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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	乙酰辅酶A衍生的类异戊二烯的生产	CN201280066027.X	2012-11-09	CN104039974A	2014-09-10	T·S·加德纳; K·M·霍金斯; A·L·梅多斯; A·E·聪; Y·策加耶
本发明中提供用于在宿主细胞中异源生产乙酰-CoA衍生的类异戊二烯的组合物和方法。在一些实施方案中，宿主细胞经遗传修饰以包含编码乙醛脱氢酶，酰化(ADA，E.C.1.2.1.10)的异源核苷酸序列，和包含利用NADP的HMG-CoA还原酶的MEV途径。在一些实施方案中，宿主细胞经遗传修饰以包含编码ADA的异源核苷酸序列和包含乙酰乙酰-CoA合酶的MEV途径。在一些实施方案中，经遗传修饰的宿主细胞还包含一种或多种编码磷酸转酮酶和磷酸转乙酰酶的异源核苷酸序列。在一些实施方案中，经遗传修饰的宿主细胞还包含天然PDH旁路的功能性破坏。本文中所描述的组合物和方法为乙酰-CoA衍生的类异戊二烯的异源生产提供节能且氧化还原平衡的路径。
2	乙酰辅酶A衍生的类异戊二烯的生产	CN201280066027.X	2012-11-09	CN104039974B	2016-10-12	T·S·加德纳; K·M·霍金斯; A·L·梅多斯; A·E·聪; Y·策加耶
本文中提供用于在宿主细胞中异源生产乙酰‑CoA衍生的类异戊二烯的组合物和方法。在一些实施方案中，宿主细胞经遗传修饰以包含编码乙醛脱氢酶，酰化(ADA，E.C.1.2.1.10)的异源核苷酸序列，和包含利用NADP的HMG‑CoA还原酶的MEV途径。在一些实施方案中，宿主细胞经遗传修饰以包含编码ADA的异源核苷酸序列和包含乙酰乙酰‑CoA合酶的MEV途径。在一些实施方案中，经遗传修饰的宿主细胞还包含一种或多种编码磷酸转酮酶和磷酸转乙酰酶的异源核苷酸序列。在一些实施方案中，经遗传修饰的宿主细胞还包含天然PDH旁路的功能性破坏。本文中所描述的组合物和方法为乙酰‑CoA衍生的类异戊二烯的异源生产提供节能且氧化还原平衡的路径。
3	通过与辅酶B合成相关的C1 碳链延伸生产7-碳化学物的方法	CN201380073741.6	2013-12-23	CN105189764A	2015-12-23	A.L.博特斯; A.V.E.康拉迪; 陈昌林; P.S.珀尔曼
本申请描述了通过在C7脂族主链底物中形成一个或两个末端官能团来生产庚二酸、7-氨基庚酸、7-羟基庚酸、庚二胺或1,7-庚二醇的生物化学途径，每个官能团包括羧基、胺或羟基。本文所述的这些途径、代谢工程和培养策略依赖于与辅酶B生物合成相关的C1延伸酶或同源物。
4	来自酸热脂环酸杆菌的嗜热的与嗜热嗜酸的糖基化基因和酶以及相关生物、方法	CN200980106043.5	2009-02-26	CN102046802A	2011-05-04	D·N·汤普森; W·A·阿佩尔; V·S·汤普森; D·W·里德; J·A·莱西
提供了来自酸热脂环酸杆菌的分离的和/或纯化的多肽和编码多肽的核酸序列。还提供了使用来自酸热脂环酸杆菌的分离的和/或纯化的多肽和核酸序列用于糖基化和/或翻译后修饰蛋白的方法。
5	METHODS OF PRODUCING 7-CARBON CHEMICALS VIA C1 CARBON CHAIN ELONGATION ASSOCIATED WITH COENZYME B SYNTHESIS	US15405514	2017-01-13	US20170204420A1	2017-07-20	Adriana Leonora Botes; Alex Van Eck Conradie; Changlin Chen; Paul S. Pearlman
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
6	PRODUCTION OF ACETYL-COENZYME A DERIVED ISOPRENOIDS	US14062798	2013-10-24	US20140154765A1	2014-06-05	Timothy Stevens GARDNER; Kristy Michelle Hawkins; Adam Leon Meadows; Annie Ening Tsong; Yoseph Tsegaye
Provided herein are compositions and methods for the heterologous production of acetyl-CoA-derived isoprenoids in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an acetaldehyde dehydrogenase, acetylating (ADA, E.C. 1.2.1.10) and an MEV pathway comprising an NADH-using HMG-CoA reductase. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an ADA and an MEV pathway comprising an acetoacetyl-CoA synthase. In some embodiments, the genetically modified host cell further comprises one or more heterologous nucleotide sequences encoding a phosphoketolase and a phosphotransacetylase. In some embodiments, the genetically modified host cell further comprises a functional disruption of the native PDH-bypass. The compositions and methods described herein provide an energy-efficient yet redox balanced route for the heterologous production of acetyl-CoA-derived isoprenoids.
7	Production of acetyl-coenzyme A derived isoprenoids	US13752293	2013-01-28	US08603800B2	2013-12-10	Timothy Stevens Gardner; Kristy Michelle Hawkins; Adam Leon Meadows; Annie Ening Tsong; Yoseph Tsegaye
Provided herein are compositions and methods for the heterologous production of acetyl-CoA-derived isoprenoids in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an acetaldehyde dehydrogenase, acetylating (ADA, E.C. 1.2.1.10) and an MEV pathway comprising an NADH-using HMG-CoA reductase. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an ADA and an MEV pathway comprising an acetoacetyl-CoA synthase. In some embodiments, the genetically modified host cell further comprises one or more heterologous nucleotide sequences encoding a phosphoketolase and a phosphotransacetylase. In some embodiments, the genetically modified host cell further comprises a functional disruption of the native PDH-bypass. The compositions and methods described herein provide an energy-efficient yet redox balanced route for the heterologous production of acetyl-CoA-derived isoprenoids.
8	Thermophilic and thermoacidophilic glycosylation genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods	US12380450	2009-02-26	US09234228B2	2016-01-12	David N. Thompson; William A. Apel; Vicki S. Thompson; David W. Reed; Jeffrey A. Lacey
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for glycosylating and/or post-translationally modifying proteins using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.
9	Production of acetyl-coenzyme a derived isoprenoids	US14062798	2013-10-24	US08859261B2	2014-10-14	Timothy Stevens Gardner; Kristy Michelle Hawkins; Adam Leon Meadows; Annie Ening Tsong; Yoseph Tsegaye
Provided herein are compositions and methods for the heterologous production of acetyl-CoA-derived isoprenoids in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an acetaldehyde dehydrogenase, acetylating (ADA, E.C. 1.2.1.10) and an MEV pathway comprising an NADH-using HMG-CoA reductase. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an ADA and an MEV pathway comprising an acetoacetyl-CoA synthase. In some embodiments, the genetically modified host cell further comprises one or more heterologous nucleotide sequences encoding a phosphoketolase and a phosphotransacetylase. In some embodiments, the genetically modified host cell further comprises a functional disruption of the native PDH-bypass. The compositions and methods described herein provide an energy-efficient yet redox balanced route for the heterologous production of acetyl-CoA-derived isoprenoids.
10	Methods Of Producing 7-Carbon Chemicals Via C1 Carbon Chain Elongation Associated With Coenzyme B Synthesis	US14138971	2013-12-23	US20140193863A1	2014-07-10	Adriana Leonora Botes; Alex Van Eck Conradie; Changlin Chen; Paul S. Pearlman
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
11	PRODUCTION OF ACETYL-COENZYME A DERIVED ISOPRENOIDS	US13752293	2013-01-28	US20130236942A1	2013-09-12	Timothy Stevens GARDNER; Kristy Michelle HAWKINS; Adam Leon MEADOWS; Annie Ening TSONG; Yoseph TSEGAYE
Provided herein are compositions and methods for the heterologous production of acetyl-CoA-derived isoprenoids in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an acetaldehyde dehydrogenase, acetylating (ADA, E.C. 1.2.1.10) and an MEV pathway comprising an NADH-using HMG-CoA reductase. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an ADA and an MEV pathway comprising an acetoacetyl-CoA synthase. In some embodiments, the genetically modified host cell further comprises one or more heterologous nucleotide sequences encoding a phosphoketolase and a phosphotransacetylase. In some embodiments, the genetically modified host cell further comprises a functional disruption of the native PDH-bypass. The compositions and methods described herein provide an energy-efficient yet redox balanced route for the heterologous production of acetyl-CoA-derived isoprenoids.
12	ＬＰＡＡＴアブレーションを有する油産生微細藻類	JP2017552485	2016-04-06	JP2018512851A	2018-05-24	フランクリン, スコット; バート, リヤズ; ザオ, シンフア
組換えDNA技法を用いることにより、所望の脂肪酸プロフィール及び位置特異的又は立体特異的プロフィールを有するトリグリセリド油を産生する油産生組換え細胞が作製される。操作される遺伝子には、ステアロイル−ACPデサチュラーゼ、デルタ12脂肪酸デサチュラーゼ、アシル−ACPチオエステラーゼ、ケトアシル−ACPシンターゼ、リゾホスファチジン酸アシルトランスフェラーゼ、ケトアシル−CoAレダクターゼ、ヒドロキシアシル−CoAデヒドラターゼ、及び/又はエノイル−CoAレダクターゼをコードするものが含まれる。産生される油は高い酸化安定性又は熱安定性を有することができ、又はフライ油、ショートニング、ロールイン用ショートニング、テンパリング脂肪、ココアバター代用物として、潤滑油として、又は様々な化学プロセスの供給原料として有用であり得る。
13	抗メタボリックシンドローム効果を持つ核酸	JP2013511193	2011-09-21	JP5860038B2	2016-02-16	光武進; 座間宏太; 五十嵐靖之; 吉田哲也; 田中嘉一; 武本浩

14	PRODUCTION OF ACETYL-COENZYME A DERIVED ISOPRENOIDS	EP12795948.4	2012-11-09	EP2776571B1	2017-04-12	GARDNER, Timothy Stevens; HAWKINS, Kristy Michelle; MEADOWS, Adam Leon; TSONG, Annie Ening; TSEGAYE, Yoseph
Provided herein are compositions and methods for the heterologous production of acetyl-CoA-derived isoprenoids in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an acetaldehyde dehydrogenase, acetylating (ADA, E.C. 1.2.1.10) and an MEV pathway comprising an NADH-using HMG-CoA reductase. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an ADA and an MEV pathway comprising an acetoacetyl-CoA synthase. In some embodiments, the genetically modified host cell further comprises one or more heterologous nucleotide sequences encoding a phosphoketolase and a phosphotransacetylase. In some embodiments, the genetically modified host cell further comprises a functional disruption of the native PDH-bypass. The compositions and methods described herein provide an energy-efficient yet redox balanced route for the heterologous production of acetyl-CoA-derived isoprenoids.
15	METHODS OF PRODUCING 7-CARBON CHEMICALS VIA C1 CARBON CHAIN ELONGATION ASSOCIATED WITH COENZYME B SYNTHESIS	EP13824707.7	2013-12-23	EP2938736A2	2015-11-04	BOTES, Adriana Leonora; CONRADIE, Alex Van Eck; CHEN, Changlin; PEARLMAN, Paul S.
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
16	アセチル−補酵素A誘導イソプレノイドの生産	JP2014541353	2012-11-09	JP6073350B2	2017-02-01	ガードナー, ティモシースティーブンス; ホーキンス, クリスティーミシェル; メドウズ, アダムレオン; ソン, アニーエニング; ツェガエ, ヨセフ

17	アセチル−補酵素Ａ誘導イソプレノイドの生産	JP2014541353	2012-11-09	JP2014532444A	2014-12-08	ティモシースティーブンスガードナー，; クリスティーミシェルホーキンス，; アダムレオンメドウズ，; アニーエニングソン，; ヨセフツェガエ，
宿主細胞におけるアセチル−CoA由来イソプレノイドの異種生産のための組成物および方法を本明細書に提供する。一部の実施形態において、前記宿主細胞は、アセトアルデヒドデヒドロゲナーゼ(アセチル化)(ADA、E.C.1.2.1.10)と、NADH使用HMG−CoAレダクターゼを含むMEV経路とをコードしている異種ヌクレオチド配列を含むように遺伝子改変されている。一部の実施形態において、前記宿主細胞は、ADAと、アセトアセチル−CoAシンターゼを含むMEV経路とをコードしている異種ヌクレオチド配列を含むように遺伝子改変される。一部の実施形態において、前記遺伝子改変された宿主細胞は、ホスホケトラーゼおよびホスホトランスアセチラーゼをコードしている1つ以上の異種ヌクレオチド配列をさらに含む。一部の実施形態において、前記遺伝子改変された宿主細胞は、天然PDH−バイパスの機能破壊をさらに含む。
18	Ali Cyclo Bacillus acidocaldarius and thermophilic from related organisms and thermophilic eosinophilic glycosylation genes and enzymes, how	JP2010548869	2009-02-26	JP2011517931A	2011-06-23	アペル，ウィリアム・エイ; トンプソン，ヴィッキ・エス; トンプソン，デーヴィッド・エヌ; リード，デーヴィッド・ダブリュー; レイシー，ジェフリー・エイ
アリサイクロバチルス・アシドカルダリウスから単離および／または精製されたポリペプチドならびに単離および／または精製されたアリサイクロバチルス・アシドカルダリウス由来ポリペプチドをコードする核酸配列を提供する。さらに、アリサイクロバチルス・アシドカルダリウスから単離および／または精製されたポリペプチドおよび核酸配列を使用して、タンパク質をグリコシル化および／または翻訳後に修飾するための方法を提供する。
19	ACP-MEDIATED PRODUCTION OF FATTY ACID DERIVATIVES	EP13826804.0	2013-12-11	EP2931742A2	2015-10-21	SIMPSON, David; DA COSTA, Bernardo; RUDE, Mathew; TRINH, Na; POPOVA, Emanuela; VENKITESWARAN, Sankaranarayanan; HELMAN, Noah; HOLDEN, Kevin
The disclosure relates to recombinant microorganisms that exhibit an increased expression of an acyl carrier protein (ACP) resulting in production of fatty acid derivatives. The disclosure further relates to methods of using the recombinant microorganisms in fermentation cultures in order to produce fatty acid derivatives and related compositions.
20	THERMOPHILIC AND THERMOACIDOPHILIC GLYCOSYLATION GENES AND ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS AND RELATED ORGANISMS, METHODS	EP09823952	2009-02-26	EP2245173A4	2011-11-02	THOMPSON DAVID N; APEL WILLIAM A; THOMPSON VICKI S; REED DAVID W; LACEY JEFFREY A
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for glycosylating and/or post-translationally modifying proteins using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.

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