nucleic acid-encoded binding compounds with a ligand, so that complexes form between the ligand and a portion of the candidate binding compounds ("binders"). Samples of binders and non-binders are then decoded by high throughput nucleic acid sequencing to give statistically significant data about the binding properties of substantially all of the candidate binding compounds, permitting them to be ranked by their respective affinities or dissociation constants. A reference compound, such as a pre-existing antibody, may be included in the reaction to identify candidates with similar or improved binding characteristics that have additional desirable characteristics, such as higher solubility, reduced immunogenicity, higher stability, or the like. | ||||||
| 115 | ARRAYS AND METHODS FOR GUIDED CELL PATTERNING | PCT/US2008050307 | 2008-01-04 | WO2008086228A3 | 2009-12-30 | ZHANG MIQIN; VEISEH MANDANA |
| Guided cell patterning arrays for single cell patterning, methods for making the arrays, and methods for using the arrays. | ||||||
| 116 | WATER TREATMENT AND MONITORING | PCT/GB2012052939 | 2012-11-29 | WO2013079938A3 | 2013-11-07 | BRIDLE HELEN; BRADLEY MARK; WU MEI |
| The present invention relates to the provision of polymers that are selected to have either; surface properties that allow protozoa, in particular Cryptosporidium and Giardia, to bind to the polymer; or have surface properties that are repellent to the binding of these protozoa. Methods for identifying suitable polymers are provided. Products comprising, consisting of, or coated with the polymers of the present invention are also provided, as well as methods of treating or monitoring water employing polymers of the present invention. | ||||||
| 117 | ASSAY SYSTEM | PCT/NZ2011000050 | 2011-04-07 | WO2011126385A3 | 2011-12-01 | SHEPHERD PETER ROBIN; WEALTHALL ROSAMUND JANE |
| The invention provides a method of forming a plurality of re-constitutable doses of at least one drug in a plurality of wells, the method including the steps of (i) placing a known amount of said drug in a suitable carrier to form a first composition having a known concentration (ii) placing at least two selected amounts of that first composition into individual wells and (iii) converting the first composition into a transportable form that can later be converted into a second composition having a known concentration and (iv) sealing the wells. | ||||||
| 118 | METHOD FOR MANUFACTURING AND APPLICATION OF RANDOM ORDERED ARRAYS OF CHEMICAL COMPOUNDS | PCT/EP2008068056 | 2008-12-19 | WO2009080766A3 | 2009-10-01 | AUER MANFRED; GSTACH HUBERT; ROTH GUENTER; WIESMUELLER KARL-HEINZ |
| The presented invention describes a method for the efficient manufacturing and application of random ordered arrays of chemical compounds. The method involves the generation of a random ordered array of beads, each bearing exactly one chemical compound. The chemical compounds from the beads of the bead array, called master, are transferred to another surface, the assay plate, generating a chemical copy of the bead array onto this surface. The assay plate could be used like any microarray. | ||||||
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