181 |
Production of borate of guanidine compound |
JP19389992 |
1992-07-21 |
JPH0641048A |
1994-02-15 |
YOSHIYAMA TETSUO |
PURPOSE:To obtain the compound in a high purity by adding an equivalent water to a guanidine compound and an organoboron compound such as an alkoxyboron in an organic solvent and reacting these components in a nonaqueous solution system. CONSTITUTION:An equivalent water is added to a guanidine compound of the formula (R<1> to R<4> are H, an alkyl, aryl, alkylaryl or hydroxyalkyl with the proviso that R<1> may be amide) (especially guanidine, 1-methylguanidine or 1,1- dimethylguanidine) and an organoboron compound (e.g. butoxyboronic acid) in an organic solvent such as butanol and these components are made to react in a nonaqueous solution system to provide the boric acid salt of guanidine compound. Since the compound having a high purity is obtained by this method, purification process is made unnecessary and production at a low cost is made possible. |
182 |
Metallic carbide and its production |
JP12991693 |
1993-05-06 |
JPH069209A |
1994-01-18 |
FUAUJII JII SHIERIFU |
PURPOSE: To produce a transition metallic carbide having a large surface area and catalytic activity for use in air pollution control, isomerization and hydrodesulfurization processes.
CONSTITUTION: A mixture of an acyclic compd. containing carbon-nitrogen- hydrogen bonding and a metallic salt is calcined to produce the objective metallic carbide. The acyclic compd. is selected from among guanidine, a deammoniated deriv. of guanidine, an adduct to guanidine and an adduct to a deammoniated deriv. of guanidine.
COPYRIGHT: (C)1994,JPO |
183 |
Production of silicate of guanidine compound |
JP10700792 |
1992-04-24 |
JPH05306264A |
1993-11-19 |
YOSHIYAMA TETSUO |
PURPOSE: To produce the subject compound of high purity, useful. as a raw material of silicon nitride, a binder and an adhesive with a simple operation in a relatively short time by reacting a guanidine compound with an organosilicon compound.
CONSTITUTION: The subject compound can be obtained by reacting a compound of the formula (R
1 to R
4 are each H, an alkyl, an aryl, an alkylaryl or a hydroxyalkyl. R
1 may be amino) with an organosilicon compound in an organic solvent (e.g. ethanol) at room temperature to 100°C for several min to several hr. The molar ratio of the compound of the formula to the organosilicon compound is 1.5 to 0.65. The subject compound is obtained in the form of fine powder and a high-purity substance can be obtained in comparison with that obtained by the aqueous solvent method.
COPYRIGHT: (C)1993,JPO&Japio |
184 |
Dicyandiamide |
JP10394892 |
1992-03-31 |
JPH05279317A |
1993-10-26 |
Hitoshi Horikiri; Seiichi Yoshida; 清一 吉田; 仁志 堀切 |
PURPOSE: To provide dicyandiamide important as an intermediate for producing melamine, guanamine, or guanidine derivatives, also usable as a flame retardant, dyeing auxiliary, nitration inhibitor for fertilizers, or epoxy curing agent, prevented from trouble developments such as caking during its storage.
CONSTITUTION: The objective dicyandiamide can be obtained by crystallization of the original dicyandiamide in the presence of a modified polyvinyl alcohol, being characterized by falling at or below 0.3 in the diffraction angle intensity ratio I
1/I
2 (where, I
1 is diffraction angle intensity for 2=14.9°; I
2 is diffraction angle intensity for 2=26.3°; 2θ is the X-ray diffraction angle for the primary crystal).
COPYRIGHT: (C)1993,JPO&Japio |
185 |
JPH0560824B2 - |
JP25612987 |
1987-10-08 |
JPH0560824B2 |
1993-09-03 |
ARUBERUTO REINERU |
|
186 |
Production of aluminate of guanidine compound |
JP1078492 |
1992-01-24 |
JPH05201954A |
1993-08-10 |
YOSHIYAMA TETSUO; ISOZAKI WATARU |
PURPOSE: To obtain a guanidine aluminate at a low cost in a short time by reacting an aqueous solution of a guanidine compound with metal aluminum in an inert gas atmosphere.
CONSTITUTION: A guanidine compound of the formula (R1 to R4 are H, alkyl, aryl, alkylaryl, hydroxyalkyl or R1 may be amino) is reacted with metal aluminum, preferably subjected to surface treatment with a diluted aqueous solution of sodium soda, in an inert gas atmosphere at normal temperature to 100°C. An aluminate of guanidine compound having very low content of impurities can be synthesized by purification at a stage of raw material, can be purified by a means such as cleaning with a solvent or recrystallization at a stage of aluminate of guanidine compound and the aluminate of guanidine compound having extremely high purity can be produced.
COPYRIGHT: (C)1993,JPO&Japio |
187 |
JPH0254822B2 - |
JP3429884 |
1984-02-27 |
JPH0254822B2 |
1990-11-22 |
UMEDA YOSHIHISA; MORIGUCHI MAKOTO; IGAI KATSUSHIGE; NAKAMURA TERUYA; FUJII AKIO; TAKEUCHI TOMIO; UMEZAWA HAMAO |
|
188 |
Production of guanidine nitrate from urea and ammonium nitrate |
JP32640688 |
1988-12-26 |
JPH02763A |
1990-01-05 |
KUREMENSU GURAMUBOU; BUORUFUGANGU KURISUTOFU; PEETAA RAITOZAAMAA; KURUTO SHIYAINOSUTO |
PURPOSE: To extend the life of a catalyst easily and to obtain guanidine nitrate continuously and industrially, by reacting urea with excess ammonium nitrate while elevating the temperature in the presence of a silicon dioxide catalyst while the catalyst being activated in specified conditions.
CONSTITUTION: For example, according to a diagram, urea, excess ammonium nitrate, and a silicon dioxide catalyst are charged into a reactor A, the temperature is elevated to 180-190°C, and a melt reaction mixture is led from a conduit pipe 3 to a filter B by a pump. The partial flow of the reaction mixture is separated continuously by filtration through a filter layer to retain the catalyst in a circulating route, the liquid product containing guanidine nitrate is obtained and supplied to after-treatment. At the same time, the starting mixture of ammonium nitrate and urea which are consumed continuously is supplied to the reactor in accordance with the removal of the product. Ammonium carbamate is taken out from the top of the reactor. The molten reaction mixture can be circulated advantageously by industrial apparatuses including a pump.
COPYRIGHT: (C)1990,JPO |
189 |
Unsaturated nbenzopyranyllactam |
JP7686789 |
1989-03-30 |
JPH01287083A |
1989-11-17 |
HAINRITSUHI KURISUTEIAN ENGURE; DEIITAA MANIA; BERUNBUARUTO SHIERUKENSU; ROORANTO UUTSU |
NEW MATERIAL: A compound of formula I {wherein R
1 is H, a 1-4C alkyl, a 1-4C alkoxyl, a halogen, trifuoromethyl or the like; R
2 is H, OH, a 1 or 2C alkoxyl, a 1 or 2 alkyl or 1 or 2C alkylcarbonyl; R
3 and R
4 are each a 1-4C alkyl; X is formula II (wherein R
6 to R
9 are each H, a 1-4C alkyl, a halogen or NO
2; and n is 0 or 1); and m is 0 or a, provided that R
1 is CO-Ar or ArSO
r [wherein Ar is a substituted (aromatic or heteroaromatic group; and r is 0-2) when m is 0]}.
EXAMPLE: Trans-3,4Dihydro-4-(1,2-dihydro2-oxopyrid-1-yl)-2,2- dimethyl-6(phenylsulfonyul)-2Hbenzo[b]pyran-3-ol.
USE: An antihypertensive, a relaxant for the bladder, intestine, gall, uterus, trachea and ureter.
PREPARATION: A compound of formula III is reacted with a lactam of formula IV.
COPYRIGHT: (C)1989,JPO |
190 |
JPH0139419B2 - |
JP2560881 |
1981-02-25 |
JPH0139419B2 |
1989-08-21 |
PEETAA SHARUKE; MANFUREETO RANGAA; KURAUSU FUUTOMATSUHAA |
|
191 |
Manufacture of high energy material |
JP25350686 |
1986-10-24 |
JPS62187436A |
1987-08-15 |
ROSU DABURIYU MIRAA; NOOMAN SHII POORU; DEIBITSUDO EICHI RICHIYAAZU |
A process for the production of a high energy nitrate ester involves reacting, in an inert organic solvent, a heterocyclic compound, selected from oxiranes, oxetanes, N-substituted aziridines and N-substituted azetidines, with either N2O4 or N2O5, and when the compound is reacted with N2O4, oxidising the O- or N-nitrate substituents or substituent in the product to O- or N-nitrate substituent or substituents. The remaining ring carbon atoms on the heterocyclic compound may be substituted or unsubstituted. Preferred substituent groups for the C and/or N ring atoms on the compound include alkyl, cyanoalkyl, haloalkyl, nitroalkyl, and substituted aryl. Several novel nitrate ester are also provided, including nitrated derivatives of polybutadiene, in which between 1% and 25% of the carbon atoms in the polymer are substituted by vicinal nitrate ester (-ONO2) groups. |
192 |
Production of epsilon-guanidinocaproic acid p-ethoxycarbonylphenyl ester or its salt |
JP13450884 |
1984-06-29 |
JPS6115868A |
1986-01-23 |
MIYAGAKI MITSUHIRO; MURATA RIYOUICHI |
PURPOSE: To obtain the titled compound useful as an antikallikrein agent, in high yield and in one step, by reacting ε-guanidinocaproic acid with ethyl p- hydroxybenzoate in the presence of a sulfonic acid anhydride and an acid acceptor.
CONSTITUTION: The objective compound of formula I can be produced by reacting (A) ε-guanidinocaproic acid of formula II or its salt with (B) ethyl p-hydroxybenzoate of formula III in the presence of (C) a sulfonic acid anhydride of formula IV (R is lower alkyl, p-methylphenyl or trifluoromethyl) and an acid acceptor (e.g. pyridine, dimethylamine, etc.) in a solvent such as dimethylformamide, acetone, etc. at room temperature for 10W30hr. The amount of the sulfonic acid anhydride is ≥1mol per 1mol of the compound of formula II.
COPYRIGHT: (C)1986,JPO&Japio |
193 |
Guanidine fungicide for agriculture and horticulture |
JP3397884 |
1984-02-24 |
JPS60178801A |
1985-09-12 |
YOSHIOKA NOBUYUKI; YAKURA KOUJI; MIURA YASUNAO; MORI YOSHIKAZU; ADACHI EIICHI; KATAOKA YASUKATSU |
PURPOSE: The titled fungicide applicable to various blights of useful vegetable such as brown rot of peach, scarb of pear, etc., reducing phytotoxicity of guazatine, etc. which was not applicable owing to it strong phytotoxicity, comprising a specific acid addition salt of a fungicidal guanidine compound as an active ingredient.
CONSTITUTION: A fungicide comprising a water-insoluble acid addition salt such as guazatine.3 laurate, guazatine.3 laurylsulfate, guazatine.3 dodecylbenzenesulfonate, etc. obtained by reacting a fungicidal guanidine compound such as guazatine[=1,1'-iminodi(octamethylene)diguanidine], etc. with an acid having ≥9, preferably 9W25 total carbon atoms and lipophilic nature as an active ingredient. A carboxylic acid, sulfuric monoester, or sulfonic acid having a lipophilic group with ≥9 total carbon atoms is preferably used as the acid. The fungicide is obtained by subjecting an acid with no lipophilic nature of the fungicidal guanidine compound of salt exchange reaction with an acid having a lipophilic group with ≥9 total carbon atoms or its alkali salt.
COPYRIGHT: (C)1985,JPO&Japio |
194 |
Novel preparation of gabexate |
JP18972182 |
1982-10-28 |
JPS5978156A |
1984-05-04 |
KAMIYA ISAO |
PURPOSE: To obtain the titled compound useful as an original drug of an injection for pancreatitis treatment, etc., by subjecting a p-(6-guanidiniumcaproyloxy) benxoic acid to ethyl esterification with ethanol in the presence of an acidic condensation agent and a base.
CONSTITUTION: A p-(6-guanidiniumcaproyloxy)benzoic acid shown by the formula I (X is anion) is reacted with ethanol shown by the formula II in the presence of an acidic condensation agent (e.g., phosphorus trichloride, cyanuric chloride, phosphorus oxychloride, etc.) and a base (e.g. potassium hydrogencarbonate, triethylamine, pyridine, etc.) in a solvent such as acetone, dimethylformamide, etc. preferably in a low-temperature range at ≤ room temperature, to give the desired compound shown by the formula III.
COPYRIGHT: (C)1984,JPO&Japio |
195 |
Guanidinobenzoate and anticomplementary agent |
JP12826980 |
1980-09-16 |
JPS5753454A |
1982-03-30 |
FUJII SETSUO; OKUTOME TOSHIYUKI; NAKAYAMA TOYOO; YAEGASHI TAKASHI; KURUMI MASATERU |
NEW MATERIAL:6'-amidino-2'-naphthyl 4-guanidinobenzoate expressed by formula I and an acid addition salt thereof.
USE: An anticomplementary agent having C1-esterase inhibitory activity and anticomplementary action. A compound useful as an antitrypsic agent useful for the remedy of pancreatitis, antiplasmin agent useful for the remedy of hemorrhagic diseases anticallicrein agent and antithrombin agent useful for the remedy for thrombosis.
PROCESS: A 4-guanidinobenzoic acid expressed by formula II or a reactive intermediate thereof, e.g. an acid halide or acid anhydride, is reacted with 6-amidino-2- naphthol expressed by formula III in a solvent, e.g. dimethylformamide or pyridine, in the presence of a dehydrohalogenating agent, e.g. potassium carbonate or pyridine, to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio |
196 |
Preparation of creatine |
JP7736478 |
1978-06-28 |
JPS554349A |
1980-01-12 |
IWAI TOMIROU; TSUNODA TOMIYASU; YAMAMOTO ICHIROU; KURONUMA MASAO |
PURPOSE: To obtain creatine, a remedy for muscular dystrophy, in high yield and purity, without forming mercaptans, by reacting an 0-alkylisourea with an aqueous solution of sarcosine maintained always alkaline.
CONSTITUTION: An 0-alkyl isourea is reacted with an aqueous solution of sarcosine always maintained at a pH of 10W12 for more than 3W4 hr to give creatine. A commercially available 30W38% aqueous solution of the sodium salt is directly used as the sarcosine. The reaction is carried out at 5°C to ordinary temperature with vigorous stirring.
COPYRIGHT: (C)1980,JPO&Japio |
197 |
Separation of organic substances having carboxyl group |
JP1597077 |
1977-02-15 |
JPS53101303A |
1978-09-04 |
EGUCHI TAMIYUKI; MORI SEIICHI; SHIMOKAWA MASAAKI |
PURPOSE: To separate organic substances efficiently at low energy from a mixed aqueous solution of inorganic salts and organic substances having carboxyl group, by hindering permeation of organic substances and making inorganic salts permeate together with water, in contact with an amphoteric membrane under pressure.
COPYRIGHT: (C)1978,JPO&Japio |
198 |
JPS5096527A - |
JP9474 |
1973-12-28 |
JPS5096527A |
1975-07-31 |
|
|
199 |
SIMPLE ASTATINE CONCENTRATION METHOD |
US17923341 |
2021-05-06 |
US20230373881A1 |
2023-11-23 |
Hiroshi TANAKA; Kazuhiro TAKAHASHI; Miho SUZUKI |
In order to produce high yields of astatine-211 without contamination of chloride ions, provided is a method for producing astatine-211, including (1) a step of generating astatine-211 by irradiating bismuth with α rays; (2) a step of heating the astatine-211 generated in step (1) to vaporize; (3) a step of cooling the astatine-211 that has been vaporized in step (2) and collecting the astatine-211 with a volatile and polar solvent to obtain an astatine-211 solution; (4) a step of adding a weak acid salt to the astatine-211 solution obtained in step (3) to obtain an astatine-211 solution containing the weak acid salt; and (5) a step of removing the solvent from the astatine-211 solution containing the weak acid salt obtained in step (4). |
200 |
Stable pemetrexed arginine salt and compositions comprising it |
US15989751 |
2018-05-25 |
US10253031B2 |
2019-04-09 |
Jacobus Theodorus Henricus Van Eupen; Borek Zaludek |
The present invention relates to arginine salt of pemetrexed of formula (1), particularly to a stable solid form thereof, and to pharmaceutical compositions comprising such salt. |