| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 361 | Spectrophotometric assay for cyanide | US749032 | 1996-11-14 | US5961469A | 1999-10-05 | Michael F. Roizen; Jon Moss |
| A method of detecting and quantifying cyanide concentration in a patient, by monitoring photometric changes resulting from the transformation of methemoglobin to cyanomethemoglobin. The present invention provides for a means of cyanide poisoning assessment in patients using the affinity of methemoglobin for cyanide to assess the photometric changes resulting from methemoglobin converting to cyanomethemoglobin, as an indicator of cyanide concentration in a patient. Appropriate corrective action can then be promptly taken. | ||||||
| 362 | Enzyme-based fluorescence biosensor for chemical analysis | US736904 | 1996-10-25 | US5952236A | 1999-09-14 | Richard B. Thompson; Marcia W. Patchan; Zhengfang Ge |
| This invention generally relates to the detection, determination, and quantitation of certain ions and small molecules involving the quenching of a fluorescent label attached to a macromolecule, often due to fluorescence energy transfer to a colored inhibitor or certain metal ions bound to the macromolecule. | ||||||
| 363 | Fertility test | US842773 | 1997-04-17 | US5914271A | 1999-06-22 | Wai Tak Law; Robert Harper |
| The fertile period in a female can be detected by monitoring the calcium and magnesium concentrations in unstimulated saliva. In the three to five day period immediately prior to ovulation, the calcium and magnesium concentrations of saliva drop. This concentration monitoring can be done by any conventional means for quantitatively assaying calcium or magnesium, such as by flow through tests, test strips, cards, charts, probes, meters, and the like. | ||||||
| 364 | Phosphate assay | US581584 | 1996-04-24 | US5898069A | 1999-04-27 | Martin Ronald Webb; Martin Hermann Brune; John Edgar Thomas Corrie |
| Disclosed is a method for measuring or detecting inorganic phosphate ion in a sample. In the method, a sample is reacted with a phosphate-binding protein containing (i) an inorganic phosphate ion binding site and (ii) a detectable label that produces a signal whose amplitude changes detectably upon the binding of inorganic phosphate ion to the binding site, under conditions effective to allow binding of phosphate in the sample to the binding site. From a change in signal, the level of inorganic phosphate ion is measured or detected. Also disclosed are phosphate binding proteins for use in the method. | ||||||
| 365 | Method and apparatus for making an improved resilient packing product | US153491 | 1993-11-17 | US5871432A | 1999-02-16 | Edwin P. Beierlorzer |
| The present invention relates of a method and apparatus for making an improved resilient packing material by forming, resiliently folding and crimping shredded strips of moistened paper material into an improved interlocking, bulk, packaging material. The method and apparatus includes a wetting or dampening system which can be selectively varied to regulate the moisture content of moistened paper material. | ||||||
| 366 | Test composition, device and method for the colorimetric determination of phosphorus | US869820 | 1997-06-05 | US5858797A | 1999-01-12 | Yuriy Vladimirovich Evtodienko; Michael Allen Van Lente |
| A unitized, one step test reagent composition, device and method is presented for the determination of phosphorus in various test sample fluids such as soil extracts. The invention is a modification of the Murphy and Riley methodology which utilizes a molybdate salt and a reducing agent to generate "molybdenum blue" in the presence of phosphate. In addition to the molybdate salt, the test reagent composition includes a chromogenic reducing agent which contributes to the color development and a solid buffer. The composition is preferably incorporated into a matrix such as paper for ease of handling. | ||||||
| 367 | Reagent for determining the ionic strength and/or the specific weight of aqueous liquids, and method | US364422 | 1994-12-27 | US5858788A | 1999-01-12 | Klaus Habenstein |
| Reagent for determining the ionic strength and/or the specific weight of aqueous liquids and a reagent for this purpose, the composition of the reagent being such that the color change indicating the ionic strength is essentially directly dependent on the specific weight of the liquid to be determined and not on a pH shift. | ||||||
| 368 | Parathyroid hormone receptor and DNA encoding same | US471494 | 1995-06-06 | US5840853A | 1998-11-24 | Gino V. Segre; Henry M. Kronenberg; Abdul-Badi Abou-Samra; Harald Juppner; John T. Potts, Jr.; Ernestina Schipani |
| DNA encoding a parathyroid hormone receptor; production and isolation of recombinant and synthetic parathyroid hormone receptor polypeptides and fragments; antibodies to parathyroid hormone receptors and receptor fragments; methods for screening candidate compounds for antagonistic or agonistic effects on parathyroid hormone receptor action; and diagnostic and therapeutic methods of these compounds are disclosed. | ||||||
| 369 | Feline urinary tract disease-detecting paper cat litter and method | US345524 | 1994-11-28 | US5830765A | 1998-11-03 | Carl V. Santioemmo; James P. Humphries |
| A cat litter which comprises a plurality of lightweight, resilient paper strips treated with a pH-indicator and/or an occult blood indicator and folded transversely into generally zig-zag shapes, enables early detection of feline urological syndrome. When wetted with alkaline urine secreted by the cat, the paper strips treated with pH indicator exhibit a noticeable color change. When wetted with cat urine containing occult or gross blood, the paper strips treated with occult blood indicator exhibit a noticeable color change. A mixture of pH indicator treated strips and occult blood indicator strips in the cat litter enables the detection of both alkaline pH and occult blood in the same urine sample. The color changes are easily visible to the observer without requiring unsanitary contact with the cat litter. | ||||||
| 370 | Doped sol-gel glasses for obtaining chemical interactions | US667746 | 1996-06-21 | US5824526A | 1998-10-20 | David Avnir; Michael Ottolenghi; Sergei Braun; Rivka Zusman |
| A sol-gel glass doped with one or more reagent that provides chemical interactions with diffusible solutes or components in an adjacent liquid or gas phase. The reagent(s), the solutes or the components can be any organic or inorganic compounds or materials of biological origin, including enzymes. The doped sol-gel glass in various forms is useful as an analytical test, chromatographic medium, sensor, catalyst or biocatalyst, electrode or enzyme electrode, and other detection devices. | ||||||
| 371 | Metal ion determination by sandwich aggregation assay | US703982 | 1996-08-28 | US5814521A | 1998-09-29 | Eddy Chapoteau; Jonathan Craine; Bronislaw P. Czech; Anand Kumar; Koon-wah Leong |
| The present invention relates to a method for the determination of polyvalent metal ions using a sandwich aggregation assay. One or more chelating agents capable of forming at least 2:1 or higher ratio stoichiometry complexes with polyvalent metal ions are attached to a suitable carrier such as latex particles through covalent bonds or by non-covalent interactions, such as hydophobic interactions. Upon complexation with the metal ions, the carriers of the complexing agent aggregate, causing an increase in light absorbance or light scattering which is proportional to the concentration of metal ions in the test sample. The measurement of the light absorbance or light scattering by a suitable instrument, such as a spectrophotometer or nephelometer provides a means for measuring the concentration of metal ions. | ||||||
| 372 | Broad range total available chlorine test strip | US822570 | 1997-03-19 | US5811254A | 1998-09-22 | Wen H. Wu |
| A composition, method, and test device for determining the total available chlorine concentration of a test sample are disclosed. The test device includes a test pad having a suitable carrier matrix incorporating an indicator reagent composition capable of converting combined available chlorine to free available chlorine and of interacting with free available chlorine to produce a detectable and measurable response for total available chlorine over a range of 0 to over 5000 ppm total available chlorine in the test sample. An indicator reagent composition contains: (a) an indicator dye that is responsive to free available chlorine, such as tetramethylbenzidine, (b) a buffer, (c) a surfactant, (d) an optional catalyst, and (e) an optional polymer. An indicator reagent composition is incorporated into a carrier matrix, like filter paper, to provide a test pad useful in a dry phase total available chlorine assay of a test sample, such as a sanitizing solution for a hemodialysis unit. | ||||||
| 373 | Metallic cation binding polypeptides and methods therefor | US773688 | 1996-12-27 | US5807695A | 1998-09-15 | Fred W. Wagner; Dwane E. Wylie; Sheldon M. Schuster |
| The invention is directed to monoclonal antibodies, their fragments, single chains and polypeptide mimics of their hypervariable regions which immunoreact with bare small moieties such as metallic cations and small organic molecules, the hybridomas for production of the monoclonal antibodies, immunogen compounds for developing the hybridomas, and methods for use of the monoclonal antibodies. | ||||||
| 374 | Fused genes and their use for determining the presence of metals or of xenobiotic compounds | US469775 | 1995-06-06 | US5786162A | 1998-07-28 | Philippe Corbisier; Maximilien Mergeay; Ludovicus Diels |
| The invention relates to a fused gene containing: the promoter sequence of (a) gene(s) encoding the resistance to one or several metal(s) or encoding the catabolism of one or several xenobiotic compound(s), said promoter being inducible in the presence of said metal(s) or xenobiotic compound(s), or both, and downstream the promoter, a gene producing a detectable signal such as light emitting gene, said gene being under the control of said promoter, said gene producing a detectable signal being located at a position such that the induction of the promoter causes the transcription of the gene producing a detectable signal and such that there is no terminator between the promoter and the gene producing a detectable signal. | ||||||
| 375 | Kit for determination of residual chlorine in water with 3,3',5,5'-tetramethylbenzidine | US565571 | 1995-11-30 | US5783149A | 1998-07-21 | Francisco Bosch Serrat |
| Colorimetric methods for determination of residual chlorine, free and combined, in water are described which comprise the use of 3,3',5,5'-tetramethylbenzidine (TMB), as well as methods and kits for determining chlorine in water by visual comparison which comprise, apart from TMB, a calibration scale. The basis for the preparation of one of the kits (or the kit described as an example) lies in the orange color that is produced by means of the reaction between chlorine and TMB, which permits a straightforward determination of residual chlorine by means of a simple visual comparison with a graduated, stable scale that is constituted either by solutions of Tropaeolin O of different concentrations or, alternatively, by a printed scale on plastic material or paper, by etching. | ||||||
| 376 | Method for quantitatively measuring white blood cells esterase activity in urine | US631581 | 1996-04-12 | US5776780A | 1998-07-07 | Jack V. Smith; Jesse M. Carter |
| Detecting white blood cells in an aliquot of urine by placing the aliquot of urine in an automated analyzer sampling cup, transferring the urine to a cuvette and injecting at least one reagent composition. The reagent composition contains a buffer, an activator such as benzalkonium chloride, an indicator and at least one substance to remove substances in the urine that cause interference with colorimetric photometry. The aliquot of urine is read in accordance with a preprogrammed code at a monochromatically specified wavelength to compare absorbance of the patient's urine with a known standard containing a known concentration of white blood cells. | ||||||
| 377 | Dried chemical compositions | US466155 | 1995-06-06 | US5776563A | 1998-07-07 | Steven N. Buhl; Bhaskar Bhayani; Chi-Sou Yu; Thuy N. Tang |
| The present invention provides dried chemical compositions comprising dried beads. Typically, the beads comprise reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers. | ||||||
| 378 | Bifunctional chelating polysaccharides | US82269 | 1993-06-23 | US5773227A | 1998-06-30 | Michael A. Kuhn; Tobias Meyer; Nancy L. Allbritton |
| This invention describes bifunctional polysaccharides conjugated to both a chelating group suitable for the selective complexation of metal cations, and a targeting peptide specific for a cellular substructure. These bifunctional polysaccharides are primarily useful for the regulation, detection and quantification of metal ion levels, such as Ca.sup.2+, Mg.sup.2+, Na.sup.+, K.sup.+, or Li.sup.+, in specific cellular structures. Localization within the cellular structure is accomplished by the targeting peptide, whereupon the large, water-soluble polysaccharide prevents diffusion of the chelating group from the targeted site. When the target cell structure is the nucleus of a fertilized egg cell, the polysaccharide-chelator conjugate remains sequestered within the nucleus until the breakdown of the nuclear envelope, whereupon the reagent becomes sequestered into both daughter nuclei. This means of tracking daughter cells is practical even through several cell divisions. | ||||||
| 379 | Method of quantitative determination of sodium ions | US601031 | 1996-05-03 | US5766870A | 1998-06-16 | Kayoko Shigenobu; Norihito Aoyama |
| The present invention relates to a method of quantitative determination of sodium ions in a sample using .beta.-galactosidase, wherein the .beta.-galactosidase reaction is conducted in the presence of at least one chelating agent selected from of 1,2-cyclohexanediamine-N,N,N',N'-tetraacetic acid, ethylenediamine-tetraacetic acid, triethylenetetranine-hexaacetic acid, diethylenetriamine-N,N,N',N",N"-pentaacetic acid, 1,3 -diminopropan-2-ol-N,N',N'-tetraacetic acid, ethylenediamine-N,N'-dipropionic acid dihydrochloride, ethylenediamine-tetrakis(methylenesulfonic acid), iminodiacetic acid, hydroxyimino-diacetic acid and nitrilotriacetic acid. The method of quantitative determination of sodium ions of the present invention is useful in clinical examinations and the accuracy in the measurement by the method is high. | ||||||
| 380 | pH measurement of body fluid | US810347 | 1997-03-03 | US5738634A | 1998-04-14 | James C. Caillouette |
| In the method for detecting pH of vaginal moisture, the steps that include providing an elongated first carrier; providing a pH detector on the carrier at an end portion thereof; manipulating the carrier to effect exposure of the detector to vaginal moisture, thereby to cause the detector to exhibit a color change; and providing a pH correlating color comparison measurement means, in sufficiently close association with the carrier and with the detector to allow visual comparison of the changed color exhibited by the detector with a pH correlated color provided by the measurement means. | ||||||
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