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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	Cytotoxic Nucleotides for Targeted Therapeutics	US13008614	2011-01-18	US20110213135A1	2011-09-01	William H. Gmeiner
The present invention provides a method of generating a nucleic acid, which specifically binds to an extracellular surface protein expressed by a cell of interest, and which nucleic acid comprises a compound of interest to be delivered to the cell of interest.
2	Multi-binding inhibitor of cyclooxygenase-2	JP2000553012	1999-06-07	JP2002517423A	2002-06-18	ジョンエイチ．グリフィン，; ジェイ．ケビンジュディス，; デボラエル．ヒギンズ，
(57)【要約】プロスタグランジンの生合成において第一に実施される工程を触媒する酵素であるシクロオキシゲナーゼ−２（ＣＯＸ−２）を阻害する多結合化合物が開示される。本発明の多結合化合物は、１つ以上のリンカーに共有結合した２〜１０個のリガンドを含有する。各リガンドは、ＣＯＸ−２に対して結合し得る部分である。本発明の多結合化合物は、炎症、痛み、発熱などの処置に有用である。
3	MULTIBINDING INHIBITORS OF CYCLOOXYGENASE-2	EP99927360.0	1999-06-07	EP1085845A2	2001-03-28	JUDICE, J., Kevin; HIGGINS, Deborah, L.; GRIFFIN, John, H.
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment of inflammation, pain, fever and the like.
4	PRODUCTION OF ENCODED CHEMICAL LIBRARIES	EP14824390.0	2014-12-11	EP3083957B1	2018-05-23	DECURTINS, Willy; FRANZINI, Raphael; NERI, Dario; SCHEUERMANN, Jörg; WICHERT, Moreno
This invention relates to the synthesis of nucleic acid-encoded chemical libraries using common adaptor sequences. Nucleic acid strands coupled to chemical moieties may be contacted with identifier oligonucleotides comprising coding sequences encoding the chemical moieties and an adaptor oligonucleotides, such that the adaptor oligonucleotide hybridizes to both the nucleic acid strands and the identifier oligonucleotides to allow ligation of the identifier oligonucleotides to the nucleic acid strands. The adaptor oligonucleotide is then removed. Nucleic acid-encoded chemical libraries, and methods of producing or screening such libraries are provided.
5	PRODUCTION OF ENCODED CHEMICAL LIBRARIES	US15106795	2014-12-11	US20170009226A1	2017-01-12	Willy Decurtins; Raphael Franzini; Dario Neri; Jörg Scheuermann; Moreno Wichert
This invention relates to the synthesis of nucleic acid-encoded chemical libraries using common adaptor sequences. Nucleic acid strands coupled to chemical moieties may be contacted with identifier oligonucleotides comprising coding sequences encoding the chemical moieties and an adaptor oligonucleotides, such that the adaptor oligonucleotide hybridizes to both the nucleic acid strands and the identifier oligonucleotides to allow ligation of the identifier oligonucleotides to the nucleic acid strands. The adaptor oligonucleotide is then removed. Nucleic acid-encoded chemical libraries, and methods of producing or screening such libraries are provided.
6	SYSTEM AND METHOD FOR THE DECONVOLUTION OF MIXED DNA PROFILES USING A PROPORTIONATELY SHARED ALLELE APPROACH	US12421124	2009-04-09	US20090270264A1	2009-10-29	Thomas L. Overson
A total forensic DNA casework management system and method for the deconvolution of mixed DNA samples using a novel, 3-rule algorithm to determine the proportional allele sharing of the sample's contributors. The process is fully document, can assess and process DNA anomalies and artifacts, and transforms raw STR data to produce final DNA profile types, peak height ratios, proportions, fitting criteria and associated graphs.
7	Cytotoxic nucleotides for targeted therapeutics	US11704090	2007-02-08	US20080026947A1	2008-01-31	William Gmeiner
The present invention provides a method of generating a nucleic acid, which specifically binds to an extracellular surface protein expressed by a cell of interest, and which nucleic acid comprises a compound of interest to be delivered to the cell of interest.
8	SYSTEM AND METHOD FOR THE DECONVOLUTION OF MIXED DNA PROFILES USING A PROPORTIONATELY SHARED ALLELE APPROACH	US14937228	2015-11-10	US20160232282A1	2016-08-11	Thomas L. Overson
A total forensic DNA casework management system and method for the deconvolution of mixed DNA samples using a novel, 3-rule algorithm to determine the proportional allele sharing of the sample's contributors. The process is fully document, can assess and process DNA anomalies and artifacts, and transforms raw STR data to produce final DNA profile types, peak height ratios, proportions, fitting criteria and associated graphs.
9	Cytotoxic nucleotides for targeted therapeutics	US13008614	2011-01-18	US08940885B2	2015-01-27	William H. Gmeiner
The present invention provides a method of generating a nucleic acid, which specifically binds to an extracellular surface protein expressed by a cell of interest, and which nucleic acid comprises a compound of interest to be delivered to the cell of interest.
10	Substance Identification Methods Using Pooling	US13664370	2012-10-30	US20140121119A1	2014-05-01	Keith E. Stormo; QuanZhou Tao; Robert H. Bogden; Evan K. Hart
A substance identification method includes combining substances into four or more intermediate subpools in wells of a subpool plate and repooling the intermediate subpools into a number of final screening pools based on a repooling design providing the subpooled substances in at least three different final screening pools. The repooling design determines coordinates locating well positions for the substances. Another substance identification method includes using a two-dimensional array of wells arranged in rows and a number of columns that is at least 1.5 times the rows. Substances in the wells are combined into a number of screening pools. Individual screening pools include substances from wells having a row identifier in common with one other well. A pooling design provides the pooled substances in two different screening pools. The pooling design determines coordinates locating well positions for the substances.
11	Multibinding inhibitors of cyclooxygenase-2	US09326916	1999-06-07	US06395724B1	2002-05-28	J. Kevin Judice; Deborah L. Higgins; John H. Griffin
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment inflammation, pain, fever and the like.
12	MULTIBINDING INHIBITORS OF CYCLOOXYGENASE-2	PCT/US9912895	1999-06-07	WO9963939A9	2001-04-12	JUDICE J KEVIN; HIGGINS DEBORAH L; GRIFFIN JOHN H
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment of inflammation, pain, fever and the like.
13	MULTIBINDING INHIBITORS OF CYCLOOXYGENASE-2	PCT/US9912895	1999-06-07	WO9963939A2	1999-12-16	JUDICE J KEVIN; HIGGINS DEBORAH L; GRIFFIN JOHN H
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment of inflammation, pain, fever and the like.

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