| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | FARBKODIERTE LAYER-BY-LAYER MIKROKAPSELN ALS KOMBINATORISCHE ANALYSEBIBLIOTHEKEN UND ALS SPEZIFISCHE OPTISCHE SENSOREN | EP03784109.5 | 2003-07-29 | EP1526915A1 | 2005-05-04 | DAEHNE, Lars; BAUDE, Barbara; VOIGT, Andreas |
| Monodisperse colloids were coated with polyelectrolytes by means of the layer-by-layer method. The template cores can remain inside or can be dissolved. Different fluorescent dyes are covalently bound in a defined amount to the polyelectrolytes. The amount of dye is controlled by varying the label content or by the Co deposition of unlabeled polymers. Different dye layers are separated from one another by intermediate layers thereby suppressing unwanted interactions. Conversely, a FRET signal can be generated between suitable dye pairs situated at short distances (0 - 6 nm) from one another. This signal can be controlled independent of the dye concentration by the number of intermediate layers. The capsule coding is read out by the variation in the excitation wavelength and emission wavelength. Macromolecules can be immobilized inside the capsules and extract complementary substances out of solutions. Particles coated in such a manner or hollow capsules can be used as sensors after inserting a sensitive intermediate layer. Changes in the size/structure of the intermediate layer can be detected either by FRET between adjacent, labeled polyelectrolyte layers or by the self-quenching/aggregate fluorescence of dyes in the sensitive layer. | ||||||
| 62 | REAGENTS THAT FACILITATE THE PURIFICATION OF COMPOUNDS SYNTHESIZED ON A SOLID SUPPORT | EP02773202.3 | 2002-08-15 | EP1418877A2 | 2004-05-19 | SEEBERGER, Peter, H.; HEWITT, Michael, C.; PALMACCI, Emma, R.; PLANTE, Obadiah, J. |
| Disclosed is a novel capping-and-tagging ('cap-tag') strategy that aids in the purification of compounds assembled by multi-step synthetic methods. The incorporation of a unique cap-tag into undesired intermediates during a multi-step synthesis allows for the straightforward removal of these undesired compounds at the conclusion of the synthetic protocol by several methods based on affinity chromatography and scavenging resins. Importantly, this invention may be exploited in any automated synthetic protocol. In preferred embodiments, the cap-tag system is exploited for the purification of carbohydrates prepared via automated solid-phase methods. | ||||||
| 63 | SUPPORTS FOR IMMOBILIZING DNA OR THE LIKE | EP99947929 | 1999-10-15 | EP1122309A4 | 2004-03-17 | TANGA MICHIFUMI; TAKAHASHI KOJIRO |
| Supports for immobilizing DNAs to present DNA libraries; and supports adequately usable in replicating DNAs by DNA amplification reactions. DNAs, etc. are immobilized on the surface of a support comprising one or more constituents selected from among diamond containing non-diamond carbon, amorphous carbon, plastic carbon and graphite. Further, a hydroxyl group is bonded to the surface of the support or a group having terminal carboxyl, which is formed by bonding hydrocarbyl to carboxyl, is bonded to the surface of the support via an ester bond or a peptide bond. | ||||||
| 64 | METHOD OF REUSING DNA-IMMOBILIZATION SUBSTRATE | EP01272814.3 | 2001-12-17 | EP1347297A1 | 2003-09-24 | TAKAHASHI, Kojiro; TAKAI, Osamu, NIHON PARKERIZING HIROSHIMA CO.,LTD.; TANGA, Michifumi, TOYO KOHAN CO., LTD. |
It is intended to provide a method of reusing a DNA-immobilization substrate whereby the expensive DNA-immobilization substrate can be efficiently utilized and a reusable DNA-immobilization substrate having the same performance as a new product without any trouble in practical use can be provided. Namely, a method of reusing a DNA-immobilization substrate characterized in that, to remove DNA from a DNA-immobilization substrate carrying the DNA immobilized by an acid-amide bond via an oligonucleotide to thereby enable the immobilization of a fresh DNA, the acid-amide bond between the substrate and the DNA is hydrolyzed with an acid or an alkali. |
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| 65 | SOLID SUPPORTS CONTAINING SCINTILLANT | EP99947759.9 | 1999-10-05 | EP1123327A1 | 2001-08-16 | SUTHERLAND, Andrew, James; CLAPHAM, Bruce |
| A support for a chemical or biological application having chemically reactive sites, the support formed from at least one scintillant monomer by polymerisation or copolymerisation of the monomer. The supports may be used for biological scintillation assays, but also find new uses in solid phase synthetic chemistry and combinatorial chemistry. | ||||||
| 66 | SUPPORTS FOR IMMOBILIZING DNA OR THE LIKE | EP99947929.8 | 1999-10-15 | EP1122309A1 | 2001-08-08 | TANGA, Michifumi, Toyo Kohan Co., Ltd.; TAKAHASHI, Kojiro |
A subject of the present invention is to provide a support with immobilized DNA as a DNA library and particularly to a support suitable for reproducing DNA in accordance with a DNA amplification reaction. In the present invention, DNA or the like is immobilized on a surface of a support made of one kind or more than material Selected from a group of a diamond including non-diamond carbon, amorphous carbon and graphite. A hydroxyl group may be bonded to a surface of the support or a group bonded to a hydro-carbon group and a carboxyl group at its terminal end may be bonded to a surface of the support through an ester linkage or a peptide linkage. |
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| 67 | 바이오칩 | KR1020080007241 | 2008-01-23 | KR101435521B1 | 2014-08-29 | 이준영; 이동호; 김재영 |
| 바이오칩이 제공된다. 상기 바이오칩은 다수의 표면 돌출부를 포함하는 기판 및 표면 돌출부 별로 커플링된 다수의 프로브를 포함한다. 프로브, 표면 돌출부, 리세스 | ||||||
| 68 | 중합체 지지체 개질제로서의 퍼플루오로술포닐 할라이드및 관련 화합물 | KR1020037009277 | 2002-01-11 | KR1020030078069A | 2003-10-04 | 홀메스,크리스토퍼; 판,이준 |
| 활성화된 지지체, 지지체-결합된 활성화제, 강산성 지지체 및 실릴화 지지체가 제공된다. 상기 활성화된 지지체는 화학식(I)을 갖는다. <화학식 I> 상기 식 중, L은 결합기 성분이고; X는 F, Cl, OH 및 삼치환된 실릴옥시이며, 그늘진 원은 고체 또는 반고체의 지지체를 나타낸다. 상기 활성화된 지지체를 고체상 유기 합성에 사용하는 방법이 또한 제공된다. | ||||||
| 69 | ＤＮＡ 고정화 기체의 재사용법 | KR1020037008230 | 2001-12-17 | KR1020030064842A | 2003-08-02 | 다까하시고지로; 다까이오사무; 단가미찌후미 |
| 고가인 DNA 고정화 기체를 유효하게 활용하고, 또한 신품과 동일한 성능을 갖고 실용에도 지장이 없는 DNA 고정화 기체의 재사용법을 제공하는 것을 목적으로 한다. DNA가 올리고머 누클레오티드를 통해 산아미드 결합에 의해 고정화되어 있는 DNA 고정화 기체로부터, 고정되어 있는 DNA를 제거하고 새로운 DNA 를 고정할 수 있는 상태로 하는 데에 있어서, 기체-DNA간 산아미드 결합을 산 또는 알칼리로 가수분해하는 것을 특징으로 하는 DNA 고정화 기체의 재사용법에 관한 것이다. | ||||||
| 70 | PERFLUORO SULFONYL HALIDES AND RELATED SPECIES AS POLYMER SUPPORT MODIFIERS | EP02714736 | 2002-01-11 | EP1352243A4 | 2008-07-02 | HOLMES CHRISTOPHER; PAN YIJUN |
| Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula (I) wherein L is a linking group component; X is F, CL, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic synthesis are also provided. | ||||||
| 71 | SEARCHABLE MOLECULAR DATABASE | EP03793902.2 | 2003-09-05 | EP1540531A1 | 2005-06-15 | ASHWORTH, P. A.Cresset BiomolecularDiscovery Ltd.; CHEESERIGHT, T.Cresset Biomolecular Discovery Ltd; MACKEY, Mark D.Cresset Biomolecular Discovery Ltd; VINTER, J. G.Cresset Biomolecular DiscoveryLtd |
| A computer system comprising a database (100) having a plurality of records is provided. Each record comprises a filed point representation representing field extrema for a conformation of a chemical structure. The database may include records for multiple conformations of the same chemical structure. Each record can have a searchable index of the filed point representation. In one embodiment the index is bit string. An indexing mechanism for generating an index, a searching mechanism for searching the database and a graphical user interface to enable a user to interface with the database (100) are also provided. | ||||||
| 72 | CARRIERS FOR COMBINATORIAL COMPOUND LIBRARIES | EP99963165 | 1999-11-30 | EP1135350A4 | 2005-03-30 | BATTERSBY BRONWYN JEAN; BRYANT DARRYN EDWARD; TRAU MATT |
| A carrier pre-encoded with information sufficient to distinguish it from a heterogeneous population of carriers is disclosed on which a compound can be synthesised. The carrier has two attributes integrally associated therewith, which attributes are detectable and/or quantifiable during synthesis of the compound and which define a code identifying the carrier before, during and after said synthesis, with the proviso that one of said attributes is other than shape, or surface deformation(s) of the carrier. The invention also encompasses a plurality of carriers that are pre-encoded as above and a method of synthesising and deconvoluting a combinatorial library using such carriers. | ||||||
| 73 | FLUOROUS REACTION AND SEPARATION SYSTEMS | EP97932333 | 1997-06-26 | EP0907625A4 | 2004-10-20 | CURRAN DENNIS P; HADIDA RUAH SABINE; HASHINO MASAHIDE; STUDER ARMIDO; WIPF PETER; JEGER PATRICK; KIM SUN-YOUNG; FERRITTO RAFAEL |
| The present invention provides several methods of synthesis and separation in which organic/fluorous phase separation techniques are used to effect separations. The present invention also provides novel compositions of matter comprising fluorous Si, Sn and Ge compounds. | ||||||
| 74 | PROCEDE D'IMMOBILISATION DE SONDES, EN PARTICULIER POUR REALISER DES PUCES BIOLOGIQUES | EP01994934.6 | 2001-12-20 | EP1343801A2 | 2003-09-17 | VINET, Françoise; HOANG, Antoine |
| The invention concerns a solid support comprising sites designed to immobilise oligonucleotide probes or proteins or biological cells provided with ligands, the sites being provided with species bound to the support by a chemical binding function. The species exhibit a diol group bound to the support by an alkyl chain. The invention is applicable to biochips. | ||||||
| 75 | LYSATE CLEARANCE AND NUCLEIC ACID ISOLATION USING SILANIZED SILICA MATRICES | EP01993684.8 | 2001-11-08 | EP1341910A1 | 2003-09-10 | BITNER, Rex, M.; SIMPSON, Daniel, J.; FLEMMING, Roderick, G.; KOLLER, Susan, C. |
| A method is provided for using a silanized silica matrix to isolate a target nucleic acids, such as plasmid DNA, fragments of DNA, chrmosomal DNA, or RNA from contaminants, including proteins, lipids, cellular debris, or non-target nucleic acids. The silanized silica matrix comprises a silica based solid phase and a plurality of silane ligands covalently attached to the surface of the solid phase. Non-target material absorbs to the silanized silica matrix in the presence of a sufficient concentration of chaotropic salt, while target nucleic acids adsorb to the matrix under other solution conditions. The method of using the sinalized silica matrix of the present invention can be used to clear solutions of disrupted biological material, and to isolate nucleic acids therefrom or from other solutions containing nucleic acids and at least one contaminant. | ||||||
| 76 | SUPPORT SOLIDE FONCTIONNALISE POUR LA SYNTHESE D'ALPHA-OXOALDEHYDES | EP00920852.1 | 2000-04-20 | EP1171405A1 | 2002-01-16 | MELNYK, Oleg; FRUCHART, Jean-Sébastien; BOUREL, Line; GRAS-MASSE, Hélène |
| The invention concerns a functionalised solid support for the synthesis of compounds comprising at least an α-oxoaldehyde function, its method for preparation and its uses, in particular for preparing a bank of organic compounds, a diagnostic reagent, a microtitration plate and a biochip, such as a DNA chip. The invention also concerns a method for the synthesis of organic compounds comprising at least an α-oxoaldehyde function and α-oxoaldehyde peptides obtained by said method. | ||||||
| 77 | CARRIERS FOR COMBINATORIAL COMPOUND LIBRARIES | EP99963165.8 | 1999-11-30 | EP1135350A1 | 2001-09-26 | BATTERSBY, Bronwyn, Jean; BRYANT, Darryn, Edward; TRAU, Matt |
| A carrier pre-encoded with information sufficient to distinguish it from a heterogeneous population of carriers is disclosed on which a compound can be synthesised. The carrier has two attributes integrally associated therewith, which attributes are detectable and/or quantifiable during synthesis of the compound and which define a code identifying the carrier before, during and after said synthesis, with the proviso that one of said attributes is other than shape, or surface deformation(s) of the carrier. The invention also encompasses a plurality of carriers that are pre-encoded as above and a method of synthesising and deconvoluting a combinatorial library using such carriers. | ||||||
| 78 | CODING COMBINATORIAL LIBRARIES WITH FLUORINE TAGS | EP98953379.9 | 1998-10-09 | EP1023317A1 | 2000-08-02 | HOCHLOWSKI, Jill, E.; SOWIN, Thomas, J.; NORBECK, Daniel, W.; WADE, Warren, S.; WHITTERN, David, N. |
| The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching 'tags' that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to the solid support by fluorine nuclear magnetic resonance spectroscopy to follow the reaction history of individual beads, and to determine the particular member of the library that is attached on the bead. | ||||||
| 79 | FLUOROUS REACTION AND SEPARATION SYSTEMS | EP97932333.0 | 1997-06-26 | EP0907625A1 | 1999-04-14 | CURRAN, Dennis, P.; HADIDA RUAH, Sabine; HASHINO, Masahide; STUDER, Armido; WIPF, Peter; JEGER, Patrick; KIM, Sun-Young; FERRITTO, Rafael |
| The present invention provides several methods of synthesis and separation in which organic/fluorous phase separation techniques are used to effect separations. The present invention also provides novel compositions of matter comprising fluorous Si, Sn and Ge compounds. | ||||||
| 80 | RAPID PURIFICATION BY POLYMER SUPPORTED QUENCH | EP97921421.0 | 1997-04-28 | EP0896590A1 | 1999-02-17 | BOLTON, Gary, L.; BOOTH, Richard J.; CRESWELL, Mark, W.; HODGES, John, C.; WARMUS, Joseph, S.; WILSON, Michael, W.; KENNEDY, Robert, Michael |
| Novel polymer-supported quenching reagents of Formula (I): P-L-Q, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one ore more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis. | ||||||
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