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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	一种治疗风湿骨病的西药组合物	CN201611078004.7	2016-11-30	CN106390131A	2017-02-15	不公告发明人
本发明公开了一种治疗风湿骨病的西药组合物，由以下重量份数的原料组成：安普那韦2-15份、甲氨蝶呤0.1-1份、奥沙利铂甘露醇注射液1-3份、磷酸二酯酶0.1-1份、糖皮质激素类药物1-5份、益赛普0.5-2份、生理盐水10-50份、骨肽片0.5-1份、阿胶粉1-3份、类固醇0.1-1份、山莨菪碱1-3份。该西药组合物通过原料复配发挥协同作用，具有毒副作用小、成本低、不会出现并发症的优点，能彻底根治风湿骨病，且不容易复发；该西药组合物制备方法简单，治疗周期短，疗效好，是一种安全有效的药物，保护了人们的健康。
2	合理的に設計された、非パリンドローム認識配列を有する単鎖メガヌクレアーゼ	JP2015115646	2015-06-08	JP2015221035A	2015-12-10	スミス,ジェイムス,ジェファーソン; ジャンツ,デレック
【課題】異なる認識配列半部位に対して特異性を持つ一対の酵素サブユニットが単鎖ポリペプチドに結合され、非パリンドローム認識配列を持つ機能的へテロ二量体を形成した、非天然由来メガヌクレアーゼの提供。【解決手段】第1モノ−LAGLIDADGメガヌクレアーゼから誘導され、第1認識半部位を有する第1LAGLIDADGサブユニットと、第2モノ−LAGLIDADGメガヌクレアーゼまたはジ−LAGLIDADGメガヌクレアーゼから誘導され、第2認識半部位を有する第2LAGLIDADGサブユニットから構成される、組換え単鎖メガヌクレアーゼ。【選択図】図1
3	合理的に設計された、非パリンドローム認識配列を有する単鎖メガヌクレアーゼ	JP2010532293	2008-10-31	JP5761996B2	2015-08-12	スミス,ジェイムス,ジェファーソン; ジャンツ,デレック

4	Improvement in quality of crude protein	JP235786	1986-01-10	JPS61177951A	1986-08-09	YURUGEN GUROTSUPU; MERUTEN SHIYURINGUMAN; PAURU PUREEFUE; UUBUE FUAUSUTO

5	合理的に設計された、非パリンドローム認識配列を有する単鎖メガヌクレアーゼ	JP2016193485	2016-09-30	JP2017051190A	2017-03-16	スミス,ジェイムス,ジェファーソン; ジャンツ,デレック
【課題】異なる認識配列半部位に対して特異性を持つ一対の酵素サブユニットが単鎖ポリペプチドに結合され、非パリンドローム認識配列を持つ機能的へテロ二量体を形成した、非天然由来のメガヌクレアーゼの提供。【解決手段】(a)野生型I−CreIメガヌクレアーゼの残基と少なくとも85%の配列同一性を有するポリペプチド配列を含み、第1認識半部位を有する第1LAGLIDADGサブユニットと、(b)野生型I−CreIメガヌクレアーゼの残基と少なくとも85%の配列同一性を有するポリペプチド配列を含み、第2認識半部位を有する第2LAGLIDADGサブユニットと、を含み、前記第1及び第2LAGLIDADGサブユニットは、ポリペプチドリンカにより共有的に結合され、前記第1認識半部位及び前記第2認識半部位のハイブリッドである非パリンドロームDNA配列を、認識及び切断することができる、組換え単鎖メガヌクレアーゼ。【選択図】図1
6	合理的に設計された、非パリンドローム認識配列を有する単鎖メガヌクレアーゼ	JP2015115646	2015-06-08	JP6050861B2	2016-12-21	スミス,ジェイムス,ジェファーソン; ジャンツ,デレック

7	Rationally designed, single-chain meganuclease having non-palindromic recognition sequence	JP2010532293	2008-10-31	JP2011501971A	2011-01-20	ジャンツ，デレック; スミス，ジェイムス，ジェファーソン
異なる認識配列半部位に対して特異性を持つ一対の酵素サブユニットが単鎖ポリペプチドに結合され、非パリンドローム認識配列を持つ機能的へテロ二量体を形成した、合理的に設計された非天然由来のメガヌクレアーゼを開示する。また本発明は、該メガヌクレアーゼを製造する方法、および該メガヌクレアーゼを使用して組換え核酸および生物を製造する方法にも関する。【選択図】図１
8	RNA依存性標的DNA修飾およびRNA依存性転写調節のための方法および組成物	JP2018097369	2018-05-21	JP2018138054A	2018-09-06	ジネク,マーテイン; チヤーペンテイエ,エマニユエル; チリンスキー,クシシユトフ; ドウドナ・ケイト,ジエイムズ・ハリソン; リム,ウエンデル; キイ,レイ; ドウドナ,ジエニフアー・エー
【課題】それぞれの新たな標的配列のために新たなタンパク質を設計する必要がない形で、ヌクレアーゼ活性、または他のタンパク質活性を、標的DNA内の異なる場所へ正確にターゲティングすることを可能にする技術を提供する。【解決手段】(i)標的DNA内の配列に対し相補的なヌクレオチド配列を含む第一セグメント;および(ii)部位特異的修飾ポリペプチドと相互作用する第二セグメントを含む、DNA標的化RNA。前記第一セグメントは標的DNA内の配列に対し100%の相補性を有する8個のヌクレオチドを含むことが出来る。【選択図】なし
9	RNA依存性標的DNA修飾およびRNA依存性転写調節のための方法および組成物	JP2015514015	2013-03-15	JP6343605B2	2018-06-13	ジネク,マーテイン; チヤーペンテイエ,エマニユエル; チリンスキー,クシシユトフ; ドウドナ・ケイト,ジエイムズ・ハリソン; リム,ウエンデル; キイ,レイ; ドウドナ,ジエニフアー・エー

10	ＲＮＡ依存性標的ＤＮＡ修飾およびＲＮＡ依存性転写調節のための方法および組成物	JP2015514015	2013-03-15	JP2015523856A	2015-08-20	ジネク，マーテイン; チヤーペンテイエ，エマニユエル; チリンスキー，クシシユトフ; ドウドナ・ケイト，ジエイムズ・ハリソン; リム，ウエンデル; キイ，レイ; ドウドナ，ジエニフアー・エー
本開示は、ターゲティング配列を含み、修飾ポリペプチドと共に、標的DNAおよび/または標的DNAと結合したポリペプチドの部位特異的修飾を与える、DNA標的化RNAを提供する。本開示はさらに、部位特異的修飾ポリペプチドを提供する。本開示はさらに、標的DNAおよび/または標的DNAと結合したポリペプチドの部位特異的修飾の方法を提供する。本開示は、標的核酸を酵素的に不活性なCas9ポリペプチドおよびDNA標的化RNAと接触させることを一般的に含む、標的細胞内の標的核酸の転写を調節する方法を提供する。該方法を実行するためのキットおよび組成物も提供される。本開示は、Cas9を産生する遺伝子改変細胞;およびCas9遺伝子導入非ヒト多細胞生物を提供する。【選択図】なし
11	RNA-유도된 표적 DNA 변형 및 전사의 RNA-유도된 조절을 위한 방법 및 조성물	KR1020177034069	2013-03-15	KR1020170134766A	2017-12-06	샤르팡티에엠마뉴엘; 도우드나제니퍼에이.; 지넥마틴; 칠린스키크지슈토프; 도우드나케이트제임스해리슨; 림웬델; 치레이
본개시내용은표적서열을포함하는 DNA-표적화 RNA를제공하고, 변형폴리펩타이드와함께, 표적 DNA 및/또는표적 DNA와연관된폴리펩타이드의부위특이적인변형을제공한다. 본개시내용은추가로, 부위특이적인변형폴리펩타이드를제공한다. 본개시내용은추가로, 표적 DNA 및/또는표적 DNA와연관된폴리펩타이드의부위특이적인변형방법을제공한다. 본개시내용은표적세포에서표적핵산의전사를조절하는방법을제공하고, 일반적으로상기표적핵산을효소적으로불활성 Cas9 폴리펩타이드및 DNA-표적화 RNA와접촉시키는것을수반한다. 본방법을수행하기위한키트및 조성물이또한제공된다. 본개시내용은 Cas9를생산하는유전적으로변형된세포; 및 Cas9 이식유전자비-인간다중세포유기체를제공한다.
12	RNA-유도된 표적 DNA 변형 및 전사의 RNA-유도된 조절을 위한 방법 및 조성물	KR1020147036096	2013-03-15	KR1020150016588A	2015-02-12	샤르팡티에엠마뉴엘; 도우드나제니퍼에이.; 지넥마틴; 칠린스키크지슈토프; 도우드나케이트제임스해리슨; 림웬델; 치레이
본 개시내용은 표적 서열을 포함하는 DNA-표적화 RNA를 제공하고, 변형 폴리펩타이드와 함께, 표적 DNA 및/또는 표적 DNA와 연관된 폴리펩타이드의 부위 특이적인 변형을 제공한다. 본 개시내용은 추가로, 부위 특이적인 변형 폴리펩타이드를 제공한다. 본 개시내용은 추가로, 표적 DNA 및/또는 표적 DNA와 연관된 폴리펩타이드의 부위 특이적인 변형 방법을 제공한다. 본 개시내용은 표적 세포에서 표적 핵산의 전사를 조절하는 방법을 제공하고, 일반적으로 상기 표적 핵산을 효소적으로 불활성 Cas9 폴리펩타이드 및 DNA-표적화 RNA와 접촉시키는 것을 수반한다. 본 방법을 수행하기 위한 키트 및 조성물이 또한 제공된다. 본 개시내용은 Cas9를 생산하는 유전적으로 변형된 세포; 및 Cas9 이식유전자 비-인간 다중세포 유기체를 제공한다.
13	PROCESSES FOR IMPROVING FERMENTATION PRODUCT YIELD USING PHOSPHOLIPASE C	EP16829361.1	2016-12-16	EP3394276A1	2018-10-31	KREEL, Nathaniel Edward
A process of recovering oil, comprising (a) converting a starch-containing material into dextrins with an alpha-amylase; (b) saccharifying the dextrins using a carbohydrate source generating enzyme to form a sugar; (c) fermenting the sugar in a fermentation medium into a fermentation product using a fermenting organism; (d) recovering the fermentation product to form a whole stillage; (e) separating the whole stillage into thin stillage and wet cake; (e') optionally concentrating the thin stillage into syrup; (f) recovering oil from the thin stillage and/or optionally the syrup, wherein a phospholipase is present and/or added during steps (a) to (c). Use of phospholipase for increasing oil recovery yields from thin stillage and/or syrup in a fermentation product production process.
14	PROCESS OF EXTRACTING OIL FROM THIN STILLAGE	EP16829360.3	2016-12-16	EP3394275A1	2018-10-31	AKERMAN, Michael, John; HOOSS, Melissa, Carrie; KREEL, Nathaniel, Edward; SHEN, Xinyu
A process of recovering oil, comprising (a) converting a starch-containing material into dextrins with an alpha-amylase; (b) saccharifying the dextrins using a carbohydrate source generating enzyme to form a sugar; (c) fermenting the sugar in a fermentation medium into a fermentation product using a fermenting organism; (d) recovering the fermentation product to form a whole stillage; (e) separating the whole stillage into thin stillage and wet cake; (e') optionally concentrating the thin stillage into syrup; (f) recovering oil from the thin stillage and/or optionally the syrup, wherein a phospholipase is present and/or added during steps (a) to (c). Use of phospholipase for increasing oil recovery yields from thin stillage and/or syrup in a fermentation product production process.
15	RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES	EP16163925.7	2008-10-31	EP3098309A1	2016-11-30	Smith, James, Jefferson; Jantz, Derek
Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non- palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases.
16	METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION	EP13793997.1	2013-03-15	EP2800811A1	2014-11-12	JINEK, Martin; DOUDNA CATE, James Harrison; LIM, Wendell; QI, Lei; CHARPENTIER, Emmanuelle; CHYLINSKI, Krysztof; DOUDNA, Jennifer A.
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
17	METHODS AND PRODUCTS FOR PRODUCING ENGINEERED MAMMALIAN CELL LINES WITH AMPLIFIED TRANSGENES	EP12792301.9	2012-06-01	EP2714936B1	2018-12-12	JANTZ, Derek; SMITH, James, Jefferson; NICHOLSON, Michael, G.
Methods of inserting genes into defined locations in the chromosomal DNA of cultured mammalian cell lines which are subject to gene amplification are disclosed. In particular, sequences of interest (e.g., genes encoding biotherapeutic proteins) are inserted proximal to selectable genes in amplifiable loci, and the transformed cells are subjected to selection to induce co-amplification of the selectable gene and the sequence of interest. The invention also relates to meganucleases, vectors and engineered cell lines necessary for performing the methods, to cell lines resulting from the application of the methods, and use of the cell lines to produce protein products of interest.
18	PROCESSES FOR PRODUCING FERMENTATION PRODUCTS	EP16826525.4	2016-12-16	EP3394274A1	2018-10-31	KANG, Zhengfang; STRAHLER, Christie Lynn; HUFFMAN, James Ron; KROGH, Kristian Bertel Romer M.
A process of recovering oil, comprising (a) converting a starch-containing material into dextrins with an alpha-amylase; (b) saccharifying the dextrins using a carbohydrate source generating enzyme to form a sugar; (c) fermenting the sugar in a fermentation medium into a fermentation product using a fermenting organism; (d) recovering the fermentation product to form a whole stillage; (e) separating the whole stillage into thin stillage and wet cake; (e') optionally concentrating the thin stillage into syrup; (f) recovering oil from the thin stillage and/or optionally the syrup, wherein a phospholipase is present and/or added during steps (a) to (c). Use of phospholipase for increasing oil recovery yields from thin stillage and/or syrup in a fermentation product production process.
19	PROCESS OF EXTRACTING OIL FROM THIN STILLAGE	EP16820538.3	2016-12-16	EP3394273A1	2018-10-31	JUMP, Joseph; VIDAL, Bernardo Jr.; SOONG, Chee-Leong; ROBERTS, Madison; HOOSS, Melissa Carrie; SHEN, Xinyu; KREEL, Nathaniel Edward
A process of recovering oil, comprising (a) converting a starch-containing material into dextrins with an alpha-amylase; (b) saccharifying the dextrins using a carbohydrate source generating enzyme to form a sugar; (c) fermenting the sugar in a fermentation medium into a fermentation product using a fermenting organism; (d) recovering the fermentation product to form a whole stillage; (e) separating the whole stillage into thin stillage and wet cake; (e') optionally concentrating the thin stillage into syrup; (f) recovering oil from the thin stillage and/or optionally the syrup, wherein a phospholipase is present and/or added during steps (a) to (c). Use of phospholipase for increasing oil recovery yields from thin stillage and/or syrup in a fermentation product production process.
20	METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION	EP17163434.8	2013-03-15	EP3241902A1	2017-11-08	CHARPENTIER, Emmanuelle; JINEK, Martin; DOUDNA CATE, James Harrison; LIM, Wendell; QI, Lei; CHYLINSKI, Krzysztof; DOUDNA, Jennifer A.
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

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