| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 401 | Sensing elements and methods for uniformly making individual sensing elements | US159799 | 1993-11-30 | US5508509A | 1996-04-16 | Masao Yafuso; Ronnie L. Pratt; Kathryn R. Bretscher; Kenneth B. Wood; John L. Dektar; James G. Bentsen |
| Sensing elements, useful in sensing the concentration of a gas, e.g., carbon dioxide, in a medium, e.g. blood, and methods for making such sensing elements are disclosed. In one embodiment, the method comprises continuously placing a sensing composition precursor in contact with a continuous web, forming a continuous sensing composition from the precursor, and applying a continuous opaque film to the sensing composition. A plurality of individual sensing elements are formed from this composite structure. These sensing elements, which each have very similar sensing characteristics, are placed in a sensor fixture for use. | ||||||
| 402 | Calibration solutions useful for analysis of biological fluids and methods employing same | US379555 | 1995-02-02 | US5505828A | 1996-04-09 | David K. Wong; Kenneth M. Curry |
| Novel calibration solutions are provided which are useful, for example, with sensor assemblies used for analysis of CO.sub.2, and optionally, for concurrent analysis of O.sub.2, especially in combination infusion fluid delivery/blood chemistry analysis systems which include a sensor assembly with each of the assembly electrodes mounted in an electrode cavity in the assembly. The analysis system used in the practice of the present invention typically includes provision for delivering infusion fluid and measuring blood chemistry during reinfusion of the physiological fluid at approximately the same flow rates. The invention calibration solutions are useful for calibrating an array of sensors capable of simultaneously measuring a number of blood chemistry parameters, including the partial pressures (tensions) of carbon dioxide and oxygen, pH (hydrogen ion), sodium, potassium, ionized calcium, ionized magnesium, chloride, glucose, lactate and hematocrit, in body fluids. More particularly, this invention relates to the use of an infusible intravenous solution to facilitate calibration on a regular basis for every individual sensor in a sensor assembly, which is in constant fluid communication with the body regardless of whether the sensors are ex vivo or in vivo. | ||||||
| 403 | DNA and vectors encoding the parathyroid hormone receptor, transformed cells, and recombinant production of PTHR proteins and peptides | US864475 | 1992-04-06 | US5494806A | 1996-02-27 | Gino V. Segre; Henry M. Kronenberg; Abdul-Badi Abou-Samra; Harald Juppner; John T. Potts, Jr.; Ernestina Schipani |
| DNA encoding a parathyroid hormone receptor; production and isolation of recombinant and synthetic parathyroid hormone receptor polypeptides and fragments; antibodies to parathyroid hormone receptors and receptor fragments; methods for screening candidate compounds for antagonistic or agonistic effects on parathyroid hormone receptor action; and diagnostic and therapeutic methods of these compounds are disclosed. | ||||||
| 404 | Method for quantitation of calcium and magnesium and the novel reagent compositions | US281808 | 1994-07-28 | US5482866A | 1996-01-09 | James B. Denton; Diane J. Dixon; Richard A. Kaufman |
| The present invention provides novel reagent compositions incorporating chlorophosphonazo III and a chelating agent and methods utilizing such compositions for the determination of magnesium and magnesium concurrently with calcium in an analytical sample as well as diagnostic test kits for such determinations. | ||||||
| 405 | Cation-sensing composite structure and compounds for use therein | US140257 | 1993-10-21 | US5474743A | 1995-12-12 | John E. Trend; Cary A. Kipke; Mitchell A. Rossman; Masao Yafuso; Sanjay L. Patil |
| A fluorescent ionophoric compound comprises a cryptand portion and a coumarin portion substituted at the 3-position with an electron withdrawing or polarizable group. The compound, which exhibits good photostability, can be incorporated into cation-sensing composite structures useful in biological and environmental testing, which can be used with conventional glass optics, by means of convenient points of covalent attachment. | ||||||
| 406 | Luminescence-optical indicator for determining the activity of alkali metal ions in a sample solution | US242974 | 1994-05-16 | US5464587A | 1995-11-07 | Max Lippitsch; Sonja Draxler; Marco J. Leiner |
| A luminescence-optical indicator for determining the activity of alkali metals based on decay time includes at least three components that are chemically bound to one another, i.e., a fluorophor, a functional group with which the luminescence decay time of the fluorophor can be influenced, and a ionophor binding the alkali metal ions to be measured in a selective and reversible manner, the effect of the functional group on the decay time of the fluorophor being altered in dependence on the activity of the alkali metal ions. | ||||||
| 407 | Ionized magnesium.sup.2+ concentrations in biological samples | US864646 | 1992-04-07 | US5460972A | 1995-10-24 | Bella T. Altura; Burton M. Altura |
| The present invention provides a method for preparing and storing biological samples prior to measuring ionized Mg.sup.2+ concentrations in order to obtain accurate and reproducible readings. A novel method for accurately reading ionized magnesium ion concentrations in biological samples is provided. A method for monitoring ionized Mg.sup.2+ concentrations and ionized Ca.sup.2+ :Mg.sup.2+ ratios in a patient, useful in diagnosing and prognosing disease states including cardiopulmonary bypass surgery, hypertension, abnormal pregnancy, head trauma, and fetal abnormalities is provided as well as a composition and a method of treating a patient with ionized Mg.sup.2+ or ionized Ca.sup.2+ and Mg.sup.2+. | ||||||
| 408 | Benzazolylcoumarin-based ion indicators for heavy metals | US246847 | 1994-05-20 | US5459276A | 1995-10-17 | Michael A. Kuhn; Richard P. Haugland; Brian M. Hoyland |
| The indicator compounds of the present invention are substituted or unsubstituted 5'-nitro-BAPTA chelators that contain a benzazolyl-coumarin substructure, and the pharmaceutically acceptable non-toxic salts and esters thereof. These compounds are useful for the detection and quantification of polycationic metal ions, particularly Zn.sup.2+, Pb.sup.2+, Ba.sup.2+, Cd.sup.2+, Hg.sup.2+ and La.sup.3+.The compounds of the invention have the structure: ##STR1## where m=2 or 3 and X can be S, O, or C(CH.sub.3).sub.2 ; optionally substituted by substituents that alter the binding affinity of the indicator, shift the spectral properties of the indicator, or act as a reactive site for the preparation of a variety of conjugates. | ||||||
| 409 | pH measurement of body fluid | US295399 | 1994-08-25 | US5425377A | 1995-06-20 | James C. Caillouette |
| The method of measuring pH of vaginal moisture, which includes providing a pH indication, color comparison measurement, and swabbing structure on a carrier stick; manipulating the stick between its opposite ends, to obtain pH indication of vaginal moisture at one end of the stick; visually interpreting that indication to also obtain pH measurement of such moisture near that one end of the stick; again manipulating the stick between its opposite ends, including endwise reversing it, to swab the vaginal cavity in the area from which pH indication was obtained; and disposing of the stick, whereby disposition of the pH indication, measurement and swabbing structure is thereby obtained in one disposal step. | ||||||
| 410 | Method for extracting elements such as lead in blood | US72598 | 1993-06-03 | US5407831A | 1995-04-18 | Jung Jing |
| A simple and sensitive method for extracting an inorganic element, including toxic metals such as lead or antimony or non-metallic elements such as arsenic, selenium or tellurium from animal blood, including human blood, is provided by the present invention. The sample of blood or portion of blood, such as red cells, is first mixed with an neutral salt solution. The mixture of cells and buffer is then exposed to a chelating resin which removes the inorganic element, such as lead, from solution. Thereafter, the resin is packed in a column and the element, such as lead, is eluted. The amount of eluted element, such as lead, is measured by conventional methods, such as atomic absorption spectrophotometry. | ||||||
| 411 | Fluorescent ion-selective diaryldiaza crown ether conjugates | US38918 | 1993-03-29 | US5405975A | 1995-04-11 | Michael A. Kuhn; Richard P. Haugland |
| This invention describes novel sensors for ions that are based on the combination of xanthylium-based dyes with metal-binding N,N'-diaryldiaza crown ethers. These sensors are primarily useful for detection and quantitation of alkali-metal ions in aqueous solution. Binding of the ion results in a change in the fluorescence properties of the indicating dye that can be correlated with the ion concentration. Methods are provided for attaching reactive groups on these sensors for conjugation to dyes, lipids and polymers and for enhancing entry of the indicators into living cells. | ||||||
| 412 | Device for quantitatively determining the concentration of metals in body fluids | US268280 | 1994-06-30 | US5405582A | 1995-04-11 | Yutaka Hayashibe; Minoru Takeya; Yasumasa Sayama |
| This invention provides a measuring method and a device suitable for the quantitative analysis of metal elements contained in body fluids comprising:using the flow injection method for reacting a sample with a reagent in a tubule and analyzing the reacted solution. In essence, the present invention provides;a method for introducing the protein liberated by the reaction of body fluid sample and protein-release reagent into a separating membrane for preventing the passage of protein to separate and remove the liberated protein, and then introducing the reacted solution into a quantitative analysis means for determining and measuring the concentration of target metal contained in the body fluid; anda quantitative analysis device for performing the foregoing method. | ||||||
| 413 | Determination of sodium ions in fluids | US907736 | 1992-06-22 | US5384247A | 1995-01-24 | Michael N. Berry; Michael-Harold Town; Georg-Burkhard Kresse; Uwe Hermann |
| A process and a reagent for the determination of ions in fluids, wherein the influence of these ions on the activity of an enzyme is measured. The ions for example are sodium, potassium, calcium, magnesium, manganese, lithium, lead, zinc, copper, iron or other heavy metals or non-metallic ions comprising chloride, bicarbonate, protons, ammonium and substances that give rise to ammonium. The enzymes which are used may be a transferase, a hydrolase, an oxidoreductase or a lyase. An essential feature is a method to exclude interferences by ions by masking the interfering ions with a binding agent. | ||||||
| 414 | Lead assay | US55761 | 1993-05-03 | US5354652A | 1994-10-11 | Ellen K. Silbergeld |
| Lead assays using .delta. aminolevulinic acid dehydratase are disclosed. | ||||||
| 415 | Method, device, and composition for the assay of ions | US919250 | 1992-07-27 | US5300439A | 1994-04-05 | Steven C. Charlton |
| A test device and method of determining the presence or concentration of a predetermined ion, such as a cation of medical interest, like sodium, potassium, calcium, magnesium or lithium, in an aqueous test sample are disclosed. The test device includes a test pad comprising a hydrophilic indicator reagent composition capable of interacting with a predetermined ion, or electrolyte, to produce a detectable or measurable response. The hydrophilic indicator reagent composition consists essentially of a hydrophobic ion specific ionophore, a hydrophobic reporter substance, and a stabilizer polymer such as gelatin. The hydrophilic indicator reagent composition, either as a film or layer, or after incorporation into a suitable carrier matrix, provides a test pad of sufficient sensitivity to the predetermined ion to achieve an accurate and trustworthy electrolyte assay of an aqueous test sample, such as plasma or serum, by a dry phase test strip assay. | ||||||
| 416 | Test swab to detect a substance on a surface and method of making and using same | US15827 | 1993-02-10 | US5278075A | 1994-01-11 | Marcia J. Stone |
| A swab is impregnated with a test reagent such that a test for a specific substance can be effected by rubbing the impregnated swab over the surface to be tested and then viewing the swab for a reagent reaction. A method for testing for a substance includes impregnating a swab with a reagent, and rubbing the swab over a surface suspected of containing the substance. If the substance is present in the surface, a reaction with the substance produces an easily detectable color on the swab tip. | ||||||
| 417 | Colorimetric methods and reagents for the assay of calcium in a test sample | US842860 | 1992-02-27 | US5262330A | 1993-11-16 | Eddy Chapoteau; Bronislaw P. Czech; Wolodymyr I. Zazulak |
| A chromogenic compound found to be especially selective in the determination of calcium in blood of the general formula (I): ##STR1## where: R is hydrogen or lower alkyl;X is CH.sub.2, CH.sub.2 CH.sub.2, CH.dbd.CH, O, S, SO.sub.2, S--S, or NR;X is CH, C--OH or N;M is p-nitrophenylazo, 2,4-dinitrophenylazo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinoneimino, bis-(4-dimethylaminophenyl) hydroxymethyl, 3-phenylisothiazolyl-5-azo, thiazolyl-5-azo, or isothiazolyl-5-azo;k is 1;l is 0 or 1; andn is 0 or 1. | ||||||
| 418 | Method of stabilizing a carbon dioxide sensor | US888550 | 1992-05-22 | US5246859A | 1993-09-21 | Alan Nelson; Henry K. Hui; Monte Bennett; Soonkap Hahn; Charles S. Bankert; Jeffrey T. Jackson |
| The method of stabilizing a carbon dioxide sensor involves formulation of a bicarbonate buffer solution in the sensor with a bicarbonate ion concentration of from about 100 mM to about 200 mM bicarbonate. The method also involves treatment of the sensor to reduce the instability that may occur in carbon dioxide sensors when such sensors are exposed to either very low or very high carbon dioxide levels for extended periods of time. The sensor is treated by exposing the sensor to an aqueous solution containing at least 2 weight percent carbon dioxide, for from several days to several months. The solution may be prepared in advance, or may be dynamically infused with carbon dioxide to provide the desired carbon dioxide content. | ||||||
| 419 | Colorimetrically measuring method of zinc | US590552 | 1990-09-26 | US5221626A | 1993-06-22 | Fujio Yamazato; Kuniaki Tokuda |
| A method for the colorimetic determination of zinc including the steps of:a) preparing a coloring reagent for zinc including1) an aqueous soluble 2-pyridylazoaminophenol derivative or a salt of a 2-pyridylazoaminophenol derivative, represented by the following formula (I): ##STR1## wherein 2 ) at least one surface active agent3) a masking agent for a metal,b) adding the coloring reagent solution to a sample solution containing zinc andc) measuring the absorbance of the solution at 555 nm. | ||||||
| 420 | Test carrier for the determination of ions | US698466 | 1991-05-10 | US5211914A | 1993-05-18 | Peter Vogel; Detlef Thym; Michael Fritz; Dan Mosoiu |
| The invention concerns a test carrier for the determination of ions containing a test layer which has a liquid-resistant, organic phase which contains a hydrophobic polymer in a homogeneous mixture with a hydrophobic, organic liquid of low volatility and an ionophore, as well as a substance which changes its colour in the presence of the ion to be determined. The test carrier is characterized in that the test layer contains particles with an oil number of 80-200 and the ionophore is homogeneously dispersed in the hydrophobic, organic phase. | ||||||
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