| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 301 | Method of assaying magnesium in human body fluid | US690420 | 1991-04-24 | US5108905A | 1992-04-28 | Yoshiko Sunahara; Shigeru Takata; Isamu Takagahara |
| Disclosed is a method of assaying the content of Mg ions in a human body fluid such as serum, urine or saliva by the use of a reactant solution containing isocitrate dehydrogenase, NADP.sup.+, isocitrate and an excess amount of a chelating agent. Almost all Mg ions as existing in a human body fluid sample to be examined are bonded with the chelating agent, and the remaining Mg ions react with NADP.sup.+ to form NADPH. Increase of the thus formed NADPH is measured to obtain a standard curve of a straight line, and the content of Mg ions in the same is determined on the basis of the standard curve. If such an excess amount of a Mg-chelating agent is not added to the reactant solution, the intended standard could not be in the form of a straight line but is in the form of a tangent curve. Using the tangent curve, the content of Mg ions in the human body fluid sample cannot be assayed accurately. | ||||||
| 302 | Method for determining manganese level in blood using a porphyrin composition | US468665 | 1990-01-23 | US5106753A | 1992-04-21 | Marvin A. Genshaw; Michael J. Pugia |
| The present invention is directed to a simple and inexpensive liquid or dry reagent assay system for detecting nanomolar amounts of manganese in body fluids in microgram per liter concentrations. More specifically, the manganese assay of this invention is directed to the optical detection of a chromogenic reaction, such as the oxidation of a redox indicator, catalyzed by a manganese porphyrin complex. | ||||||
| 303 | Test device for detection of molybdate, vanadate and ferric ions | US707793 | 1991-05-30 | US5106581A | 1992-04-21 | Ivars Jaunakais; James K. Jaunakais |
| Improved method and device for detection and semi-quantitative colorimetric determination of molybdate, ferric, and vanadate ions in aqueous solutions and coolant systems containing ethylene glycol and coolant additive. The disclosed device comprises of test strips of absorbent support carrier or water resistant film impregnated uniformly with a hydroxylamine salt and a polyhydroxy organic acid such as gallic acid or its derivatives. Molybdate ions result in an orange/brown colorataion, ferric and vanadate ions result in a grey-blue/black coloration with color intensity directly proportional to concentration of ions. | ||||||
| 304 | Method of detecting cations using a tetra substituted cyclohexane | US562463 | 1990-08-03 | US5096832A | 1992-03-17 | Morton Raban; David T. Durocher |
| Disclosed is a tetra substituted cyclohexane having an ionophore in the one and two positions wherein the ionophore may be the same or different and is selected from the group consisting of a crown, a podand and a cryptand wherein the ionophore is capable of complexing with a metal or ammonium cation. Positions four and five are substituted by an electron donor group and an electron acceptor group. Also disclosed is a method for detecting the concentration of cations in a fluid by subjecting the fluid to the tetra substituted cyclohexane composition which will thereby complex the cation in the fluid. The cations are preferably alkali metal and alkaline earth metal cations. The fluid may be an aqueous or non-aqueous fluid or body fluids. | ||||||
| 305 | Reagents for determining cations | US699188 | 1991-05-13 | US5096831A | 1992-03-17 | Eddy Chapoteau; Bronislaw P. Czech; Carl R. Gebauer; Koon-Wah Leong; Anand Kumar |
| The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and ##STR2## wherein X is CH, N or COH; andY includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2. | ||||||
| 306 | Assay for lithium using tetra-substituted aryl cyclic formazan dyes | US394037 | 1989-08-14 | US5051367A | 1991-09-24 | Mary H. Delton; Shari L. Eiff |
| Tetra-substituted aryl cyclic formazan dyes are useful in assaying for lithium. The dyes have the structure: ##STR1## in which X represents CN or NO.sub.2 ;Y represents CH.sub.2 CH.sub.2, CH.sub.2 CH.sub.2 CH.sub.2 or CH.sub.2 CH.sub.2 --O--CH.sub.2 CH.sub.2 ; andR.sub.1, R.sub.2, R.sub.3 and R.sub.4 each independently represent butyl, halogen, alkoxy or NO.sub.2. | ||||||
| 307 | Method of determining the amount of the substances or ions contained in an ionic solution or a non-deionized solution and a one-sidebarrier-covered crystal oscillator used therefor | US404513 | 1989-09-08 | US5049808A | 1991-09-17 | Yoshio Okahata |
| A method of determining the amount of the substances or ions contained in an ionic solution or a non-deionized solution by measuring the frequency of a one side barrier-covered crystal oscillator comprising a crystal oscillator, a barrier to cover over one of the electrodes of the crystal oscillator through a predetermined insulative space so as to prevent the ionic solution or the non-deionized solution from permeating therethrough and an adsorption film cast on the other electrode of the crystal oscillator, in situ in the state that the one side barrier-covered crystal oscillator is dipped in the ionic solution or the non-deionized solution, and the one side barrier-covered crystal oscillator used therefor. | ||||||
| 308 | Reagent for determining cations | US201576 | 1988-06-01 | US5045475A | 1991-09-03 | Eddy Chapoteau; Bronislaw P. Czech; Carl R. Gebauer; Koon-Wah Leong; Anand Kumar |
| The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and--Q-- is ##STR2## wherein X and CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2. | ||||||
| 309 | Determination of the acid-base status of blood | US882638 | 1986-07-07 | US5041387A | 1991-08-20 | Rolf Zander; Hans U. Wolf |
| In order to simplify the operation for determination of the acid-base status of blood, composed of the values for pH, pCO.sub.2 and the base excess BE, the base excess BE is determined through measurement of the pH-value at a pCO.sub.2 of about 0 mn Hg. The pH-values may be determined photometrically, in which case the indicator solution for measuring the actual blood-pH is an aqueous solution of 40 micromol/l bromthymol blue plus 0.2 g/l sodium dodecylsulfate plus 1% ethanol; and for measurement of the base excess BE is an aqueous solution of 65 micro mol/l naphtholphthalein plus 0.2 g/l sodium dodecylsulfate plus 15% dimethylsulfoxide, which are measured at a wavelength of 635 nm. If desired, one may use a single solution for measuring both actual blood-pH as well as the base excess BE, composed of 16 micromol/l bromthymol blue plus 34 micromol/l naphtholphthalein plus 0.15 g/l sodium dodecylsulfate, which is measured at 615 nm wavelength. | ||||||
| 310 | Adducts of an anion of an oxa acid and a keto compound, process for the preparation of said adducts, and process for the determination of the concentration of the anions of oxa acids using said keto compounds | US166868 | 1988-03-11 | US5037968A | 1991-08-06 | Wilhelm Simon; Erno Pretsch |
| Keto compounds in which to the carbon atom in the neighboring position to the keto compounds there is bonded at least one strongly electron attracting substituent and/or in which there is conjugating with the carbon-oxygen-double bond of the keto group a .pi.-electron system have the ability of interacting selectively with the anions of oxa acids yielding adducts, chelates or complexes.Provided that in the corresponding keto compounds the keto group is a part of a chromophore, then the shifting of the absorption in the visible range or the ultraviolet range of the wave lengths is observed, compared with the corresponding absorption of the free keto compound.The corresponding keto compounds are used for the determination of the anions of the oxa acids and they e.g. can be the ion sensitive component of a corresponding ions sensitive part for the determination of said anions. Several of said keto compounds can be also used as color indicator for the anions of the oxa acids. | ||||||
| 311 | Blood gas/electrolytes calibrator and methods of making and using the same | US559547 | 1990-07-18 | US5023186A | 1991-06-11 | Kathryn D. Herring |
| Aqueous solutions containing buffers and electrolytes are adjusted to levels required for calibration of both blood gas analyzers and ion selective electrolyte analyzers. A control material, composed of similar matrix, is adjusted to three levels of blood gas and electrolyte conditions. These quality control materials are used to monitor blood gas/electrolyte laboratory instrumentation. | ||||||
| 312 | Fluorescent polymers | US829350 | 1986-02-13 | US5019350A | 1991-05-28 | David Rhum; Richard S. Matthews |
| A sensor for the determination of the concentration of a dissolved substance in an aqueous medium comprising an optical fiber having on the distal end thereof an adherent, water-insoluble organic polymer having a plurality of fluorescent organic substituents, which may be the same or different, covalently bonded to said polymer through ester or amide linkages. | ||||||
| 313 | Control for blood gas/calcium analysis instrumentation | US553989 | 1990-07-16 | US5013666A | 1991-05-07 | Ching Chiang |
| A liquid control standard for the use in the quality assurance of blood analysis instrumentation systems is disclosed. The liquid control standard is able to act as a control standard for blood gas instrumentation systems measuring pH, pCO.sub.2 and pO.sub.2 of blood, as a liquid control standard for ion selective electrode instrumentation systems for the measuring of electrolytes such as ionized calcium and total calcium as well as Na, K and Li ions in the blood and, optionally, as a control standard for a co-oximeter measuring the amount of total hemoglobin present in the blood and the relative amounts of other hemoglobin fractions present in the blood. | ||||||
| 314 | Chromogenic cryptahemispherands and their preparation | US349465 | 1989-05-09 | US5011924A | 1991-04-30 | Donald J. Cram; Eddy Chapoteau; Bronislaw P. Czech; Carl R. Gebauer; Roger C. Helgeson; Anand Kumar; Koon-Wah Leong |
| The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic cryptahemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;a, b, m and n, same or different, are 1 to about 3; and x, y, same or different, are 1 to about 4.A test device utilizing one or more of the compounds for performing such measurements is also disclosed. | ||||||
| 315 | Terpolymer composition with bound indicator dye for fiber optic probe | US314561 | 1989-02-23 | US4906249A | 1990-03-06 | Eric Fogt; Linda Cahalan; Cheryl Feia; Jeff Schweitzer; Pat Cahalan |
| An improved pH probe based on fiber optics and a unique cross-linked terpolymer of methacrylamidopropyl-trimethyl ammonium chloride, sodium acrylamidopropane sulfonate, and acrylamide, the terpolymer having bound thereto an indicator dye. | ||||||
| 316 | Tetra-substituted aryl cyclic formazan dyes | US145341 | 1988-01-19 | US4892937A | 1990-01-09 | Mary H. Delton; Shari L. Eiff |
| Novel tetra-substituted aryl cyclic formazan dyes are useful in assaying for Li.sup.+. | ||||||
| 317 | Agent and process for the determination of calcium | US855254 | 1986-04-24 | US4871678A | 1989-10-03 | Hans P. Wahl; Uwe Wurzburg |
| An agent and process are used for the determination of calcium in liquids. The agent contains essentially orthocresolphthalein complexone, an acid and a zwitterionic buffer and is characterized in that the buffer contains at least one sulphonic acid amine of the general formula ##STR1## wherein R.sub.1 and R.sub.2 are identical or different and denote H or alkyl, hydroxyalkyl or cycloalkyl having in each case up to 8 C atoms andR.sub.3 denotes alkyl or hydroxyalkyl having up to 8 C atoms. | ||||||
| 318 | Chromogenic reactive for determining the iron content and the iron-binding capacity of biological liquids | US947133 | 1986-12-29 | US4810656A | 1989-03-07 | Giorgio Torelli |
| The present invention relates to a chromogenic reagent for determining the iron content and the iron-binding capacity of serum, comprising chromazurol B, a buffer for keeping the pH at 4.5-5, a surface-active substance in a concentration of at least 500 mg/l, a salt suitable for imparting an ionic strength expressed in terms of NaCl concentration of at least 100 g/l and an aminoacid suitable for selectively binding the Cu.sup.2+ ions, in a concentration expressed in terms of glycine concentration ranging between 1 and 40 g/l. | ||||||
| 319 | Calcium complexing dyes and their use in analytical compositions, elements and methods | US37303 | 1987-04-10 | US4795712A | 1989-01-03 | John L. Toner; Bruce J. Murray; Bruce E. Babb; Michael W. Sundberg |
| Novel chromogenic derivatives of 1,2-bis-(o-aminoaryloxy)ethane-N,N,N',N'-tetraacetic acid are useful for the determination of calcium ions in both solution and dry assays. These compounds comprise a dye moiety which is directly conjugated to the acetic acid substituted-nitrogen atom and which enables the compounds to exhibit maximum absorbance at a wavelength generally greater than 400 nm before complexation. When the compounds are complexed with calcium ions, the absorbance shifts to a shorter wavelength. | ||||||
| 320 | Method for measuring calcium | US796194 | 1985-11-08 | US4724216A | 1988-02-09 | Chung C. Young; Linda M. Mulholland |
| A releasing reagent for releasing, as ionized calcium, protein-bound calcium in a biological sample for measurement of the ionized calcium, together with any ionized calcium originally present in the sample, using a calcium ion specific electrode, the releasing reagent including monochlorocoacetate salt, formate salt, and formic acid, in concentrations sufficient to render the pH of the sample, when mixed with the reagent, in the range of 4.0 to 5.5. Also disclosed is a method of measuring calcium in a liquid sample using such a releasing reagent. | ||||||
QQ群二维码
意见反馈
意见反馈