| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | CD83在联合治疗中的用途 | CN201410370758.4 | 2007-08-16 | CN104177464A | 2014-12-03 | C·尼科莱特; S·布兰德; Z·钟; H·王; J·阿尔普; S·拉姆查兰; M·L·巴罗雅 |
| 本发明涉及改进的抑制和/或预防不希望有的免疫应答的方法，包括使用CD83。在某些实施方式中，对受试者共施用CD83和至少一种其它免疫抑制化合物。本发明也提供了产生致耐受性树突细胞和调节性T细胞的方法。这些细胞可以用来在体外产生用于治疗目的的另外的细胞，或它们可以用来在体内抑制和/或预防不希望有的免疫应答。本发明的方法可以用来预防或减少自身免疫疾病的严重程度，也可以用来诱导对于至少一种诸如治疗性蛋白质或移植组织的治疗性组合物的耐受性。 | ||||||
| 2 | CD83在联合治疗中的用途 | CN201410370758.4 | 2007-08-16 | CN104177464B | 2017-04-12 | C·尼科莱特; S·布兰德; Z·钟; H·王; J·阿尔普; S·拉姆查兰; M·L·巴罗雅 |
| 本发明涉及改进的抑制和/或预防不希望有的免疫应答的方法，包括使用CD83。在某些实施方式中，对受试者共施用CD83和至少一种其它免疫抑制化合物。本发明也提供了产生致耐受性树突细胞和调节性T细胞的方法。这些细胞可以用来在体外产生用于治疗目的的另外的细胞，或它们可以用来在体内抑制和/或预防不希望有的免疫应答。本发明的方法可以用来预防或减少自身免疫疾病的严重程度，也可以用来诱导对于至少一种诸如治疗性蛋白质或移植组织的治疗性组合物的耐受性。 | ||||||
| 3 | Use of CD83 in Combination Therapies | US15155287 | 2016-05-16 | US20160324926A1 | 2016-11-10 | Charles Nicolette; Stephen Brand; Zhen Zhong; Hao Wang; Jacqueline Arp; Siobhan Ramcharran; Miren Lorea Baroja |
| The present invention relates to improved methods of suppressing and/or preventing an undesired immune response comprising the use of CD83. In some embodiments, CD83 is coadministered to a subject with at least one other immunosuppressive compound. Methods are also provided for generating tolerogenic dendritic cells and regulatory T cells. These cells can be used in vitro to produce additional cells for therapeutic purposes or they can be used in vivo to suppress and/or prevent an undesired immune response. Methods of the invention can be used to prevent or reduce the severity of autoimmune diseases and can also be used to induce tolerance to at least one therapeutic composition, such as a therapeutic protein or transplanted tissue. | ||||||
| 4 | Use of CD83 in Combination Therapies | US14872356 | 2015-10-01 | US20160008440A1 | 2016-01-14 | Charles Nicolette; Stephen Brand; Zhen Zhong; Hao Wang; Jacqueline Arp; Siobhan Ramcharran; Miren Lorea Baroja |
| The present invention relates to improved methods of suppressing and/or preventing an undesired immune response comprising the use of CD83. In some embodiments, CD83 is coadministered to a subject with at least one other immunosuppressive compound. Methods are also provided for generating tolerogenic dendritic cells and regulatory T cells. These cells can be used in vitro to produce additional cells for therapeutic purposes or they can be used in vivo to suppress and/or prevent an undesired immune response. Methods of the invention can be used to prevent or reduce the severity of autoimmune diseases and can also be used to induce tolerance to at least one therapeutic composition, such as a therapeutic protein or transplanted tissue. | ||||||
| 5 | Use of CD83 in combination therapies | US12308306 | 2007-08-16 | US20140010821A1 | 2014-01-09 | Charles Nicolette; Stephen Brand; Zhen Zhong; Hao Wang; Jacqueline Arp; Siobhan Ramcharran; Miren Lorea Baroja |
| The present invention relates to improved methods of suppressing and/or preventing an undesired immune response comprising the use of CD83. In some embodiments, CD83 is coadministered to a subject with at least one other immunosuppressive compound. Methods are also provided for generating tolerogenic dendritic cells and regulatory T cells. These cells can be used in vitro to produce additional cells for therapeutic purposes or they can be used in vivo to suppress and/or prevent an undesired immune response. Methods of the invention can be used to prevent or reduce the severity of autoimmune diseases and can also be used to induce tolerance to at least one therapeutic composition, such as a therapeutic protein or transplanted tissue. | ||||||
| 6 | Use of cd83 in combination therapy | JP2009525563 | 2007-08-16 | JP2010501556A | 2010-01-21 | アープ，ジャクリーン; ツォン，ツェン; ニコレット，チャールズ; バロジャ，ミリン・ロレア; ブランド，スティーブン; ラムチャーラン，ショバン; ワン，ハオ |
| 本発明は、ＣＤ８３の使用を含む、望ましくない免疫応答を抑制および／または予防する改善された方法に関する。 いくつかの実施形態において、ＣＤ８３を、少なくとも１つの他の免疫抑制性化合物とともに、被験体に同時投与する。 寛容誘導性樹状細胞および制御性Ｔ細胞を産生するための方法も提供される。 これらの細胞は、治療目的のためのさらなる細胞を産生するために、インビトロにおいて使用可能であり、または望ましくない免疫応答を抑制および／または予防するために、インビボにおいて使用可能である。 本発明の方法は、自己免疫疾患を予防するため、またはその重症度を減少させるために使用可能であり、治療用タンパク質または移植組織のような、少なくとも１つの治療用組成物に対する寛容誘導性を誘導するためにも使用可能である。 | ||||||
| 7 | Use of cd83 in combination therapy | JP2009525563 | 2007-08-16 | JP5570808B2 | 2014-08-13 | ニコレット，チャールズ; ブランド，スティーブン; ツォン，ツェン; ワン，ハオ; アープ，ジャクリーン; ラムチャーラン，ショバン; バロジャ，ミリン・ロレア |
| 8 | USE OF CD83 IN COMBINATION THERAPIES | EP07811339.6 | 2007-08-16 | EP2051987A2 | 2009-04-29 | NICOLETTE, Charles; BRAND, Stephen; ZHONG, Zhen; WANG, Hao; ARP, Jacqueline; RAMCHARRAN, Siobhan; BAROJA, Mirin Lorea |
| The present invention relates to improved methods of suppressing and/or preventing an undesired immune response comprising the use of CD83. In some embodiments, CD83 is coadministered to a subject with at least one other immunosuppressive compound. Methods are also provided for generating tolerogenic dendritic cells and regulatory T cells. These cells can be used in vitro to produce additional cells for therapeutic purposes or they can be used in vivo to suppress and/or prevent an undesired immune response. Methods of the invention can be used to prevent or reduce the severity of autoimmune diseases and can also be used to induce tolerance to at least one therapeutic composition, such as a therapeutic protein or transplanted tissue. | ||||||
| 9 | 併用療法におけるCD83の使用 | JP2014095908 | 2014-05-07 | JP5898260B2 | 2016-04-06 | ニコレット,チャールズ; ブランド,スティーブン; ツォン,ツェン; ワン,ハオ; アープ,ジャクリーン; ラムチャーラン,ショバン; バロジャ,ミリン・ロレア |
| 10 | Use of cd83 in combination therapy | JP2014095908 | 2014-05-07 | JP2014193881A | 2014-10-09 | CHARLES NICOLETTE; STEPHEN BRAND; ZHONG ZHEN; WANG HAO; JACQUELINE ARP; RAMCHARRAN SIOBHAN; MIRIN LOREA BAROJA |
| PROBLEM TO BE SOLVED: To provide an improved method for suppressing and/or preventing an undesired immune response, including use of CD83.SOLUTION: CD83 is simultaneously administered to a subject together with at least one of other immunosuppressive compounds. A method for producing a tolerance- inducible dendritic cell and a regulatory T cell is also provided. These cells can be used in vitro for producing a further cell for therapeutic purpose and can be used in vivo for suppressing and/or preventing an undesired immune response. They can be used for preventing an autoimmune disease or for reducing its seriousness, and also can be used for inducing tolerance-inductivity into at least one therapeutic composition such as therapeutic protein or transplanted tissue. | ||||||
| 11 | USE OF CD83 IN COMBINATION THERAPIES | EP07811339.6 | 2007-08-16 | EP2051987B1 | 2014-11-19 | NICOLETTE, Charles; BRAND, Stephen; ZHONG, Zhen; WANG, Hao; ARP, Jacqueline; RAMCHARRAN, Siobhan; BAROJA, Mirin Lorea |
| 12 | Use of soluble CD83 for perfusing a tissue for transplantation | EP14167252.7 | 2007-08-16 | EP2789625A1 | 2014-10-15 | Nicolette, Charles; Brand, Stephen; Zhong, Zhen; Wang, Hao; Arp, Jacqueline; Ramcharran, Siobhan; Baroja, Mirin Lorea |
The present invention relates to improved methods of suppressing and/or preventing an undesired immune response comprising the use of CD83. In some embodiments, CD83 is coadministered to a subject with at least one other immunosuppressive compound. Methods are also provided for generating tolerogenic dendritic cells and regulatory T cells. These cells can be used in vitro to produce additional cells for therapeutic purposes or they can be used in vivo to suppress and/or prevent an undesired immune response. Methods of the invention can be used to prevent or reduce the severity of autoimmune diseases and can also be used to induce tolerance to at least one therapeutic composition, such as a therapeutic protein or transplanted tissue.
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| 13 | Use of soluble CD83 for perfusing a tissue for transplantation | EP14167252.7 | 2007-08-16 | EP2789625B1 | 2018-06-06 | Nicolette, Charles; Brand, Stephen; Zhong, Zhen; Wang, Hao; Arp, Jacqueline; Ramcharran, Siobhan; Baroja, Mirin Lorea |
| The present invention relates to improved methods of suppressing and/or preventing an undesired immune response comprising the use of CD83. In some embodiments, CD83 is coadministered to a subject with at least one other immunosuppressive compound. Methods are also provided for generating tolerogenic dendritic cells and regulatory T cells. These cells can be used in vitro to produce additional cells for therapeutic purposes or they can be used in vivo to suppress and/or prevent an undesired immune response. Methods of the invention can be used to prevent or reduce the severity of autoimmune diseases and can also be used to induce tolerance to at least one therapeutic composition, such as a therapeutic protein or transplanted tissue. | ||||||
| 14 | USE OF CD83 IN COMBINATION THERAPIES | EP07811339 | 2007-08-16 | EP2051987A4 | 2011-08-03 | NICOLETTE CHARLES; BRAND STEPHEN; ZHONG ZHEN; WANG HAO; ARP JACQUELINE; RAMCHARRAN SIOBHAN; BAROJA MIRIN LOREA |
| 15 | 병용 요법에 있어서 ＣＤ83의 용도 | KR1020087032243 | 2007-08-16 | KR1020090041366A | 2009-04-28 | 니콜레트찰스; 브랜드스티븐; 종젠; 왕하오; 에이알피재클린; 람차란시오반; 바로자미린로리아 |
| The present invention relates to improved methods of suppressing and/or preventing an undesired immune response comprising the use of CD83. In some embodiments, CD83 is coadministered to a subject with at least one other immunosuppressive compound. Methods are also provided for generating tolerogenic dendritic cells and regulatory T cells. These cells can be used in vitro to produce additional cells for therapeutic purposes or they can be used in vivo to suppress and/or prevent an undesired immune response. Methods of the invention can be used to prevent or reduce the severity of autoimmune diseases and can also be used to induce tolerance to at least one therapeutic composition, such as a therapeutic protein or transplanted tissue. | ||||||
| 16 | 병용 요법에 있어서 ＣＤ83의 용도 | KR1020087032243 | 2007-08-16 | KR101521197B1 | 2015-05-18 | 니콜레트찰스; 브랜드스티븐; 종젠; 왕하오; 에이알피재클린; 람차란시오반; 바로자미린로리아 |
| 본발명은 CD83의사용을포함함을특징으로하여원치않는면역반응을억제및/또는예방하는개선된방법에관한것이다. 일부구체예에서, CD83은적어도하나의다른면역억제화합물과함께대상에병용투여된다. 관용수지상세포및 조절 T 세포를발생시키기위한방법이또한제공된다. 이들세포는시험관내에서치료목적의추가세포를생산하는데사용하거나, 생체내에서원치않는면역반응을억제하고/하거나예방하기위해사용할수 있다. 본발명의방법은자가면역질환의중증도를예방하거나감소시키기위해사용할수 있으며, 또한적어도하나의치료조성물, 예를들어, 치료단백질또는이식조직에대한내성을유도하기위해사용할수 있다. | ||||||
| 17 | USE OF CD83 IN COMBINATION THERAPIES | PCT/US2007018048 | 2007-08-16 | WO2008024242A3 | 2008-10-23 | NICOLETTE CHARLES; BRAND STEPHEN; ZHONG ZHEN; WANG HAO; ARP JACQUELINE; RAMCHARRAN SIOBHAN; BAROJA MIRIN LOREA |
| The present invention relates to improved methods of suppressing and/or preventing an undesired immune response comprising the use of CD83. In some embodiments, CD83 is coadministered to a subject with at least one other immunosuppressive compound. Methods are also provided for generating tolerogenic dendritic cells and regulatory T cells. These cells can be used in vitro to produce additional cells for therapeutic purposes or they can be used in vivo to suppress and/or prevent an undesired immune response. Methods of the invention can be used to prevent or reduce the severity of autoimmune diseases and can also be used to induce tolerance to at least one therapeutic composition, such as a therapeutic protein or transplanted tissue. | ||||||
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