TYPE II FATTY ACID SYSTHESIS ENZYMES IN REVERSE B-OXIDATION |
|||||||
| 申请号 | EP15740946 | 申请日 | 2015-01-26 | 公开(公告)号 | EP3099763A4 | 公开(公告)日 | 2017-08-02 |
| 申请人 | UNIV RICE WILLIAM M; | 发明人 | GONZALEZ RAMON; CLOMBURG JAMES M; VICK JACOB E; | ||||
| 摘要 | This disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis (“FAS”) pathway that can be used in combination with thiolases to operate a functional reversal of the β-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the β-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their α-, β-, and ω-functionalized derivatives from renewable carbon sources can be achieved. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
QQ群二维码
意见反馈
意见反馈