子分类：
- C12Y114/15001： ..樟脑5-单加氧酶(1.14.15.1)
- C12Y114/15002： ..樟脑1,2-单加氧酶(1.14.15.2)
- C12Y114/15003： ..烷烃1-单加氧酶(1.14.15.3)
- C12Y114/15004： ..类固醇11-β-单加氧酶(1.14.15.4)
- C12Y114/15005： ..皮质酮18-单加氧酶(1.14.15.5)
- C12Y114/15006： ..胆固醇单加氧酶(侧链裂解)(1.14.15.6),即细胞色素P450scc
- C12Y114/15007： ..胆碱单加氧酶(1.14.15.7)
- C12Y114/15008： ..类固醇15-β-单加氧酶(1.14.15.8)
- C12Y114/15802： ..球形烯单加氧酶(1.14.15.B2),即无环类胡萝卜素2-酮酶
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | ω‑官能化羧酸及其酯的生物技术生产 | CN201611053536.5 | 2016-11-25 | CN107034246A | 2017-08-11 | S.沙费尔; T.哈斯; W.布吕金格; R.迈尔 |
| 本发明涉及ω‑官能化羧酸及其酯的生物技术生产。提供了用于从至少一种烷烃生产至少一种ω‑官能化羧酸酯的微生物细胞，其中所述细胞经遗传修饰以相对于野生型细胞增加以下的表达：(i)能够将所述烷烃转化为相应的1‑烷醇的酶E1；(ii)能够将(i)的1‑烷醇转化为相应的1‑烷醛的酶E2；(iii)能够将(ii)的1‑烷醛转化为相应的烷酸的酶E3；(iv)能够将(iii)的烷酸转化为相应的烷酸酯的酶E4；和(iv)能够将(iv)的烷酸酯转化为相应的ω‑羟基‑烷酸酯的酶E5，且其中所述细胞不包含相对于野生型细胞增加选自以下的以下酶E20‑E24中的至少一种的表达的遗传修饰：‑E20酰基‑ACP硫酯酶，‑E21酰基‑CoA硫酯酶，‑E22酰基‑CoA:ACP转酰酶，‑E23聚酮化合物合酶，和‑E24己酸合酶。 | ||||||
| 2 | A xylene monooxygenase-producing strain Arthrobacter woluwensis and its application | US15573874 | 2017-08-28 | US20180346947A1 | 2018-12-06 | Guangsheng Li; Tao Yang; Gangqiang Wan; Xinxin Qu |
| The present invention belongs to microbial technology field and relates to a strain producing toluene o-xylene monooxygenase (Arthrobacter woluwensis) HW-1 and its application in preparation of 5-methylpyrazine-2-carboxylic acid by microbial fermentation. The present invention providing a new strain HW-1 which could produce toluene o-xylene monooxygenase, and the strain is identified as Arthrobacter woluwensis. The strain is firstly found to convert 2, 5-dimethylpyrazine by bio-fermentation to obtain the medicine intermediate 5-methylpyrazine-2-carboxylic acid. The concentration of accumulated product could reach 34.19 g/L and the yield rate is 81.4% by shake flask fermentation. Compared with 20.41 g/L reported in the literature, this method has a greater advantage and could be industrialized. The conditions to prepare 5-methylpyrazine-2-carboxylic acid provided in the present invention is mild, the reaction process is controllable and has good performance in environmental protection and energy saving. So this invention has great value in industry. | ||||||
| 3 | Alkane oxidation by a modified hydroxylase | JP2009549270 | 2008-02-08 | JP2010517579A | 2010-05-27 | ファサン，ルーディ |
| 本発明は修飾ヒドロキシラーゼに関連する。 本発明はさらに、該修飾ヒドロキシラーゼを発現する細胞、および適当な基質を該細胞に接触させることでヒドロキシル化アルカンを生成する方法に関連する。
【選択図】 なし |
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| 4 | ALKANE OXIDATION BY MODIFIED HYDROXYLASES | US15942001 | 2018-03-30 | US20180273983A1 | 2018-09-27 | Frances Arnold; Peter Meinhold; Matthew W. Peters; Rudi Fasan; Mike M.Y. Chen |
| This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells. | ||||||
| 5 | Alkane oxidation by modified hydroxylases | US15224900 | 2016-08-01 | US09963720B2 | 2018-05-08 | Frances Arnold; Peter Meinhold; Matthew W. Peters; Rudi Fasan; Mike M. Y. Chen |
| This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells. | ||||||
| 6 | CHLOROPHYLLASE OVERPRODUCTION TO ENHANCE PHOTOSYNTHETIC EFFICIENCY | US15454018 | 2017-03-09 | US20170267984A1 | 2017-09-21 | Kelsey M. McNeely; Joseph C. Weissman |
| Recombinant microorganisms and methods for using the same are disclosed herein for producing biomass or at least one biomolecule. These methods comprise culturing a photosynthetic microorganism that can overexpress a chlorophyllase, and optionally isolating biomass and/or at least one biomolecule from the culture. | ||||||
| 7 | ALKANE OXIDATION BY MODIFIED HYDROXYLASES | EP08729436 | 2008-02-08 | EP2121907A4 | 2011-03-02 | FASAN RUDI |
| This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells. | ||||||
| 8 | ALKANE OXIDATION BY MODIFIED HYDROXYLASES | EP08729436.9 | 2008-02-08 | EP2121907A2 | 2009-11-25 | FASAN, Rudi |
| This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells. | ||||||
| 9 | ALKANE OXIDATION BY MODIFIED HYDROXYLASES | PCT/US2008053472 | 2008-02-08 | WO2008098198A3 | 2008-12-24 | FASAN RUDI |
| This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells. | ||||||
| 10 | ALKANE OXIDATION BY MODIFIED HYDROXYLASES | PCT/US2008053472 | 2008-02-08 | WO2008098198A2 | 2008-08-14 | FASAN RUDI |
| This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells. | ||||||
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