| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 241 | RECOVERING UNREACTED INTERMEDIATE FROM DESALINATED AND DESOLVENTIZED DIMERISATION REACTION MIXTURE BY ULTRAFILTRATION | US12620691 | 2009-11-18 | US20110021828A1 | 2011-01-27 | OLE MAGNE HOMESTAD; ODD EINAR INGVOLDSTAD |
| This invention relates generally to industrial preparation of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), a non-ionic X-ray contrasting agent. It further relates to a method of recovering intermediate 5-acetamido-N,N-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”) from the desalinated and desolventized dimerisation reaction mixture. In particular, the present invention employs ultrafiltration to recover non-crystalline Compound A to reduce the overall cost of iodixanol manufacture, increase the yield of iodixanol, and facilitate the subsequent purification procedures to meet the regulatory purity requirement of iodixanol. | ||||||
| 242 | ADSORPTIVE PURIFICATION METHOD FOR IODIXANOL | US12581957 | 2009-10-20 | US20110021824A1 | 2011-01-27 | LARS TERJE HOLMAAS; OLE MAGNE HOMESTAD; DIDRIK MALTHE-SORENSSEN; ERIC PRESSMAN; ALBERT SANTO STELLA |
| This invention relates generally to non-ionic X-ray contrast agents. It further relates to a method of using solid adsorbents to reduce backpeaks content in the purification of iodixanol. In particular, it relates to the use of non-polar organic adsorbents with the average pore diameter smaller than about 30 nm. Specific examples of adsorbents of the instant invention include non-polar acrylic ester, di-vinyl benzene resins, poly-styrene di-vinyl benzene resins, and carbon adsorbents. In certain embodiments, upwards of 30% of the backpeak levels and 60% N-acetyl cyclic iodixanol levels are reduced for a 5% loss of iodixanol. | ||||||
| 243 | PURIFICATION PROCEDURE FOR THE PREPARATION OF THE RADIOACTIVE TRACER 3'-DEOXY-3'- [18F] LUOROTHYMIDINE ([18F] FLT) | US12602410 | 2008-04-22 | US20100314322A1 | 2010-12-16 | Claudio Pascali; Anna Bogni |
| A procedure for the preparation of the radioactive tracer 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) comprises the following steps: a) preparation of anhydrous [18F]F-fluoride; b) labelling of a precursor, for example 3-N-Boc-1-[5′-O-(4, 4′-dimethoxytrityl)-3′-O-nitrophenylsulfonyl-2′-deoxy-β-D-lyxofuranosyl] thymidine; c) hydrolysis of the mixture obtained by means of the previous steps; d) purification of the mixture to obtain the radioactive tracer [18F]FLT. In this procedure steps a), b) and c) are carried out by means of known methods. In step d) the mixture obtained after step c) is purified by means of the passage through a ventilated filter and one or more cartridges of the cationic exchange type (e.g. a Chromafix PS-H+), one or more cartridges of the reversed phase type, and finally a passage through cartridges either of the alumina N type, or diol cartridges, or anionic exchange cartridges or a combination thereof. Furthermore, the mixture which is present in the cartridges is eluted with H2O for injection, whereby the resulting product is forwarded to a container or ampoule for the collection of [18F]FLT. | ||||||
| 244 | DISTILLATION OF IONIC LIQUIDS | US12675445 | 2008-08-15 | US20100300870A1 | 2010-12-02 | Klemens Massonne; Michael Siemer; Werner Mormann; Wei Leng |
| Method of distilling mixtures comprising salts having a melting point of less than 200° C. at 1 bar (ionic liquids), wherein the cation of the ionic liquid comprises a heterocyclic ring system having at least one nitrogen atom and all nitrogen atoms of the heterocyclic ring system have an organic group as substituent, the anion of the ionic liquid is a compound having at least one carboxylate group (carboxylate for short) or at least one phosphate group (phosphate for short) and the distance from the surface via which the heat of distillation is introduced in the distillation (vaporizer surface) to the surface at which condensation takes place (condenser surface) is less than 50 cm at least one point, with the vaporizer surface and condenser surface themselves having at least one length dimension of greater than 50 cm. | ||||||
| 245 | Method for producing α-methylstyrene and heat-resistant styrene-based copolymer using the α-methylstyrene | US12226224 | 2007-04-16 | US07772336B2 | 2010-08-10 | Yuji Okada; Kenji Ebara |
| An object of the present invention is to provide highly pure α-methylstyrene by efficiently removing polar substances present in the α-methylstyrene. The present invention discloses a method for purifying α-methylstyrene by reacting polar substances contained in the α-methylstyrene in the presence of a basic substance, and separating a reaction product of the polar substance and the α-methylstyrene. | ||||||
| 246 | METHODS OF ADMINISTERING TETRAHYDROBIOPTERIN, ASSOCIATED COMPOSITIONS, AND METHODS OF MEASURING | US12577509 | 2009-10-12 | US20100111918A1 | 2010-05-06 | Daniel I. Oppenheimer; Alejandro Dorenbaum; Augustus Okhamafe; Erik Foehr; Sianna Castillo; Paul J. Kostel |
| The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample. | ||||||
| 247 | METHOD OF ISOLATING TARGET SUBSTANCE USING MEMBRANE AND APPARATUS THEREFOR | US12531993 | 2008-03-19 | US20100101997A1 | 2010-04-29 | Yasuhiro Tateishi |
| A separation apparatus using a membrane for diafiltration, which provides precise fractionation of a target substance by monitoring and regulating permeability of the target substance based on measurement values and analytical values indicating separation status, such as physical values and concentration of a permeate liquid, a circulating liquid and an internal circulating liquid in a membrane device. A diafiltration process including adding a cleaning liquid to an treating liquid which contains multiple target substances and extracting a target substance into the permeate liquid supplied from a membrane separation apparatus to fractionate the target substance from other target substances remaining in a residual liquid. In the present invention, permeability of the target substance is controlled by regulating or controlling at least one operating parameter, such as a flow rate of the permeate liquid, operating pressure and temperature of the membrane separation apparatus, and concentration and amount of a circulating liquid, to a predetermined range based on a separation status index and/or a progress index of a separating operation. | ||||||
| 248 | Fluorous Oligonucleotide Reagents and Affinity Purification of Oligonucleotides | US12582432 | 2009-10-20 | US20100087634A1 | 2010-04-08 | David A. Berry; William H. Pearson |
| Fluorous-tagged oligonucleotide reagents and an oligonucleotide purification methodology making use thereof, the method comprising: Synthesizing oligonucleotides using oligonucleotide reagents each bearing at least one fluorous group to yield a mixture of synthesis products and reagents, the mixture including at least one target synthesized oligonucleotide bearing at least one fluorous group; passing the mixture through a separation medium having an affinity for the at least one fluorous group so that the target synthesized oligonucleotide bearing at least one fluorous group is adsorbed by the separation medium; washing the separation medium with at least a first solvent to selectively dissociate therefrom substantially all synthesis products and reagents of the heterogenous mixture other than the at least one target synthesized oligonucleotide bearing at least one fluorous group; and subsequently dissociating the at least one synthesized oligonucleotide from the separation medium, with or without the fluorous group. | ||||||
| 249 | Method for producing molecular compound | US11850493 | 2007-09-05 | US07655820B2 | 2010-02-02 | Masato Amaike; Seiji Sasaoka; Shigeru Kawamuko; Yasuaki Hashimoto; Eiji Takemura |
| A method for producing a molecular compound which comprises mixing and kneading a solid host compound and a solid or liquid guest compound by using a kneader and optionally followed by extruding and granulating, wherein the method further comprises one or more of the steps of holding the product at a temperature which is 50° C. or higher and not higher than the emission temperature for the guest compound, washing the formed molecular compound with a solvent capable of dissolving the guest compound, pulverizing in advance the solid host compound, and adding a poor solvent such as water prior to mixing and kneading. The method allows the production of a molecular compound having improved stability. | ||||||
| 250 | PROCESS FOR WORKING UP SOLVENT-CONTAINING HYDROGENATION PRODUCT MIXTURES | US12307367 | 2007-07-16 | US20090314992A1 | 2009-12-24 | Rolf Pinkos; Jens Heimann; Hans-Martin Polka; Heiko Urtel; Gunther Windecker |
| The present invention relates to a process for separating off solvents from solvent-comprising hydrogenation outputs from a catalytic hydrogenation process, which comprise at least one water-soluble hydrogenation product having at least one alcohol, lactone, ether, lactam or amino group in a solvent which is immiscible or not completely miscible with water and has a boiling point below 100° C., wherein water is added to the hydrogenation output, the solvent-comprising phase is separated off and recirculated to the hydrogenation. | ||||||
| 251 | METHOD FOR THE PURIFICATION OF RADIOLABELLED COMPOUNDS | US12375555 | 2007-07-25 | US20090312564A1 | 2009-12-17 | Erik Arstad |
| The invention relates to methods and apparatus for purifying a radiolabelled compound. The method comprises (i) passing a crude reaction mixture comprising the desired radiolabelled compound and one or more contaminants in a solvent through a narrow bore vessel at elevated temperature such that the organic solvent and either the radiolabelled compound or one or more contaminants is vaporised forming a vaporised component, and (ii) collecting the resulting vaporised component by condensing into a collection vessel. | ||||||
| 252 | Methods of Administering Tetrahydrobiopterin, Associated Compositions, And Methods of Measuring | US12329838 | 2008-12-08 | US20090076014A1 | 2009-03-19 | Daniel I. Oppenheimer; Alejandro Dorenbaum |
| The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample. | ||||||
| 253 | PROCESS FOR PRODUCING HIGH PURITY EXO-ALKENYLNORBORNENE | US12187297 | 2008-08-06 | US20090054714A1 | 2009-02-26 | Andrew Bell; Dane Jablonski; Elaine Koronich; Brian Knapp; Dino Amoroso |
| Embodiments of the present invention are directed generally to methods for producing high purity exo-alkenylnorbornenes from a mixture of conformational isomers thereof. | ||||||
| 254 | Solvents containing cycloalkyl alkyl ethers and process for production of the ethers | US12222572 | 2008-08-12 | US20080312125A1 | 2008-12-18 | Idan Kim; Genichi Ohta; Kazuo Teraishi; Kiyoshi Watanabe |
| The present inventions are (A) a solvent comprising at least one cycloalkyl alkyl ether (1) represented by the general formula: R1—O—R2 (wherein R1 is cyclopentyl or the like; and R2 is C1-10 alkyl or the like); (B) a method of preparations the ethers (1) characterized by reacting an alicyclic olefin with an alcohol in the presence of an acid ion-exchange resin having a water content of 5 wt % or less. The solvent is useful as cleaning solvent for electronic components, precision machinery components or the like, reaction solvent using various chemical reactions, extraction solvent for extracting objective organic substances, solvent or remover for electronic and electrical materials, and so on. The process enables industrially advantageous production of the objective cycloalkyl alkyl ethers (1). | ||||||
| 255 | Continuous Crystallisation Process of Iodinated Phenyl Derivatives | US11996985 | 2006-07-28 | US20080214867A1 | 2008-09-04 | Jan Cervenka; Khalid Hussain; Arne W. Aabye |
| The invention describes a process for the purification of iodinated aryl compounds where the purification is performed by continuous crystallisation of a crude product in a solvent with addition of anti-solvent. The continuous crystallisation process is performed in one or more crystallisers at a temperature up to the boiling point of the content of the crystalliser. | ||||||
| 256 | System for purification and analysis of radiochemical products yielded by microfluidic synthesis devices | US11895636 | 2007-08-23 | US20080064110A1 | 2008-03-13 | Arkadij Elizarov; Hartmuth Kolb; Jianzhong Zhang |
| The present application is generally directed to microfluidic devices and methods for the achievement and assessment of chemical and radiochemical purity of (microfluidic) radio-synthesis products. More particularly, the current application relates to systems for purification and analysis of radiochemical products yielded by microfluidic synthesis devices. | ||||||
| 257 | Switchable solvents and methods of use thereof | US11717172 | 2007-03-13 | US20080058549A1 | 2008-03-06 | Philip Jessop; Charles Eckert; Charles Liotta |
| A solvent that reversibly converts from a nonionic liquid mixture to an ionic liquid upon contact with a selected trigger, e.g., contact with CO2, is described. In preferred embodiments, the ionic solvent is readily converted back to the nonionic liquid mixture. The nonionic liquid mixture includes an amidine or guanidine or both, and water, alcohol, or a combination thereof. Single component amine solvents that reversibly convert between ionic and non-ionic states are also described. Some embodiments require increased pressure to convert; others convert at 1 atmosphere. | ||||||
| 258 | PROCESSING OF REACTION SOLUTIONS FROM WHOLE-CELL BIOTRANSFORMATIONS | US11766189 | 2007-06-21 | US20080006579A1 | 2008-01-10 | Harald Groeger; Claudia Rollmann; Helge Werner; Francoise-Christine Chamouleau; Dittmar Orzewski |
| A product is enriched by a method for the processing of a reaction solution, in which: a) a pH value of the reaction solution is adjusted to less than 4; wherein said reaction solution comprises a whole-cell catalyst, an aqueous component, and an organic component, wherein the organic component contains a product to be enriched; and b) the reaction solution is filtered in the presence of a filter aid, thereby enriching the product. | ||||||
| 259 | Multi-stage cryogenic acid gas removal | US11384279 | 2006-03-21 | US07294327B2 | 2007-11-13 | Timmons S. McClanahan; Michael C. Crim |
| A relatively simple and energy efficient multiple stage cryogenic process for the purification of a hydrogen-rich stream by the removal of acid gases, mainly CO2 and H2S, by method of autorefrigeration and delivering or producing those acid gases, mainly CO2, at pressure sufficiently high for disposal by containment, commonly known as sequestration. Autorefrigeration is comprised of (a) condensing acid gases from the syngas stream by cooling the syngas, (b) separating the liquefied acid gases from the syngas, and (c) evaporating the liquefied acid gases at a pressure lower than that of the syngas to provide cooling. The process is composed of multiple autorefrigeration stages to generate multiple acid gas product streams with a pressure as high as practical in each stream so as to lessen the power needed to pressurize the acid gas streams for sequestration. The final autorefrigeration stage utilizes an antifreeze liquid that allows the final stage to operate below the freezing point of CO2; thus allowing more acid gas removal. The antifreeze liquid is an alcohol or a mixture of alcohols with a freezing point lower than about minus 110 degrees F. and a boiling point higher than about 100 degrees F. The process includes hydrogen recovery and recycle as well as recovery of the energy contained in the sulfur bearing compounds. The process is especially well suited for CO2 removal/sequestration from a coal (or petroleum coke) gasification process. | ||||||
| 260 | Multi-stage cryogenic acid gas removal | US11384279 | 2006-03-21 | US20070221541A1 | 2007-09-27 | Timmons McClanahan; Michael Crim |
| A relatively simple and energy efficient multiple stage cryogenic process for the purification of a hydrogen-rich stream by the removal of acid gases, mainly CO2 and H2S, by method of autorefrigeration and delivering or producing those acid gases, mainly CO2, at pressure sufficiently high for disposal by containment, commonly known as sequestration. Autorefrigeration is comprised of (a) condensing acid gases from the syngas stream by cooling the syngas, (b) separating the liquefied acid gases from the syngas, and (c) evaporating the liquefied acid gases at a pressure lower than that of the syngas to provide cooling. The process is composed of multiple autorefrigeration stages to generate multiple acid gas product streams with a pressure as high as practical in each stream so as to lessen the power needed to pressurize the acid gas streams for sequestration. The final autorefrigeration stage utilizes an antifreeze liquid that allows the final stage to operate below the freezing point of CO2; thus allowing more acid gas removal. The antifreeze liquid is an alcohol or a mixture of alcohols with a freezing point lower than about minus 110 degrees F. and a boiling point higher than about 100 degrees F. The process includes hydrogen recovery and recycle as well as recovery of the energy contained in the sulfur bearing compounds. The process is especially well suited for CO2 removal/sequestration from a coal (or petroleum coke) gasification process. | ||||||
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