| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 261 | Purification methods | US10560508 | 2005-05-11 | US20070148647A1 | 2007-06-28 | Sajinder Luthra; Frank Brady; Nicholas Jeffery; Erik Arstad; Alexander Gibson; Duncan Wynn; Alan Cuthbertson; Magne Solbakken |
| The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group. The general concept being illustrated by the scheme: | ||||||
| 262 | Membrane separation process | US11283215 | 2005-11-18 | US20070114177A1 | 2007-05-24 | Craig Sabottke |
| The invention relates to an improved membrane pervaporation and vapor permeation system in which the vacuum is produced by a fluid passing through a Venturi-type nozzle. The fluid is chosen from solvents that have little or no affinity for the permeate molecules. It is applicable over process feed rates, and can be used for the separation of aromatic species from hydrocarbon. | ||||||
| 263 | Cross-linked polymine and use thereof for the immobilization of acidic or electrophilic compounds present in a solution | US10558264 | 2004-04-29 | US20070017872A1 | 2007-01-25 | Didier Stien |
| The invention relates to a process for immobilizing acidic or electrophilic compounds in a solution. The process is characterized in that it consists in bringing a crosslinked polyimine, which is insoluble in the medium and in which the imino groups are —NH-groups, into contact with said compounds and in then separating, by filtration, the modified polyimine obtained. The crosslinked polyimine comprises linear segments composed of —HN—R1—NH—R2—Ar—R3-units in which R1, R2 and R3 are identical or different alkylene or alkenylene groups and Ar represents an aromatic group. The process is of use for fixing undesirable compounds or for purifying acidic compounds. | ||||||
| 264 | Fluorous oligonucleotide reagents and affinity purification of oligonucleotides | US11320218 | 2005-12-28 | US20060178507A1 | 2006-08-10 | David Berry; William Pearson |
| Fluorous-tagged oligonucleotide reagents and an oligonucleotide purification methodology making use thereof, the method comprising: Synthesizing oligonucleotides using oligonucleotide reagents each bearing at least one fluorous group to yield a mixture of synthesis products and reagents, the mixture including at least one target synthesized oligonucleotide bearing at least one fluorous group; passing the mixture through a separation medium having an affinity for the at least one fluorous group so that the target synthesized oligonucleotide bearing at least one fluorous group is adsorbed by the separation medium; washing the separation medium with at least a first solvent to selectively dissociate therefrom substantially all synthesis products and reagents of the heterogenous mixture other than the at least one target synthesized oligonucleotide bearing at least one fluorous group; and subsequently dissociating the at least one synthesized oligonucleotide from the separation medium, with or without the fluorous group. | ||||||
| 265 | Method for liquid/liquid extraction of molecular weight fractions of perfluorinated polyethers | US10802164 | 2004-03-16 | US20050209468A1 | 2005-09-22 | John Burns |
| A liquid/liquid extraction method is used for separating a perfluorinated polyether (PFPE) into two molecular-weight distributions using an alcohol or cyclic ether as one solvent and a fluorinated solvent as the other solvent. The more polar alcohol or cyclic ether solvent extracts the lower molecular weight PFPE and the less polar fluorinated solvent extracts the higher molecular weight PFPE. In addition, when the PFPE is a mixture of PFPEs with different end groups, such as a mixture of predominantly Z-Tetraol but with other PFPEs with Z-Dol end groups, there is an enrichment of the Z-Tetraol in the more polar solvent. The preferred PFPE is a mixture of PFPEs in as-purchased Z-Tetraol and the preferred solvents are methanol or trifluoroethanol as one solvent and a perfluorinated hydrocarbon, such as perfluorohexane, as the other solvent. | ||||||
| 266 | Sublimation purifying method and apparatus | US10239064 | 2001-03-19 | US06878183B2 | 2005-04-12 | Mahito Soeda; Shuhei Hotta; Kazuo Ishii |
| This invention relates to a method for sublimation refining which gives a high-purity product in high yield while preventing corrosion of the apparatus, contamination of the product and change in quality of the product and to an apparatus useful for the method. The apparatus of this invention for sublimation refining comprises a heat generating unit made of a material generating heat by electromagnetic induction, sublimating unit A and collecting units B and C, respectively independently controllable in temperature by electromagnetic induction heating and the inner surface or the inner tube of the sublimating or collecting unit is made of a material like metal and ceramic inert to sublimable substances. According to the method of this invention for sublimation refining, a sublimable substance is introduced to sublimating unit A, the sublimating unit is heated by electromagnetic induction thereby sublimating the sublimable substance, the sublimate is introduced to collecting unit B containing a zone controlled in temperature by electromagnetic induction heating and the object sublimable substance is collected. | ||||||
| 267 | Reaction and separation methods | US09506779 | 2000-02-18 | US06749756B1 | 2004-06-15 | Dennis P. Curran; Oscar de Frutos Garcia; Yoji Oderaotoshi |
| A method of separating compounds that includes the steps of: tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second organic compound with a second tagging moiety different from the first tagging moiety to result in a second tagged compound; and separating the first tagged compound from a mixture including the second tagged compound using a separation technique based upon differences between the first tagging moiety and the second tagging moiety. The present invention also provides a method for carrying out a chemical reaction including the steps of: tagging a plurality of compounds with different tagging moieties to create tagged compounds, conducting at least one chemical reaction on a mixture of the tagged compounds to produce a mixture of tagged products, and separating the mixture of tagged products by a separation technique based upon differences in the tagging moieties. | ||||||
| 268 | Method and device for eliminating oxygen contained in aqueous monomer solutions | US10048984 | 2002-02-19 | US06716273B1 | 2004-04-06 | Juergen Schulte; Detlef Albin |
| A continuous process for removing oxygen from aqueous monomer solutions, including flowing an inert gas and a monomer solution in a column-shaped apparatus as a countercurrent, wherein the monomer solution is added at the head of the apparatus, flows through the apparatus as a liquid column, and is withdrawn slightly above the bottom, at least one section of the liquid column is mixed in radial flow direction and in a turbulent fashion, and the at least one section of the liquid column is mixed using at least one stirring element which is one of a turbine disk and a dispersing disk. | ||||||
| 269 | Screening for optimal yield in the crystallisation of multicomponent systems | US10415808 | 2003-10-06 | US20040045498A1 | 2004-03-11 | Alan Arthur Smith; Lisa Lynn Agocs; Benjamin Mckay; Francois Gilardoni |
| A method of determining the optimal yield of a target compound comprises: (a) determining the initial composition of a mixture of compounds containing the target compound; (b) dissolving the mixture in a solvent; (c) placing a quantity of the solution in a plurality of vessels; (d) optionally, placing a portion of a different derivatising agent in each vessel; (e) causing crystallisation to occur; (f) analysing the contents of the vessels after the crystallisation has approached equilibrium to determine the compositions of the liquors and the compositions of the solids; and (g) comparing the compositions determined in step (f) to profile the performance of each system (by calculated means) in terms of the projected maximum yield of target compound is an optimised crystallisation process. | ||||||
| 270 | Process for the crystallization of non-sucrose substances | US10181280 | 2002-11-18 | US20030131784A1 | 2003-07-17 | Kristian Eriksson; Juha Nurmi; Jouko Virtanen |
| The invention relates to a process for the crystallization of substances having a narrow metastable supersaturation zone. In the process the saturation of a solution is gradually increased and the solution is seeded for the crystallization. The seeding is performed at a seeding point which is selected in response to a signal received from said process indicating imminent or initial spontaneous nucleation. The process provides a good crystal yield and a crystalline product having a uniform crystal structure and a narrow crystal size distribution. | ||||||
| 271 | Thromoboxane B2 metabolite and methods for regulating aspirin-related platelet action | US10157431 | 2002-05-28 | US20030124615A1 | 2003-07-03 | Gordon E. Ens |
| Disclosed are unique methods for identifying the lowest, yet optimal, aspirin doses for patients. These methods are also characterized as having little to no aspirin-related side-effects. These methods may be used pre-as well as post-thrombotic event, and employs a patient's urinary thromboxane B2 metabolic levels (e.g., 11-dehydrothromboxane B2), to identify the patient's platelet activation level. A patient's urinary thromboxane B2 metabolic level is then used to calculate and appropriate and individualized treatment effective for utilizing platelet activation. Kits for utilizing this technique are also provided. In yet another particular aspect, the invention provides a method for utilizing a random urine sample obtained from a patient to determine whether a patient or particular individual's current dosage of aspirin is providing an adequate and appropriate level of inhibition of platelet activation levels, as compared to inhibition levels observed in individuals not taking aspirin. Also provided are methods that include use of neutraceuticals in combination with the aspirin dosing regimen of the invention. The present invention further includes calibrant preparations. In some embodiments, these calibrants comprise urine, particularly human urine that is identified in repeated trials to provide a consistent and reproduceable level of thromboxane B2 metabolite. As such, they function as control preparations that reduce error from intra-assay sampling measurements. | ||||||
| 272 | Method and equipment for continuous and selective inclusion separation | US10009627 | 2001-10-26 | US20030073831A1 | 2003-04-17 | Isamu Uemasu; Kozo Hara; Hideki Takahashi |
| In a reaction system having at least two liquid-liquid interfaces between an organic phase of raw material containing a compound(s) to be separated and an aqueous phase of an aqueous solution of inclusion-complexing agent and between that aqueous phase and an organic phase(s) of extraction solvent(s), the compound(s) to be separated is entrapped into the aqueous phase through formation of an inclusion complex(es) of the inclusion-complexing agent with the compound(s), while the compound(s) is entrapped into the organic phase(s) of extraction solvent(s) through dissociation of said inclusion complex(es). The foregoing operation is performed using, for example, a squarish U-shaped tube or an H-shaped tube with bottom plates. Preferred examples of inclusion-complexing agent include highly water-soluble branched cyclodextrins. | ||||||
| 273 | Impurities separation by distillation | US09938012 | 2001-08-23 | US06478930B2 | 2002-11-12 | Vijai P. Gupta |
| A distillation procedure is provided for the separation of impurities from organic materials such as glycols and glycol ethers whereby a liquid stripping component is interfaced into a distillation column with or below the organic material introduction, heat being provided by a reboiler, the stripping component and impurities being removed overhead. | ||||||
| 274 | Separation of olefins from paraffins using ionic liquid solutions | US09735176 | 2000-12-12 | US06339182B1 | 2002-01-15 | Curtis L. Munson; Laura C. Boudreau; Michael S. Driver; William L. Schinski |
| Methods for separating olefins from non-olefins, such as parafins, including cycloparaffins, oxygenates and aromatics, are provided. The methods use metal salts to complex olefins, allowing the non-olefins to be separated by a variety of methods, including decantation and distillation. The metal salts are dissolved in ionic liquids, which tend to have virtually no vapor pressure, and which poorly solubilize the non-olefins. Accordingly, the non-olefins phase separate well, and can be distilled without carrying over any of the ionic liquid into the distillate. Preferred salts are Group IB salts, more preferably silver salts. A preferred silver salt is silver tetrafluoroborate. Preferred ionic liquids are those which form stable solutions or dispersions of the metal salts, and which do not dissolve the non-olefins. Further, if the olefins are subject to isomerization, the ionic liquid is preferably relatively non-acidic. The methods involve forming a solution of a suitable olefin-complexing salt in an appropriate ionic liquid. An olefin-containing mixture is contacted with the ionic liquid/salt solution, and the olefins are adsorbed. After the paraffins are removed, the olefins can be isolated by desorption. The olefin-containing mixture can be in the gas phase, or in the liquid phase. The flow of olefin-containing mixtures over/through the ionic liquid can be, for example, co-current, counter-current, or staged in stirred tanks. Countcrcurrent is preferred as it is the most efficient. The methods can be optimized using combinatorial chemistry. | ||||||
| 275 | Impurities separation by distillation | US09938012 | 2001-08-23 | US20020000366A1 | 2002-01-03 | Vijai P. Gupta |
| A distillation procedure is provided for the separation of impurities from organic materials such as glycols and glycol ethers whereby a liquid stripping component is interfaced into a distillation column with or below the organic material introduction, heat being provided by a reboiler, the stripping component and impurities being removed overhead. | ||||||
| 276 | Separation processes | US09526039 | 2000-03-15 | US06307109B1 | 2001-10-23 | Jeffrey Scott Kanel; David Robert Bryant; Brian Michael Roesch; Ailene Gardner Phillips |
| This invention relates to a process for separating one or more products from a reaction product fluid comprising a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more products, one or more nonpolar reaction solvents and one or more polar reaction solvents, in which said reaction product fluid exhibits phase behavior depicted by FIG. 1, wherein said process comprises (1) supplying said reaction product fluid from a reaction zone to a separation zone, (2) controlling concentration of said one or more nonpolar reaction solvents and said one or more polar reaction solvents, temperature and pressure in said separation zone sufficient to obtain by phase separation two immiscible liquid phases depicted by regions 2, 4 and 6 of FIG. 1 comprising a polar phase and a nonpolar phase and to prevent or minimize formation of three immiscible liquid phases depicted by region 5 of FIG. 1 and one homogeneous liquid phase depicted by regions 1, 3 and 7 of FIG. 1, and (3) recovering said polar phase from said nonpolar phase or said nonpolar phase from said polar phase. | ||||||
| 277 | Separation processes | US09526434 | 2000-03-15 | US06303829B1 | 2001-10-16 | Jeffrey Scott Kanel; John Nicholas Argyropoulos; Ailene Gardner Phillips; Brian Michael Roesch; John Robert Briggs; Max Min Lee; John Michael Maher; David Robert Bryant |
| This invention relates to a process for separating one or more products from a reaction product fluid comprising a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more products, one or more nonpolar reaction solvents and one or more polar reaction solvents, wherein said process comprises (1) subjecting said reaction product fluid to fractional countercurrent extraction with at least two immiscible extraction solvents, said at least two immiscible extraction solvents comprising at least one nonpolar extraction solvent and at least one polar extraction solvent, to obtain a nonpolar phase comprising said metal-organophosphorus ligand complex catalyst, said optionally free organophosphorus ligand, said one or more nonpolar reaction solvents and said at least one nonpolar extraction solvent and a polar phase comprising said one or more products, said one or more polar reaction solvents and said at least one polar extraction solvent, and (2) recovering said polar phase from said nonpolar phase; wherein (i) the organophosphorus ligand has a partition coefficient Kp1 defined herein between the nonpolar phase and the polar phase of greater than about 5, and (ii) the one or more products have a partition coefficient Kp2 defined herein between the nonpolar phase and the polar phase of less than about 2.0. | ||||||
| 278 | Process for the removal of heavy metals | US09423315 | 1999-12-30 | US06239301B1 | 2001-05-29 | Marco Villa; Vincenzo Cannata; Alessandro Rosi; Pietro Allegrini |
| A method for the removal of heavy metals from solutions of organic compounds by treatment with cysteine or with an N-acylcysteine is described. Organic compounds with a content of heavy metal, for example palladium, particularly low and suitable for the preparation of compounds with pharmacologic activity can be isolated from the resultant solutions. | ||||||
| 279 | Method for separating an organic compound from an aqueous medium | US09530915 | 2000-05-08 | US06187935B1 | 2001-02-13 | Benoît Gosselin; Michel Strebelle |
| Process for the manufacture of an organic compound in a water-containing liquid medium, according to which a mixture of reaction products comprising the organic compound, water and by-products is collected, at least a portion of the organic compound is separated from the mixture of reaction products, an effluent containing water and by-products is collected, an organic solvent is added to the effluent and the mixture containing the effluent and the solvent is subjected to a distillation treatment. | ||||||
| 280 | Method for eliminating inhibitors of polymerization of monomer mixtures using an alumina with optimized form | US09341956 | 1999-09-09 | US06174480B1 | 2001-01-16 | Christophe Nedez |
| The invention relates to a process for adsorption of polymerization inhibitors from ethylenically unsaturated monomers, in which these inhibitors are placed in contact with an alumina produced by forming by drop coagulation or by extrusion-blending. | ||||||
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