| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | Method of immobilizing probes, in particular for producing biochips | US11206058 | 2005-08-18 | US20050277155A1 | 2005-12-15 | Francoise Vinet; Antoine Hoang |
| The invention relates to a solid support comprising sites intended for the immobilization of oligonucleotide probes or of proteins or of biological cells having ligands, the sites being provided with chemical species bound to the support by a chemical binding function. The chemical species have a diol group connected to the support by an alkyl chain. Application to biochips. | ||||||
| 22 | Perfluoro sulfonyl halides and related species as polymer support modifiers | US10044784 | 2002-01-11 | US20030124612A1 | 2003-07-03 | Christopher Holmes; Yijun Pan |
| Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula: 1 wherein L is a linking group component; X is F, Cl, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic synthesis are also provided. | ||||||
| 23 | POLYMERS AS A SUPPORT FOR COMBINATORIAL SYNTHESIS | US09230076 | 1999-03-08 | US20020025507A1 | 2002-02-28 | YONG PAN |
| nullThreedimensionalnull polymers of very small size can be used in the context of synthesis. These polymers provide simple isolation routes by avoiding the need for workup following the reactions, preworkup characterization, high yield, high capacity and reusability. Of equal importance, these polymers provide a more efficient route to combinatorial synthesis of small molecules. This provides greatly enhanced efficiency for making and screening molecules for physical/biological properties. | ||||||
| 24 | Polyaryl-poly(ethylene glycol) supports for solution-phase combinatorial synthesis | US923299 | 1997-09-04 | US5877214A | 1999-03-02 | Ronald M. Kim |
| The present invention is directed to the certain polyaryl-poly(ethylene glycol) compounds ("polyaryl-PEG" compounds) which are useful as soluble polyvalent supports in the preparation of combinatorial libraries of compounds. The resultant combinatorial libraries are useful in screening for biologically active moieties in the drug discovery process or in developing compounds with desired physical and chemical properties. | ||||||
| 25 | Functionalised solid support for alpha-oxoaldehyde synthesis | US10196900 | 2002-07-15 | US08178474B1 | 2012-05-15 | Oleg Melnyk; Jean-Sebastien Fruchart; Line Bourel; Helene Gras-Masse |
| The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one α-oxoaldehyde function, to a process for preparing it and to its applications, in particular for the preparation of a library of organic compounds, of a diagnostic reagent, of a microtitration plate and of a biochip, such as a DNA chip. The present invention also relates to a process for the synthesis of organic compounds comprising at least one α-oxoaldehyde function and to the α-oxoaldehyde peptides obtained using this process. | ||||||
| 26 | PERFLUORO SULFONYL HALIDES AND RELATED SPECIES AS POLYMER SUPPORT MODIFIERS | US12760840 | 2010-04-15 | US20110028751A1 | 2011-02-03 | Christopher Holmes; Yijun Pan |
| Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula: wherein L is a linking group component; X is F, Cl, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic synthesis are also provided. | ||||||
| 27 | Systems and methods for automated quality control of polymer synthesis | US11173952 | 2005-07-01 | US07799527B2 | 2010-09-21 | Nels A. Olson; Bahram Ghaffarzadeh Kermani; Hongji Ren; Theo Kotseroglou |
| The invention provides systems and methods for evaluating synthetic reactions such as polymer synthesis reactions. Evaluation of a synthetic reaction product can be based on a quantitative measure of synthesis such as coupling efficiency or yield, and various parameters determined from a separation record obtained for the synthetic reaction product. The invention further provides methods for evaluating a separation method based on various parameters determined from a separation record. The invention can be used to select an appropriate treatment for a synthetic reaction product such as a separation treatment or treatments related to further processing for the desired product. The methods are particularly useful for automated selection of treatments for synthetic reaction products. | ||||||
| 28 | Programmed changes in hybridization conditions to improve probe signal quality | US11440866 | 2006-05-24 | US20080171665A1 | 2008-07-17 | James M. Minor |
| A method of improving signal-to-noise performance of a probe. A probe or set of probes is provided for hybridization with a sample. The probe or set of probes is hybridized with the sample at a first hybridization stringency over a first hybridization time period. Following the hybridization over the first hybridization time period, the probe or set of probes is hybridized with the sample at a second hybridization stringency over a second hybridization time period. A method of improving signal-to-noise performance of probes on an array includes providing a sample containing sequences that provide perfect complementary matches to sequences contained on at least some of said probes; and hybridizing the probes with the sample, while cycling the stringency of hybridization conditions during the hybridization. | ||||||
| 29 | Perfluoro sulfonyl halides and related species as polymer support modifiers | US10466124 | 2003-07-10 | US20040106151A1 | 2004-06-03 | Christopher Holmes; Yijun Pan |
| Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula (I) wherein L is a linking group component; X is F, CL, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic sync) thesis are also provided. | ||||||
| 30 | Polymers based on N-carbamyl-N'-dimethylsilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries | US10058433 | 2002-01-28 | US06740712B2 | 2004-05-25 | Enzo Cereda; Carlo Maria Pellegrini; Monica Quai; Walter Barbaglia |
| The present invention relates to polymers characterized by novel silicon linkers based on the carbamyl piperazine moiety, methods of preparing these polymers and their use in the solid phase synthesis of compounds or libraries of compounds embracing a phenyl ring in their structure. | ||||||
| 31 | Resins having vinyl ether linker for the solid phase organic synthesis | US10111671 | 2002-04-26 | US06723798B1 | 2004-04-20 | SungEun Yoo; YoungDae Gong; JinSoo Seo |
| The present invention relates to a resin having a vinyl ether linker and more particularly, to a resin having a vinyl ether linker expressed by formula (I), useful for the synthesis of compounds having hetero atoms such as alcohol, thiol, imidazole, triazole and tetrazole by employing combinatorial chemical synthesis on solid supports. | ||||||
| 32 | Reagents that facilitate the purification of compounds synthesized on a solid support | US10219129 | 2002-08-15 | US20030232978A1 | 2003-12-18 | Peter H. Seeberger; Michael C. Hewitt; Emma R. Palmacci; Obdiah J. Plante |
| Disclosed is a novel capping-and-tagging (nullcap-tagnull) strategy that aids in the purification of compounds assembled by multi-step synthetic methods. The incorporation of a unique cap-tag into undesired intermediates during a multi-step synthesis allows for the straightforward removal of these undesired compounds at the conclusion of the synthetic protocol by several methods based on affinity chromatography and scavenging resins. Importantly, this invention may be exploited in any automated synthetic protocol. In preferred embodiments, the cap-tag system is exploited for the purification of carbohydrates prepared via automated solid-phase methods. | ||||||
| 33 | Rapid purification by polymer supported quench | US09804860 | 2001-03-13 | US06506701B1 | 2003-01-14 | Gary L. Bolton; Richard J. Booth; Mark W. Creswell; John C. Hodges; Joseph S. Warmus; Michael W. Wilson |
| Novel polymer-supported quenching reagents of Formula I, P—L—Q I wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis. | ||||||
| 34 | Polymers based on N-carbamyl-N'-dimethysilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries | US10058433 | 2002-01-28 | US20020120072A1 | 2002-08-29 | Enzo Cereda; Carlo Maria Pellegrini; Monica Quai; Walter Barbaglia |
| The present invention relates to polymers characterized by novel silicon linkers based on the carbamyl piperazine moiety, methods of preparing these polymers and their use in the solid phase synthesis of compounds or libraries of compounds embracing a phenyl ring in their structure. | ||||||
| 35 | Coding combinatorial libraries with fluorine tags | US08949987 | 1997-10-14 | US06168913A | 2001-01-02 | Jill Edie Hochlowski; Thomas J. Sowin; Daniel W. Norbeck; Warren S. Wade; David N. Whittern |
| The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching “tags” that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to the solid support by fluorine nuclear magnetic resonance spectroscopy to follow the reaction history of individual beads, and to determine the particular member of the library that is attached on the bead. | ||||||
| 36 | Fluorous reaction and separation systems | US80274 | 1998-05-15 | US6156896A | 2000-12-05 | Dennis P. Curran; Sabine Hadida Ruah; Masahide Hoshino; Armido Studer; Peter Wipf; Patrick Jeger; Sun-Young Kim; Rafael Ferritto |
| The present invention provides several methods of synthesis and separation in which organic/fluorous phase separation techniques are used to effect separations. The present invention also provides novel compositions of matter comprising fluorous Si, Sn and Ge compounds. | ||||||
| 37 | ＤＮＡ 고정화 기체의 재사용법 | KR1020037008230 | 2001-12-17 | KR100523720B1 | 2005-10-26 | 다까하시고지로; 다까이오사무; 단가미찌후미 |
| It is intended to provide a method of reusing a DNA-immobilization substrate whereby the expensive DNA-immobilization substrate can be efficiently utilized and a reusable DNA-immobilization substrate having the same performance as a new product without any trouble in practical use can be provided. Namely, a method of reusing a DNA-immobilization substrate characterized in that, to remove DNA from a DNA-immobilization substrate carrying the DNA immobilized by an acid-amide bond via an oligonucleotide to thereby enable the immobilization of a fresh DNA, the acid-amide bond between the substrate and the DNA is hydrolyzed with an acid or an alkali. <IMAGE> | ||||||
| 38 | 바이오칩 | KR1020080007241 | 2008-01-23 | KR1020090081261A | 2009-07-28 | 이준영; 이동호; 김재영 |
| A bio chip is provided to analyze concrete ingredient of bio sample by observing the reaction between a probe and bio sample and read various date. A bio chip comprises a substrate(11) and probe(200). The substrate comprises plural surface protrusions(50). The plurality of probes are formed by coupling by each the surface protrusion. The surface protrusion and substrate is in one form. The probe is classified into non-prove cell area which does not form coupling and probe cell area which forms coupling. The surface protrusion is formed at the plural probe cell areas. | ||||||
| 39 | Method for fixation of probe especially for production of biological chips | JP2011223141 | 2011-10-07 | JP2012008150A | 2012-01-12 | VINET FRANCOISE; ANTOINE JUAN |
| PROBLEM TO BE SOLVED: To provide a solid supporting body constituted by a substrate including a site which provides chemical species bonded to a substrate via a functional group chemically bonded at a site at which the fixation of biological cells including oligonucleotide probe, protein or ligand is intended.SOLUTION: In order to provide a solution for overcoming the defect seen in the conventional art, the method for obtaining an aldehyde functional group (allowing the fixation of a probe) by conversion of an epoxide via diol is proposed. | ||||||
| 40 | Method of manufacturing a substrate for immobilizing the Dna | JP2000575999 | 1999-10-15 | JP3907411B2 | 2007-04-18 | 通文 丹花; 浩二郎 高橋 |
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