| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 261 | Method for detecting total ketone bodies in urine | US616479 | 1996-03-19 | US5801059A | 1998-09-01 | Jack V. Smith; Jesse M. Carter |
| Aliquot of a urine sample is placed in a first automated analyzer sampling cup and a known standard is placed in a second cup. The urine sample and standard are transferred to separate cuvettes and at least one reagent composition in an aqueous medium is injected into the cuvette. The reagent composition contains a compound to remove substances in the urine interfering with a calorimetric reaction, a compound to convert B-hydroxybutyric acid in the urine to acetoacetic acid in the presence of nicotinamide adenine dinucleotide and reading at a specified wavelength to determine quantitatively the total ketone bodies in the patient's urine. | ||||||
| 262 | Feline urinary tract disease-detecting paper cat litter and method | US444956 | 1995-05-19 | US5780385A | 1998-07-14 | Carl V. Santioemmo; James P. Humphries |
| A cat litter which comprises a plurality of lightweight, resilient paper strips treated with a pH-indicator and/or an occult blood indicator and folded transversely into generally zig-zag shapes, enables early detection of feline urological syndrome. When wetted with alkaline urine secreted by the cat, the paper strips treated with pH indicator exhibit a noticeable color change. When wetted with cat urine containing occult or gross blood, the paper strips treated with occult blood indicator exhibit a noticeable color change. A mixture of pH indicator treated strips and occult blood indicator strips in the cat litter enables the detection of both alkaline pH and occult blood in the same urine sample. The color changes are easily visible to the observer without requiring unsanitary contact with the cat litter. | ||||||
| 263 | Method and reagent for the determination of iron | US680255 | 1996-07-11 | US5763281A | 1998-06-09 | Ralph Weisheit; Renate Luz |
| In order to determine iron in serum by releasing the bound iron through addition of a protein denaturing agent, reduction of the released iron to Fe.sup.2+, addition of a color reagent solution and photometric measurement of the color complex that forms, a mixture of a denaturing agent containing urea or a urea derivative and a fatty alcohol polyglycol ether are added to the sample solution. | ||||||
| 264 | Estrogen or estradiol need determination by vaginal acidity determination | US699251 | 1996-08-19 | US5735801A | 1998-04-07 | James C. Caillouette |
| In the method of determining need for human estrogen replacement therapy or estrogen or estradiol dose change, the steps include determining local acidity proximate a moist wall surface of the vagina, as differing from desired threshold level (pH 4.5), and administering sufficient estrogen or estradiol to result in change in acidity toward such level. | ||||||
| 265 | Calcium receptor-active molecules | US485588 | 1995-06-07 | US5688938A | 1997-11-18 | Edward M. Brown; Forrest H. Fuller; Steven C. Hebert; James E. Garrett, Jr. |
| The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies. | ||||||
| 266 | Metal ion-ligand coordination complexes, antibodies directed thereto, and assays using such antibodies | US436068 | 1995-05-05 | US5681960A | 1997-10-28 | David K. Johnson |
| The present invention relates to the field of immunoassays for metal ions. The invention presents: metal ion-ligand coordination complexes ("MLC"), novel ligands, antibodies specific for MLC, immunoassays utilizing the foregoing, and methods for selecting said antibodies. | ||||||
| 267 | Metal ion-ligand coordination complexes, antibodies directed thereto, and assays using such antibodies | US435680 | 1995-05-05 | US5670627A | 1997-09-23 | David K. Johnson |
| The present invention relates to the field of immunoassays for metal ions. The invention presents: metal ion-ligand coordination complexes ("MLC"), novel ligands, antibodies specific for MLC, immunoassays utilizing the foregoing, and methods for selecting said antibodies. | ||||||
| 268 | Method and apparatus for making an improved resilient packing product | US459347 | 1995-06-02 | US5656008A | 1997-08-12 | Edwin P. Beierlorzer |
| The present invention relates of a method and apparatus for making an improved resilient packing material by forming, resiliently folding and crimping shredded strips of moistened paper material into an improved interlocking, bulk, packaging material. The method and apparatus includes a wetting or dampening system which can be selectively varied to regulate the moisture content of moistened paper material. | ||||||
| 269 | Monoclonal antibodies specific for metallic cations and method therefor | US266163 | 1994-06-27 | US5639624A | 1997-06-17 | Fred W. Wagner; Dwane E. Wylie; Sheldon M. Schuster |
| The invention is directed to monoclonal antibodies, their fragments, single chains and polypeptide mimics of their hypervariable regions which immunoreact with bare small moieties such as metallic cations the hybridomas for production of the monoclonal antibodies, immunogen compounds for developing the hybridomas, and methods for use of the monoclonal antibodies. | ||||||
| 270 | Veterinary diagnostic test | US642409 | 1996-05-03 | US5629211A | 1997-05-13 | Kazuhiro Tsutsumi |
| A composite reagent, for a veterinary diagnostic test, which contains a color reagent substance to produce a color by reacting with either one or both of magnesium (Mg) ions and calcium (Ca) ions, a polyoxyethylene alkylphenyl ether, and a masking agent for interfering metal ions in a urine of an animal other than the Mg ions and the Ca ions. | ||||||
| 271 | Method for optically measuring chemical analytes | US102806 | 1993-08-06 | US5624847A | 1997-04-29 | Joseph R. Lakowicz; Henryk Szmacinski |
| A system and method in which a photoluminescent ligand is added to a sample to be analyzed in the form of a photoluminescent probe having intrinsic analyte-induced lifetime changes. The method preferably employs phase-modulation fluorometry to measure the lifetime changes. Specific probes are disclosed for measuring various analytes, particularly ionic solutes, including H.sup.+, Ca.sup.2+ and K.sup.+. | ||||||
| 272 | Monoclonal antibody assay and kit for detecting metal cations in body fluids | US469489 | 1995-06-06 | US5620856A | 1997-04-15 | Randall R. Carlson; Jay S. Stout; Dwane E. Wylie; Fred W. Wagner; Malcolm Riddell |
| The invention provides method and kits for detecting a metallic cation in a sample of a body fluid. The preferred method and kits include the use of at least two different types of antibodies having different specificities. In the preferred method, the sample of body fluid can be contacted with an effective amount of a capture antibody specific for a naturally occurring polypeptide that can bind the metallic cation to form a first antigen-antibody complex. An effective amount of an antibody specific for an epitope on a metallic cation-naturally occurring polypeptide complex or an antibody specific for a metallic cation is added to the first antigen-antibody complex to form a second antigen-antibody complex. The amount of the metallic cation in the sample of body fluid is determined by detecting the amount of the second antigen-antibody complex. | ||||||
| 273 | Lead detection method and reggents utilizing aminolevulinic acid dehydratase and tertiary phosphines | US419845 | 1995-04-11 | US5552297A | 1996-09-03 | Martin Wong; John M. Ramp; John M. Brackett |
| A method and kit for simplifying and improving the sensitivity and accuracy of a lead assay for a sample solution suspected of containing lead determines the extent of a reaction between a substrate and a disulfide enzyme in the presence of an activating reagent which contains a water-soluble tertiary phosphine reagent so as to increase the activity of the disulfide enzyme for reaction with the substrate. For a colorimetric determination of the enzyme activity a chromophore is formed upon reaction with a selected component of the sample solution in the presence of a colorimetric enhancing reagent. The colorimetric enhancing reagent contains a metal ion such as cupric ion or ferric ion which is soluble in the sample solution. The extent of the chromophore formation is then photometrically determined. | ||||||
| 274 | Method of making a blood gas/electrolyte control | US403092 | 1995-03-13 | US5518929A | 1996-05-21 | Kathryn D. Herring |
| Aqueous solutions containing buffers and electrolytes are adjusted to levels required for calibration of both blood gas analyzers and ion selective electrolyte analyzers. A control material, composed of similar matrix, is adjusted to three levels of blood gas and electrolyte conditions. These quality control materials are used to monitor blood gas/electrolyte laboratory instrumentation. | ||||||
| 275 | Certain pyridyl and isoquinolyl carbinolamine derivatives | US176360 | 1993-12-30 | US5476939A | 1995-12-19 | David K. Johnson |
| The present invention relates to the field of immunoassays for metal ions. The invention presents: metal ion-ligand coordination complexes ("MLC"), novel ligands, antibodies specific for MLC, immunoassays utiliizing the foregoing, and methods for selecting said antibodies. | ||||||
| 276 | Enzyme amplified, complex linked, competitive and non-competitive assays for the detection of metal ions | US156567 | 1993-11-22 | US5459040A | 1995-10-17 | Bruce D. Hammock; Ferenc Szurdoki; Horacio Kido |
| Methods of assaying for the presence or amount of a metal ion in a sample suspected of containing such ions. In one aspect, an enzyme amplified sandwich assay is provided which relies upon the ability of the analyte (metal ion) to form a complex with two complexing agents (chelators). In this assay, the first sandwich chelator is immobilized on a solid support, while the second sandwich chelator is linked to a reporter group (e.g., an enzyme). This assay combines the specific recognition of the analyte by the first and second sandwich chelators with the great signal amplification offered by the reporter group (e.g., enzyme). In another aspect, a competitive assay is provided that relies on the competitive inhibition of complex formation between the coating ligand (i.e., the chelator attached to the solid support) and the organometallic compound attached to the reporter group (e.g., enzyme) by the metal ions of interest present in the sample.Using the methods of the present invention, hazardous metals, environmental pollutants, and other biomolecules can be selectively detected at ppb/ppt concentrations. More particularly, using the methods of the present invention, highly toxic metals (mercury, lead, cadmium, etc.) that pose serious human and environmental health hazards can be selectively detected at ppb/ppt concentrations. The methods of the present invention are particularly useful because they do not require the use of high affinity, highly specific antibodies which are expensive and difficult to produce. | ||||||
| 277 | Process for testing for substances in liquids | US105842 | 1993-08-13 | US5416028A | 1995-05-16 | Marcia J. Stone |
| A method for detecting a substance in a liquid sample involving precipitating a substance from the liquid sample and filtering it from the liquid sample. The precipitate is then contacted by an oxidizing agent and tested for the substance of interest by contacting the precipitate with a dye that forms a visible reaction when exposed to the substance. | ||||||
| 278 | Determination of ions in fluids | US907735 | 1992-06-22 | US5409814A | 1995-04-25 | Michael N. Berry; Michael-Harold Town; Georg-Burkhard Kresse; Uwe Herrmann |
| A process and a reagent for the determination of ions in fluids, wherein the influence of these ions on the activity of an enzyme is measured. The ions for example are sodium, potassium, calcium, magnesium, manganese, lithium, lead, zinc, copper, iron or other heavy metals or non-metallic ions comprising chloride, bicarbonate, protons, ammonium and substances that give rise to ammonium. The enzymes which are used may be a transferase, a hydrolase, an oxidoreductase or a lyase. An essential feature is a method to exclude interferences by ions by masking the interfering ions with a binding agent. | ||||||
| 279 | Method and device for quantitatively determining the concentration of metals in body fluids | US268292 | 1994-06-30 | US5407832A | 1995-04-18 | Yutaka Hayashibe; Minoru Takeya; Yasumasa Sayama |
| This invention provides a measuring method and a device suitable for the quantitative analysis of metal elements contained in body fluids comprising:using the flow injection method for reacting a sample with a reagent in a tubule and analyzing the reacted solution. In essence, the present invention provides;a method for introducing a body fluid sample and a protein release reagent into a carrier solution, reacting the two solutions with one another in the tubule in order to liberate the protein contained in the body fluid sample, followed by introducing the reacted solution into a quantitative analysis means for determining and measuring the concentration of target metal(s) contained in the body fluid; anda quantitative analysis device for performing the foregoing method. | ||||||
| 280 | Sensor with improved drift stability | US160687 | 1993-11-30 | US5403746A | 1995-04-04 | James G. Bentsen; Kenneth B. Wood |
| The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO.sub.2 or ammonia) in a medium such as blood which has improved drift stability. In a preferred embodiment, the sensors of the present invention comprise microcompartments of an aqueous phase having a pH sensitive sensing component within a hydrophobic barrier phase. The sensors of the present invention are substantially free of partitioning species other than the analyte of interest which can migrate from one phase to the other in response to a change in pH in the aqueous phase and which substantially affect the concentration dependent signal. In an alternative embodiment, the sensors of the present invention are constructed so as to retard the migration of partitioning species, thus reducing the initial rate of drift. | ||||||
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