| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 血浆中氨基酸分析用标准液 | CN201280035466.4 | 2012-07-19 | CN103688166B | 2016-12-07 | 早川昌子; 新保和高; 吉田宽郎 |
| 一种血浆中氨基酸分析用外标液，其含有下述(1)和(2)：(1)选自下述A成分的至少1种氨基酸，每种的浓度为0.0007M～0.49M；(2)(i)选自下述B成分的至少1种氨基酸，每种的浓度为选自A成分的氨基酸之中浓度最低的氨基酸的0.2倍～0.9倍；(ii)选自下述C成分的至少1种氨基酸，每种的浓度为选自A成分的氨基酸之中浓度最低的氨基酸的0.1倍～0.4倍；或者(iii)选自下述D成分的至少1种氨基酸，每种的浓度为选自A成分的氨基酸之中浓度最低的氨基酸的0.05倍～0.2倍,A成分：缬氨酸、甘氨酸、丙氨酸和谷氨酰胺；B成分：丝氨酸、脯氨酸、苏氨酸、牛磺酸、亮氨酸、异亮氨酸、赖氨酸、组氨酸、苯丙氨酸和酪氨酸；C成分：天冬酰胺、鸟氨酸、精氨酸和色氨酸；D成分：谷氨酸、蛋氨酸、瓜氨酸和胱氨酸。 | ||||||
| 2 | 用于分析试验的个体化质量对照物 | CN201280052657.1 | 2012-09-07 | CN103890584A | 2014-06-25 | A·艾布拉赫姆; C·斯佩茨; K·德瓦尔 |
| 将合并的各含有选定量分析物的固体珠，以及具有生物流体属性的待测定的液体基本基质一起组成试剂盒，所述试剂盒使实验室技术人员能在使用时从中制备特定分析物的液体对照物，并且优选制备根据特定试验个体化的相同分析物的不同水平的一系列此类对照物。 | ||||||
| 3 | 用于分析试验的个体化质量对照物 | CN201280052657.1 | 2012-09-07 | CN103890584B | 2016-08-17 | A·艾布拉赫姆; C·斯佩茨; K·德瓦尔 |
| 将合并的各含有选定量分析物的固体珠，以及具有生物流体属性的待测定的液体基本基质一起组成试剂盒，所述试剂盒使实验室技术人员能在使用时从中制备特定分析物的液体对照物，并且优选制备根据特定试验个体化的相同分析物的不同水平的一系列此类对照物。 | ||||||
| 4 | 血浆中氨基酸分析用标准液 | CN201280035466.4 | 2012-07-19 | CN103688166A | 2014-03-26 | 早川昌子; 新保和高; 吉田宽郎 |
| 一种血浆中氨基酸分析用外标液，其含有下述(1)和(2)：(1)选自下述A成分的至少1种氨基酸，每种的浓度为0.0007M～0.49M；(2)(i)选自下述B成分的至少1种氨基酸，每种的浓度为选自A成分的氨基酸之中浓度最低的氨基酸的0.2倍～0.9倍；(ii)选自下述C成分的至少1种氨基酸，每种的浓度为选自A成分的氨基酸之中浓度最低的氨基酸的0.1倍～0.4倍；或者(iii)选自下述D成分的至少1种氨基酸，每种的浓度为选自A成分的氨基酸之中浓度最低的氨基酸的0.05倍～0.2倍,A成分：缬氨酸、甘氨酸、丙氨酸和谷氨酰胺；B成分：丝氨酸、脯氨酸、苏氨酸、牛磺酸、亮氨酸、异亮氨酸、赖氨酸、组氨酸、苯丙氨酸和酪氨酸；C成分：天冬酰胺、鸟氨酸、精氨酸和色氨酸；D成分：谷氨酸、蛋氨酸、瓜氨酸和胱氨酸。 | ||||||
| 5 | 血浆中氨基酸分析用内标液、内标物质及血浆中氨基酸的定量方法 | CN201610531124.1 | 2012-07-19 | CN106226527A | 2016-12-14 | 早川昌子; 新保和高; 吉田宽郎 |
| 一种血浆中氨基酸分析用内标液、内标物质及血浆中氨基酸的定量方法。该血浆中氨基酸分析用内标液含有利用1种以上的稳定同位素进行过标记的脯氨酸、甘氨酸、缬氨酸、蛋氨酸、色氨酸、酪氨酸、牛磺酸、异亮氨酸、苯丙氨酸和天冬酰胺，其中牛磺酸的浓度为最高浓度。 | ||||||
| 6 | 参比材料中不稳定分析物的稳定化 | CN201480025820.4 | 2014-05-06 | CN105264384A | 2016-01-20 | A·艾布拉赫姆; K·德瓦尔; C·斯佩茨 |
| 本发明提供了包含稳定分析物和冻干不稳定分析物的试验对照材料，及其制备和使用方法。本发明提供了用于临床实验室的稳定多分析物质量对照材料。本发明所述的多分析物对照材料解决了不稳定对照溶液的问题，并且在使用时可快速并容易地制备，并可满足实验室关于分析物稳定性的质量需求。 | ||||||
| 7 | 用于同时分析能够彼此络合的蛋白质的校准物/对照物 | CN200980101750.5 | 2009-01-07 | CN101918834B | 2014-05-28 | J·W·贝库斯; J·郑; G·巴什里安斯 |
| 本发明公开了组合物和方法，该组合物和方法包括两种或更多种蛋白质，其中蛋白质中的至少一种已被改变以减弱其相互识别和结合。此类组合物在方法和分析中可用作参照物、校准物或对照物，该方法和分析用于测定可能存在于所关注的样品中的蛋白质中的一种或多种的量、或确认该样品中的该蛋白质中的一种或多种的存在。更具体地讲，本发明涉及组合物和方法，该组合物和方法包括改变的胎盘生长因子-1(P1GF-1)和可溶性fms样酪氨酸激酶(sFlt-1)，以及用于测定所关注的样品中的sFlt-1和/或P1GF-1的量或确认所关注的样品中的sFlt-1和/或P1GF-1的存在的方法。 | ||||||
| 8 | 用于同时分析能够彼此络合的蛋白质的校准物/对照物 | CN200980101750.5 | 2009-01-07 | CN101918834A | 2010-12-15 | J·W·贝库斯; J·郑; G·巴什里安斯 |
| 本发明公开了组合物和方法，该组合物和方法包括两种或更多种蛋白质，其中蛋白质中的至少一种已被改变以减弱其相互识别和结合。此类组合物在方法和分析中可用作参照物、校准物或对照物，该方法和分析用于测定可能存在于所关注的样品中的蛋白质中的一种或多种的量、或确认该样品中的该蛋白质中的一种或多种的存在。更具体地讲，本发明涉及组合物和方法，该组合物和方法包括改变的胎盘生长因子-1(P1GF-1)和可溶性fms样酪氨酸激酶(sFlt-1)，以及用于测定所关注的样品中的sFlt-1和/或P1GF-1的量或确认所关注的样品中的sFlt-1和/或P1GF-1的存在的方法。 | ||||||
| 9 | Marker for generating binding information on biomolecules and nucleic acids, preparation method therefor, and method and apparatus for analyzing biomolecule by using same | US15031009 | 2014-05-08 | US10072286B2 | 2018-09-11 | Sung-Chun Kim |
| The present invention relates to a reference substance and a nucleic acid chip for generating binding information on biomolecules and analysis single-stranded nucleic acids in a biosample composed of biomolecules; a method for preparing the same; and a method for analyzing biomolecules using the same, and the reference substance and the nucleic acid chip can be used for analyzing the biological significance of the biomolecules. In addition, the present invention relates to a method for preparing an external reference substance and a biochip for generating the binding information on biomolecules and ligands; and a method for analyzing biomolecules using the same. The external reference substance and the biochip of the present invention can be used in the field of analyzing the biological significance of the biomolecules. | ||||||
| 10 | Stimulus-sensitive microparticles and methods of use | US14429901 | 2013-09-27 | US09988686B2 | 2018-06-05 | William M. Strauss |
| Provided are stimulus-sensitive microparticles and their use, e.g., in tracking the efficiency of recovery of a rare cell population (e.g., circulating tumor cells) from a mixture of cells; and in supplying control nucleic acids to index a molecular assay independent of the rare cell selection steps. | ||||||
| 11 | Customized quality controls for analytical assays | US15296901 | 2016-10-18 | US09909959B2 | 2018-03-06 | Alireza Ebrahim; Christopher Spates; Karl De Vore |
| Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay. | ||||||
| 12 | Customized quality controls for analytical assays | US14938780 | 2015-11-11 | US09599543B2 | 2017-03-21 | Alireza Ebrahim; Christopher Spates; Karl De Vore |
| Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay. | ||||||
| 13 | CUSTOMIZED QUALITY CONTROLS FOR ANALYTICAL ASSAYS | US14938780 | 2015-11-11 | US20160061694A1 | 2016-03-03 | Alireza Ebrahim; Christopher Spates; Karl De Vore |
| Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay. | ||||||
| 14 | CALIBRATION MATERIAL DELIVERY DEVICES AND METHODS | US14557327 | 2014-12-01 | US20150153351A1 | 2015-06-04 | Kelley J. LIPMAN; Michael F. TOMASCO; Peter Uy-Vu LY; Jennifer Yuh-Jen CHEN; Paul D. REYNOLDS; John F. LARKIN; Robin S. GAFFNEY; Kimberly J. TANSEY; Christopher L. STEWART; Raúl ESCUTIA; Robert W. BOWERS |
| A device includes: a first portion configured to be grasped by the hand of the user, and a second portion defining a reservoir containing a control material, wherein the control material contains a target analyte in a known or predetermined concentration. | ||||||
| 15 | Reference, calibrator, or control composition of PIGF-1 and sFlt-1 | US12349695 | 2009-01-07 | US08148157B2 | 2012-04-03 | John W. Backus; Jian Zheng; George Bashirians |
| Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such compositions are useful as reference, calibrators or controls in methods and assays for determining the amount of one or more of the proteins that may be present in a sample of interest or in confirming the presence of one or more of the proteins in the sample. More particularly, it relates to compositions and methods comprising altered placental growth factor-1 (PlGF-1) and soluble fms-like tyrosine kinase (sFlt-1) and methods for determining the amount or confirming the presence of sFlt-1 and/or PlGF-1 in a sample of interest. | ||||||
| 16 | CALIBRATION MATERIAL DELIVERY DEVICES AND METHODS | US12957215 | 2010-11-30 | US20110294152A1 | 2011-12-01 | Kelley J. Lipman; Michael F. Tomasco; Peter Uy-Vu Ly; Jennifer Yuh-Jen Chen; Paul D. Reynolds; John F. Larkin; Robin S. Gaffney; Kimberly J. Tansey; Christopher L. Stewart; Raúl Escutia; Robert W. Bowers |
| A device is described that includes: a first portion configured to be grasped by the hand of the user, and a second portion defining a reservoir containing a control material, wherein the control material contains a target analyte in a known or predetermined concentration. Related arrangements and methods are also described. | ||||||
| 17 | Control solution for photometric analysis | US10387115 | 2003-03-11 | US20040180444A1 | 2004-09-16 | Minna A. Rannikko; Donna M. Murray; Donna M. Rafferty |
| An aqueous control solution is disclosed for use with a spectrophotometer or photometric test strip that includes a predetermined amount of an analyte, a hydrophobic reference dye and a surfactant. In one embodiment, the aqueous control solution is applied to a photometric test strip having a chemical that oxidizes glucose and consequently forms hydrogen peroxide which reacts with an indicator dye that is also present on the strip. In this embodiment, the control solution includes a predetermined amount of glucose, an infrared reference dye, sodium dodecyl sulfate, and the indicator dye, such as sulforhodamine B. | ||||||
| 18 | Multi-analyte reference solutions with stable pO2 in zero headspace containers | US10652398 | 2003-08-29 | US20040047771A1 | 2004-03-11 | Dennis R. Conlon; Minna A. Rannikko; Kevin J. Sullivan; Robert B. Green |
| Multi-analyte reference solutions having a stable partial pressure of oxygen (pO2) in zero headspace packaging and methods for preparing such solutions are disclosed. The solutions have long shelf and use lives when stored at room temperature and are packaged in laminated foil containers having low or no oxygen reactivity. Access devices are also disclosed. | ||||||
| 19 | Reagent cocktail preparation for the rapid production of serum | US08169968 | 1993-12-17 | US06248547B1 | 2001-06-19 | Frank M. LaDuca |
| A cocktail reagent preparation for the rapid production of serum contains thrombin, snake venom, and protamine sulfate. The preparation employs very small quantities of clot promoting substances which behave in a synergistic manner such that rapid clotting of highly heparinized blood is achieved without altering the chemical analysis of the blood enzymes, proteins, sugars, or electrolytes. Thus, clinicians who rely upon the results of such tests can more closely monitor organ and tissue function and adjust patient therapies accordingly. | ||||||
| 20 | Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets | US128066 | 1993-09-28 | US5487971A | 1996-01-30 | Stein Holme; William A. L. Heaton |
| The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes adenine and a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 25.0 grams of dextrose, between about 3.0 grams and about 6.0 grams of sodium citrate, and between about 2.0 grams and about 4.2 grams of sodium bicarbonate. The red cell storage medium is isotonic and has a pH in a range of between about 6.8 and about 7.4. The red cell storage medium is capable of storing and preserving red cells for at least 49 days. | ||||||
QQ群二维码
意见反馈
意见反馈