子分类:
序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
1 Compositions Comprising A Sirt6 Activator As A Component Of A Yeast Ferment Extract And A DNA Repair Enzyme US15365109 2016-11-30 US20170071845A1 2017-03-16 Nadine Pernodet; Kelly Dong; Edward Pelle
Compositions of the invention comprise 8-oxoguanine glycosylase (OGG1) and SIRT6 activating peptide G-A-G-V-S-A-E-NH2. Compositions of the invention exhibit anti-aging effects by promoting the repair of skin cell DNA and/or by protecting skin cell DNA from UV damage.
2 Rapid N-Glycan Release from Glycoproteins using Immobilized Glycosylase Columns US15381039 2016-12-15 US20170175099A1 2017-06-22 Marton Szigeti; Akos Szekrenyes; Zsolt Keresztessy; Andras Guttman
N-glycosylation profiling of glycoprotein biotherapeutics is an essential step in each phase of product development in the biopharmaceutical industry. For example, during clone selection hundreds of clones should be analyzed quickly from limited amounts of samples. On the other hand, identification of disease related glycosylation alterations can serve as early indicators for various pathological conditions in the biomedical field. We describe an improved packed bed column PNGase F functionalized column reactor. The reactor may be packed into a pipette tip column. In some embodiments, a second column or mixed stationary phase may be packed into the column to capture and purify the cleaved glycan prior to analysis. Complete N-glycan removal can be obtained in 10 minutes from all major N-linked glycoprotein types. The approach can be readily applied to automated sample preparation systems, such as liquid handling robots.
3 Compositions comprising a Sirt6 activator as a component of a yeast ferment extract and a DNA repair enzyme US15365109 2016-11-30 US10022314B2 2018-07-17 Nadine Pernodet; Kelly Dong; Edward Pelle
Compositions of the invention comprise 8-oxoguanine glycosylase (OGG1) and SIRT6 activating peptide G-A-G-V-S-A-E-NH2. Compositions of the invention exhibit anti-aging effects by promoting the repair of skin cell DNA and/or by protecting skin cell DNA from UV damage.
4 Compositions comprising a SIRT6 activator and a DNA repair enzyme US14949967 2015-11-24 US09539196B2 2017-01-10 Nadine Pernodet; Kelly Dong; Edward Pelle
Compositions of the invention comprise 8-oxoguanine glycosylase (OGG1) and SIRT6 activating peptide G-A-G-V-S-A-E-NH2. Compositions of the invention exhibit anti-aging effects by promoting the repair of skin cell DNA and/or by protecting skin cell DNA from UV damage.
5 Compositions Comprising A Sirt6 Activator And A DNA Repair Enzyme US14949967 2015-11-24 US20160158139A1 2016-06-09 Nadine Pernodet; Kelly Dong; Edward Pelle
Compositions of the invention comprise 8-oxoguanine glycosylase (OGG1) and SIRT6 activating peptide G-A-G-V-S-A-E-NH2. Compositions of the invention exhibit anti-aging effects by promoting the repair of skin cell DNA and/or by protecting skin cell DNA from UV damage.
6 Sirt6活性化剤及びDNA修復酵素を含有する組成物 JP2017530267 2015-11-23 JP6391837B2 2018-09-19 パーノデット,ナディーン; ドン,ケリー; ペッレ,エドワード
7 Sirt6活性化剤及びDNA修復酵素を含有する組成物 JP2017530267 2015-11-23 JP2017538700A 2017-12-28 パーノデット,ナディーン; ドン,ケリー; ペッレ,エドワード
本発明の組成物は8-オキソグアニングリコシラーゼ(OGG1)及びSIRT6活性化ペプチドG-A-G-V-S-A-E-NH2を含有する。本発明の組成物は、皮膚細胞DNAの修復を促進すること、及び/又はUV損傷から皮膚細胞DNAを保護することによって抗老化作用を発揮する。【選択図】図2
8 SIRT6 활성화제 및 DNA 복구 효소를 포함하는 조성물 KR1020177015599 2015-11-23 KR1020170082591A 2017-07-14 페르노데트,나딘; 동,켈리; 펠레,에드워드
본발명의조성물은 8-옥소구아닌글리코실라제 (OGG1) 및 SIRT6 활성화펩티드 G-A-G-V-S-A-E-NH를포함한다. 본발명의조성물은피부세포 DNA의복구를촉진하고/거나 UV 손상으로부터피부세포 DNA를보호함으로써항노화효과를나타낸다.
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