| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 381 | Lightweight disposable kitty litter box | US466253 | 1995-06-06 | US5727499A | 1998-03-17 | Steven E. Armington; Carl V. Santoiemmo; Dale Panasewicz |
| A lightweight disposable kitty litter box comprises a container which forms a closed receptacle (110) and fresh kitty litter (20) which is enclosed within the closed receptacle (122). The kitty litter (20) comprises a resilient paper product having a density between 0.01 and 0.10 ounces per cubic inch. The container is convertible between a closed condition in which it forms a closed receptacle (110) and an open condition in which it forms an open receptacle (122). To supply a kitty litter box for a cat, the container is converted into the open condition to form the open receptacle to thereby allow the cat access to the fresh kitty litter (20). The cat may then interact with the fresh kitty litter (20) until it reaches a sanitarily unacceptable state. The sanitarily unacceptable kitty litter is then enclosed in the closed container by converting the container into the closed condition. The container and the sanitarily unacceptable kitty litter enclosed therein may then be disposed as a unit. | ||||||
| 382 | Optical indicator for determining the activity of an ion in a sample | US645891 | 1996-05-14 | US5723340A | 1998-03-03 | Hellfried Karpf |
| An optical indicator for determining the activity of an ion in a sample is provided with an ionophor which is capable of selectively binding the ion to be measured. The ionophor has at least two functional groups that can form an electron donor acceptor (EDA) complex, the complex bond being broken up by the attachment of the ion to be determined. This will lead to a change in at least one of the measurable optical properties of the indicator in dependence on the activity of the ion to be measured. | ||||||
| 383 | Emulsion for robust sensing | US562036 | 1995-11-22 | US5714122A | 1998-02-03 | Kathryn R. Bretscher; James A. Baker; Kenneth B. Wood; Mai T. Nguyen; Monica A. Hamer; Christopher J. Rueb |
| The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO.sub.2 or ammonia) in a medium such as blood which has superior dry web sensor performance, enhanced sensor consistency for transparent sensor calibration, improved autoclave stability and rapid rehydration of the sensor. In a preferred embodiment, the sensors of the present invention comprise microcompartments of an aqueous phase having a pH sensitive indicator component and a nonionic amphipathic surfactant within a hydrophobic barrier phase comprising a plurality of dispersed hydrophobic particles. | ||||||
| 384 | Quantitative determination method for sodium ions | US530336 | 1995-11-29 | US5700652A | 1997-12-23 | Toshio Tadano; Akira Miike; Jun Umemoto |
| The present invention relates to a method for quantitatively determining sodium ions in a sample using .beta.-galactosidase in an aqueous medium, wherein a .beta.-galactosidase reaction is carried out in the presence of a cation which competes with the sodium ion. The method of the present invention is good in accurate determination and reproducibility and enables the simple and quick quantitative determination of sodium ions. | ||||||
| 385 | Method for detecting a mammal's prior exposure to radiation or radiomimetic chemicals | US547197 | 1995-10-24 | US5691157A | 1997-11-25 | Joseph K. Gong; Chester A. Glomski |
| The present invention is directed to a method for detecting a mammal's prior exposure to radiation or radiomimetic agents. Labeled antibodies are employed to determine the quantity of transferrin receptors on the red blood cells of the mammal. The quantity of transferrin receptors on the red blood cells of the mammal is correlated to the mammal's prior exposure. | ||||||
| 386 | Feline urinary tract disease-detecting transversely folded paper cat litter | US444706 | 1995-05-19 | US5685259A | 1997-11-11 | Carl V. Santioemmo; James P. Humphries |
| A disposable cat litter box includes a container and a fresh litter enclosed within the container. The container is convertible between a closed condition in which it forms a closed receptacle and an open condition in which it forms an open receptacle. The fresh litter comprises a plurality of transversely folded paper strips which exhibit a noticeable color change when wetted with cat urine having a predetermined characteristic of feline disease. | ||||||
| 387 | Reagent for measurement of magnesium ion | US960364 | 1993-09-23 | US5683889A | 1997-11-04 | Hitoshi Kondou; Kazuhiko Nagata; Kazue Kawahara |
| The present invention relates to a reagent for measurement of magnesium ions utilizing a complex of magnesium ion with adenosine 5'-triphosphate as a substrate of glucokinase derived from bacteria of the genus Zymomonas. By using this reagent, enough measuring range to measure a magnesium ion in various samples such as biological fluids, foodstuffs, etc. can be accomplished and, at the same time, the measurement can be made with high precision and reliability even in a sample containing a magnesium ion in low concentration. Further, the reagent of the present invention is superior in operation property by reducing a dilution operation, and has sufficient performance for a routine method for determination of magnesium ions. | ||||||
| 388 | Metal ion-ligand coordination complexes, antibodies directed thereto, and assays using such antibodies | US449606 | 1995-05-23 | US5670645A | 1997-09-23 | David K. Johnson |
| The present invention relates to the field of immunoassays for metal ions. The invention presents: metal ion-ligand coordination complexes ("MLC"), novel ligands, antibodies specific for MLC, immunoassays utiliizing the foregoing, and methods for selecting said antibodies. | ||||||
| 389 | Method and compositions for making ACSF and ACSF antagonists | US177323 | 1994-01-04 | US5668106A | 1997-09-16 | William I. Wood; Thomas John Martin |
| The complete amino acid and nucleotide sequence for adenylate cyclase stimulating factor is provided, thereby facilitating the synthesis of ACSF in recombinant cell culture. ACSF amino acid sequence variants and ACSF antibodies are provided which are useful in the treatment of humoral hypercalcemia of malignancy or in immunoassays for ACSF. In particular, antibodies capable of binding only the C-terminal domains of ACSF are useful in immunoassays for ACSF which avoid interference by parathyroid hormone. Also provided are novel polypeptides selected from the group of the ACSF basic peptide, the ACSF C-terminal peptide, or the ACSF domain containing both of the basic and C-terminal peptides. | ||||||
| 390 | PH and amine test elements | US689758 | 1996-08-13 | US5660790A | 1997-08-26 | Paul J. Lawrence; Peter U. Ly; David R. Shockey |
| Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable means rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls. | ||||||
| 391 | Metal ion-ligand coordination complexes, antibodies directed thereto, and assays using such antibodies | US435364 | 1995-05-05 | US5654160A | 1997-08-05 | David K. Johnson |
| The present invention relates to the field of immunoassays for metal ions. The invention presents: metal ion-ligand coordination complexes ("MLC"), novel ligands, antibodies specific for MLC, immunoassays utiliizing the foregoing, and methods for selecting said antibodies. | ||||||
| 392 | Metal ion-ligand coordination complexes, antibodies directed thereto, and assays using such antibodies | US435678 | 1995-05-05 | US5631172A | 1997-05-20 | David K. Johnson |
| The present invention relates to the field of immunoassays for metal ions. The invention presents: metal ion-ligand coordination complexes ("MLC"), novel ligands, antibodies specific for MLC, immunoassays utilizing the foregoing, and methods for selecting said antibodies. | ||||||
| 393 | Method for the determination of specific gravity of fluids | US546904 | 1995-10-23 | US5631163A | 1997-05-20 | Michael J. Pugia; Rena A. Ide |
| Disclosed are a method and device for the determination of specific gravity in aqueous systems, particularly urine. The invention improves upon the known systems for detecting specific gravity by the use of a polyelectrolyte polymer and pH indicator by the addition of a crown ether ionophore which enhances the ability of the reagent system to indicate the fluid's specific gravity. | ||||||
| 394 | Sensor with improved drift stability | US375304 | 1995-01-20 | US5607645A | 1997-03-04 | James G. Bentsen; Kenneth B. Wood |
| The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO.sub.2 or ammonia) in a medium such as blood which has improved drift stability. In a preferred embodiment, the sensors of the present invention comprise microcompartments of an aqueous phase having a pH sensitive sensing component within a hydrophobic barrier phase. The sensors of the present invention are substantially free of partitioning species other than the analyte of interest which can migrate from one phase to the other in response to a change in pH in the aqueous phase and which substantially affect the concentration dependent signal. In an alternative embodiment, the sensors of the present invention are constructed so as to retard the migration of partitioning species, thus reducing the initial rate of drift. | ||||||
| 395 | Optical sensor for the measurement of pH in a fluid, and related sensing compositions and methods | US74749 | 1993-06-10 | US5607644A | 1997-03-04 | Alan Olstein; William Fowler; Jo Pritchard |
| An optical sensor is provided for measuring the pH of a fluid sample. The sensor is formulated using a fluorescent polymer composition comprising a copolymer of a water-dispersable, polyether-containing urethane olefin precursor and a fluorescent monomer species, wherein the ratio of precursor and fluorescent monomer species is such that a predetermined apparent pKa is provided. The sensor is prepared by coating the distal end of an optical waveguide with the fluorescent polymer composition, and curing the copolymer contained in the composition, e.g., by exposure to radiation of a suitable wavelength. | ||||||
| 396 | Process and apparatus for testing for substances in liquids | US441312 | 1995-05-15 | US5567619A | 1996-10-22 | Marcia J. Stone |
| A method for detecting a substance in a liquid sample involves precipitating a substance from the liquid sample and filtering it from the liquid sample. The precipitate is then tested for the substance of interest by contacting the precipitate with a dye that forms a visible reaction when exposed to the substance. A releasing agent may be used after filtering the precipitate and prior to testing the precipitate with a dye. | ||||||
| 397 | Reagent composition for measuring ionic strength or specific gravity of aqueous solution samples | US962563 | 1992-10-19 | US5565363A | 1996-10-15 | Kenji Iwata; Masako Shiojiri; Nobuyuki Tokioka |
| A reagent composition comprising (a) one or more pH buffers, (b) one or more pH indicators, and (c) one or more surfactants as a sensitizer, is suitable for measuring ionic strength or specific gravity of aqueous solution samples such as urine rapidly and precisely. | ||||||
| 398 | Method for measuring total body tissue iron stores | US512466 | 1995-08-08 | US5552268A | 1996-09-03 | Victor D. Herbert; Spencer Shaw; Elizabeth Jayatilleke |
| A non-invasive method to measure total body tissue iron stores comprising recovering iron released from total ferritin contained in a body fluid sample derived from a host, measuring the ferritin-iron in the total ferritin and thereby determining total body tissue iron stores. Such an assay is utilized for diagnosing negative iron balance as well as positive iron balance, wherein the latter promotes cancer, coronary artery disease, atherosclerosis, and hepatic failure among other diseases, as well as the susceptibility to such diseases. | ||||||
| 399 | Monoclonal antibody assay and kit for detecting metal cations in body fluids | US96671 | 1993-06-22 | US5532136A | 1996-07-02 | Randall R. Carlson; Jay S. Stout; Dwane E. Wylie; Fred W. Wagner; Malcolm Riddell |
| The invention provides method and kits for detecting a metallic cation in a sample of a body fluid. The preferred method and kits include the use of at least two different types of antibodies having different specificities. In the preferred method, the sample of body fluid can be contacted with an effective amount of a capture antibody specific for a naturally occurring polypeptide that can bind the metallic cation to form a first antigen-antibody complex. An effective amount of an antibody specific for an epitope on a metallic cation-naturally occurring polypeptide complex or an antibody specific for a metallic cation is added to the first antigen-antibody complex to form a second antigen-antibody complex. The amount of the metallic cation in the sample of body fluid is determined by detecting the amount of the second antigen-antibody complex. | ||||||
| 400 | Automated urinalysis method | US429292 | 1995-04-24 | US5516700A | 1996-05-14 | Jack V. Smith; Jesse M. Carter |
| A method that provides techniques for determination of urinary constituents (Blood (Red Blood Cells/Hemoglobin), Leukocytes, pH, Specific Gravity, Bacterial Reductase/Nitrite/Indole activity, Total Ketone Bodies, Protein, and Glucose) at low chemically significant levels with a carrier independent reagent system that can be placed on a high throughput autoanalyzers. Thus, giving the analyst the ability to run multiple urinary assays on a single sample of urine simultaneously with the ability to compare to reference standards on the same run. This system is designed to neutralize urinary interfering substances. This method is fast, efficient, an adaptable to many of the currently available discrete and continuous flow automated analyzers, effective at sample to reagent ratios of 1 to 13 or more. This method is applicable to samples with high turbidity, high ionic strength, high color content, wide pH extremes, and buffer strengths, among other interfering substances. | ||||||
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