| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
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| 201 | IMPROVED PROCESS FOR PREPARING O-CHLOROMETHYLPHENYLGLYOXYLIC ESTERS, IMPROVED PROCESS FOR PREPARING (E)-2-(2-CHLOROMETHYLPHENYL)-2-ALKOXIMINOACETIC ESTERS, AND NOVEL INTERMEDIATES FOR THEIR PREPARATION | EP08736074.9 | 2008-04-10 | EP2134673A1 | 2009-12-23 | WIEGAND, John-Matthias; LUETTGEN, Karsten; SKRANC, Wolfgang |
| An improved process for preparing o-chloromethylphenylglyoxylic esters of the formula (I) which comprises converting a compound of the formula (II) by reaction with magnesium into the corresponding Grignard reagent which is then reacted with a compound of the formula (III) to give the compound of the formula (IV) which is then cleaved by reaction with a chloroformic ester of the formula ClCOOR4 or by reaction with phosgene to give the compound of the formula (I), followed by the isolation of the compound of the formula (I), and also an improved process for preparing (E)-2-(2-chloromethylphenyl)- 2-alkoximinoacetic esters of the formula (VII) and intermediates for their preparation. | ||||||
| 202 | METHOD FOR PRODUCING BIPHENYL DERIVATIVE | EP07829693.6 | 2007-10-12 | EP2075241A1 | 2009-07-01 | HAYASHI, Tamio; NAKATANI, Jiro |
Provided is a method for producing a biphenyl derivative, with an industrially high yield and excellent productivity, by use of a raw material which is low in cost and toxicity. More specifically, the method for producing the biphenyl derivative represented by general formula (1) is characterized in that a chlorine atom in a benzene derivative represented by general formula (2) reacts with magnesium metal to convert the benzene derivative into a Grignard reagent, and then the Grignard reagent is subjected to a coupling reaction in the presence of a catalyst and a dichloropropane:
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| 203 | GRIGNARD REACTIONS IN MICROREACTORS | EP07765155.2 | 2007-07-11 | EP2044087A2 | 2009-04-08 | ROBERGE, Dominique; BIELER, Nikolaus; DUCRY, Laurent |
| The present invention relates to a process for Grignard type reactions comprising mixing at least two fluids in a microreactor having at least two injection points. | ||||||
| 204 | PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVES | EP06822282 | 2006-10-25 | EP1955990A4 | 2009-02-18 | HAYASHI TAMIO; NAKATANI JIRO |
| A process for the production of biphenyl derivatives represented by the general formula (1), which is characterized by comprising reacting the chlorine atom of a benzene derivative represented by the general formula (2) with metallic magnesium to form a Grignard reagent and coupling two molecules of the Grignard reagent with each other in the presence of a catalyst and which is excellent in industrial productivity by virtue of its using inexpensive and easily available raw materials. (1) (2) (wherein A’s are at least one member selected from between trifluoromethyl and fluoro; and n is an integer of 1 to 4) | ||||||
| 205 | VERFAHREN ZUR HERSTELLUNG VON GRIGNARDVERBINDUNGEN | EP99914565.9 | 1999-04-01 | EP1070070B1 | 2008-07-23 | BOYMOND, Laure; ROTTLÄNDER, Mario; CAHIEZ, Gérard; KNOCHEL, Paul |
| The invention relates to a method for producing grignard compounds of formula (I). The invention also relates to compounds of formula (I) in polymer bonded compounds of formula (Ia). The invention further relates to the use of the inventive method to produce substance libraries and to the use of compounds of formulae (I) and (Ia) in chemical synthesis. | ||||||
| 206 | SOLUTIONS OF ANHYDROUS LANTHANIDE SALTS AND ITS PREPARATION | EP06793139.4 | 2006-09-01 | EP1937407A1 | 2008-07-02 | KNOCHEL, Paul; KRASOVSKIY, Arkady; KOPP, Felix |
| The present invention relates to anhydrous solutions of MX3-Z LiA in a solvent, wherein M is a lanthanide including lanthanum, or yttrium or indium; z > 0; and X and A are independently or both monovalent anions, preferably Cl, Br or I. The solution is readily prepared by dissolving or suspending MX3 or its hydrate and z equiv LiA in water or hydrophilic solvents, or mixtures thereof, removing the solvent under vacuum and dissolving the resulting powder in another solvent. The solution of MX3-Z LiA can advantageously be used e.g. in addition reactions of Grignard reagents to ketones and imines. Even the catalytic use of MX3-Z LiA is possible. | ||||||
| 207 | Grignard reactions in microreactors | EP06014883.0 | 2006-07-18 | EP1889849A1 | 2008-02-20 | The designation of the inventor has not yet been filed |
The present invention relates to a process for Grignard type reactions comprising mixing at least two fluids in a microreactor having at least two injection points.
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| 208 | Solutions of anhydrous lanthanide salts and its preparation | EP05019026.3 | 2005-09-01 | EP1759765A1 | 2007-03-07 | Knochel, Paul; Krasovskiy, Arkady; Kopp, Felix |
The present invention relates to anhydrous solutions of MX3•z LiA in a solvent, wherein M is a lanthanide including lanthanum, or yttrium or indium; z > 0; and X and A are independently or both monovalent anions, preferably Cl, Br or I. The solution is readily prepared by dissolving or suspending MX3 or its hydrate and z equiv LiA in water or hydrophilic solvents, or mixtures thereof, removing the solvent under vacuum and dissolving the resulting powder in another solvent. The solution of MX3•z LiA can advantageously be used e.g. in addition reactions of Grignard reagents to ketones and imines. Even the catalytic use of MX3•z LiA is possible. |
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| 209 | Process for preparing vinylphosphates | EP06008485.2 | 2003-05-29 | EP1754709A1 | 2007-02-21 | Miller, Joseph A. |
The present invention provides a process for preparing a vinylphosphate comprising reacting an enolizable ketone with a sterically hindered Grignard reagent and a halophosphate diester. |
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| 210 | Method of preparing organomagnesium compounds | EP04008081.4 | 2004-04-02 | EP1582523A1 | 2005-10-05 | Knochel, Paul, Prof. Dr.; Krasovskiy, Arkady, Dr. |
The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts - LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method. |
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| 211 | VERFAHREN ZUR HERSTELLUNG VON GRIGNARDVERBINDUNGEN | EP99914565.9 | 1999-04-01 | EP1070070A1 | 2001-01-24 | BOYMOND, Laure; ROTTLÄNDER, Mario; CAHIEZ, Gérard; KNOCHEL, Paul |
| The invention relates to a method for producing grignard compounds of formula (I). The invention also relates to compounds of formula (I) in polymer bonded compounds of formula (Ia). The invention further relates to the use of the inventive method to produce substance libraries and to the use of compounds of formulae (I) and (Ia) in chemical synthesis. | ||||||
| 212 | BENZYLMAGNESIUMHALOGENIDE ODER ALLYLMAGNESIUMHALOGENIDE ENTHALTENDE SYNTHESEMITTEL UND VERFAHREN ZU DEREN HERSTELLUNG | EP99907379.4 | 1999-01-18 | EP1056750A1 | 2000-12-06 | RITTMEYER, Peter; LISCHKA, Uwe; HAUK, Dieter |
| The invention relates to synthesis agents containing benzyl magnesium halogenides and allyl magnesium halogenides (Grignard reagents) with 2-methyl-tetrahydrofuran as solvent, and to a method for producing same. | ||||||
| 213 | Herstellung und Verwendung von (3-Alkoxyphenyl)magnesiumchloriden | EP97101270.3 | 1997-01-28 | EP0790251A3 | 1999-09-22 | Finkam, Michael, Dr.; Kohnen, Thomas; Winter, Werner, Prof. Dr. |
Es wird ein Verfahren zur Herstellung von (3-Alkoxyphenyl)magnesiumchloriden sowie deren Verwendung zur Umsetzung bestimmter Carbonylverbindungen beschrieben. |
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| 214 | CARBONYLATION OF ORGANIC ZINC COMPOUNDS | PCT/EP2011054104 | 2011-03-18 | WO2011113925A3 | 2011-12-01 | KNOCHEL PAUL; BERNHARDT SEBASTIAN; METZGER ALBRECHT |
| The invention relates to methods for producing organic compounds comprising at least one functional group, in particular carboxylic acids, alcohols, esters, amides, ketones, aldehydes or amines, and to compounds for the production thereof, to uses and to the production of such compounds. The compounds used are compounds of formula (Ia) or (Ib): R-Zn-X·MgX2·LiCl, (Ia); R1R2-Zn·2MgX2·2LiCl, (Ib), where R, R1 and R2 are organic groups and X is a halide. | ||||||
| 215 | METHOD FOR ALLYLATING AND VINYLATING ARYL, HETEROARYL, ALKYL, AND ALKENE HALOGENIDES USING TRANSITION METAL CATALYSIS | PCT/EP2011051390 | 2011-02-01 | WO2011098375A2 | 2011-08-18 | GOTTA MATTHIAS; LEHNEMANN BERND WILHELM; CZAPLIK WALDEMAR MAXIMILIAN; MAYER MATTHIAS; JACOBI VON WANGELIN AXEL |
| The invention relates to a method for producing organic compounds of the general formula (I) R-R' (I), by reacting a corresponding compound of the general formula (II) R-X (H), where X stands for fluorine, chlorine, bromine, or iodine, forming a magnesium organic compound of the general formula (III) [M+]n [RmMgXkY1] (III), compounds of the formula (III) being reacted with a compound of the general formula (IV), characterized in that the reaction of (III) with (IV) is performed in the presence of a) catalytic quantities of an iron compound, relative to the compound of the general formula (II), and optionally in the presence b) of an additive comprising nitrogen, oxygen, and/or phosphorous in a catalytic or stoichiometric quantity relative to the compound of the general formula (II). | ||||||
| 216 | METHOD FOR THE PREPARATION OF A COMPOUND OF THE GENERAL FORMULA R1-R1 AND/OR R1-R2 USING HOMO AND HETERO COUPLING REACTIONS | PCT/EP2007052181 | 2007-03-08 | WO2007128601A2 | 2007-11-15 | KNOCHEL PAUL; MAYR HERBERT; KRASOVSKIY ARKADY; KIENLE MARCEL; DUBBAKA SRINIVAS REDDY; DEL AMO VICENTE; TISHKOV ALEXANDER |
| The present application relates to a method for the preparation of a compound of the general formula R1-R2 (I) and/or R1-R1 (II) comprising providing a compound of the general formula R1 dM | ||||||
| 217 | C-C AND C-N COUPLING CATALYST COMPRISING TRANSITION METAL AND CARBENE | PCT/US0105549 | 2001-02-22 | WO0166248A3 | 2002-02-14 | NOLAN STEVEN P; HUANG JINKUN; TRUDELL MARK L; ZHANG CHUNMING; LEE HON MAN |
| This invention provides a process for conducting reactions to form carbon-to-carbon or carbon-to-nitrogen bonds. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in various types of couplings of aryl halides and/or aryl pseudohalides. A Suzuki coupling, for example, can be carried out by mixing, in a liquid medium, at least one strong base; at least one aryl halide or aryl pseudohalide in which all substituents are other than boronic acid groups, wherein the aryl halide has, directly bonded to the aromatic ring(s), at least one halogen atom selected from the group consisting of a chlorine atom, a bromine atom, and an iodine atom; at least one arylboronic acid in which all substituents are other than chlorine atoms, bromine atoms, iodine atoms, or pseudohalide groups; at least one metal compound comprising at least one metal atom selected from nickel, palladium, and platinum, wherein the formal oxidation state of the metal is zero or two; and at least one N-heterocyclic carbene. One preferred type of N-heterocyclic carbene is an imidazoline-2-ylidene of the formula (I) wherein R<1> and R<2> are each, independently, alkyl or aryl groups having at least 3 carbon atoms, R<3> and R<4> are each, independently, a hydrogen atom, a halogen atom, or a hydrocarbyl group. | ||||||
