| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | MODULATORS OF GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE PROTEINS | US15107481 | 2014-12-23 | US20160319324A1 | 2016-11-03 | Shanthini Sockanathan; Sungjin Park |
| The present invention relates to glycerophosphodiester phosphodiesterase (GDE) proteins. More specifically, the present invention relates to targeting GDE proteins to modulate its glycosylphosphatidylinositol (GPI)-cleaving activity. In a specific embodiment, the present invention provides a GDE modulator that modulates the surface GPI anchor cleavage activity of GDE. | ||||||
| 2 | MINIMAL BACTERIAL GENOME | US14733743 | 2015-06-08 | US20150344837A1 | 2015-12-03 | John I. Glass; Hamilton O. Smith; Clyde A. Hutchison lll; Nina Y. Alperovich; Nacyra Assad-Garcia |
| The present invention relates, e.g., to a minimal set of protein-coding genes which provides the information required for replication of a free-living organism in a rich bacterial culture medium, wherein (1) the gene set does not comprise the 100 genes listed in Table 2; and/or wherein (2) the gene set comprises the 382 protein-coding genes listed in Table 3 and, optionally, one of more of: a set of three genes encoding ABC transporters for phosphate import (genes MG410, MG411 and MG412; or genes MG289, MG290 and MG291); the lipoprotein-encoding gene MG185 or MG260; and/or the glycerophosphoryl diester phosphodiesterase gene MG293 or MG385. | ||||||
| 3 | Minimal bacterial genome | US11546364 | 2006-10-12 | US20070122826A1 | 2007-05-31 | John Glass; Hamilton Smith; Clyde Hutchison; Nina Alperovich; Nacyra Assad-Garcia |
| The present invention relates, e.g., to a minimal set of protein-coding genes which provides the information required for replication of a free-living organism in a rich bacterial culture medium, wherein (1) the gene set does not comprise the 101 genes listed in Table 2; and/or wherein (2) the gene set comprises the 381 protein-coding genes listed in Table 3 and, optionally, one of more of: a set of three genes encoding ABC transporters for phosphate import (genes MG410, MG411 and MG412; or genes MG289, MG290 and MG291); the lipoprotein-encoding gene MG185 or MG260; and/or the glycerophosphoryl diester phosphodiesterase gene MG293 or MG385. | ||||||
| 4 | Minimal bacterial genome | JP2008535578 | 2006-10-12 | JP2009511051A | 2009-03-19 | ナサイラ アッサド‐ガルシア; ニーナ ワイ． アルペロビッチ; ジョン ティー． グラス; ハミルトン オー． スミス; クライド エー． サード ハッチソン |
| 本発明は、例えば、栄養豊富な細菌培養培地における自由生活生物の複製に必要な情報を提供するタンパク質コード遺伝子の最小限のセットに関し、ここで、（1）該遺伝子セットは、表2に列挙される101個の遺伝子を含まず；かつ／または（2）該遺伝子セットは、表3に列挙される381個のタンパク質コード遺伝子、および、任意で、以下の1つまたは複数を含む：リン酸取り込みのためのABC輸送体をコードする3個の遺伝子のセット（MG410、MG411、およびMG412遺伝子；もしくはMG289、MG290、およびMG291遺伝子）；リポタンパク質コード遺伝子MG185もしくはMG260；ならびに／またはグリセロホスホリルジエステルホスホジエステラーゼ遺伝子MG29もしくはMG385。 | ||||||
| 5 | MINIMAL BACTERIAL GENOME | EP06825527.2 | 2006-10-12 | EP1951874A1 | 2008-08-06 | GLASS, John, T.; SMITH, Hamilton, O.; HUTCHISON, Clyde, A. III; ALPEROVICH, Nina, Y.; ASSAD-GARCIA, Nacyra |
| The present invention relates, e.g., to a minimal set of protein-coding genes which provides the information required for replication of a free-living organism in a rich bacterial culture medium, wherein (1) the gene set does not comprise the 101 genes listed in Table 2; and/or wherein (2) the gene set comprises the 381 protein-coding genes listed in Table 3 and, optionally, one of more of: a set of three genes encoding ABC transporters for phosphate import (genes MG410, MG411 and MG412; or genes MG289, MG290 and MG291); the lipoprotein-encoding gene MG185 or MG260; and/or the glycerophosphoryl diester phosphodiesterase gene MG293 or MG385. | ||||||
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