| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVES | EP06822282.7 | 2006-10-25 | EP1955990A1 | 2008-08-13 | HAYASHI, Tamio; NAKATANI, Jiro |
A process for the production of biphenyl derivatives according to the present invention represented by the following general formula (1), wherein the chlorine atom of a benzene derivative represented by the following general formula (2) is reacted with metallic magnesium to form a Grignard reagent, and wherein two molecules of the Grignard reagent are coupled to each other in the presence of a catalyst. This process is excellent in industrial productivity by virtue of using inexpensive and easily available raw materials.
|
||||||
| 182 | GRIGNARD PROCESSES WITH INCREASED CONTENT OF DIPHENYLCHLOROSILANES | EP04815122.9 | 2004-12-17 | EP1701965A1 | 2006-09-20 | NGUYEN, Binh, Thanh |
| Three improved Grignard processes are used for preparing phenyl-containing chlorosilane products wherein the yield of diphenylchlorosilanes as a product is maximized, while the yield of phenylchlorosilanes as a product is minimized. In one embodiment, the process involves contacting a phenyl Grignard reagent, an ether solvent, an aromatic halogenated coupling solvent and a trichlorosilane. In another embodiment, the process involves contacting a phenyl Grignard reagent, an ether solvent, an aromatic halogenated coupling solvent, a trichlorosilane, and a phenylchlorosilane. In yet another embodiment, the process involves contacting a phenyl Grignard reagent, an ether solvent, an aromatic halogenated coupling solvent, and a phenylchlorosilane. In each embodiment, the reactants are present in particular mole ratios of the components. | ||||||
| 183 | GRIGNARD PROCESSES WITH IMPROVED YIELDS OF DIPHENYLCHLOROSILANES AS PRODUCTS | EP04815121.1 | 2004-12-17 | EP1701964A1 | 2006-09-20 | NGUYEN, Binh, Thanh; BEDBURY, Curtis, John; HUMBURG, Roger, Edwin; JACOB, Susan, Mary; RATCLIFF, Sarah, Jane; WATERMAN, John, Dennis |
| A Grignard process for preparing phenyl-containing chlorosilane products, in particular diphenylchlorosilanes, is carried out in three embodiments. In the first embodiment, the reactants of the Grignard process are a phenyl Grignard reagent, an ether solvent, a trichlorosilane, and an aromatic hydrocarbon coupling solvent. In the second embodiment, the reactants of the Grignard process are a phenyl Grignard reagent, an ether solvent, a phenylchlorosilane, and an aromatic hydrocarbon coupling solvent. In the third embodiment, the reactants of the Grignard process are a phenyl Grignard reagent, an ether solvent, a trichlorosilane, a phenylchlorosilane, and an aromatic hydrocarbon coupling solvent. In each embodiment, the reactants are present in a particular mole ratio. | ||||||
| 184 | A microreactor | EP03250834.3 | 2003-02-11 | EP1336431A3 | 2006-01-18 | Gilligan, Mark Peter Timothy; Homewood, Philip James; Whiffin, Rowland |
A microreactor with a sensor 9, 11 in a reaction channel 6. The sensor comprises a pair of spaced apart electrodes through which an AC voltage is passed. The amplitude and phase of the current flowing between the electrodes is monitored allowing the impedance of the reaction fluid between the electrodes to be measured.
|
||||||
| 185 | REAKTION VON CARBONYLVERBINDUNGEN MIT METALLORGANISCHEN REAGENZIEN | EP01900150.2 | 2001-01-10 | EP1246784B9 | 2006-01-18 | KOOP, Ulrich; KRUMMRADT, Holger; SCHWARZ, Michael; STOLDT, Jöran; ECKSTEIN, Jürgen; ZEHNER, Stefan; MELICHAR, Wolfgang |
| The invention relates to a novel method for carrying out reactions of carbonyl compounds with organometallic reagents, especially grignard reagents. The inventive method is characterised in that the organometallic reagent and the carbonyl compound are provided and tempered separately in a suitable solvent before being pumped into a tempered mini/micromixer. | ||||||
| 186 | REAKTION VON CARBONYLVERBINDUNGEN MIT METALLORGANISCHEN REAGENZIEN | EP01900150.2 | 2001-01-10 | EP1246784B1 | 2005-10-19 | KOOP, Ulrich; KRUMMRADT, Holger; SCHWARZ, Michael; STOLDT, Jöran; ECKSTEIN, Jürgen; ZEHNER, Stefan; MELICHAR, Wolfgang |
| The invention relates to a novel method for carrying out reactions of carbonyl compounds with organometallic reagents, especially grignard reagents. The inventive method is characterised in that the organometallic reagent and the carbonyl compound are provided and tempered separately in a suitable solvent before being pumped into a tempered mini/micromixer. | ||||||
| 187 | PROCESS FOR PREPARING VINYLAROMATIC COMPOUNDS | EP03731499.4 | 2003-05-29 | EP1509484A2 | 2005-03-02 | MILLER, Joseph, A. |
| The present invention provides a process for preparing a vinylaromatic compound comprising reacting an arylmetal reagent selected from arylmagnesium reagents and aryllithium reagents with a vinylphosphate in the presence of a palladium catalyst. The present invention also provides a process for preparing a vinylphosphate comprising reacting an enolizable ketone with a sterically hindered Grignard reagent and a halophosphate diester. | ||||||
| 188 | SOLVENTS CONTAINING CYCLOALKYL ALKYL ETHERS AND PROCESS FOR PRODUCTION OF THE ETHERS | EP02738825.5 | 2002-06-27 | EP1405840A1 | 2004-04-07 | KIN, Idan; OHTA, Genichi; TERAISHI, Kazuo; WATANABE, Kiyoshi |
The present inventions are (A) a solvent comprising at least one cycloalkyl alkyl ether (1) represented by the general formula: R1-O-R2 (wherein R1 is cyclopentyl or the like; and R2 is C1-10 alkyl or the like); (B) a method of preparations the ethers (1) characterized by reacting an alicyclic olefin with an alcohol in the presence of an acid ion-exchange resin having a water content of 5 wt% or less. The solvent is useful as cleaning solvent for electronic components, precision machinery components or the like, reaction solvent using various chemical reactions, extraction solvent for extracting objective organic substances, solvent or remover for electronic and electrical materials, and so on. The process enables industrially advantageous production of the objective cycloalkyl alkyl ethers (1). |
||||||
| 189 | Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles | EP02102055.7 | 2002-07-25 | EP1279656A2 | 2003-01-29 | MILLER, Joseph A. |
Methods are provided for the construction of unsymmetrical biaryl compounds and alkylated aromatic compounds from arylnitriles using a nickel or palladium catalyzed coupling in which the catalyst has at least one phosphorus ligand. |
||||||
| 190 | AN IMPROVED SYNTHESIS AND PURIFICATION OF (R*,R*)-2- (DIMETHYLAMINO) METHYL]-1-( 3-METHOXYPHENYL) CYCLOHEXANOL HYDROCHLORIDE | EP99930115.3 | 1999-05-20 | EP1077923A1 | 2001-02-28 | JARVI, Esa, T.; GRAYSON, Neile, A.; HALVACHS, Robert, E. |
| (R*,R*)-2-[ (dimethylamino) methyl]-1-( 3-methoxyphenyl) cyclohexanol (Tramadol) is synthesized in a Grignard reaction in the presence of an additive resulting in a higher trans:cis ratio of product than is obtained in the absence of the additive. The Grignard reaction between 3 bromoanisole and the appropriate Mannich base in the presence of an amine or ether additive gives the amine product in an improved trans/cis ratio. The base is converted to its hydrochloride and recrystallized from a low molecular weight nitrile such as acetonitrile until a greater than 98 % trans/cis ratio is obtained. Recrystallization from isopropanol gives (R*,R*)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride free of the nitrile solvent. A hydrochloride of Tramadol can be synthesized without increasing a ratio of trans:cis by including a step in which HCl is added to Tramadol base in the presence of toluene. | ||||||
| 191 | METHOD OF PRODUCING AN ORGANIC SILICON COMPOUND | EP12815863.1 | 2012-12-25 | EP2797855A1 | 2014-11-05 | TANIGUCHI, Yoshinori; SUGIURA, Yasushi |
| A method of producing an organic silicon compound includes a step of reaction of the following: (A) a reactive silane compound represented by General Formula (1) below: R1mSiY(4-m) (wherein R1 is a monovalent organic group (except for the group represented by Y) or a hydrogen atom; Y indicates a chlorine atom or a group represented by —OR2; R2 indicates a monovalent hydrocarbon group having 1 to 30 carbon atoms; and m is a number in the range of 0 to 3), (B) a halogenated organic compound represented by General Formula (2) below: R3—X (wherein R3 indicates a monovalent organic group; and X is a halogen atom), and (C) metallic magnesium (Mg) in the presence of (D) an organic solvent containing at least one type of ether type compound. | ||||||
| 192 | METHOD FOR PRODUCING A BIPHENYL DERIVATIVE | EP07829693.6 | 2007-10-12 | EP2075241B1 | 2013-09-25 | HAYASHI, Tamio; NAKATANI, Jiro |
| 193 | UNIVERSAL GRIGNARD METATHESIS POLYMERIZATION | EP07814646.1 | 2007-08-31 | EP2061825B1 | 2013-05-22 | MCCULLOUGH, Richard, D.; IOVU, Mihaela, C.; OSAKA, Itaru |
| 194 | GRIGNARD PROCESSES WITH INCREASED CONTENT OF DIPHENYLCHLOROSILANES | EP04815122.9 | 2004-12-17 | EP1701965B1 | 2013-01-23 | NGUYEN, Binh, Thanh |
| 195 | VERFAHREN ZUR ALLYLIERUNG UND VINYLIERUNG VON ARYL-, HETEROARYL-, ALKYL- UND ALKENYLHALOGENIDEN UNTER ÜBERGANGSMETALLKATALYSE | EP11702820.9 | 2011-02-01 | EP2534117A2 | 2012-12-19 | GOTTA, Matthias; LEHNEMANN, Bernd Wilhelm; CZAPLIK, Waldemar Maximilian; MAYER, Matthias; JACOBI VON WANGELIN, Axel |
| The invention relates to a method for producing organic compounds of the general formula (I) R-R' (I), by reacting a corresponding compound of the general formula (II) R-X (H), where X stands for fluorine, chlorine, bromine, or iodine, forming a magnesium organic compound of the general formula (III) [M +]n [R mM gX kY 1] (III), compounds of the formula (III) being reacted with a compound of the general formula (IV), characterized in that the reaction of (III) with (IV) is performed in the presence of a) catalytic quantities of an iron compound, relative to the compound of the general formula (II), and optionally in the presence b) of an additive comprising nitrogen, oxygen, and/or phosphorous in a catalytic or stoichiometric quantity relative to the compound of the general formula (II). | ||||||
| 196 | VERFAHREN ZUR HERSTELLUNG OPTISCH AKTIVER ALPHA-ALKYLCARBONYLVERBINDUNGEN | EP08802340.3 | 2008-09-18 | EP2190809B1 | 2011-06-08 | BREIT, Bernhard; STUDTE, Christopher |
| The present invention relates to a method for the production of optically active α alkyl carbonyl compounds while preserving the stereo information of the base compound. To this end, a carbonyl compound is used as the base compound that has a leaving group in the α position, which is substituted by an alkyl group under inversion of the configuration. The substitution of the leaving group is carried out utilizing an alkyl/magnesium Grignard, and a zinc(II)salt, or a zinc organyl. The method according to the invention enables the production of optically active α alkyl carbonyl compounds at very mild temperature (such as 0°C) using easily illustrated base compounds and cost-effective, non-toxic catalysts, wherein a very high yield may additionally be obtained. | ||||||
| 197 | PREPARATION AND USE OF MAGNESIUM AMIDES | EP07703987.3 | 2007-01-18 | EP1981893B1 | 2011-06-08 | KNOCHEL, Paul; KRASOVSKIY, Arkady; KRASOVSKAYA, Valeria; ROHBOGNER, Christoph, Josef; CLOSOSKI, Gliuliano, Cesar |
| The present application relates to mixed Mg/Li amides of the general formula R1R2N-Mg(NR3R4)mX,.m zLiY (II) wherein R1, R2, R3, and R4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together, or R3 and R4 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 and at least one of R3 and R is other than H; X and Y are, independently, selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; HaIOn , wherein n = 3 or 4 and Hal is selected from Cl, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RXCO2; an alcoholate of the general formula ORX; a thiolate of the general formula SRX; RXP(O)O2; or SCORX; or SCSRX; OnSRx, wherein n = 2 or 3; or NOn, wherein n = 2 or 3; and a derivative thereof; wherein Rx is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, or H; m is O or 1 ; and z > O; as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases. | ||||||
| 198 | GRIGNARD REACTIONS IN MICROREACTORS | EP07765155.2 | 2007-07-11 | EP2044087B1 | 2011-05-04 | ROBERGE, Dominique; BIELER, Nikolaus; DUCRY, Laurent |
| The present invention relates to a process for Grignard type reactions comprising mixing at least two fluids in a microreactor having at least two injection points. | ||||||
| 199 | METHOD FOR PRODUCING BIPHENYL DERIVATIVE | EP07829693 | 2007-10-12 | EP2075241A4 | 2011-01-05 | HAYASHI TAMIO; NAKATANI JIRO |
| 200 | VERFAHREN ZUR HERSTELLUNG OPTISCH AKTIVER ALPHA-ALKYLCARBONYLVERBINDUNGEN | EP08802340.3 | 2008-09-18 | EP2190809A1 | 2010-06-02 | BREIT, Bernhard; STUDTE, Christopher |
| The present invention relates to a method for the production of optically active α alkyl carbonyl compounds while preserving the stereo information of the base compound. To this end, a carbonyl compound is used as the base compound that has a leaving group in the α position, which is substituted by an alkyl group under inversion of the configuration. The substitution of the leaving group is carried out utilizing an alkyl/magnesium Grignard, and a zinc(II)salt, or a zinc organyl. The method according to the invention enables the production of optically active α alkyl carbonyl compounds at very mild temperature (such as 0°C) using easily illustrated base compounds and cost-effective, non-toxic catalysts, wherein a very high yield may additionally be obtained. | ||||||
QQ群二维码
意见反馈
意见反馈