| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 用于逐一细胞分析的参考对照 | CN200980140599.6 | 2009-07-24 | CN102177437B | 2014-06-04 | 安德烈亚斯·范阿格托万; 法布里斯·马莱格 |
| 一种用于在流式细胞分析仪上逐一细胞分析的参考对照，其包含由被渗透的血细胞制成的细胞类似物和悬浮介质，所述血细胞内含有被聚集的胞内蛋白质和被保留的该胞内蛋白质的抗原位点，具有可渗透抗体的细胞膜。参考对照在被制备后可被冷冻并在使用前解冻。细胞类似物在其内进一步包含荧光标记物。还公开了一种制备参考对照的方法和一种使用参考对照的方法，其作为内部对照或者独立对照用于测定血样中的细胞血红蛋白和细胞血红蛋白变体。 | ||||||
| 2 | 血液学线性对照组合物、体系和使用方法 | CN200780042053.8 | 2007-11-13 | CN101535804B | 2013-04-24 | 内里·奥尔蒂斯; 西奥多·J·盖鲁洛 |
| 一种线性对照体系，其包括一系列线性对照组合物，各个线性对照组合物在悬浮介质中包含白细胞类似物和稳定化红细胞。在该系列对照组合物中，白细胞类似物的浓度从0.2×103个类似物/微升提高到800×103个类似物/微升，并且在至少一个对照组合物中，白细胞类似物的浓度大于120×103个类似物/微升。通过轻轻混合，该稳定化红细胞可促进白细胞类似物在悬浮介质中的单分散。该对照组合物进一步包含血小板类似物，或者另外包含网织红细胞和/或有核红细胞类似物。该线性对照体系允许检验血液分析仪在延伸的浓度范围内对白细胞、红细胞和血小板的可报告的测定范围和测量的线性。 | ||||||
| 3 | 用于逐一细胞分析的参考对照 | CN200980140599.6 | 2009-07-24 | CN102177437A | 2011-09-07 | 安德烈亚斯·范阿格托万; 法布里斯·马莱格 |
| 一种用于在流式细胞分析仪上逐一细胞分析的参考对照，其包含由被渗透的血细胞制成的细胞类似物和悬浮介质，所述血细胞内含有被聚集的胞内蛋白质和被保留的该胞内蛋白质的抗原位点，具有可渗透抗体的细胞膜。参考对照在被制备后可被冷冻并在使用前解冻。细胞类似物在其内进一步包含荧光标记物。还公开了一种制备参考对照的方法和一种使用参考对照的方法，其作为内部对照或者独立对照用于测定血样中的细胞血红蛋白和细胞血红蛋白变体。 | ||||||
| 4 | 血液学线性对照组合物、体系和使用方法 | CN200780042053.8 | 2007-11-13 | CN101535804A | 2009-09-16 | 内里·奥尔蒂斯; 西奥多·J·盖鲁洛 |
| 一种线性对照体系，其包括一系列线性对照组合物，各个线性对照组合物在悬浮介质中包含白细胞类似物和稳定化红细胞。在该系列对照组合物中，白细胞类似物的浓度从0.2×103个类似物/微升提高到800×103个类似物/微升，并且在至少一个对照组合物中，白细胞类似物的浓度大于120×103个类似物/微升。通过轻轻混合，该稳定化红细胞可促进白细胞类似物在悬浮介质中的单分散。该对照组合物进一步包含血小板类似物，或者另外包含网织红细胞和/或有核红细胞类似物。该线性对照体系允许检验血液分析仪在延伸的浓度范围内对白细胞、红细胞和血小板的可报告的测定范围和测量的线性。 | ||||||
| 5 | JPS4940928B1 - | JP1799070 | 1970-03-04 | JPS4940928B1 | 1974-11-06 | |
| 6 | Hematological control of reticulocyte and nucleated red blood cell | JP2004367853 | 2004-12-20 | JP2005233935A | 2005-09-02 | JACOBS DANA B; PRICE PAUL W; ORTIZ NERY; GERULA THEODORE J |
| <P>PROBLEM TO BE SOLVED: To provide a hematological control capable of being mixed without interferences with other components present in a hematological control product or functions of parameters. <P>SOLUTION: The hematological control has biological high molecules adhering to the surfaces of particles mimicking blood. In a flow cytometer or a blood analyzing device, components of a blood sample such as reticulocytes or nucleated red blood cell of a blood cell sample are mimicked. A method for preparing and using the hematological control is provided. <P>COPYRIGHT: (C)2005,JPO&NCIPI | ||||||
| 7 | Hematological control product | JP2004372225 | 2004-12-22 | JP2005128029A | 2005-05-19 | YOUNG CAROLE |
| <P>PROBLEM TO BE SOLVED: To provide a control product to diagnose the cause of a malfunction of an instrument. <P>SOLUTION: The present invention is (a) at least one analogue of leukocyte subsets. The analogue of leukocyte subsets is derived from red blood cells that are processed to have resistance to decomposition caused by resolvents used in a hematological examination method, and curbs response against reagents used to operate instruments. The present invention is also (b) a hematological control product that includes plastic beads. <P>COPYRIGHT: (C)2005,JPO&NCIPI | ||||||
| 8 | REFERENCE CONTROL FOR OPTICAL MEASUREMENT OF NUCLEATED RED BLOOD CELLS OF A BLOOD SAMPLE | EP04785312.2 | 2004-09-30 | EP1668353A1 | 2006-06-14 | LI, Yi; ORTIZ, Nery; YOUNG, Carole, J.; GALVEZ, Santiago |
| Reference control compositions and the method of use are disclosed for measurement of nucleated red blood cells, which includes one set of synthetic spherical particles having a mean particle diameter ranging from 6.2 µm to 6.8 µm and a refractive index from 1.58 to 1.62 monodispersed in an aqueous suspension medium. The synthetic spherical particles have optical properties simulating optical properties of nucleated red blood cells as measured by optical measurements. The reference control composition can further include a second set of the synthetic spherical particles having optical properties simulating optical properties of white blood cells. Further disclosed is a reference control system which includes a series of reference control compositions, each having an amount of one type of synthetic spherical particles which have optical properties simulating the optical properties of nucleated red blood cells having a specific cell maturity. | ||||||
| 9 | Control or calibration solutions for fluid analysis | EP87309618.4 | 1987-10-30 | EP0266216A2 | 1988-05-04 | Terashima, Masaaki, c/o Fuji Photo Film Co.Ltd. |
A control or calibration solution is described, wherein said control or calibration solution is used in fluid-component analysis for determining a particular analyte which is a solid state or a liquid state at ordinary temperature, comprising a water phase, a particular substance being the same or similar to said particular analyte to be analyzed, and a water-insoluble dispersed phase. The solution is useful as a control solution for daily evaluation of the precision of a fluid component (especially blood component) analyzing system, and as a calibrator for making a calibration curve of a particular analyte in fluid (especially whole blood) using a dry chemical analysis element containing at least a porous spreading layer and a reagent layer. |
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| 10 | Reference control for cell by cell analysis | US13800995 | 2013-03-13 | USRE45617E1 | 2015-07-21 | Andreas Van Agthoven; Fabrice Malergue |
| A reference control for cell by cell analysis on flow cytometric analyzers contains cellular analogs made of permeated blood cells containing therein aggregated intracellular proteins and preserved antigenic sites thereof, having cellular membrane permeable to antibodies and a suspension medium. The reference control is frozen after being prepared and thawed prior to use. The cellular analogs further contain a fluorescence marker therein. Further disclosed are a method of making the reference control and a method using the reference control, as an internal or stand-alone control, for measurements of cellular hemoglobin and cellular hemoglobin variant of a blood sample. | ||||||
| 11 | Hematology linearity control composition, system and method of use | US11938853 | 2007-11-13 | US07754487B2 | 2010-07-13 | Nery Ortiz; Theodore J. Gerula |
| A linearity control system includes a series of linearity control compositions, each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositions increases from 0.2×103 to 800×103 analogs per microliter, and the concentration of the white blood cell analogs in at least one control composition is greater than 120×103 analogs per microliter. The stabilized red blood cells facilitate mono-dispersion of the white blood cell analogs in the suspension medium by gently mixing. The control compositions further include platelet analogs, or additionally include reticulocyte and/or nucleated red blood cell analogs. The linearity control system allows the verification of the reportable measurement range and linearity of the measurements of hematology analyzers for white blood cells, red blood cells and platelets in extended concentration ranges. | ||||||
| 12 | Hematology controls for reticulocytes and nucleated red blood cells | US10741390 | 2003-12-19 | US07195919B2 | 2007-03-27 | Dana B. Jacobs; Paul W. Price; Nery Ortiz; Theodore J. Gerula |
| The present invention is drawn to a hematology control made from particles a particle having a biopolymer attached to a surface of the particle. The particle simulates a component of a blood sample, such as a reticulocyte or nucleated red blood cell component of a blood cell sample in a flow cytometer or hematology analysis instrument. The present invention is further drawn to methods of making and using the hematology control. | ||||||
| 13 | Quality control method | US11136889 | 2005-05-25 | US20050221496A1 | 2005-10-06 | Carole Young; Michael Elliott; Nancy Naylor-Schlipp; Timothy Fischer |
| A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pup volume settings; instrument laser alignments; instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods. | ||||||
| 14 | Reference control for optical measurement of nucleated red blood cells of a blood sample | US10955104 | 2004-09-30 | US20050074894A1 | 2005-04-07 | Yi Li; Nery Ortiz; Carole Young; Santiago Galvez |
| Reference control compositions and the method of use are disclosed for measurement of nucleated red blood cells, which includes one set of synthetic spherical particles having a mean particle diameter ranging from 6.2 μm to 6.8 μm and a refractive index from 1.58 to 1.62 monodispersed in an aqueous suspension medium. The synthetic spherical particles have optical properties simulating optical properties of nucleated red blood cells as measured by optical measurements. The reference control composition can further include a second set of the synthetic spherical particles having optical properties simulating optical properties of white blood cells. Further disclosed is a reference control system which includes a series of reference control compositions, each having an amount of one type of synthetic spherical particles which have optical properties simulating the optical properties of nucleated red blood cells having a specific cell maturity. | ||||||
| 15 | Quality control method | US10909561 | 2004-08-02 | US20050048656A1 | 2005-03-03 | Carole Young; Michael Elliott; Nancy Naylor-Schlipp; Timothy Fischer |
| A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pump volume settings; instrument laser alignments: instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods. | ||||||
| 16 | Method for control or calibration in a chemical analytical determination | US417270 | 1995-04-05 | US5547874A | 1996-08-20 | Masaaki Terashima |
| An aqueous dispersion used for control or calibration of a dry analysis element comprising at least one color producing reagent and a porous layer, which comprises water-insoluble liquid particles having a mean particle size of from about 0.01 to about 10 .mu.m selected from the group consisting of phthalates, trimellitates, phosphates, benzoates, amides, phenols, aliphatic esters, hydrocarbons, halogenated hydrocarbons, adipates, sebacates and natural polymers dispersed therein and a substance which is the same as or similar to the analyte to be determined wherein said substance is selected from the group consisting of glucose, urea, uric acid, creatinine, bilirubin, hemoglobin, triolein, glycerine, cholesterol, triglyceride, (NH.sub.4).sub.2 SO.sub.4, NH.sub.4 Cl, CaCl.sub.2, Ca(NO.sub.3).sub.2, MgCl.sub.2, NaCl, KCl, K.sub.2 HPO.sub.4, (NH.sub.4).sub.2 SO.sub.4, Ca(NO.sub.3).sub.2, and NaNO.sub.3. | ||||||
| 17 | Method for control or calibration in a chemical analytical determination | US915290 | 1992-07-20 | US5308767A | 1994-05-03 | Masaaki Terashima |
| A method for control or calibration in a chemical analytical determination using a dry analysis element comprising at least one color-producing reagent and a porous layer, wherein the method comprises applying an aqueous dispersion onto the porous layer and measuring the optical density of the color produced, wherein the aqueous dispersion comprises a substance which is the same as or similar to an analyte to be determined and water-insoluble particles dispersed therein, wherein the particles are particles of a homopolymer, a copolymer, phthalates, trimellitates, phosphates, benzoates, amides, phenols, aliphatic esters, hydrocarbons, halogenated hydrocarbons, adipates, sebacates and natural polymers. | ||||||
| 18 | Shelf-stable milk calibration standards | US987825 | 1992-12-09 | US5288642A | 1994-02-22 | Jeffrey D. Turner |
| A calibration standard for calibrating machines which count the somatic cells in a milk sample, comprises an aqueous dispersion of microbeads bearing a fluorescent dye, a suspending agent, and an electrolyte; the dye has an excitation wavelength below 580 nm and a fluorescence emission wavelength in the range of 550 to 660 nm, with the excitation wavelength being at least 10 nm below the emission wavelength; the microbeads are present in a predetermined number per unit volume of dispersion; typically the standard contains 1.times.10.sup.5 to 9.times.10.sup.5 beads/ml. | ||||||
| 19 | Calibrating fluid for automated hematology instruments | US3705110D | 1971-04-21 | US3705110A | 1972-12-05 | LOUDERBACK ALLAN L; YOUHNE YOUNG |
| A CALIBRATING FLUID FOR AUTOMATED INSTRUMENTS FOR BLOOD CELL COUNTING AND HEMOGLOBIN DETERMINATION COMPRISING AN ADMIXTURE OF NIGROSIN DYE AND A CARBON BLACK DISPERSION IN DILUTE AQUEOUS SOLUTION WHICH EXHIBITS ABSORBANCE LINEARITY IN THE VISIBLE AND ULTRAVIOLET RANGE HAVING SUSPENDED THEREIN SYNTHETIC LATEX PARTICLES WITH A 5 TO 15 MICRON PARTICLE SIZE RANGE.
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| 20 | Hematology control standard comprising washed red blood cells and synthetic latex particles | US3558522D | 1969-03-05 | US3558522A | 1971-01-26 | LOUDERBACK ALLAN L; YOUHNE YOUNG |
| A HERMATOLOGY CONTROL STANDARD FOR THE CALIBRATION OF BLOOD CELL COUNTING APPARATUS AND A METHOD FOR THE PREPARATION THEREOF BY ADMIXING PREDETERMINED AMOUNTS OF WASHED RED BLOOD CELLS AND SYNTHETIC LATEX PARTICLES HAVING A 5 TO 15 MICRON PARTICLE SIZE RANGE IN A FLUID SUSPENSION OF A KNOWN AMOUNT OF SERUM ALBUMIN.
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