| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 全氟磺酰卤化物和相关物质作为聚合物载体改性剂 | CN02806352.X | 2002-01-11 | CN1524181A | 2004-08-25 | C·霍尔梅斯; Y·潘 |
| 本发明提供了活化的载体、载体连接的活化剂、强酸性载体、和甲硅烷基化载体；所述活化的载体具有通式(I)，其中L为连接基团组分；X为F，Cl，OH、和三元取代的甲硅烷氧基；带阴影的圆表示固体或半固体载体。本发明还提供了在固相有机合成中使用活化的载体的方法。 | ||||||
| 2 | 全氟磺酰卤化物和相关物质作为聚合物载体改性剂 | CN02806352.X | 2002-01-11 | CN100480701C | 2009-04-22 | C·霍尔梅斯; Y·潘 |
| 本发明提供了活化的载体、载体连接的活化剂、强酸性载体、和甲硅烷基化载体；所述活化的载体具有通式(I)，其中L为连接基团组分；X为F，Cl，OH、和三元取代的甲硅烷氧基；带阴影的圆表示固体或半固体载体。本发明还提供了在固相有机合成中使用活化的载体的方法。 | ||||||
| 3 | DNA－固定化基质的重新利用方法 | CN01821551.3 | 2001-12-17 | CN1215330C | 2005-08-17 | 高桥浩二郎; 高井修; 丹花通文 |
| 本发明提供DNA-固定化基质的再使用方法，由此使得昂贵的DNA-固定化基质可有效被利用，且提供可再使用的DNA-固定化基质，该基质具有与新产品相同的性能且在实际应用中无任何问题。即，一种DNA-固定化基质的再使用方法，其特征在于从携带由酰胺键通过寡核苷酸固定的DNA的DNA-固定化基质上去除DNA而由此使得可以固定新的DNA，在基质和DNA之间的酰胺键用酸或碱来水解。 | ||||||
| 4 | DNA－固定化基质的再使用方法 | CN01821551.3 | 2001-12-17 | CN1484764A | 2004-03-24 | 高桥浩二郎; 高井修; 丹花通文 |
| 本发明提供DNA－固定化基质的再使用方法，由此使得昂贵的DNA－固定化基质可有效被利用，且提供可再使用的DNA－固定化基质，该基质具有与新产品相同的性能且在实际应用中无任何问题。即，一种DNA－固定化基质的再使用方法，其特征在于从携带由酰胺键通过寡核苷酸固定的DNA的DNA－固定化基质上去除DNA而由此使得可以固定新的DNA，在基质和DNA之间的酰胺键用酸或碱来水解。 | ||||||
| 5 | 用于α－氧代醛合成的官能化固相支持物 | CN00809066.1 | 2000-04-20 | CN1356968A | 2002-07-03 | O·梅尔尼克; J-S·弗鲁查特; L·布雷尔; H·格拉斯-马西 |
| 本发明涉及用于合成含有至少一个α－氧代醛基的化合物的官能化固相支持物、其制备方法和用途,特别是制备有机化合物库、诊断试剂、微量滴定板和生物芯片,如DNA芯片。本发明还涉及合成含有至少一个α－氧代醛基的有机化合物的方法和用所述方法获得的α－氧代醛肽。 | ||||||
| 6 | Perfluoro sulfonyl halides and related species as polymer support modifiers | US10466124 | 2002-01-11 | US07700524B2 | 2010-04-20 | Christopher Holmes; Yijun Pan |
| Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula (I) wherein L is a linking group component; X is F, CL, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic sync) thesis are also provided. | ||||||
| 7 | BIOCHIP HAVING INCREASED PROBE DENSITY | US12357270 | 2009-01-21 | US20090186777A1 | 2009-07-23 | June-Young LEE; Dong-Ho LEE; Jae-Young KIM |
| A biochip can include a substrate having surface features of protrusions or recesses and probes coupled to each of the surface features. A biochip can include a substrate having recess regions and probes coupled to each of the recess regions, wherein a surface of each of the recess regions has convexes and concaves. A biochip can include a substrate having recess regions, immobilization layers conformally formed in the recess regions, and probes coupled onto each of the immobilization layers. The biochip can be divided into probe cell regions to which the probes are coupled, wherein the recess regions are formed in the probe cell regions, and non-probe cell regions, wherein a surface of each of the non-probe cell regions can include an exposed surface of the substrate. | ||||||
| 8 | Polymers based on N-carbamyl-N'-dimethylsilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries | US10766981 | 2004-01-29 | US07164018B2 | 2007-01-16 | Enzo Cereda; Carlo Maria Pellegrini; Monica Quai; Walter Barbaglia |
| The present invention relates to polymers characterized by novel silicon linkers based on the carbamyl piperazine moiety, methods of preparing these polymers and their use in the solid phase synthesis of compounds or libraries of compounds embracing a phenyl ring in their structure. | ||||||
| 9 | Method of reusing DNA-immobilization substrate | US10451399 | 2001-12-17 | US07078517B2 | 2006-07-18 | Kojiro Takahashi; Osamu Takai; Michifumi Tanga |
| It is intended to provide a method of reusing a DNA-immobilization substrate whereby the expensive DNA-immobilization substrate can be efficiently utilized and a reusable DNA-immobilization substrate having the same performance as a new product without any trouble in practical use can be provided. Namely, a method of reusing a DNA-immobilization substrate characterized in that, to remove DNA from a DNA-immobilization substrate carrying the DNA immobilized by an acid-amide bond via an oligonucleotide to thereby enable the immobilization of a fresh DNA, the acid-amide bond between the substrate and the DNA is hydrolyzed with an acid or an alkali. | ||||||
| 10 | Polymers based on N-carbamyl-N'-dimethylsilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries | US10766981 | 2004-01-29 | US20040186243A1 | 2004-09-23 | Enzo Cereda; Carlo Maria Pellegrini; Monica Quai; Walter Barbaglia |
| The present invention relates to polymers characterised by novel silicon linkers based on the carbamyl piperazine moiety, methods of preparing these polymers and their use in the solid phase synthesis of compounds or libraries of compounds embracing a phenyl ring in their structure. | ||||||
| 11 | Method of reusing dna-immobilization substrate | US10451399 | 2003-12-09 | US20040092005A1 | 2004-05-13 | Kojiro Takahashi; Osamu Takai; Michifumi Tanga |
| It is intended to provide a method of reusing a DNA-immobilization substrate whereby the expensive DNA-immobilization substrate can be efficiently utilized and a reusable DNA-immobilization substrate having the same performance as a new product without any trouble in practical use can be provided. Namely, a method of reusing a DNA-immobilization substrate characterized in that, to remove DNA from a DNA-immobilization substrate carrying the DNA immobilized by an acid-amide bond via an oligonucleotide to thereby enable the immobilization of a fresh DNA, the acid-amide bond between the substrate and the DNA is hydrolyzed with an acid or an alkali. | ||||||
| 12 | Method of immobilizing probes, in particular for producing bio chips | US10451072 | 2003-06-20 | US20040039116A1 | 2004-02-26 | Francoise Vinet; Antoine Hoang |
| The invention relates to a solid support comprising sites intended for the immobilization of oligonucleotide probes or of proteins or of biological cells having ligands, the sites being provided with chemical species bound to the support by a chemical binding function. The chemical species have a diol group connected to the support by an alkyl chain. Application to biochips. | ||||||
| 13 | Supports for immobilizing DNA or the like | US09807611 | 2001-07-16 | US06607908B1 | 2003-08-19 | Michifumi Tanga; Kojiro Takahashi |
| A subject of the present invention is to provide a support with immobilized DNA as a DNA library and particularly to a support suitable for reproducing DNA in accordance with a DNA amplification reaction. In the present invention, DNA or the like is immobilized on a surface of a support made of one kind or more than material Selected from a group of a diamond including non-diamond carbon, amorphous carbon and graphite. A hydroxyl group may be bonded to a surface of the support or a group bonded to a hydrocarbon group and a carboxyl group at its terminal end may be bonded to a surface of the support through an ester linkage or a peptide linkage. | ||||||
| 14 | Rapid purification by polymer supported quench | US09171258 | 1998-10-15 | US06306959B1 | 2001-10-23 | Gary L. Bolton; Richard J. Booth; Mark W. Creswell; John C. Hodges; Joseph S. Warmus; Michael W. Wilson |
| Novel polymer-supported quenching reagents of Formula (I): P-L-Q, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis. | ||||||
| 15 | Fluorine-based reaction and separation system | JP50431998 | 1997-06-26 | JP4050321B2 | 2008-02-20 | パトリック イェーガー; ピーター ウィプフ; デニス ピー カーラン; スン ヨウン キム; アルミド シュトゥーデル; マサヒデ ハシノ; ルアー サビーン ハディーダ; ラファエル フェルリット |
| 16 | Lysate clearance and nucleic acid isolation using a silane-treated silica substrate | JP2002542074 | 2001-11-08 | JP2004513634A | 2004-05-13 | コラー スーザン シー; シンプソン ダニエル ジェイ; ビトナー レックス エム; フレミング ローデリック ジー |
| プラスミドＤＮＡ、ＤＮＡの断片、染色体ＤＮＡ、またはＲＮＡなどの標的核酸を、たんぱく質、脂質、細胞破片、あるいは非標的核酸を含む夾雑物から単離するためにシラン処理シリカ基質を用いる方法が提供される。 シラン処理シリカ基質は、シリカベース固相および前記固相の表面に共有結合した複数のシランリガンドを含む。 非標的物質は、十分な濃度のカオトロピック塩の存在においてシラン処理シリカ基質に吸着する一方で、標的核酸は、他の溶液条件下で前記基質に吸着する。 本発明のシラン処理シリカ基質を用いる方法は、破壊された生体物質を溶液から除去するため、およびそこから、あるいは核酸や少なくとも１の夾雑物を含む他の溶液から核酸を単離するために使用されうる。 | ||||||
| 17 | Carrier for combinatorial compound library | JP2000585186 | 1999-11-30 | JP2002531424A | 2002-09-24 | エドワード ブライアント ダリン; ジーン バタースビー ブロンウィン; トラウ マット |
| (57)【要約】 化合物をその上で合成し得る担体の不均一集団から識別するのに充分な情報を予め符号化された担体が開示される。 この担体は一体的に担体と関連している二つの属性を持っており、その属性は該化合物の合成中に検出可能及び／又は定量可能であり、該合成の前、間、及び後において担体を同定する符号を規定するものであるが、該属性の一つが該担体の形状又は表面変形以外のものであることを条件とする。 本発明は上記のように予め符号化された複数の担体をも包含し、そしてこのような担体を用いるコンビナトリアルライブラリーを合成し解読する方法をも包含する。 | ||||||
| 18 | Rapid purification by the polymer support quenched | JP53997997 | 1997-04-28 | JP2000511949A | 2000-09-12 | ウイルスン，マイクル・ダブリユー; ウオーマス，ジヨウゼフ・エス; クレスウエル，マーク・ダブリユー; ケネデイ，ロバート・エム; ブース，リチヤード・ジエイ; ボウルトン，ゲイリー・エル; ホツジズ，ジヨン・シー |
| (57)【要約】 式（Ｉ）：Ｐ−Ｌ−Ｑ（式中、Ｐは可溶性又は不溶性である低い化学反応性のポリマーであり、Ｑは不必要な副生物、又は過剰の反応物と選択的共有結合反応が可能な１つ又は１つより多くのクェンチ試薬、又はそれらの酸又は塩基付加塩であり、そしてＬはＰ及びＱを連結する１つ又は１つより多くの化学的に強固なリンカーである）の化合物、並びにそれらの製造方法及び有機合成、組合せ化学及び自動化された有機合成における合成中間物質及び製造物の迅速精製におけるそれらの使用方法が記述されている。 | ||||||
| 19 | CARRIERS FOR COMBINATORIAL COMPOUND LIBRARIES | US13107628 | 2011-05-13 | US20110312613A1 | 2011-12-22 | Bronwyn Jean Battersby; Darryn Edward Bryant; Matt Trau |
| A carrier pre-encoded with information sufficient to distinguish it from a heterogeneous population of carriers is disclosed on which a compound can be synthesised. The carrier has two attributes integrally associated therewith, which attributes are detectable and/or quantifiable during synthesis of the compound and which define a code identifying the carrier before, during and after said synthesis, with the proviso that one of said attributes is other than shape, or surface deformation(s) of the carrier. The invention also encompasses a plurality of carriers that are pre-encoded as above and a method of synthesising and deconvoluting a combinatorial library using such carriers. | ||||||
| 20 | Systems and methods for automated quality control of polymer synthesis | US11173952 | 2005-07-01 | US20070003941A1 | 2007-01-04 | Nels Olson; Bahram Kermani; Hongji Ren; Theo Kotseroglou |
| The invention provides systems and methods for evaluating synthetic reactions such as polymer synthesis reactions. Evaluation of a synthetic reaction product can be based on a quantitative measure of synthesis such as coupling efficiency or yield, and various parameters determined from a separation record obtained for the synthetic reaction product. The invention further provides methods for evaluating a separation method based on various parameters determined from a separation record. The invention can be used to select an appropriate treatment for a synthetic reaction product such as a separation treatment or treatments related to further processing for the desired product. The methods are particularly useful for automated selection of treatments for synthetic reaction products. | ||||||
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