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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
161	CONTROL OF pH IN AQUEOUS UREA-CONTAINING SOLUTIONS UTILIZING AMINO ACID-CONTAINING COMPOSITIONS	US14775325	2014-03-13	US20160025754A1	2016-01-28	Laura Uretsky; Kevin Horan
Aqueous calibration or quality control reagents that include urea are disclosed; the reagents may further include at least one amino acid-containing composition to provide pH stability thereto. Methods of production and use thereof are also disclosed.
162	USING GALECTIN-BINDING CARBOHYDRATES AS PREDICTORS OF MELANOMA PROGRESSION AND METASTASIS	US14760558	2014-01-16	US20150355185A1	2015-12-10	Charles J. DIMITROFF
Disclosed herein are assays and methods to determine tumor malignancy, for example, in melanoma or ovarian carcinoma, by determining the expression level of Gal-1 ligands. Also provided are methods to assess the metastatic potential of a tumor.
163	NEUROFURANS-INDICES OF OXIDANT STRESS	US14643343	2015-03-10	US20150247841A1	2015-09-03	Garret A. Fitzgerald; John A. Lawson; Wenliang Song
The invention is drawn to a new class of isoeicosanoids that have been identified as products of the oxidation of docosahexaenoic acid (DHA). The invention provides compositions and methods related to the new class of molecules.
164	LYOPHILISED DABIGATRAN	US14709519	2015-05-12	US20150240288A1	2015-08-27	Joachim STANGIER
The invention relates to a lyophilised form of dabigatran of formula I its use as a calibrator in the assays for the determination of pharmacodinamic effects of dabigatran etexilate as well as such assays per se.
165	Method for the Direct Detection and/or Quantification of at Least One Compound with a Molecular Weight of at Least 200	US14350265	2012-10-08	US20150212101A1	2015-07-30	Joan Perello Berstard; Ciriaco Maraschiello de Zuani; Irene Lentheric; Paula Mendoza de las Heras; Fernando Tur Espinosa; Eva Tur Tur; Maximo Encabo Alarcon; Eva Martin Becerra; Maria de Mar Benito Amengual; Bernat Isern Amengual
The present invention relates to method for the direct detection and/or quantification of at least one compound with a molecular weight of at least 200, wherein the compound to be detected and/or quantified is a chemically complex molecule, wherein said chemically complex molecule is substituted with at least two groups —R, wherein each R group means independently —OH, —OP(O)(OH)2 or —P(O)(OH)2, with the proviso that at least two R are independently selected from —P(O)(OH)2 and —OP(O)(OH)2, wherein the compound or compounds to be detected and/or quantified are within a biological matrix, wherein said biological matrix is a biological fluid, a biological tissue, stomach contents, intestine contents, stool sample or a culture cells, wherein the method comprises performing a chromatography and identifying the retention time and/or the intensity of the signal by means of a mass or radioactivity detector.
166	STAIN, PROCESS FOR STAINING AND ACQUIRING NORMALIZED SIGNAL	US14499364	2014-09-29	US20150017658A1	2015-01-15	GREGORY ALAN COOKSEY; JOHN T. ELLIOTT; ANNE L. PLANT
A kit includes a reference probe to react with a first sample; and an analyte probe to combine with a second sample, a marker and a spectral probe to react to form the analyte probe to combine with the second sample, the marker to react with the reference probe to form the analyte probe to combine with the second sample, or a combination thereof. A process for staining includes forming a reference composition by reacting a reference probe and a first sample to form a reference; and forming an analyte composition by combining an analyte probe and a second sample to form an analyte.
167	Control solution for use in testing an electrochemical system	US13682380	2012-11-20	US08716024B2	2014-05-06	Jing Lin; Fu Hsiung Tsai; Huan-Ping Wu; Nicole D. Ellis; Henry C. Arndt
A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.
168	METHODS FOR MEASURING CONCENTRATIONS OF BIOMOLECULES	US13967816	2013-08-15	US20140065636A1	2014-03-06	Tim West; Andrew Corey Paoletti
The present invention provides methods for measuring the absolute concentration of a biomolecule of interest in a subject. Such biomolecules may be implicated in one or more neurological and neurodegenerative diseases or disorders. Also provided is a method for determining whether a therapeutic agent affects the in vivo metabolism of a central nervous system derived biomolecule. Also provided are kits for performing the methods of the invention.
169	CUSTOMIZED QUALITY CONTROLS FOR ANALYTICAL ASSAYS	US13594227	2012-08-24	US20130221281A1	2013-08-29	Alireza Ebrahim; Christopher Spates; Karl De Vore
Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay.
170	Polypeptide as standard for proteome analysis	US12599960	2008-04-15	US08399402B2	2013-03-19	Robert Beynon; Simon Gaskell; Julie Pratt; Claire Eyers
The present invention provides a polypeptide as standard for peptide analysis by mass spectrometry comprising at least 16 peptides selected from the group consisting of the peptides of SEQ ID NO: 1 to SEQ ID NO: 22 or variants thereof, together with an artificial protein comprising the polypeptide, a vector comprising a nucleic acid encoding the polypeptide, a kit for proteome analysis, a selection of peptides for calibration an devaluation of mass spectrometers and chromatographs for proteome analysis and uses thereof.
171	IMMUNOASSAY STANDARDS AND MEASUREMENT OF CLINICAL BIOMARKERS USING INTRA-ASSAY CALIBRATION STANDARDS	US13577463	2011-02-09	US20120309028A1	2012-12-06	Paul Rhyne; Claudio Mapelli; Oi Tak Allen Wong; Flora Berisha; Robert John Neely
The present invention provides novel compositions and methods for creating quantitative standards to calibrate analytes. These compositions and methods enable the creation of standards and calibrators for analyzing analytes and measuring clinical biomarkers. Also provided are kits comprising the novel compositions for use in assays, for example sandwich immunoassays.
172	FORMALIN-FIXED ISOTOPE-LABELED REFERENCE STANDARDS AND METHODS FOR FABRICATION AND USE THEREOF	US13413110	2012-03-06	US20120231469A1	2012-09-13	Brian M. BALGLEY
One or more cells are labeled with minor stable isotopes, characterized, and preserved for subsequent use as a bio-specimen reference standard. The one or more cells are grown in culture media supplied with minor stable isotopes in concentrations substantially different from normally occurring concentrations, thereby supplanting major stable isotopes that would normally be incorporated into the proteins of the cells. The proteins of the cells are thus labeled by the minor stable isotopes and can be used in proteomic characterization of the cells. The cells are preserved by fixation as a reference standard. Cells of the reference standard are mixed with the sample and subject to mass spectrometry evaluation, whereby the labeled proteins of the reference standard can be used in determining the proteome of the sample.
173	DETECTION OF AUTOANTIBODIES REACTIVE WITH PANCREATIC ISLET CELL ANTIGENIC MOLECULES AND/OR INSULIN	US13412419	2012-03-05	US20120225955A1	2012-09-06	Bernard Rees SMITH; Jadwiga Furmaniak; Michael Powell
A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules (GAD, 1A2) and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method. After addition of the sample one or more complexes comprising `antigenic molecule of fist source!-`analyte auto antibody!-`antigenic molecule of second source! The antigenic molecule of first source is immobilised to a solid phase, the second is labeled.
174	Detection of autoantibodies reactive with pancreatic islet cell antigenic molecules and/or insulin	US10496528	2002-11-26	US08129132B2	2012-03-06	Bernard Rees Smith; Jadwiga Furmaniak; Michael Powell
A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method.
175	LYOPHILISED DABIGATRAN	US13147242	2010-01-27	US20120040384A1	2012-02-16	Joachim Stangier
The invention relates to a lyophilised form of dabigatran of formula (I) its use as a calibrator in the assays for the determination of pharmacodinamic effects of dabigatran etexilate as well as such assays per se. In the preparation of the lyophilised standards, dabigatran is dissolved in an aqueous acidic solution before freeze-drying.
176	NEUROFURANS-INDICES OF OXIDANT STRESS	US12812399	2009-01-09	US20100285500A1	2010-11-11	Garret A. Fitzgerald; John A. Lawson; Wenliang Song
The invention is drawn to a new class of isoeicosanoids that have been identified as products of the oxidation of docosahexaenoic acid (DHA). The invention provides compositions and methods related to the new class of molecules.
177	Homogeneous populations of molecules	US10949471	2004-09-24	US07781173B2	2010-08-24	Joseph W. Amshey; Roumen A. Bogoev
The invention provides populations of molecules that are prepared as, or treated to become, homogeneous for one or more molecular characteristics. In an aspect, the invention relates to molecular weight standards that may be used to determine the molecular weight or apparent molecular weight of uncharacterized molecules, such as proteins and nucleic acids, as well as in other applications. In one aspect, the molecular weight standards are pre-stained.
178	Calibrator For Immunoassays	US12343047	2008-12-23	US20090176319A1	2009-07-09	John F. R. Robertson; Andrea Murray; Caroline Chapman; Anthony Barnes
The invention generally relates to the field of immunoassays. In particular, the invention relates to use of a calibrator material to calibrate immunoassays for autoantibodies.
179	Cartridge for monitoring the function of a device for testing blood platelet function, method for function monitoring, and use of a test fluid	US11017945	2004-12-22	US07521247B2	2009-04-21	Jacob De Haan
A cartridge for monitoring the function of a device for blood platelet diagnosis has a housing which includes a test chamber and a holding chamber. A fluid volume of a test fluid is present inside the holding chamber. An air cushion is arranged above the fluid volume. A measurement cell, which has a capillary tube, is fitted in the upper part of the test chamber.
180	Normalisation of microarray data based on hybridisation with an internal reference	US10499476	2002-12-17	US20050153290A1	2005-07-14	Marinus Gerardus Van Beuningen
The invention relates to methods and corresponding arrays especially suited to correct for signal errors due to variations in sample preparation. Methods and compositions for performing quantitative array-based assays are provided. In the subject methods, both a reporter and an analyte is employed, where the reporter is characterized by binding selectively to an internal reference present on the array, i.e. at least a subset of, if not all of, the spots present on the array employed in the method contain an internal reference which can be bound by reporter.

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