| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 产生肌苷的微生物以及使用其生产肌苷的方法 | CN200880002307.8 | 2008-01-15 | CN101583709A | 2009-11-18 | 朴英薰; 赵光命; 李熙种; 李珍南 |
| 本发明涉及一种产生肌苷的微生物以及使用其生产肌苷的方法。肌苷属于嘌呤核苷，是一种在5’－肌苷酸合成中非常重要的原料。更具体地说，本发明涉及通过使编码核苷水解酶II的基因失活，并且使编码5’－核苷酸酶的基因被增强表达来高浓度产生肌苷的棒状杆菌属重组微生物，该微生物仍保留了产氨短杆菌CJIP2401(KCCM－10610)的特征。 | ||||||
| 2 | 产生肌苷的微生物以及使用其生产肌苷的方法 | CN200880002307.8 | 2008-01-15 | CN101583709B | 2012-07-04 | 朴英薰; 赵光命; 李熙种; 李珍南 |
| 本发明涉及一种产生肌苷的微生物以及使用其生产肌苷的方法。肌苷属于嘌呤核苷，是一种在5’-肌苷酸合成中非常重要的原料。更具体地说，本发明涉及通过使编码核苷水解酶II的基因失活，并且使编码5’-核苷酸酶的基因被增强表达来高浓度产生肌苷的棒状杆菌属重组微生物，该微生物仍保留了产氨短杆菌CJIP2401(KCCM-10610)的特征。 | ||||||
| 3 | 生产肌苷的棒杆菌属微生物及使用其生产肌苷的方法 | CN200980104049.9 | 2009-01-02 | CN101939413B | 2012-06-13 | 金喆河; 崔宗秀; 金祯焕; 金炯锡; 权重根; 安泰旻; 黄水渊; 沈栽益; 白珉知; 权娜罗; 崔惠真 |
| 公开了具有生产肌苷能力的棒杆菌属微生物，其中所述肌苷分解代谢途径被阻断，并且其具有渗漏腺嘌呤营养缺陷型表型且还具有渗漏鸟嘌呤营养缺陷型。还公开了生产肌苷的方法，所述方法包括培养所述棒杆菌属微生物。 | ||||||
| 4 | 生产肌苷的棒杆菌属微生物及使用其生产肌苷的方法 | CN200980104049.9 | 2009-01-02 | CN101939413A | 2011-01-05 | 金喆河; 崔宗秀; 金祯焕; 金炯锡; 权重根; 安泰旻; 黄水渊; 沈栽益; 白珉知; 权娜罗; 崔惠真 |
| 公开了具有生产肌苷能力的棒杆菌属微生物，其中所述肌苷分解代谢途径被阻断，并且其具有渗漏腺嘌呤营养缺陷型表型且还具有渗漏鸟嘌呤营养缺陷型。还公开了生产肌苷的方法，所述方法包括培养所述棒杆菌属微生物。 | ||||||
| 5 | Microorganism Producing Inosine and Method of Producing Inosine Using the Same | US12522004 | 2008-01-15 | US20100081173A1 | 2010-04-01 | Young-hoon Park; Kwang-myung Cho; Hee-jong Lee; Jin-nam Lee |
| The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus producing inosine at high concentration by inactivating the gene encoding nucleoside hydrolase II and by enhancing the expression of the gene encoding 5′-nucleotidase, which still retains the characteristics of Corynebacterium ammoniagenes CJIP2401 (KCCM-10610). | ||||||
| 6 | Microorganism producing inosine and method of producing inosine using the same | US12522004 | 2008-01-15 | US08168422B2 | 2012-05-01 | Young-hoon Park; Kwang-myung Cho; Hee-jong Lee; Jin-nam Lee |
| The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus producing inosine at high concentration by inactivating the gene encoding nucleoside hydrolase II and by enhancing the expression of the gene encoding 5′-nucleotidase, which still retains the characteristics of Corynebacterium ammoniagenes CJIP2401 (KCCM-10610). | ||||||
| 7 | Inosine producing microorganism belonging to the genus Corynebacterium and process of producing inosine using the same | US12811778 | 2009-01-02 | US08551736B2 | 2013-10-08 | Chul Ha Kim; Jong Soo Choi; Jeong Hwan Kim; Hyoung Seok Kim; Jung Gun Kwon; Tae Min Ahn; Soo Youn Hwang; Jae Ick Sim; Min Ji Baek; Na Ra Kwon; Hye Jin Choi |
| A microorganism of the genus Corynebacterium having the ability to produce inosine in which the inosine catabolic pathway is blocked and that has a leaky adenine auxotrophic phenotype and further has a leaky guanine auxotrophic phenotype and a method of producing inosine, the method including culturing the microorganism of the genus Corynebacterium are disclosed. | ||||||
| 8 | Microorganism producing inosine and method of producing inosine using the same | US13229166 | 2011-09-09 | US08187840B2 | 2012-05-29 | Young-hoon Park; Kwang-myung Cho; Hee-jong Lee; Jin-nam Lee |
| The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus producing inosine at high concentration by inactivating the gene encoding nucleoside hydrolase II and by enhancing the expression of the gene encoding 5′-nucleotidase, which still retains the characteristics of Corynebacterium ammoniagenes CJIP2401 (KCCM-10610). | ||||||
| 9 | Microorganism Producing Inosine and Method of Producing Inosine Using the Same | US13229166 | 2011-09-09 | US20110318783A1 | 2011-12-29 | Young-hoon Park; Kwang-myung Cho; Hee-jong Lee; Jin-nam Lee |
| The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus producing inosine at high concentration by inactivating the gene encoding nucleoside hydrolase II and by enhancing the expression of the gene encoding 5′-nucleotidase, which still retains the characteristics of Corynebacterium ammoniagenes CJIP2401 (KCCM-10610). | ||||||
| 10 | INOSINE PRODUCING MICROORGANISM BELONGING TO THE GENUS CORYNEBACTERIUM AND PROCESS OF PRODUCING INOSINE USING THE SAME | US12811778 | 2009-01-02 | US20110003342A1 | 2011-01-06 | Chul Ha Kim; Jong Soo Choi; Jeong Hwan Kim; Hyoung Seok Kim; Jung Gun Kwon; Tae Min Ahn; Soo Youn Hwang; Jae Ick Sim; Min Ji Baek; Na Ra Kwon; Hye Jin Choi |
| A microorganism of the genus Corynebacterium having the ability to produce inosine in which the inosine catabolic pathway is blocked and that has a leaky adenine auxotrophic phenotype and further has a leaky guanine auxotrophic phenotype and a method of producing inosine, the method including culturing the microorganism of the genus Corynebacterium are disclosed. | ||||||
| 11 | Method of producing microorganism of the genus Corynebacterium and inosine using the same with the inosine-producing ability | JP2010541403 | 2009-01-02 | JP2011508599A | 2011-03-17 | タエ ミン アン; ジョン ファン キム; チュル ハ キム; ヒョン ソック キム; ジュン グン クウォン; ナ ラ クォン; ジャエ イック シム; ジョン スー チョイ; ヒ ジン チョイ; ミン ジ バク; スー ヨウン ファン |
| イノシン分解経路が遮断され、漏出型のアデニン要求性、及び望ましくは、漏出型のグアニン要求性をさらに有することを特徴とするイノシン生産能を有するコリネバクテリウム属微生物、及び該微生物を培養する段階を含む、イノシンを生産する方法が開示される。
|
||||||
| 12 | Method of producing microorganism of the genus Corynebacterium and inosine using the same with the inosine-producing ability | JP2010541403 | 2009-01-02 | JP5377514B2 | 2013-12-25 | チュル ハ キム; ジョン スー チョイ; ジョン ファン キム; ヒョン ソック キム; ジュン グン クウォン; タエ ミン アン; スー ヨウン ファン; ジャエ イック シム; ミン ジ バク; ナ ラ クォン; ヒ ジン チョイ |
| 13 | MICROORGANISM OF THE GENUS CORYNEBACTERIUM HAVING THE ABILITY TO PRODUCE INOSINE, AND AN INOSINE PRODUCTION METHOD USING THE SAME | EP09700802.3 | 2009-01-02 | EP2233563B1 | 2013-11-13 | KIM, Chul Ha; CHOI, Jong Soo; KIM, Jeong Hwan; KIM, Hyoung Seok; KWON, Jung Gun; AHN, Tae Min; HWANG, Soo Youn; SIM, Jae Ick; BAEK, Min Ji; KWON, Na Ra; CHOI, Hye Jin |
| 14 | SYNTHETIC FLUOROURIDINE-ACTIVATING ENZYME FOR CANCER THERAPY | EP05743019.1 | 2005-05-10 | EP1747270A2 | 2007-01-31 | DEGANO, Massimo; c/o DIBIT San Raffaele; GIABBAI, Barbara; c/o DIBIT San Raffaele |
| A chimeric protein essentially comprising a first moiety having an activity of nucleoside hydrolase (NH) and a second moiety having an activity of uracil phosphorybosil transferase (UPRT), the first and the second moiety being optionally linked by an extra amino acid sequence, nucleic acids encoding for the same, vectors for use in suicide gene therapy, chemotherapeutic composition comprising the protein. | ||||||
| 15 | MICROORGANISM PRODUCING INOSINE AND METHOD OF PRODUCING INOSINE USING THE SAME | EP08704775.9 | 2008-01-15 | EP2115120B1 | 2016-10-05 | PARK, Young-Hoon; CHO, Kwang-Myung; LEE, Hee-Jong; LEE, Jin-Nam |
| 16 | MICROORGANISM OF THE GENUS CORYNEBACTERIUM HAVING THE ABILITY TO PRODUCE INOSINE, AND AN INOSINE PRODUCTION METHOD USING THE SAME | EP09700802.3 | 2009-01-02 | EP2233563A2 | 2010-09-29 | KIM, Chul Ha; CHOI, Jong Soo; KIM, Jeong Hwan; KIM, Hyoung Seok; KWON, Jung Gun; AHN, Tae Min; HWANG, Soo Youn; SIM, Jae Ick; BAEK, Min Ji; KWON, Na Ra; CHOI, Hye Jin |
A microorganism of the genus Corynebacterium having the ability to produce inosine in which the inosine catabolic pathway is blocked and that has a leaky adenine auxotrophic phenotype and further has a leaky guanine auxotrophic phenotype and a method of producing inosine, the method including culturing the microorganism of the genus Corynebacterium are disclosed. |
||||||
| 17 | MICROORGANISM OF THE GENUS CORYNEBACTERIUM HAVING THE ABILITY TO PRODUCE INOSINE, AND AN INOSINE PRODUCTION METHOD USING THE SAME | EP09700802 | 2009-01-02 | EP2233563A4 | 2011-08-17 | KIM CHUL HA; CHOI JONG SOO; KIM JEONG HWAN; KIM HYOUNG SEOK; KWON JUNG GUN; AHN TAE MIN; HWANG SOO YOUN; SIM JAE ICK; BAEK MIN JI; KWON NA RA; CHOI HYE JIN |
| 18 | MICROORGANISM PRODUCING INOSINE AND METHOD OF PRODUCING INOSINE USING THE SAME | EP08704775 | 2008-01-15 | EP2115120A4 | 2010-04-28 | PARK YOUNG-HOON; CHO KWANG-MYUNG; LEE HEE-JONG; LEE JIN-NAM |
| 19 | MICROORGANISM PRODUCING INOSINE AND METHOD OF PRODUCING INOSINE USING THE SAME | EP08704775.9 | 2008-01-15 | EP2115120A1 | 2009-11-11 | PARK, Young-Hoon; CHO, Kwang-Myung; LEE, Hee-Jong; LEE, Jin-Nam |
| The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5'-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus producing inosine at high concentration by inactivating the gene encoding nucleoside hydrolase II and by enhancing the expression of the gene encoding 5 '-nucleotidase, which still retains the characteristics of Corynebacterium ammoniagenes CJIP2401 (KCCM-10610). | ||||||
| 20 | 이노신을 생산하는 미생물 및 그를 이용한 이노신 제조방법 | KR1020070004341 | 2007-01-15 | KR100882418B1 | 2009-02-05 | 박영훈; 조광명; 이희종; 이진남 |
| 본 발명은 5'-이노신산(5'-inosinic acid)의 합성 원료로서 중요한 물질인 퓨린계 뉴클레오시드(nucleoside) 중의 하나인 이노신(inosine)을 생산하는 미생물 및 그를 이용한 이노신의 제조방법에 관한 것이다. 더욱 상세하게는, 본 발명은 코리네박테리움 암모니아게네스 CJIP2401(KCCM-10610) 균주의 특성을 지니고 있으면서, 뉴클레오시드 하이드롤라아제 II를 코딩하는 유전자가 불활성화되고 5'-뉴클레오티다아제(5'-nucleotidase)를 코딩하는 유전자의 발현이 강화된 고농도의 이노신을 생산할 수 있는 재조합 코리네박테리움 속 미생물 및 그를 이용한 이노신의 생산 방법에 관한 것이다. 코리네박테리움 암모니아게네스, 이노신, 뉴클레오시드 하이드롤라제 II, 5'-뉴클레오티다아제 | ||||||
QQ群二维码
意见反馈
意见反馈