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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
41	ANTIBODIES TO ARGININOSUCCINATE SYNTHASE AND RELATED METHODS	US14794273	2015-07-08	US20160009821A1	2016-01-14	Wei He; Yunyun Guo; Bor-Wen Wu
Provided are antibodies, and antigen-binding fragments thereof, which specifically bind to argininosuccinate synthase, and related compositions, kits, and methods of use thereof, for instance, as companion diagnostics to identify suitable subjects for arginine deprivation or depletion therapies such as ADI-PEG 20 and other arginine deiminase (ADI) polypeptide-based therapies.
42	METHODS FOR PRODUCING 3-HYDROXYPROPIONIC ACID AND OTHER PRODUCTS	US13916534	2013-06-12	US20140045231A1	2014-02-13	Michael D. LYNCH; Ryan T. GILL; Tanya E.W. LIPSCOMB
This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.
43	WOUND HEALING	US11574442	2005-08-31	US20090170910A1	2009-07-02	Stephen M. Gunnigle
The present invention relates to the use of p38 MAP kinase inhibitors and p38 MAP kinase inhibition to promote wound healing.
44	ANTIBODIES TO ARGININOSUCCINATE SYNTHASE AND RELATED METHODS	EP15819121.3	2015-07-08	EP3166972A1	2017-05-17	HE, Wei; GUO, Yunyun; WU, Bor-Wen
Antibodies, and antigen-binding fragments, which specifically bind to argininosuccinate synthase, and related compositions, kits, and methods of use, which are useful as companion diagnostics to identify suitable subjects for arginine deprivation or depletion therapies such as ADI-PEG 20 and other arginine deiminase (ADI) polypeptide-based therapies.
45	IMPROVED NGS WORKFLOW	EP15741310.5	2015-06-11	EP3155130A2	2017-04-19	ZHANG, Rui; SEE, Leong, Ting; ROUGH, Siow, San; YONG, Yeo, Qiang; SMIRNOV, Arseny; CHAO, Lou, Ping
The present invention relates to improved semi-automated methods that permit the extraction of nucleic acids from samples, preparation of PCR and post-PCR preparation steps of DNA- libraries for next-generation sequencings methods that can be conducted. The methods and additional aspects relating to such methods are less laborious, safe costs, reagents and are less prone to contamination than comparable methods that are not automated.
46	RECOMBINANT MICROORGANISM METABOLIZING 3,6-ANHYDRIDE-L-GALACTOSE AND A USE THEREOF	EP14794024	2014-05-07	EP2995684A4	2017-01-04	KIM KYOUNG HEON; CHOI IN-GEOL; YUN EUN-JU; LEE SAE YOUNG; KIM HEE TAEK
The present invention relates to a recombinant microorganism metabolizing 3,6-anhydro-L-galactose and a use thereof, and, more particularly, can produce ethanol from a recombinant microorganism expressing an enzyme group involved in a metabolic pathway of 3,6-AHG.
47	METHOD FOR PRODUCING 3-HYDROXYPROPIONIC ACID AND OTHER PRODUCTS	EP10819620	2010-09-27	EP2480673A4	2014-10-08	LYNCH MICHAEL D; GILL RYAN T; WARNECKE-LIPSCOMB TANYA
This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.
48	METHOD FOR PRODUCING 3-HYDROXYPROPIONIC ACID AND OTHER PRODUCTS	EP10819620.5	2010-09-27	EP2480673A1	2012-08-01	LYNCH, Michael, D.; GILL, Ryan, T.; WARNECKE-LIPSCOMB, Tanya
This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.
49	METHOD FOR PRODUCING 3-HYDROXYPROPIONIC ACID AND OTHER PRODUCTS	EP10819620.5	2010-09-27	EP2480673B1	2018-05-23	LYNCH, Michael, D.; GILL, Ryan, T.; WARNECKE-LIPSCOMB, Tanya
This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.
50	CATION CHELATOR HOT START	EP15701120.6	2015-01-15	EP3099810A1	2016-12-07	AZZAWI, Alexander; PEIST, Ralf
The invention is in the field of regulation of enzymatic activity in nucleic acid modifying reactions. It describes a method of regulating enzymatic activity by adding chelating agents to the reaction composition and exploits the fact that both the binding of divalent cations to these chelating agents and the pH of commonly used buffers is temperature dependent. PCR experiments that are hampered by non-specific side products can be regulated such that the target sequence is amplified in a more specific manner.
51	RECOMBINANT MICROORGANISM METABOLIZING 3,6-ANHYDRIDE-L-GALACTOSE AND A USE THEREOF	EP14794024.1	2014-05-07	EP2995684A1	2016-03-16	KIM, Kyoung Heon; CHOI, In-Geol; YUN, Eun-Ju; LEE, Sae Young; KIM, Hee Taek
The present invention relates to a recombinant microorganism metabolizing 3,6-anhydro-L-galactose and a use thereof, and, more particularly, can produce ethanol from a recombinant microorganism expressing an enzyme group involved in a metabolic pathway of 3,6-AHG.
52	WOUND HEALING	EP05794386.2	2005-08-31	EP1786409A1	2007-05-23	GUNNIGLE, Stephen M.
The present invention relates to the use of p38 MAP kinase inhibitors and p38 MAP kinase inhibition to promote wound healing.
53	３，６―안하이드로―Ｌ―갈락토오스를 대사하는 재조합 미생물 및 이의 용도	KR1020140054263	2014-05-07	KR1020140133455A	2014-11-19	김경헌; 최인걸; 이세영; 윤은주; 김희택
본 발명은 3,6-안하이드로-L-갈락토오스를 대사하는 재조합 미생물 및 이의 용도에 관한 것으로, 보다 상세하게는 3,6-AHG의 대사 경로에 관여하는 효소 군을 발현하는 재조합 미생물로부터 에탄올을 제조할 수 있다.
54	3-히드록시프로피온산 및 다른 생성물의 제조 방법	KR1020127010712	2010-09-27	KR1020140015136A	2014-02-06	린치,마이클,디.; 길,리안,티.; 워넥케-립스콤,타냐
본 발명은 3-히드록시프로피온산을 포함하는 화학 생성물의 제조를 위해 말로닐-CoA의 이용이 증가된, 대사적으로 조작된 미생물 균주, 예컨대 박테리아 균주에 관한 것이다.
55	IMPROVED NGS WORKFLOW	PCT/IB2015000926	2015-06-11	WO2015189685A3	2016-03-03	ZHANG RUI; SEE LEONG TING; ROUGH SIOW SAN; YONG YEO QIANG; SMIRNOV ARSENY; CHAO LOU PING
The present invention relates to improved semi-automated methods that permit the extraction of nucleic acids from samples, preparation of PCR and post-PCR preparation steps of DNA- libraries for next-generation sequencings methods that can be conducted. The methods and additional aspects relating to such methods are less laborious, safe costs, reagents and are less prone to contamination than comparable methods that are not automated.
56	IMPROVED NGS WORKFLOW	PCT/IB2015000926	2015-06-11	WO2015189685A2	2015-12-17	ZHANG RUI; SEE LEONG TING; ROUGH SIOW SAN; YONG YEO QIANG; SMIRNOV ARSENY; CHAO LOU PING
The present invention relates to improved semi-automated methods that permit the extraction of nucleic acids from samples, preparation of PCR and post-PCR preparation steps of DNA- libraries for next-generation sequencings methods that can be conducted. The methods and additional aspects relating to such methods are less laborious, safe costs, reagents and are less prone to contamination than comparable methods that are not automated.
57	HBV RNASE H PURIFICATION AND ENZYME INHBITORS	PCT/US2013072201	2013-11-27	WO2014085568A3	2014-08-28	TAVIS JOHN; HU YUAN
Provided herein are methods for the obtention of an active HBV RNaseH preparation and its use in screening methods to identify potential inhibitors of the enzyme for possible use as therapeutic agents. Also provided are methods of treatment using agents identified according to the screen.

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