专利检索_ 作用于配对供体的与分子氧结合或还原的氧化还原酶专利检索_ 作用于配对供体的与分子氧结合或还原的氧化还原酶专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
41	Luciferase biosensors for camp	US12454643	2009-05-19	US20090305280A1	2009-12-10	Brock Binkowski; Lance P. Encell; Monika G. Wood; Keith V. Wood; Kris Zimmerman; Paul Otto; Gediminas Vidugiris; Pete Stecha
A modified luciferase protein which is a sensor for molecules including cAMP is provided. The modified luciferase protein includes one or more heterologous amino acid sequences, at least one of which directly or indirectly interacts with cAMP.
42	MICROORGANISM INCLUDING GENE ENCODING PROTEIN HAVING HYDROXYLASE ACTIVITY AND METHOD OF REDUCING CONCENTRATION OF FLUORINATED METHANE IN SAMPLE USING THE SAME	EP16169537.4	2016-05-13	EP3093337A2	2016-11-16	SONG, Seunghoon; KIM, Taeyong; PARK, Jinhwan; PARK, Joonsong; JUNG, Yukyung; CHU, Hunsu; SONG, Jiyoon; CHO, Kwangmyung
A microorganism including a foreign gene encoding a protein having a hydroxylase activity that reduces the concentration of CH_nF_4-n (n is an integer of 0 to 3) in a sample, as well as a composition including the microorganism, and a method of reducing the concentration of CH_nF_4-n in a sample using the microorganism.
43	CYTOCHROME P450 AND CYTOCHROME P450 REDUCTASE POLYPEPTIDES, ENCODING NUCLEIC ACID MOLECULES AND USES THEREOF	EP13850891	2013-10-31	EP2914729A4	2016-11-02	BOHLMANN CARL JOERG; DIAZ CHAVEZ MARIA LUISA; MONIODIS JESSIE
Provided are cytochrome P450 polypeptides, including cytochrome P450 santalene oxidase polypeptides, cytochrome P450 bergamotene oxidase polypeptides and cytochrome P450 reductase polypeptides. Also provided are nucleic acid molecules encoding the cytochrome P450 polypeptides. Cells containing the nucleic acids and/or the polypeptides are provided as are methods for producing terpenes, such as santalols and bergamotols, by culturing the cells.
44	METHOD FOR PREPARING TRANSGENIC PLANT WITH INCREASED 20-HYDROXYECDYSONE CONTENT BY USING SPINACIA OLERACEA-DERIVED CYP85 GENE, AND PLANT PREPARED THEREBY	EP14866244.8	2014-11-27	EP3075238A1	2016-10-05	RIU, Key Zung; BOO, Kyung Hwan; AHN, Jong Cheol
The present invention relates to a method for producing a transgenic plant which has increased content of 20-hydroxyecdysone compared to a wild type plant by transforming a plant cell with a recombinant vector containing a gene encoding CYP85 (cytochrome P450, 85 family) protein derived from spinach (Spinacia oleracea), a transgenic plant with increased content of 20-hydroxyecdysone compared to a wild type plant which is produced by the above method and a seed thereof, a composition for increasing content of 20-hydroxyecdysone in plant which contains a gene encoding CYP85 protein derived from Spinacia oleracea as an effective component, a method for producing a transgenic plant with enhanced insect resistance according to transformation of a plant cell with a recombinant vector containing a gene encoding CYP85 derived from Spinacia oleracea, a transgenic plant with enhanced insect resistance which is produced by the above method and a seed thereof, and a composition for enhancing insect resistance of a plant which contains a gene encoding CYP85 protein derived from Spinacia oleracea as an effective component.
45	PROTEIN HAVING GLYCOALKALOID BIOSYNTHASE ACTIVITY, AND GENE ENCODING SAME	EP10812057.7	2010-08-30	EP2471927B1	2015-12-23	UMEMOTO Naoyuki; SASAKI Katsunori

46	METHODS AND MATERIALS FOR BIOSYNTHESIS OF MOGROSIDE COMPOUNDS	EP13799312.7	2013-12-04	EP2929043A1	2015-10-14	LIU, Yaoquan; HANSEN, Jørgen; HOUGHTON-LARSEN, Jens; MURALI, Muthuswamy Panchapagesa; KUMAR, Sathish; RASMUSSEN, Nina, Nicoline
The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.
47	PROTEIN HAVING GLYCOALKALOID BIOSYNTHASE ACTIVITY, AND GENE ENCODING SAME	EP10812057.7	2010-08-30	EP2471927A1	2012-07-04	UMEMOTO Naoyuki; SASAKI Katsunori
An object of the present invention is to provide DNA of a glycoalkaloid biosynthetic enzyme of a solanaceous plant (Solanaceae) such as a potato. The present invention relates to a protein having glycoalkaloid biosynthetic enzyme activity of a solanaceous plant such as a potato and a method for producing/detecting a novel organism using a gene encoding the protein.
48	LUCIFERASE BIOSENSORS FOR cAMP	EP09750966.5	2009-05-19	EP2281046B1	2012-01-25	ENCELL, Lance, P.; ZIMMERMAN, Kris; OTTO, Paul; VIDUGIRIS, Gediminas; STECHA, Pete; BINKOWSKI, Brock; WOOD, Monika, G.; WOOD, Keith, V.
A modified luciferase protein which is a sensor for molecules including cAMP is provided. The modified luciferase protein includes one or more heterologous amino acid sequences, at least one of which directly or indirectly interacts with cAMP.
49	Protein having glycoalkaloid biosynthetic enzyme activity and gene encoding the same	US15409397	2017-01-18	US10138491B2	2018-11-27	Naoyuki Umemoto; Katsunori Sasaki
An object of the present invention is to provide DNA of a glycoalkaloid biosynthetic enzyme of a solanaceous plant (Solanaceae) such as a potato. The present invention relates to a protein having glycoalkaloid biosynthetic enzyme activity of a solanaceous plant such as a potato and a method for producing/detecting a novel organism using a gene encoding the protein.
50	Pipecolinic acid 4-hydroxylase and method for producing 4-hydroxy amino acid using same	US15115028	2015-01-27	US09969988B2	2018-05-15	Makoto Hibi; Jun Ogawa; Ryoma Miyake; Hiroshi Kawabata
The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic acid in the presence of 2-oxoglutaric acid and iron(II) ions to produce trans-4-hydroxy-L-pipecolic acid, and a method for producing 4-hydroxy amino acid, which method comprises reacting the pipecolic acid 4-hydroxylase protein, cells containing the protein, a treated product of the cells, and/or a culture liquid obtained by culturing the cells, with α-amino acid to produce 4-hydroxy amino acid: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18 except that one or several amino acids are deleted, substituted, and/or added, and having pipecolic acid 4-hydroxylase activity; and (C) a polypeptide having an amino acid sequence that is not less than 80% identical to the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18, and having pipecolic acid 4-hydroxylase activity.
51	Enzymes and methods for producing omega-3 fatty acids	US14332202	2014-07-15	US09938486B2	2018-04-10	James Robertson Petrie; Anne Maree Mackenzie; Qing Liu; Pushkar Shrestha; Peter David Nichols; Susan Irene Ellis Blackburn; Maged Peter Mansour; Stanley Suresh Robert; Dion Matthew Frederick Frampton; Xue-Rong Zhou; Surinder Pal Singh; Craig Christopher Wood
The present invention relates generally to the field of recombinant fatty acid synthesis, particularly in transgenic plants. The application describes genes involved in fatty acid synthesis and provides methods and vectors for the manipulation of fatty acid composition of plant oils. In particular, the invention provides constructs for achieving the integration of multiple heterologous genes involved in fatty acid synthesis into the plant genome, such that the resulting plants produce altered levels of polyunsaturated fatty acids. Also described are methods for enhancing the expression of fatty acid biosynthesis enzymes by co-expressing a silencing suppressor within the plant storage organ.
52	ENZYMES AND METHODS FOR PRODUCING OMEGA-3 FATTY ACIDS	US15642223	2017-07-05	US20180087004A1	2018-03-29	James Robertson Petrie; Anne Maree Mackenzie; Qing Liu; Pushkar Shrestha; Peter David Nichols; Susan Irene Ellis Blackburn; Maged Peter Mansour; Stanley Suresh Robert; Dion Matthew Frederick Frampton; Xue-Rong Zhou; Surinder Pal Singh; Craig Christopher Wood
The present invention relates generally to the field of recombinant fatty acid synthesis, particularly in transgenic plants. The application describes genes involved in fatty acid synthesis and provides methods and vectors for the manipulation of fatty acid composition of plant oils. In particular, the invention provides constructs for achieving the integration of multiple heterologous genes involved in fatty acid synthesis into the plant genome, such that the resulting plants produce altered levels of polyunsaturated fatty acids. Also described are methods for enhancing the expression of fatty acid biosynthesis enzymes by co-expressing a silencing suppressor within the plant storage organ.
53	ENZYMES AND METHODS FOR PRODUCING OMEGA-3 FATTY ACIDS	US15661697	2017-07-27	US20180010141A1	2018-01-11	James Robertson Petrie; Anne Maree Mackenzie; Qing Liu; Pushkar Shrestha; Peter David Nichols; Susan Irene Ellis Blackburn; Maged Peter Mansour; Stanley Suresh Robert; Dion Matthew Frederick Frampton; Xue-Rong Zhou; Surinder Pal Singh; Craig Christopher Wood
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ω3 destaurases, Δ5 elongases and Δ6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.
54	PLANT CYTOCHROME P450	US15469731	2017-03-27	US20170369896A2	2017-12-28	Thilo Hans Winzer; Tracy Carol Walker; Ian Alexander Graham
This disclosure relates to the isolation and sequencing of nucleic acid molecules that encode cytochrome P450 polypeptides from a Papaver somniferum cultivar; uses in the production of noscapine and identification of poppy cultivars that include genes that comprise said nucleic acid molecules.
55	Oxygenase-Based Biosensing Systems For Measurement Of Halogenated Alkene Concentrations	US14348426	2012-10-01	US20170269001A9	2017-09-21	Kenneth F. Reardon; Brian C. Heinze
A biosensing system that measures the concentration of halogenated alkenes is disclosed.
56	INDOLE-DERIVED COMPOUND PRODUCTION	US15323996	2015-07-07	US20170204424A1	2017-07-20	Aldwin Anterola
Among the various aspects of the present disclosure is the provision of a transgenic organism, an artificial DNA construct, and methods for producing a transgenic organism for indigo, indirubin, and other indole-derived compound production. Another aspect of the present disclosure is the provision of a transgenic organism wherein the indole-derived compound imparts color to the transgenic organism or to a portion of the transgenic organism.
57	PLANT CYTOCHROME P450	US15469731	2017-03-27	US20170198299A1	2017-07-13	Thilo Hans Winzer; Tracy Carol Walker; Ian Alexander Graham
This disclosure relates to the isolation and sequencing of nucleic acid molecules that encode cytochrome P450 polypeptides from a Papaver somniferum cultivar; uses in the production of noscapine and identification of poppy cultivars that include genes that comprise said nucleic acid molecules.
58	Artemisinin derivatives, methods for their preparation and their use as antimalarial agents	US14438833	2013-10-28	US09663532B2	2017-05-30	Rudi Fasan; Kai-Dong Zhang
Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections are provided. Methods are provided for the production of artemisinin derivatives via functionalization of positions C7 and C6a, and optionally, in conjunction with modifications at positions C10 and C9, via chemoenzymatic methods. Recombinant cytochrome P450 polypeptides are also provided for use in the methods. The artemisinin derivatives can be used for the treatment of malaria and other parasitic infections, alone or in combination with other antiparasitic drugs.
59	Protein having glycoalkaloid biosynthetic enzyme activity and gene encoding the same	US13392790	2010-08-30	US09598699B2	2017-03-21	Naoyuki Umemoto; Katsunori Sasaki
An object of the present invention is to provide DNA of a glycoalkaloid biosynthetic enzyme of a solanaceous plant (Solanaceae) such as a potato. The present invention relates to a protein having glycoalkaloid biosynthetic enzyme activity of a solanaceous plant such as a potato and a method for producing/detecting a novel organism using a gene encoding the protein.
60	Soybean transgenic event MON 87708 and methods of use thereof	US14745241	2015-06-19	USRE46292E1	2017-01-31	Ronald J. Brinker; Wen C. Burns; Paul C. C. Feng; Anju Gupta; Sio Wai Hoi; Marianne Malven; Kunsheng Wu
The invention provides a transgenic soybean event MON 87708 plant and plants, plant cells, seeds, plant parts, and commodity products derived from event MON 87708. The invention also provides polynucleotides specific for event MON 87708 and plants, plant cells, seeds, plant parts, and commodity products comprising polynucleotides specific for event MON 87708. The invention also provides methods related to event MON 87708.

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