| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | Method for the electro-addressable functionalization of electrode arrays | US11930267 | 2007-10-31 | US09212430B1 | 2015-12-15 | Jason C. Harper; Ronen Polsky; Shawn M. Dirk; David R. Wheeler; Dulce C. Arango; Susan M. Brozik |
| A method for preparing an electrochemical biosensor uses bias-assisted assembly of unreactive -onium molecules on an electrode array followed by post-assembly electro-addressable conversion of the unreactive group to a chemical or biological recognition group. Electro-addressable functionalization of electrode arrays enables the multi-target electrochemical sensing of biological and chemical analytes. | ||||||
| 62 | RNA labeling method | US13354023 | 2012-01-19 | US09163329B2 | 2015-10-20 | Emily Marine Leproust; Gusti Zeiner; Petula N. D'andrade |
| A method of sample analysis is provided. In certain embodiments, the method involves: a) obtaining a fragmented RNA sample comprising fragments of long RNA molecules and short RNA molecules; b) ligating an adaptor to an end of the RNA of the fragmented RNA sample to produce an adaptor-ligated sample; c) hybridizing said adaptor-ligated sample to an array of nucleic acid probes; and d) reading said array to obtain an estimate of the abundance of a long RNA in the RNA sample and an estimate of the abundance a small RNA in the RNA sample. | ||||||
| 63 | Arrays and methods for guided cell patterning | US13846681 | 2013-03-18 | US09146229B2 | 2015-09-29 | Miqin Zhang; Mandana Veiseh |
| Guided cell patterning arrays for single cell patterning are disclosed. The arrays include a plurality of cell adhesion sites that are individually isolated on an inert surface. Each cell adhesion site has one or more cell adhesion peptides having affinity to a cell surface receptor. The inert surface is resistant to cell adhesion. | ||||||
| 64 | MICROARRAY SUBSTRATE, MICROARRAY, MICROFLUIDIC SYSTEM AND METHODS FOR PREPARING THE SAME | US14446017 | 2014-07-29 | US20150038364A1 | 2015-02-05 | Bo Zheng; Hui Feng |
| A microarray substrate including a piece of fluoropolymer whose surface is modified with polydopamine, in which the polydopamine forms an array of microspots on the surface of the fluoropolymer piece, and allows immobilization of molecules or cells. A microarray including the substrate, a microfluidic system designed for dispensing reagents onto selected locations on the surface of substrates, and a method for preparing the substrate and the microarray, in which a dopamine solution is dispensed onto the fluoropolymer piece using the microfluidic system, and forms an array of polydopamine microspots serving as the reaction sites for microarray analysis. | ||||||
| 65 | Water Treatment and Monitoring | US14361663 | 2012-11-29 | US20140329715A1 | 2014-11-06 | Helen Bridle; Mark Bradley; Mei Wu |
| The present invention relates to the provision of polymers that are selected to have either; surface properties that allow protozoa, in particular Cryptosporidium and Giardia, to bind to the polymer; or have surface properties that are repellent to the binding of these protozoa. Methods for identifying suitable polymers are provided. Products comprising, consisting of or coated with the polymers of the present invention are also provided, as well as methods of treating or monitoring water employing polymers of the present invention. | ||||||
| 66 | ARRAYS AND METHODS FOR GUIDED CELL PATTERNING | US13846681 | 2013-03-18 | US20140018260A1 | 2014-01-16 | Miqin Zhang; Mandana Veiseh |
| Guided cell patterning arrays for single cell patterning are disclosed. The arrays include a plurality of cell adhesion sites that are individually isolated on an inert surface. Each cell adhesion site has one or more cell adhesion peptides having affinity to a cell surface receptor. The inert surface is resistant to cell adhesion. | ||||||
| 67 | PROTEIN OR PEPTIDE PRINTING METHOD, PROTEIN ARRAY OR PEPTIDE ARRAY AND FUNCTIONAL PROTEIN OR FUNCTIONAL PEPTIDE IDENTIFICATION METHOD | US13772835 | 2013-02-21 | US20130237430A1 | 2013-09-12 | Takanori Ichiki; Manish Biyani; Hirofumi Shiono |
| The present invention relates to a protein or peptide printing method, comprising (a) a step for preparing nucleic acids and a cell-free protein synthesis system in an engraved plate composed of microscopic grooves having a specific opening shape, (b) a step for superimposing a substrate on the engraved plate so as to contact a protein or peptide to be synthesized in the microscopic grooves, and (c) a step for synthesizing the protein or peptide from the nucleic acids using the cell-free protein synthesis system in the microscopic grooves, and immobilizing the protein or peptide on the substrate along the specific opening shapes of the microscopic grooves. | ||||||
| 68 | BIOMARKERS OF LUNG FUNCTION | US13541462 | 2012-07-03 | US20130149389A1 | 2013-06-13 | Jason FLORA; Barbara K. Zedler; Edward Lenn Murrelle; Mark Leppert; Edwin J.C.G. van den Oord; Bradley Todd Webb; Timothy York; Gaurav S. J. B. Rana; Jeffrey S. Edmiston; Willie J. McKinney |
| Cigarette smoking is a primary determinant of chronic obstructive pulmonary disease (COPD), which is the fourth leading cause of morbidity and mortality in the United States. Unique proteins associated with COPD capable of differentiating subjects likely to experience rapid (RPD) or slow (SLW) decline in lung function have been identified using comprehensive high-throughput proteomic approaches. Thirty peptides, which mapped to 21 unique proteins, were linearly associated with annualized rates of lung function decline among smokers with COPD characterized as having rapid or slow decline and smokers without COPD. Using three different statistical approaches to assess the data, the RPD and SLW groups are differentiated by 55 peptides, which mapped to 33 unique proteins. A number of the identified peptides are proteolytic fragments of proteins that are involved in the complement and/or coagulation systems, have anti-protease activity, or metabolic functions. | ||||||
| 69 | METHOD FOR MASS PRODUCTION OF HIGH-PURITY NUCLEOTIDES | US13524029 | 2012-06-15 | US20130109059A1 | 2013-05-02 | Sunghoon KWON; Hyoki KIM; Howon LEE; Sungsik KIM; Taehoon RYU |
| Provided is a method of mass-producing high-purity nucleotides including providing a sequencing substrate having a clonal library of oligonucleotides on a solid support, sequencing the clonal library, obtaining measured location data of the solid support on the sequencing substrate, mapping pixel data of a signal generated from the solid support given as a result of the sequencing with the measured location data, extracting the solid support having a desired base sequence from the sequencing substrate using the mapping result, and amplifying an oligonucleotide on the extracted solid support to replicate on a large scale. | ||||||
| 70 | HIGH-DENSITY BIOCHEMICAL ARRAY CHIPS | US13221648 | 2011-08-30 | US20120224050A1 | 2012-09-06 | Bryan P. Staker |
| An array chip useful for biochemical assays is provided wherein the chip includes a field region arranged with attachment sites according to a first pitch and at least one track region having a one-dimensional spot pattern arranged according to a second pitch that is less dense and is a non-integer multiple of the first pitch so that one-dimensional Moiré averaging may be applied in the track region, thereby to attain alignment of the chip to the optical instrumentation with a higher density of attachment sites. | ||||||
| 71 | METHOD FOR A HIGHLY SENSITIVE DETECTION AND QUANTIFICATION OF BIOMOLECULES USING SECONDARY ION MASS SPECTROMETRY (SIMS) | US13395238 | 2010-09-15 | US20120172249A1 | 2012-07-05 | Camille Ripoll; Victor Norris; Guillaume Legent; Anthony Delaune |
| The present invention relates to an improved method for detecting and quantifying the presence or absence of a number of biomolecules in a sample using the SIMS technique and arrays for use in said method. | ||||||
| 72 | METHOD FOR SCREENING NEW DRUG CANDIDATE INHIBITING TARGET PROTEIN-PROTEIN INTERACTION FOR DEVELOPMENT OF FIRST-IN-CLASS DRUG | US13322651 | 2010-05-28 | US20120129722A1 | 2012-05-24 | So Youn Kim |
| The present invention relates to a method for screening a substance inhibiting protein-protein interactions, and more particularly to a method for screening a substance inhibiting protein-protein interactions, the method comprising using a protein chip having immobilized thereon spots comprising a mixture of a sol-gel material and a protein. According to the invention, a protein chip can be easily manufactured in a 96-well plate using a sol-gel material, whereby an inhibitor that inhibits protein-protein interactions can be easily screened from a library of natural substances. | ||||||
| 73 | RNA LABELING METHOD | US13354023 | 2012-01-19 | US20120122702A1 | 2012-05-17 | Emily Marine Leproust; Gusti Zeiner; Petula N. D'andrade |
| A method of sample analysis is provided. In certain embodiments, the method involves: a) obtaining a fragmented RNA sample comprising fragments of long RNA molecules and short RNA molecules; b) ligating an adaptor to an end of the RNA of the fragmented RNA sample to produce an adaptor-ligated sample; c) hybridizing said adaptor-ligated sample to an array of nucleic acid probes; and d) reading said array to obtain an estimate of the abundance of a long RNA in the RNA sample and an estimate of the abundance a small RNA in the RNA sample. | ||||||
| 74 | SUBSTRATE FOR PRODUCING ORGANIC NANOCRYSTALS | US12181084 | 2008-07-28 | US20100021744A1 | 2010-01-28 | Allan S. Myerson; In Sung Lee |
| Substrates for growing small crystals, the substrates having a first layer consisting of glass, polymer, and/or metal; a second layer having hydrophilic SAMs and hydrophobic SAMs, wherein the hydrophilic SAMs are located only on discrete islands on the first layer and the hydrophobic SAMs are located only on areas of the first layer free of hydrophilic SAMs. | ||||||
| 75 | Method and device for dual array hybridization karyotype analysis | US12353395 | 2009-01-14 | US20090186775A1 | 2009-07-23 | Norma Nowak; Jeffrey M. Conroy; Anthony Johnson |
| A method, a device and a platform for a dual assay, co-hybridization of labeled nucleic acid molecules utilizing two independent microarray platforms are provided herein. The dual hybridization method and device, including for example, each of a BAC based array and an oligonucleotide array provide simultaneous replication and/or validation of data for a single assay sample and in the same container, using two or more microarray slides. | ||||||
| 76 | Microarray-based method for rapid identification of cells, microorganisms, or protein mixtures | US09957775 | 2001-09-21 | US20020187464A1 | 2002-12-12 | Mark S. Klempner; Jane W. Pepper; Brian T. Cunningham |
| The invention provides compositions and methods for the detection, identification, and quantification of microorganisms, cells, or protein mixtures in a sample. | ||||||
| 77 | Detection of nucleic and sequence differences using the ligase detection reaction with addressable arrays | EP10075458.9 | 1997-02-05 | EP2332958B1 | 2016-04-20 | Barany, Francis; Barany, George; Hammer, Robert P.; Kempe, Maria; Blok, Herman; Zirvi, Monib |
| The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support. The ligation phase can be preceded by an amplification process. The present invention also relates to a kit for practicing this method, a method of forming arrays on solid supports, and the supports themselves. | ||||||
| 78 | HIGH-DENSITY BIOCHEMICAL ARRAY CHIPS | EP11822596 | 2011-08-31 | EP2611954A4 | 2015-04-29 | STAKER BRYAN P |
| An array chip useful for biochemical assays is provided wherein the chip includes a field region arranged with attachment sites according to a first pitch and at least one track region having a one-dimensional spot pattern arranged according to a second pitch that is less dense and is a non-integer multiple of the first pitch so that one-dimensional Moiré averaging may be applied in the track region, thereby to attain alignment of the chip to the optical instrumentation with a higher density of attachment sites. | ||||||
| 79 | METHOD OF ANALYZING BINDING INTERACTIONS | EP11827086 | 2011-09-20 | EP2619578A4 | 2014-03-26 | DUBRIDGE ROBERT B |
| 80 | METHOD OF ANALYZING BINDING INTERACTIONS | EP11827086.7 | 2011-09-20 | EP2619578A2 | 2013-07-31 | DUBRIDGE, Robert, B. |
| The invention is directed to methods for obtaining statistically significant information about how structural elements of proteins, e.g. position and identity of amino acid residues in binding domains, relate to functional properties of interest, such as binding affinity, specificity, and the like. In some embodiments, such information is collected by reacting under binding conditions a focused library of candidate nucleic acid-encoded binding compounds with a ligand, so that complexes form between the ligand and a portion of the candidate binding compounds ("binders"). Samples of binders and non-binders are then decoded by high throughput nucleic acid sequencing to give statistically significant data about the binding properties of substantially all of the candidate binding compounds, permitting them to be ranked by their respective affinities or dissociation constants. A reference compound, such as a pre-existing antibody, may be included in the reaction to identify candidates with similar or improved binding characteristics that have additional desirable characteristics, such as higher solubility, reduced immunogenicity, higher stability, or the like. | ||||||
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