| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | FLUOROUS PHOSPHINES AND PROCESS FOR THEIR PREPARATION | EP99949444.6 | 1999-09-29 | EP1117668A1 | 2001-07-25 | RICHTER, Bodo; DE WOLF, Aloysius, Cornelius, Adrianus; VAN KOTEN, Gerard; DEELMAN, Berth, Jan |
| A fluorous phosphine wherein the phosphor is coupled to at least one aryl or alkyl moiety, to which moiety a fluorous tail is coupled, wherein a spacer group, containing a non-carbon atom, is positioned between the aryl or alkyl moiety and the fluorous tail, a process for the preparation of said phosphines, metalcomplexes, catalysts and catalyst compounds therefrom and their use in catalysis. | ||||||
| 162 | VERFAHREN ZUR STEREOSELEKTIVEN HERSTELLUNG VON GRIGNARDVERBINDUNGEN UND DEREN VERWENDUNG | EP99934559.8 | 1999-07-02 | EP1102796A1 | 2001-05-30 | BOYMOND, Laure; ROTTLÄNDER, Mario; CAHIEZ, Gerard; KNOCHEL, Paul |
| The invention relates to a method for the stereoselective production of grignard compounds of formula (I), to polymer-bonded compounds of formula (Ia), to the use of the method for producing libraries of substances and to the use of the compounds of formulae (I) and (Ia) in stereoselective chemical synthesis. | ||||||
| 163 | Herstellung und Verwendung von (3-Alkoxyphenyl)magnesiumchloriden | EP97101270.3 | 1997-01-28 | EP0790251A2 | 1997-08-20 | Finkam, Michael, Dr.; Kohnen, Thomas; Winter, Werner, Prof. Dr. |
Es wird ein Verfahren zur Herstellung von (3-Alkoxyphenyl)magnesiumchloriden sowie deren Verwendung zur Umsetzung bestimmter Carbonylverbindungen beschrieben. |
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| 164 | 삼환계 유사체, 이의 제조방법과 용도 | KR1020177029352 | 2016-03-03 | KR1020170125970A | 2017-11-15 | 난파준; 리보량; 잔양; 장샤오웨이; 시옹윙; 후스찬; 장양밍 |
| 본발명은일련의일반식I로표시되는천연산물피리피로펜A(Pyripyropene A)구조를가지는유사체및 이의제조방법과용도에관한것으로, 구체적으로는본 발명은천연산물피리피로펜A(Pyripyropene A)의유사체, 그제조방법과아테롬성동맥경화등 심혈관질병치료중 아실-CoA: 콜레스테롤아실기전이효소2(ACAT2)의억제제로서의용도에관한것이다. | ||||||
| 165 | 전이 금속 촉매작용을 이용한 아릴, 헤테로아릴, 알킬 및 알켄 할로게나이드의 알릴화 및 비닐화 방법 | KR1020127023324 | 2011-02-01 | KR101536041B1 | 2015-07-10 | 고타,마티아스; 레네만,베른트빌헬름; 차플릭,발데마르막시밀리안; 마이어,마티아스; 야코비폰반겔린,악셀 |
| 본발명은하기화학식 II의해당화합물을반응시켜하기화학식 III의유기마그네슘화합물을형성한후에, 화학식 III의화합물을하기화학식 IV의화합물과반응시킴으로써하기화학식 I의유기화합물을제조하는방법이며, 화합물 III과화합물 IV의반응을, a) 화학식 II의화합물에대하여촉매량의철 화합물의존재하에, 및임의로는 b) 화학식 II의화합물에대하여촉매량또는화학량론적양의질소, 산소및/또는인을포함하는첨가제의존재하에수행하는것을특징으로하는방법에관한것이다. <화학식 I> R-R' <화학식 II> R-X 상기식에서, X는플루오린, 염소, 브로민또는아이오딘이다. <화학식 III> [M][RMgXY] <화학식 IV> | ||||||
| 166 | 비페닐 유도체의 제조 방법 | KR1020097003605 | 2007-10-12 | KR101482594B1 | 2015-01-14 | 하야시타미오; 나카타니지로 |
| 저렴하고 독성이 낮은 원료를 사용함으로써 공업적으로 높은 수율로 생산성이 우수한 비페닐 유도체의 제조 방법을 제공한다. 하기 일반식(1)로 나타내어지는 비페닐 유도체의 제조 방법에 있어서, 하기 일반식(2)로 나타내어지는 벤젠 유도체의 염소 원자를 마그네슘 금속과 반응시켜 그리냐르 시약으로 전화시키고, 상기 그리냐르 시약끼리를 촉매 및 디클로로프로판의 존재 하에서 커플링 반응시키는 것을 특징으로 한다. (단, A는 알킬기, 알콕시기, 알콕시메틸기, 비닐기, 페닐기, 염소로부터 선택되는 하나 이상을 나타내고, n은 1∼4의 정수로 한다.) 비페닐 유도체의 제조 방법 | ||||||
| 167 | 시클로알킬 알킬 에테르 화합물의 제조방법 | KR1020097015801 | 2002-06-27 | KR1020090085711A | 2009-08-07 | 킨이단; 오오타겐이치; 테라이시카즈오; 와타나베키요시 |
| A solvent containing at least one cycloalkyl alkyl ether (1) represented by the general formula: R1-O-R2 (wherein R1 is cyclopentyl or the like; and R2 is C1-10 alkyl or the like); and a process for the production of the ethers (1), characterized by reacting an alicyclic olefin with an alcohol in the presence of an acid ion-exchange resin having a water content of 5 wt% or below. The solvent is useful as cleaning solvent for electronic components, precision machinery components or the like, reaction solvent for various chemical reactions, extraction solvent for extracting objective organic substances, solvent or remover for electronic and electrical materials, and so on. The process enables industrially advantageous production of the objective cycloalkyl alkyl ethers (1). ® KIPO & WIPO 2009 | ||||||
| 168 | 생성물로서의 디페닐클로로실란의 수율이 향상된 그리냐르방법 | KR1020067013486 | 2004-12-17 | KR1020060123433A | 2006-12-01 | 응옌빈타잉; 베드버리커티스존; 험버그로저에드윈; 제이콥수잔매리; 래트클리프사라제인; 워터맨존데니스 |
| A Grignard process for preparing phenyl-containing chlorosilane products, in particular diphenylchlorosilanes, is carried out in three embodiments. In the first embodiment, the reactants of the Grignard process are a phenyl Grignard reagent, an ether solvent, a trichlorosilane, and an aromatic hydrocarbon coupling solvent. In the second embodiment, the reactants of the Grignard process are a phenyl Grignard reagent, an ether solvent, a phenylchlorosilane, and an aromatic hydrocarbon coupling solvent. In the third embodiment, the reactants of the Grignard process are a phenyl Grignard reagent, an ether solvent, a trichlorosilane, a phenylchlorosilane, and an aromatic hydrocarbon coupling solvent. In each embodiment, the reactants are present in a particular mole ratio. | ||||||
| 169 | 디페닐클로로실란의 함량을 증가시키는 그리냐드 공정 | KR1020067013631 | 2004-12-17 | KR1020060121283A | 2006-11-28 | 응옌빈타잉 |
| Three improved Grignard processes are used for preparing phenyl- containing chlorosilane products wherein the yield of diphenylchlorosilanes as a product is maximized, while the yield of phenylchlorosilanes as a product is minimized. In one embodiment, the process involves contacting a phenyl Grignard reagent, an ether solvent, an aromatic halogenated coupling solvent and a trichlorosilane. In another embodiment, the process involves contacting a phenyl Grignard reagent, an ether solvent, an aromatic halogenated coupling solvent, a trichlorosilane, and a phenylchlorosilane. In yet another embodiment, the process involves contacting a phenyl Grignard reagent, an ether solvent, an aromatic halogenated coupling solvent, and a phenylchlorosilane. In each embodiment, the reactants are present in particular mole ratios of the components. | ||||||
| 170 | CLASS OF TRICYCLIC ANALOGUE, PREPARATION METHOD AND USE THEREOF | EP16764175.2 | 2016-03-03 | EP3272755A1 | 2018-01-24 | NAN, Fajun; LI, Boliang; ZHAN, Yang; ZHANG, Xiaowei; XIONG, Ying; HU, Xichan; ZHANG, Yangming |
The present invention relates to a series of analogues having a structure of a natural product Pyripyropene A as represented by formula I, and preparation method and use thereof, and particularly relates to analogues of the natural product Pyripyropene A, preparation method and application thereof in treating cardiovascular diseases such as atherosclerosis, etc. as an inhibitor of an acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2).
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| 171 | SOLUTIONS OF ANHYDROUS LANTHANIDE SALTS AND ITS PREPARATION | EP06793139.4 | 2006-09-01 | EP1937407B1 | 2015-04-22 | KNOCHEL, Paul; KRASOVSKIY, Arkady; KOPP, Felix |
| 172 | Verfahren zur Herstellung von Styrolderivaten | EP12170697.2 | 2012-06-04 | EP2671866A1 | 2013-12-11 | Die Erfindernennung liegt noch nicht vor |
Es wird ein Verfahren bereitgestellt, welches die Synthese einer großen Anzahl an Styrolderivaten unter Bildung von C-C Bindungen ermöglicht, wobei ökonomisch vorteilhafte Substrate, leicht zugängliche Kohlenstoffnucleophile und sowohl kostengünstige als auch ökologisch unproblematische Katalysatorsysteme eingesetzt werden können, welche eine Reaktion unter milden Bedingungen und eine große Kompatibilität mit funktionellen Gruppen an den beteiligten Reaktionspartnern erlauben. |
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| 173 | Process for the production of cycloalkyl alkyl ethers | EP10189460.8 | 2002-06-27 | EP2279995B1 | 2013-09-18 | Kin, Idan; Ohta, Genichi; Teraishi, Kazuo; Watanabe, Kiyoshi |
| 174 | Grignard reactions in microreactors | EP09011852.2 | 2007-07-11 | EP2138500B1 | 2012-11-21 | Bieler, Nikolaus; Ducry, Laurent; Roberge, Dominique |
| 175 | Process for producing cycloalkyl alkyl ethers | EP10189460.8 | 2002-06-27 | EP2279995A3 | 2012-01-11 | Kin, Idan; Ohta, Genichi; Teraishi, Kazuo; Watanabe, Kiyoshi |
The invention consists in a process for producing a cycloalkyl alkyl ether compound of formula (1): R1-O-R2, wherein R1 represents a cyclopentyl group or cyclohexyl group which may have a substituent and R2 represents an alkyl group having 1 to 10 carbon atoms or a cycloalkyl group having 3 to 8 carbon atoms which may have a substituent; said process comprising reacting an alicyclic olefin with an alcohol in the presence of an acidic ion-exchange resin having a water content of 5 wt.-% or less. Preferably, the process comprises reacting a gaseous alicyclic olefin with a gaseous alcohol in the presence of an acidic ion-exchange resin having a water content of 5 wt.-% or less. |
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| 176 | Preparation and use of magnesium amides | EP11166878.6 | 2007-01-18 | EP2360161A1 | 2011-08-24 | Knochel, Paul; Krasovskiy, Arkady; Krasovskaya, Valeria; Rohbogner, Christoph, Josef; Clososki, Gliuliano, Cesar |
The present invention relates to a reagent of the general formula R1R2N-Mg(NR3R4)mX1-m·zLiY(II) wherein R1, R2, R3, and R4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together, or R3 and R4 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 and at least one of R3 and R4 is other than H; X and Y are, independently, selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; HalOn, wherein n = 3 or 4 and Hal is selected from Cl, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RXCO2; an alcoholate of the general formula ORX; a thiolate of the general formula SRX; RXP(O)O2; or SCORX; or SCSRX; OnSRX, wherein n = 2 or 3; or NOn, wherein n = 2 or 3; and a derivative thereof; wherein RX is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, or H; m is 1; and z > 0; or as adduct with a solvent. |
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| 177 | PROCESS FOR THE PRODUCTION OF TERTIARY ALCOHOLS | EP08773960.3 | 2008-07-10 | EP2178812A1 | 2010-04-28 | McGARRITY, John; DJOJO, Francis |
| Tertiary alcohols are prepared by reacting carboxylic esters with Grignard reagents in ethereal solvents in the presence of lanthanum trichloride and lithium chloride. The method is particularly suitable for the production of (αS)-α-[3-[(1E)-2-(7-chloro-2-quino- linyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol of formula (A) which is an intermediate in the production of montelukast. | ||||||
| 178 | GRIGNARD PROCESSES WITH IMPROVED YIELDS OF DIPHENYLCHLOROSILANES AS PRODUCTS | EP04815121.1 | 2004-12-17 | EP1701964B1 | 2009-11-25 | NGUYEN, Binh, Thanh; BEDBURY, Curtis, John; HUMBURG, Roger, Edwin; JACOB, Susan, Mary; RATCLIFF, Sarah, Jane; WATERMAN, John, Dennis |
| 179 | MAGNESIUMORGANISCHES SYNTHESEMITTEL | EP07712440.2 | 2007-03-05 | EP1994037A1 | 2008-11-26 | HABER, Steffen; HAUK, Dieter; WIETELMANN, Ulrich; DAWIDOWSKI, Dirk; RITTMEYER, Peter; RÖDER, Jens |
| The invention provides an organomagnesium synthesis agent, a process for preparing this synthesis agent, and its use. | ||||||
| 180 | PREPARATION AND USE OF MAGNESIUM AMIDES | EP07703987.3 | 2007-01-18 | EP1981893A1 | 2008-10-22 | KNOCHEL, Paul; KRASOVSKIY, Arkady; KRASOVSKAYA, Valeria; ROHBOGNER, Christoph, Josef; CLOSOSKI, Gliuliano, Cesar |
| The present application relates to mixed Mg/Li amides of the general formula R1R2N-Mg(NR3R4)mX,.m zLiY (II) wherein R1, R2, R3, and R4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together, or R3 and R4 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 and at least one of R3 and R is other than H; X and Y are, independently, selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; HaIOn , wherein n = 3 or 4 and Hal is selected from Cl, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RXCO2; an alcoholate of the general formula ORX; a thiolate of the general formula SRX; RXP(O)O2; or SCORX; or SCSRX; OnSRx, wherein n = 2 or 3; or NOn, wherein n = 2 or 3; and a derivative thereof; wherein Rx is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, or H; m is O or 1 ; and z > O; as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases. | ||||||
