| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | Preparation of aqueous solution of addition product of guanidine phosphate and formaldehyde | JP21516985 | 1985-09-30 | JPS6187656A | 1986-05-06 | MATSUMOTO TAKETO; WAKAMATSU MASAAKI; SATO HISATOMO |
| PURPOSE: To obtain an aqueous solution containing guanidine phosphate component useful as a flame-retarding treatment agent for paper and plywood in high concentration, easily, by carrying out the addition reaction of guanidine carbonate or guanidine with formaldehyde, and neutralizing the reaction product with phosphoric acid. CONSTITUTION: Guanidine carbonate which is an addition product of weakly acidic carbonic acid and guanidine, or alkaline guanidine, is made to react with formaldehyde at 20W100°C, preferably 50W70°C for 15W60min, and the reaction product is neutralized with phosphoric acid, and then cooled to obtain the objective compound. The amount of formaldehyde is 0.5W3mol per 1mol of the guanidine component, and that of phosphoric acid is up to neutral equivalent. The objective product is a concentrated aqueous solution containing 20W150 pts.wt. of the guanidine phosphate component per 100pts.wt. COPYRIGHT: (C)1986,JPO&Japio | ||||||
| 122 | JPS611063B2 - | JP12826980 | 1980-09-16 | JPS611063B2 | 1986-01-13 | FUJII SETSUO; OKUTOME TOSHUKI; NAKAYAMA TOYOO; YAEGASHI TAKASHI; KURUMI MASATERU |
| 123 | Alphamenine, its relating compound and their synthesis | JP10788883 | 1983-06-17 | JPS606647A | 1985-01-14 | UMEZAWA HAMAO; AOYANAGI TAKAAKI; TATSUTA KUNIAKI; NAKAMURA TAKESHI; FUKATSU SHIYUNZOU |
| PURPOSE: To produce the titled compound useful as an immunoactivator and analgesic agent, easily, in high yield, by condensing an α-amino acid derivative with a malonic acid diester alkali metal salt, and removing the protecting group from the product. CONSTITUTION: The objective compound of formula IV (the steric configuration of the C atom labeled with * is R, S or its combination) can be produced by (1) condensing (A) the α-amino acid derivative of formula I (R 1 is α-amino acid residue, etc. corresponding to the α-amino acid molecule minus α-carboxyl group; X is Br or I) with (B) the substituted or unsubstituted malonic acid diester alkali metal salt of formula II (R 2 is H, 1W6C alkyl, etc.; R 3 is 1W4C alkyl or carboxyl-protecting group; Me is alkali metal) in an organic solvent such as formamide at 0W15°C, and (2) removing the protecting group from the reaction product by conventional decarboxyl reaction or decarboxylate reaction. COPYRIGHT: (C)1985,JPO&Japio | ||||||
| 124 | JPS59500B2 - | JP7736478 | 1978-06-28 | JPS59500B2 | 1984-01-07 | IWAI TOMIRO; TSUNODA TOMYASU; YAMAMOTO ICHIRO; KURONUMA MASAO |
| 125 | Preparation of 6-guanidinocaproic acid-p-ethoxy- carbonylphenyl ester or its salt | JP6035582 | 1982-04-13 | JPS58177960A | 1983-10-18 | MATSUMOTO TAKASHI |
| PURPOSE: To obtain the titled compound useful as a remedy for pancreatitis inexpensively in high yield, by reacting a polyhalogenophenyl ester of 6-guanidinocaproic acid or its salt with ethyl p-hydroxybenzoate. CONSTITUTION: A novel polyhalogenophenyl ester of 6-guanidino-caproic acid shown the formula I (X is halogen; n is 3W5) or its salt is reacted with ethyl p- hydroxybenzoate shown by the formula II in a solvent such as pyridine, benzene, etc. at 40W160°C for 5W24hrs, to give the desired substance shown by the formula III. Preferably the reaction is carried out in dehydrated pyridine solvent under heating at 50W100°C. COPYRIGHT: (C)1983,JPO&Japio | ||||||
| 126 | JPS5523823B2 - | JP9474 | 1973-12-28 | JPS5523823B2 | 1980-06-25 | |
| 127 | JPS50129522A - | JP3267774 | 1974-03-25 | JPS50129522A | 1975-10-13 | |
| 128 | JPS49102824A - | JP1193974 | 1974-01-30 | JPS49102824A | 1974-09-28 | |
| 129 | 組成物及びその製造方法 | JP2016177392 | 2016-09-12 | JP6469053B2 | 2019-02-13 | 西村 直之; 東條 正弘 |
| 130 | Composition comprising an aqueous solution of a hexasubstituted guanidinium chloride | JP2008023337 | 2008-02-01 | JP4755211B2 | 2011-08-24 | ガリー・レイ・ファレー; ジョウセフ・ジェイ・カリンギ; ダニエル・ジョウセフ・ブルネル; トーマス・リンク・グゲンハイム; ピーター・デイビッド・フェルプス; ラリー・アイビス・フラワース; ロイ・レイ・オドル |
| 131 | Phase transfer catalyst composition | JP2008023337 | 2008-02-01 | JP2008120825A | 2008-05-29 | CARINGI JOSEPH J; FALER GARY RAY; PHELPS PETER DAVID; GUGGENHEIM THOMAS LINK; FLOWERS LARRY IVIS; BRUNELLE DANIEL JOSEPH; ODLE ROY RAY |
| <P>PROBLEM TO BE SOLVED: To provide a phase transfer catalyst composition containing an aqueous solution of hexasubstituted guanidinium chlorides. <P>SOLUTION: The invention relates to a new preparation method for hexasubstituted guanidinium chlorides. According to the method, hexasubstituted guanidinium chlorides are provided in high yield as the aqueous solutions, optionally also containing alkali metal chlorides. The solutions may be employed as the sources of hexasubstituted guanidinium salts useful as phase transfer catalysts for the reaction of alkali metal salts of dihydroxyaromatic compounds with substituted imides to form polyetherimides or their intermediates. <P>COPYRIGHT: (C)2008,JPO&INPIT | ||||||
| 132 | Production method of guanidines | JP4280097 | 1997-01-22 | JP3890543B2 | 2007-03-07 | 真一 八児; 一行 渡辺 |
| 133 | Preparation of aminoalkyl guanidine | JP50165295 | 1994-06-01 | JP3662925B2 | 2005-06-22 | シエーボム，ハンス・フレードリク; ニユーストリヨーム，ヤーン−エーリク |
| 134 | Production method of aluminate of guanidine compound | JP10700692 | 1992-04-24 | JP3263428B2 | 2002-03-04 | 哲生 吉山 |
| 135 | Use of at least one of no synthase inhibitors in the treatment of sensitive skin | JP51633097 | 1996-10-01 | JP3110050B2 | 2000-11-20 | ラシャリエール， オリヴィエ ドゥ; ライオネル ブレトン， |
| 136 | Deoxyspergualin analogues, their preparation and use as therapeutic | JP3507995 | 1995-02-23 | JP2874839B2 | 1999-03-24 | RENAUT PATRICE; LEBRETON LUC; DUTARTRE PATRICK; DERREPAS PHILIPPE; SAMRETH SOTH |
| 137 | Optically active (s) - (-) and (r) - (+) - preparation of Deoxys par guar phosphorus and novel intermediates | JP25425396 | 1996-09-26 | JP2854289B2 | 1999-02-03 | SHUEBAO WAN; JON KEI SOTSUTASHIRU |
| 138 | Use of at least one of no synthase inhibitors in the treatment of sensitive skin | JP51633097 | 1996-10-01 | JPH10511404A | 1998-11-04 | ラシャリエール， オリヴィエ ドゥ; ライオネル ブレトン， |
| (57)【要約】 敏感肌の治療および／または防止を目的とする化粧品組成物中の活性成分としての、少なくとも１つのＮＯシンターゼ阻害剤の使用が開示されている。 薬理組成物、特に敏感肌の治療を意図する皮膚科組成物の調製のための、少なくとも１つのＮＯシンターゼ阻害剤の使用も開示されている。 | ||||||
| 139 | Aqueous solution of hexasubstituted guanidium chloride, its production and use | JP175797 | 1997-01-09 | JPH09328461A | 1997-12-22 | JIYOUSEFU JIEI KARINGI; GARII REI FUAREE; PIITAA DEIBITSUDO FUERUPUSU; TOOMASU RINKU GUGENHAIMU; RARII AIBISU FURAWAASU; DANIERU JIYOUSEFU BURUNERU; ROI REI ODORU |
| PROBLEM TO BE SOLVED: To obtain the subject aqueous solution giving a phase-transfer catalyst in high yield by a specific method. SOLUTION: (A) Phosgene is passed through a mixture containing (B) an aliphatic or alicyclic secondary amine and (C) a low-polar organic solvent and water at 40-80°C and pH10-1-3. The amount of water is selected to form an aqueous solution of an alkali metal salt having a concentration corresponding to ≥95wt.% of the saturated concentration and the amount of the component B is selected to give a product having a concentration of 25-95wt.% in the component C. The equivalent ratio of the component A to B is set to (1-1.15):1 and the volume ratio of the component C to water is set to (0.8-5):1. Water, the component B, etc., are removed from the reaction mixture and the concentration of the produced tetrasubstituted urea is adjusted to 40-80wt.%. Furthermore, the component A is introduced into the system in an amount sufficient to react with whole existing water and give an equivalent ratio to the tetrasubstituted urea of 1.05-1.15 and the unreacted component A is removed from the produced anhydrous reaction mixture. The mixture is mixed with the component B, the obtained hexasubstituted guanidium salt is diluted with water in a basic medium and the aqueous phase is separated from the organic phase. COPYRIGHT: (C)1997,JPO | ||||||
| 140 | Substituted bezoylguanidine, production of the same, use of the same as medicine or diagnostic agent and medicine containing the same | JP25431696 | 1996-09-26 | JPH09124584A | 1997-05-13 | ANDOREEASU BUAIHIERUTO; YOOAHIMU BURENDERU; HAINTSUUBUERUNAA KUREEMAN; HANSU YOOHEN RANGU; YANNROOBERUTO SHIYUBUARUKU; UUDOO ARUBUSU; BUORUFUGANGU SHIYORUTSU |
| PROBLEM TO BE SOLVED: To obtain the subject new compound expressed by a specific formula, useful for the production of a medicine for the treatment or prevention of arrhythmia, myocardial infarct and angina pectoris. SOLUTION: This substituted benzoylguanidine is a compound of formula I {at least one of R(1) to R(3) is R(6)-C(OH) 2 [C(6) is a 1-3C is a 1-3C perfluoroalkyl], and others are each H, OH, F, Cl, Br, I, a 1-6C alkyl, etc.; R(4), R(5) are each H, a 1-3C alkyl, F, Cl, Br, I, CN, etc.}, e.g. 4-(1',1'- bishydroxy-2',2',2'-trifluoro) ethyl-benzoylguanidine hydrochloric acid salt. Further, in order to obtain the compound, it is preferable to react a compound of formula II (L is an easily nucleophilically substitutable leaving group) with guanidine. COPYRIGHT: (C)1997,JPO | ||||||
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