子分类：
- G01N2496/05： .包含血细胞或血浆
- G01N2496/10： .包含颗粒以模拟血细胞
- G01N2496/15： .包含染料以模拟光吸收,例如血红素
- G01N2496/25： .包含添加聚合物以稳定生物物质以防止降解或保持粘度或密度,例如明胶,聚丙烯酰胺,聚乙烯醇(酪蛋白 G01N 2333/4731,白蛋白 G01N2333/76,多糖 G01N 2400/10)
- G01N2496/45： .包含蛋白酶抑制剂,例如磺酰氟,氯甲基酮,有机磷农药(基于肽的蛋白酶抑制剂 G01N 2333/81)
- G01N2496/70： .包含溶解氧、碳酸氢盐及类似物的血液气体控制溶液
- G01N2496/80： .包含胆甾醇、葡萄糖及类似物的多分析物参考溶液
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | Lyophilized dabigatran | JP2011546830 | 2010-01-27 | JP2012516993A | 2012-07-26 | ヨアヒム スタンジエール |
| The invention relates to a lyophilised form of dabigatran of formula (I) its use as a calibrator in the assays for the determination of pharmacodinamic effects of dabigatran etexilate as well as such assays per se. In the preparation of the lyophilised standards, dabigatran is dissolved in an aqueous acidic solution before freeze-drying. | ||||||
| 62 | Detection of autoantibody reactive with pancreatic islet cell antigenic molecule and/or insulin | JP2009153633 | 2009-06-29 | JP2009265109A | 2009-11-12 | SMITH BERNARD REES; FURMANIAK JADWIGA; POWELL MICHAEL |
| <P>PROBLEM TO BE SOLVED: To provide a method and a kit useful in detecting autoantibodies reactive with pancreatic islet cell antigenic molecules and/or insulin, for example a method and a kit useful in detecting autoantibodies indicative of the onset or presence of insulin dependent diabetes mellitus (IDDM type 1 diabetes). <P>SOLUTION: A method is provided for screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit is provided for use in such a method. <P>COPYRIGHT: (C)2010,JPO&INPIT | ||||||
| 63 | Cartridge for monitoring function of device for testing blood platelet action, method for function monitoring, and use of test fluid | JP2004370513 | 2004-12-22 | JP2005181339A | 2005-07-07 | DE HAAN JACOB |
| <P>PROBLEM TO BE SOLVED: To provide a cartridge for monitoring the function of a device for testing a blood platelet action, a method for function monitoring, and a method of the use of a test fluid. <P>SOLUTION: The cartridge for monitoring the function of the device for blood platelet diagnosis has a housing 1 which includes a test chamber 3 and a holding chamber 5. A fluid volume 7 of a test fluid 4 is present inside the holding chamber 5. An air cushion 6 is arranged above the fluid volume 7. A measurement cell 8, which has a capillary tube 9, is fitted in the upper part of the test chamber 3. <P>COPYRIGHT: (C)2005,JPO&NCIPI | ||||||
| 64 | Detection of autoantibodies that react to islet cell antigen molecule and or insulin | JP2003549916 | 2002-11-26 | JP2005512056A | 2005-04-28 | スミス，バーナード，リース; パウエル，マイケル; ファーマニアック，ジャドウィガ |
| 膵島細胞抗原分子及びインスリン、或いは一つ以上のその変異体、類似体、誘導体、又は断片から選択された一つ以上の抗原分子に反応する検体の自己抗体に関して、動物被検体から取得した体液試料をスクリーニングする方法と、こうした方法において使用するキット。 | ||||||
| 65 | THYROGLOBULIN QUANTITATION BY MASS SPECTROSCOPY | US15906078 | 2018-02-27 | US20180196062A1 | 2018-07-12 | Yanni Zhang; Nigel J. Clarke; Richard E. Reitz |
| Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample. | ||||||
| 66 | Mass-spectrometric resistance determination by growth measurement | US14892340 | 2014-04-03 | US10011860B2 | 2018-07-03 | Christoph Lange; Katrin Sparbier |
| The invention relates to a mass-spectrometric method to determine microbial resistances to antibiotics, in which the microbes are cultured in a medium comprising an antibiotic, and a mass spectrum of the microbes is acquired after they have been cultured. The method is characterized by the fact that any microbial growth taking place during the culture is mass-spectrometrically determined with the aid of a reference substance, which is added in a dosed amount and is co-measured in the mass spectrum, wherein a growth in microbes indicates the resistance to the antibiotic. | ||||||
| 67 | Method Of Using An Electrochemical Test Sensor | US15903902 | 2018-02-23 | US20180180565A1 | 2018-06-28 | Jing Lin; Fu Hsiung Tsai; Huan-Ping Wu; Nicole D. Ellis; Henry C. Arndt |
| A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt. | ||||||
| 68 | Mass spectrometric assays for peptides | US15056798 | 2016-02-29 | US09970943B2 | 2018-05-15 | N. Leigh Anderson |
| Methods for interpretation of mass spectrometric tests for clinical biomarkers in which the amounts of internal standards are set to equal clinical evaluation thresholds, and preparations for adding stable isotope labeled peptide species to sample digests while minimizing losses and alterations in peptide stoichiometry. | ||||||
| 69 | Calibration method for photometry | US14966804 | 2015-12-11 | US09952234B2 | 2018-04-24 | Martin Horstmann; Fridl Lang |
| A method for determining a physical property of a biological sample. The method comprises the steps of: acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer with a first photometry module; acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer with a second photometry module; determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals; acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module; determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals; acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent; and determining a physical property of the biological sample using the measurement signal and the lot calibration. | ||||||
| 70 | Thyroglobulin quantitation by mass spectroscopy | US15443805 | 2017-02-27 | US09915663B2 | 2018-03-13 | Yanni Zhang; Nigel J. Clarke; Richard E. Reitz |
| Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample. | ||||||
| 71 | Customized quality controls for analytical assays | US15296901 | 2016-10-18 | US09909959B2 | 2018-03-06 | Alireza Ebrahim; Christopher Spates; Karl De Vore |
| Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay. | ||||||
| 72 | Method for Assessing Protein Identity and Stability | US15783883 | 2017-10-13 | US20180031570A1 | 2018-02-01 | John Brian Mumm; Peter Van Vlasselaer |
| The present invention relates to methods and other technologies that may be used to determine whether compositions (e.g., pharmaceutical compositions) comprising interleukin-10 molecules (e.g., pegylated interleukin-10) meet particular product-related specifications prior to being administered to a subject for the treatment and/or prevention of the diseases, disorders and conditions, and/or the symptoms thereof, described herein. | ||||||
| 73 | REAGENTS FOR POTENTIOMETRIC MAGNESIUM ION SELECTIVE ELECTRODE SENSORS AND METHODS OF PRODUCTION AND USE THEREOF | US15317688 | 2015-06-08 | US20170122901A1 | 2017-05-04 | Wei Zhang; Kevin Horan |
| Reagents are disclosed for use with potentiometric magnesium ion selective electrodes, along with kits containing same as well as methods of use thereof. Before explaining at least one embodiment of the inventive concept(s) in detail by way of exemplary drawings, experimentation, results, and laboratory procedures, it is to be understood that the inventive concept(s) is not limited in its application to the details of construction and the arrangement of the components set forth in the following description or illustrated in the drawings, experimentation and/or results. | ||||||
| 74 | IMMUNOASSAY STANDARDS AND MEASUREMENT OF CLINICAL BIOMARKERS USING INTRA-ASSAY CALIBRATION STANDARDS | US15285750 | 2016-10-05 | US20170082641A1 | 2017-03-23 | Paul Rhyne; Claudio Mapelli; Oitak Allen Wong; Flora Berisha; Robert John Neely |
| The present invention provides novel compositions and methods for creating quantitative standards to calibrate analytes. These compositions and methods enable the creation of standards and calibrators for analyzing analytes and measuring clinical biomarkers. Also provided are kits comprising the novel compositions for use in assays, for example sandwich immunoassays. | ||||||
| 75 | Customized quality controls for analytical assays | US14938780 | 2015-11-11 | US09599543B2 | 2017-03-21 | Alireza Ebrahim; Christopher Spates; Karl De Vore |
| Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay. | ||||||
| 76 | ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE | US15287605 | 2016-10-06 | US20170023568A1 | 2017-01-26 | Susan E. Brophy; David J. Hawksworth; Dinesh O. Shah; Robert W. Siegel; Bryan C. Tieman; Bailin Tu; Joan D. Tyner; Robert N. Ziemann |
| The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi. | ||||||
| 77 | FORMALIN-FIXED ISOTOPE-LABELED REFERENCE STANDARDS AND METHODS FOR FABRICATION AND USE THEREOF | US15159969 | 2016-05-20 | US20160334410A1 | 2016-11-17 | Brian M. BALGLEY |
| One or more cells are labeled with minor stable isotopes, characterized, and preserved for subsequent use as a bio-specimen reference standard. The one or more cells are grown in culture media supplied with minor stable isotopes in concentrations substantially different from normally occurring concentrations, thereby supplanting major stable isotopes that would normally be incorporated into the proteins of the cells. The proteins of the cells are thus labeled by the minor stable isotopes and can be used in protcomic characterization of the cells. The cells are preserved by fixation as a reference standard. Cells of the reference standard are mixed with the sample and subject to mass spectrometry evaluation, whereby the labeled proteins of the reference standard can be used in determining the proteome of the sample. | ||||||
| 78 | Anti-T. cruzi antibodies and methods of use | US14686351 | 2015-04-14 | US09482667B2 | 2016-11-01 | Susan E. Brophy; David J. Hawksworth; Dinesh O. Shah; Robert W. Siegel; Bryan C. Tieman; Bailin Tu; Joan D. Tyner; Robert N. Ziemann |
| The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi. | ||||||
| 79 | MASS SPECTROMETRIC ASSAYS FOR PEPTIDES | US15056798 | 2016-02-29 | US20160282361A1 | 2016-09-29 | N. Leigh ANDERSON |
| Methods for interpretation of mass spectrometric tests for clinical biomarkers in which the amounts of internal standards are set to equal clinical evaluation thresholds, and preparations for adding stable isotope labeled peptide species to sample digests while minimizing losses and alterations in peptide stoichiometry. | ||||||
| 80 | CUSTOMIZED QUALITY CONTROLS FOR ANALYTICAL ASSAYS | US14938780 | 2015-11-11 | US20160061694A1 | 2016-03-03 | Alireza Ebrahim; Christopher Spates; Karl De Vore |
| Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay. | ||||||
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