| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 201 | Method for purifying methacrylic acid | US14366673 | 2012-12-26 | US09238610B2 | 2016-01-19 | Tomomichi Hino; Shinpei Kato; Hideyuki Sonobe; Manabu Hoshino |
| Provided is a crystallization method by which a highly-pure methacrylic acid crystal can be produced with high productivity. The method for purifying methacrylic acid according to the present disclosure involves using crude methacrylic acid having a maleic acid concentration of 2000 ppm by mass or less and an acrylic acid concentration of 2000 ppm by mass or less and setting the slurry temperature to −10 to 10° C. in order to crystallize methacrylic acid. A suspension-type jacket-cooling-system crystallization vessel is used as the crystallization apparatus, and an absolute value of the difference between a crystallization temperature and a temperature of a cooling medium in the jacket is preferably 15° C. or less. | ||||||
| 202 | METHOD FOR PREPARING ANHYDROUS SUGAR ALCOHOL | US14435630 | 2013-10-15 | US20150299216A1 | 2015-10-22 | Hoon RYU; Young Jae JUNG; Jin Kyung KIM; Do Hyun KYUNG; Hyuk Min PARK; Seong Ho CHO |
| The present invention relates to a method for preparing anhydrous sugar alcohol, and more particularly, to a cheap and highly efficient method for preparing anhydrous sugar alcohol having a high final purity of at least 99%, and having good ion content, pH, conductivity, and color properties. According to the method, a hydrogenated sugar is dehydrated so as to be transformed into anhydrous sugar alcohol, and a series of processes including distillation, crystallization, decoloration, and ion exchange resin treatment are conducted. | ||||||
| 203 | Sublimation method for the purification of organic small molecules | US14238825 | 2012-08-03 | US09139488B2 | 2015-09-22 | Lei Dai; Lifei Cai |
| Disclosed is an improved sublimation method for the purification of organic small molecules. The new method features that barriers are applied in the collection region of sublimation tube so that the gas flow path is modified to pass through or bypass the barriers from the heating region to the vacuum pump. The arrangement of the barriers can effectively separate the main product from the impurities. The main product is enriched in a collection region, while the volatile impurities are enriched in an impurity region. This method has been proved to improve the quality of sublimed materials substantially according to the purity measurements and OLED performance tests. | ||||||
| 204 | PROCESS FOR THE PURIFICATION OF A CYCLOHEXANE AIR OXIDATION PRODUCT STREAM | US14415159 | 2012-07-19 | US20150232393A1 | 2015-08-20 | David Lee Valdez |
| A method is disclosed for removing contaminants from a feed stream to a hydrogenation process that begins with providing a product mixture from an air oxidation reaction. A first liquid separation process and cooling procedure is used on the product mixture to form a cooled product mixture and a first vapor stream. The cooled product mixture is then subjected to a water wash to form a washed product mixture and an aqueous exit stream, wherein a majority of the water soluble other oxidation products from the cooled product mixture are present in the aqueous exit stream. Next, the washed product stream undergoes a second liquid separation and water removal to form a treated product mixture and a second vapor stream. Finally, the treated product mixture is recovered and can be fed to a hydrogenation process. | ||||||
| 205 | Butanol manufacturing method | US13635066 | 2011-03-16 | US09056805B2 | 2015-06-16 | Masateru Ito; Izumi Morita; Shinichi Yamane; Katsushige Yamada |
| Highly pure butanol can be produced by a method for producing butanol, the method comprising: Step A, wherein a butanol-containing solution is filtered through a nanofiltration membrane and a butanol-containing solution is recovered from the permeate side; Step B, wherein the butanol-containing solution obtained in Step A is passed through a reverse osmosis membrane and thereby concentrated to cause two-phase separation into a butanol phase and an aqueous phase; and Step C, wherein butanol is recovered from the butanol phase obtained in Step B. | ||||||
| 206 | SOLVENT-FREE PROCESSING, SYSTEM AND METHODS | US14537341 | 2014-11-10 | US20150152018A1 | 2015-06-04 | Jeffrey C. Raber; Sytze Elzinga |
| Disclosed is a process for purifying one or more chemical constituents from plant matter using extraction with a fluid that is not a solvent, for example, with a vegetable oil. The extracted chemical constituents may then optionally be further processed by heating in order to induce desired chemical transformations. The extracted chemical constituents are also processed by concentrating at reduced pressure, for example, by distillation. | ||||||
| 207 | Intelligently controlled spectrometer methods and apparatus | US12764808 | 2010-04-21 | US09024255B2 | 2015-05-05 | Mark A. Osgood; Ching Wu |
| The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching machenism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. | ||||||
| 208 | Purification procedure for the preparation of the radioactive tracer 3′-deoxy-3′-[18F] fluorothymidine ([18F]FLT) | US12602410 | 2008-04-22 | US09005447B2 | 2015-04-14 | Claudio Pascali; Anna Bogni |
| A procedure for the preparation of the radioactive tracer 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) comprises the following steps: a) preparation of anhydrous [18F]F-fluoride; b) labelling of a precursor, for example 3-N-Boc-1-[5′-O-(4,4′-dimethoxytrityl)-3′-O-nitrophenylsulfonyl-2′-deoxy-β-D-lyxofuranosyl]thymidine; c) hydrolysis of the mixture obtained by means of the previous steps; d) purification of the mixture to obtain the radioactive tracer [18F]FLT. In this procedure steps a), b) and c) are carried out by means of known methods. In step d) the mixture obtained after step c) is purified by means of the passage through a ventilated filter and one or more cartridges of the cationic exchange type (e.g. a Chromafix PS-H+), one or more cartridges of the reversed phase type, and finally a passage through cartridges either of the alumina N type, or diol cartridges, or anionic exchange cartridges or a combination thereof. Furthermore, the mixture which is present in the cartridges is eluted with H2O for injection, whereby the resulting product is forwarded to a container or ampoule for the collection of [18F]FLT. | ||||||
| 209 | Purification method | US13517276 | 2010-10-08 | US08969580B2 | 2015-03-03 | Eric Horn; Steven Fairway; Dimitrios Mantzilas; Nigel Powell |
| A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of b amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE). | ||||||
| 210 | Process for removing, isolating and purifying dicarboxylic acids | US13806904 | 2011-05-31 | US08957249B2 | 2015-02-17 | Wolfgang Tietz; Joachim Schulze |
| A process for removing, isolating and purifying dicarboxylic acid from fermentation broths, which includes the following steps: 1) removal of the biomass and any solids present from the fermentation broth in two successive stages, 2) removal of the dicarboxylic acid solution from the biomass-free fermentation broth by simulated moving bed (SMB) chromatography, 3) fine purification of the dicarboxylic acid solution, 4) multistage evaporative concentration and crystallization, and 5) separation and drying of the crystals. | ||||||
| 211 | SORBENT COMPRISING ON ITS SURFACE A CATIONIC OR PROTONIZABLE ALIPHATIC RESIDUE FOR THE PURIFICATION OF ORGANIC MOLECULES | US14344718 | 2012-09-17 | US20150005487A1 | 2015-01-01 | Markus Arendt; Björn Degel; Thomas Schwarz; Gerhard Stumm; Martin Welter |
| The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbent according to the invention for the purification of organic molecules, in particular pharmaceutically active compounds, preferably in chromatographic application. | ||||||
| 212 | MULTI-DIMENTIONAL ION MOBILITY SEPARATOR METHOD AND APPARATUS | US14214590 | 2014-03-14 | US20140346339A1 | 2014-11-27 | Ching Wu; Christopher Hilton |
| One aspect of the present invention is to extract multiple ionic species in a FAIMS into one or more IMS drift tubes simultaneously. By adjusting FAIMS operational parameters, ions in FAIMS are detected on IMS detectors through separation in FAIMS and/or separation and collection in the IMS. This method provides a continuous separation of specific ions from an ion swarm by employing a high-field differential mobility analyzer (FAIMS) with a plurality of orthogonal transitions paths spaced incrementally along the electrodes which allow additional separation by a conventional IMS drift tube. The components of the sample can be collected or detected. | ||||||
| 213 | Adhesive composition, film adhesive, and method for producing the adhesive composition | US12458259 | 2009-07-07 | US08877884B2 | 2014-11-04 | Motoki Takahashi; Hirofumi Imai; Takahiro Asai; Koichi Misumi; Toshiyuki Ogata |
| An adhesive composition is disclosed which includes a polymer prepared by copolymerizing a monomer containing a polymerizable group, the polymer including a low-molecular-weight component having a molecular weight equivalent to 1% or less of the weight-average molecular weight of the polymer, the low-molecular-weight component is contained in a range of not less than 0 weight % to less than 0.3 weight % of the total weight of the polymer. This allows provision of an adhesive composition having great adhesive strength in a high-temperature environment, especially at temperatures from 140° C. to 200° C., as well as high heat resistance and favorable crack resistance. | ||||||
| 214 | ISOLATION OF ANHYDRO SUGAR ALCOHOLS BY SELECTIVE ADSORBENTS | US14331327 | 2014-07-15 | US20140323746A1 | 2014-10-30 | Johan VAN DEN BERGH; Jacob Adriaan MOULIJN |
| A method is disclosed for recovering anhydrosugar alcohols from a mixture comprising closely related compounds, such as sugar alcohols. In the method the mixture is contacted with an adsorbent, whereby the anhydrosugar alcohols are selectively adsorbed. The anhydrosugar alcohols can be recovered by desorption from the adsorbent, using a desorbing solvent. | ||||||
| 215 | POLYOL-INDUCED EXTRACTION OF WATER FROM ORGANIC LIQUIDS | US14209228 | 2014-03-13 | US20140263050A1 | 2014-09-18 | John R. Sowa, JR.; Wyatt R. Murphy, JR.; Mithilesh Deshpande |
| Disclosed are methods of extracting water from a composition of an organic liquid and water, using a polyol. | ||||||
| 216 | Method for preparing a glycol mono-tertiary-butylether compound | US14000648 | 2012-02-21 | US08766015B2 | 2014-07-01 | Myeong-Seok Kim; Jae-Hoon Uhm; Min-Sup Park; Hyoung-Jae Seo; Kyoung-Tae Min |
| Disclosed is a method of preparing a glycol mono-tertiary-butyl ether compound using a C4 hydrocarbon mixture containing isobutene and a glycol compound as reactants, in which a glycol di-tertiary-butyl ether compound as a byproduct is decomposed into isobutene and a glycol compound and the obtained isobutene and glycol compound are recycled as reactants, whereby product yield per unit raw material may be maximized. The method includes a catalytic reaction step for preparing a glycol mono-tertiary-butyl ether compound and a glycol di-tertiary-butyl ether compound as a byproduct by reaction between a glycol compound and a C4 hydrocarbon mixture containing isobutene in the presence of an acidic catalyst, a byproduct extraction step for separating the glycol mono-tertiary-butyl ether compound and the glycol di-tertiary-butyl ether compound, prepared through the catalytic reaction step, using a hydrophilic extractant and a lipophilic extractant, and a byproduct decomposition and recycling step for decomposing the separated glycol di-tertiary-butyl ether compound into a glycol compound and isobutene and recycling the decomposed glycol compound and isobutene as the reactants to the catalytic reaction step. | ||||||
| 217 | Method for purification of nucleic acids, particularly from fixed tissue | US13133182 | 2009-11-20 | US08703931B2 | 2014-04-22 | Heike Euting; Guido Hennig; Alexandre Izmailov |
| The invention relates to a method for purification of nucleic acids, to a kit for performing the method according to the invention and to a new application of magnetic particles for purification of a biological sample. The method according to the invention comprises the following steps: a) accommodating of the sample in a first sample vessel in an aqueous solution and lysing of the sample under non-chaotropic conditions; suspending of first magnetic particles in the solution and inserting of the first sample vessel in a sample vessel holder, wherein the sample vessel is inserted in the annular interior space of a ring magnet associated with the sample vessel holder; separating of the solution from the magnetic particles; and isolating of the nucleic acids from the solution. | ||||||
| 218 | Processes for removal of dibenzofulvene | US13020838 | 2011-02-04 | US08703912B2 | 2014-04-22 | Yuji Nishiuchi; Terutoshi Kimura |
| A dibenzofulvene amine adduct is removed by contacting a reaction mixture containing the dibenzofulvene amine adduct, which is obtained by reacting, for deprotection, an amino acid compound protected with an Fmoc group with an amine compound containing a nitrogen atom which is bonded to at least one hydrogen atom, with carbon dioxide, and removing the carbonate of the dibenzofulvene amine adduct. Alternatively, a dibenzofulvene amine adduct is removed by mixing a reaction mixture during a deprotection reaction of the amino acid compound protected with an Fmoc group, or after the reaction with an amine compound containing a nitrogen atom which is bonded to at least one hydrogen atom to give a mixture containing the dibenzofulvene amine adduct, contacting the mixture with carbon dioxide, and removing the carbonate of the dibenzofulvene amine adduct. | ||||||
| 219 | Utilizing ionic liquids for hydrofluorocarbon separation | US11525466 | 2006-09-22 | US08628644B2 | 2014-01-14 | Mark B. Shiflett; Akimichi Yokozeki |
| The present invention relates to a process for separating close-boiling and azeotropic components of mixtures, wherein said mixtures contain at least one hydrofluorocarbon compound, using at least one ionic liquid. | ||||||
| 220 | Processing of reaction solutions from whole-cell biotransformations | US11766189 | 2007-06-21 | US08613857B2 | 2013-12-24 | Harald Groeger; Claudia Rollmann; Helge Werner; Francoise-Christine Chamouleau; Dittmar Orzewski |
| A product is enriched by a method for the processing of a reaction solution, in which: a) a pH value of the reaction solution is adjusted to less than 4; wherein said reaction solution comprises a whole-cell catalyst, an aqueous component, and an organic component, wherein the organic component contains a product to be enriched; and b) the reaction solution is filtered in the presence of a filter aid, thereby enriching the product. | ||||||
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