专利检索_ 作用于配对供体的与分子氧结合或还原的氧化还原酶专利检索_ 作用于配对供体的与分子氧结合或还原的氧化还原酶专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
101	ENZYMES AND METHODS FOR PRODUCING OMEGA-3 FATTY ACIDS	EP17182502.9	2009-11-17	EP3260544A1	2017-12-27	PETRIE, James, Robertson; MACKENZIE, Anne Maree; LIU, Qing; SHRESTHA, Pushkar; NICHOLS, Peter David; BLACKBURN, Susan, Irene, Ellis; MANSOUR, Maged, Peter; ROBERT, Stanley, Suresh; FRAMPTON, Dion, Matthew, Frederick; ZHOU, Xue-Rong; SINGH, Surinder, Pal; WOOD, Craig, Christopher
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ω3 destaurases, Δ5 elongases and Δ6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.
102	PLANT CYTOCHROME P450	EP11748702.5	2011-07-18	EP2596012B1	2017-12-06	WINZER, Thilo; WALKER, Tracy Carol; GRAHAM, Ian Alexander
This disclosure relates to the isolation and sequencing of nucleic acid molecules that encode cytochrome P450 polypeptides from a Papaver somniferum cultivar; uses in the production of noscapine and identification of poppy cultivars that include genes that comprise said nucleic acid molecules.
103	DETERGENT COMPOSITION COMPRISING A FATTY ACID DECARBOXYLASE	EP16168822.1	2016-05-09	EP3243896A1	2017-11-15	LANT, Neil Joseph; BETTIOL, Jean-Luc Philippe; GONZALES, Denis Alfred
A detergent composition, preferably a manual dishwashing detergent composition and method of washing comprising a surfactant system and a fatty acid decarboxylase enzyme.
104	MANUFACTURING METHOD FOR IMPROVED PROTEIN-CONTAINING FOOD AND FORMULATION FOR IMPROVING PROTEIN-CONTAINING FOOD	EP15734961	2015-01-07	EP3092907A4	2017-10-25	SATO HIROAKI; NAKAGOSHI HIROYUKI; KOTANI MASAO; KOBAYASHI YOSHIE

105	ENZYMES AND METHODS FOR PRODUCING OMEGA-3 FATTY ACIDS	EP09827035.8	2009-11-17	EP2358882B1	2017-07-26	PETRIE, James, Robertson; MACKENZIE, Anne Maree; LIU, Qing; SHRESTHA, Pushkar; NICHOLS, Peter David; BLACKBURN, Susan, Irene, Ellis; MANSOUR, Maged, Peter; ROBERT, Stanley, Suresh; FRAMPTON, Dion, Matthew, Frederick; ZHOU, Xue-Rong; SINGH, Surinder, Pal; WOOD, Craig, Christopher
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides É3 destaurases, ”5 elongases and ”6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.
106	PIPECOLINIC ACID POSITION-4 HYDROXYLASE AND METHOD FOR PRODUCING 4-HYDROXYAMINO ACID USING SAME	EP15742961	2015-01-27	EP3101123A4	2017-06-28	HIBI MAKOTO; OGAWA JUN; MIYAKE RYOMA; KAWABATA HIROSHI
The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic acid in the presence of 2-oxoglutaric acid and iron(II) ions to produce trans -4-hydroxy-L-pipecolic acid, and a method for producing 4-hydroxy amino acid, which method comprises reacting the pipecolic acid 4-hydroxylase protein, cells containing the protein, a treated product of the cells, and/or a culture liquid obtained by culturing the cells, with ±-amino acid to produce 4-hydroxy amino acid: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18 except that one or several amino acids are deleted, substituted, and/or added, and having pipecolic acid 4-hydroxylase activity; and (C) a polypeptide having an amino acid sequence that is not less than 80% identical to the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18, and having pipecolic acid 4-hydroxylase activity.
107	MICROORGANISM INCLUDING GENE ENCODING PROTEIN HAVING HYDROXYLASE ACTIVITY AND METHOD OF REDUCING CONCENTRATION OF FLUORINATED METHANE IN SAMPLE USING THE SAME	EP16169537.4	2016-05-13	EP3093337A3	2017-03-15	SONG, Seunghoon; KIM, Taeyong; PARK, Jinhwan; PARK, Joonsong; JUNG, Yukyung; CHU, Hunsu; SONG, Jiyoon; CHO, Kwangmyung
A microorganism including a foreign gene encoding a protein having a hydroxylase activity that reduces the concentration of CH_nF_4-n (n is an integer of 0 to 3) in a sample, as well as a composition including the microorganism, and a method of reducing the concentration of CH_nF_4-n in a sample using the microorganism.
108	TYPE II FATTY ACID SYSTHESIS ENZYMES IN REVERSE B-OXIDATION	EP15740946.7	2015-01-26	EP3099763A1	2016-12-07	GONZALEZ, Ramon; CLOMBURG, James, M.; VICK, Jacob, E.
This disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis ("FAS") pathway that can be used in combination with thiolases to operate a functional reversal of the β-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the β-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their α-, β-, and ω-functionalized derivatives from renewable carbon sources can be achieved.
109	ARTEMISININ DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTIMALARIAL AGENTS	EP13850986.4	2013-10-28	EP2912169A1	2015-09-02	FASAN, Rudi
Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections are provided. Methods are provided for the production of artemisinin derivatives via functionalization of positions C7 and C6a, and optionally, in conjunction with modifications at positions C10 and C9, via chemoenzymatic methods. Recombinant cytochrome P450 polypeptides are also provided for use in the methods. The artemisinin derivatives can be used for the treatment of malaria and other parasitic infections, alone or in combination with other antiparasitic drugs.
110	PLANT CYTOCHROME P450	EP11748702.5	2011-07-18	EP2596012A2	2013-05-29	WINZER, Thilo; WALKER, Tracy Carol; GRAHAM, Ian Alexander
This disclosure relates to the isolation and sequencing of nucleic acid molecules that encode cytochrome P450 polypeptides from a Papaver somniferum cultivar; uses in the production of noscapine and identification of poppy cultivars that include genes that comprise said nucleic acid molecules.
111	ENZYMES AND METHODS FOR PRODUCING OMEGA-3 FATTY ACIDS	EP09827035	2009-11-17	EP2358882A4	2012-05-02	PETRIE JAMES ROBERTSON; MACKENZIE ANNE MAREE; LIU QING; SHRESTHA PUSHKAR; NICHOLS PETER DAVID; BLACKBURN SUSAN IRENE ELLIS; MANSOUR MAGED PETER; ROBERT STANLEY SURESH; FRAMPTON DION MATTHEW FREDERICK; ZHOU XUE-RONG; SINGH SURINDER PAL; WOOD CRAIG CHRISTOPHER
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides É3 destaurases, ”5 elongases and ”6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.
112	ENZYMES AND METHODS FOR PRODUCING OMEGA-3 FATTY ACIDS	EP09827035.8	2009-11-17	EP2358882A1	2011-08-24	PETRIE, James, Robertson; MACKENZIE, Anne Maree; LIU, Qing; SHRESTHA, Pushkar; NICHOLS, Peter David; BLACKBURN, Susan, Irene, Ellis; MANSOUR, Maged, Peter; ROBERT, Stanley, Suresh; FRAMPTON, Dion, Matthew, Frederick; ZHOU, Xue-Rong; SINGH, Surinder, Pal; WOOD, Craig, Christopher
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides É3 destaurases, ”5 elongases and ”6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.
113	SOYBEAN TRANSGENIC EVENT MON 87708 AND METHODS OF USE THEREOF	EP10817646.2	2010-08-26	EP2478000B1	2018-04-11	BRINKER, Ronald, J.; BURNS, Wen, C.; FENG, Paul, C.C.; GUPTA, Anju; HOI, Sio-wai; MALVEN, Marianne; WU, Kunsheng
The invention provides a transgenic soybean event MON 87708 plant and plants, plant cells, seeds, plant parts, and commodity products derived from event MON 87708. The invention also provides polynucleotides specific for event MON 87708 and plants, plant cells, seeds, plant parts, and commodity products comprising polynucleotides specific for event MON 87708. The invention also provides methods related to event MON 87708.
114	TYPE II FATTY ACID SYSTHESIS ENZYMES IN REVERSE B-OXIDATION	EP15740946	2015-01-26	EP3099763A4	2017-08-02	GONZALEZ RAMON; CLOMBURG JAMES M; VICK JACOB E
This disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis (“FAS”) pathway that can be used in combination with thiolases to operate a functional reversal of the β-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the β-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their α-, β-, and ω-functionalized derivatives from renewable carbon sources can be achieved.
115	METHOD FOR PREPARING TRANSGENIC PLANT WITH INCREASED 20-HYDROXYECDYSONE CONTENT BY USING SPINACIA OLERACEA-DERIVED CYP85 GENE, AND PLANT PREPARED THEREBY	EP14866244	2014-11-27	EP3075238A4	2017-06-14	RIU KEY ZUNG; BOO KYUNG HWAN; AHN JONG CHEOL
The present invention relates to a method for producing a transgenic plant which has increased content of 20-hydroxyecdysone compared to a wild type plant by transforming a plant cell with a recombinant vector containing a gene encoding CYP85 (cytochrome P450, 85 family) protein derived from spinach (Spinacia oleracea), a transgenic plant with increased content of 20-hydroxyecdysone compared to a wild type plant which is produced by the above method and a seed thereof, a composition for increasing content of 20-hydroxyecdysone in plant which contains a gene encoding CYP85 protein derived from Spinacia oleracea as an effective component, a method for producing a transgenic plant with enhanced insect resistance according to transformation of a plant cell with a recombinant vector containing a gene encoding CYP85 derived from Spinacia oleracea, a transgenic plant with enhanced insect resistance which is produced by the above method and a seed thereof, and a composition for enhancing insect resistance of a plant which contains a gene encoding CYP85 protein derived from Spinacia oleracea as an effective component.
116	ARTEMISININ DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTIMALARIAL AGENTS	EP13850986	2013-10-28	EP2912169A4	2016-11-23	FASAN RUDI
Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections are provided. Methods are provided for the production of artemisinin derivatives via functionalization of positions C7 and C6a, and optionally, in conjunction with modifications at positions C10 and C9, via chemoenzymatic methods. Recombinant cytochrome P450 polypeptides are also provided for use in the methods. The artemisinin derivatives can be used for the treatment of malaria and other parasitic infections, alone or in combination with other antiparasitic drugs.
117	MANUFACTURING METHOD FOR IMPROVED PROTEIN-CONTAINING FOOD AND FORMULATION FOR IMPROVING PROTEIN-CONTAINING FOOD	EP15734961.4	2015-01-07	EP3092907A1	2016-11-16	SATO, Hiroaki; NAKAGOSHI, Hiroyuki; KOTANI, Masao; KOBAYASHI, Yoshie
A method for producing a modified food containing a protein and a preparation for modifying a food containing a protein are provided. A food raw material containing a protein is treated by using an oxidizing agent and/or an oxidoreductase in combination with a metal and/or a metal-containing substance to produce a food containing a protein.
118	MICROSOMES IRREVERSIBLEMENT INHIBES POUR DES CYP450 LEURS UTILISATIONS DANS LE PHENOTYPAGE ENZYMATIQUE DES VOIES METABOLIQUES	EP14806674.9	2014-12-05	EP3077527A1	2016-10-12	CARADEC, Fabrice; PARMENTIER, Yannick; POTHIER, Corinne
The invention relates to a method for preparing isolated microsomes containing an irreversibly inhibited cytochrome P450 (CYP450). The isolated microsome is characterized in that a cytochrome P450 thereof is irreversibly inhibited by an irreversible inhibitor. The invention also relates to the use of the isolated microsomes according to the invention in a method for phenotyping enzymatic reactions of a drug candidate.
119	Microsomes irreversiblement inhibés pour des CYP450 leurs utilisations dans le phénotypage enzymatique des voies métaboliques	EP13306674.6	2013-12-05	EP2881470A1	2015-06-10	Carardec, Fabrice; Parmentier, Yannick; Pothier, Corinne
Méthode de préparation de microsomes isolés comprenant un cytochrome P450 (CYP450) irréversiblement inhibé. Microsome isolé caractérisé dont un cytochrome P450 est irréversiblement inhibé par un inhibiteur non réversible. Utilisation des microsomes isolés selon l'invention dans une méthode de phénotypage des réactions enzymatiques d'un candidat médicament.
120	SOYBEAN TRANSGENIC EVENT MON 87708 AND METHODS OF USE THEREOF	EP10817646	2010-08-26	EP2478000A4	2014-05-14	BRINKER RONALD J; BURNS WEN C; FENG PAUL C C; GUPTA ANJU; HOI SIO-WAI; MALVEN MARIANNE; WU KUNSHENG
The invention provides a transgenic soybean event MON 87708 plant and plants, plant cells, seeds, plant parts, and commodity products derived from event MON 87708. The invention also provides polynucleotides specific for event MON 87708 and plants, plant cells, seeds, plant parts, and commodity products comprising polynucleotides specific for event MON 87708. The invention also provides methods related to event MON 87708.

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