| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | Self-addressable and self-assembling microelectronic system and device for molecular biological analysis and diagnosis | JP2006273187 | 2006-10-04 | JP2007057540A | 2007-03-08 | HELLER MICHAEL J; TU EUGENE |
| <P>PROBLEM TO BE SOLVED: To provide a self-addressable and self-assembling microelectronic system and a device for molecular biological analysis and diagnosis capable of detecting a unique nucleic acid sequence of a low number of copies in individual cells and more easily distinguishing positive signals on the basis of artificial or non-specific signals than hybridization on a solid carrier. <P>SOLUTION: The device can be fabricated using both microlithographic and micro-machining techniques. Specific binding entities include molecular biological molecules such as nucleic acids and polypeptides. The device can subsequently control the transport and reaction of analytes or reactants at addressed specific micro-locations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated. <P>COPYRIGHT: (C)2007,JPO&INPIT | ||||||
| 122 | Bio-array chip reaction device and a method of manufacturing the same | JP2005227258 | 2005-08-04 | JP3884048B2 | 2007-02-21 | ダブリュー ゴース ヴァージニア; エル ウィンクラー ジェームズ; エム ベッセマー ドナルド |
| A body (2700) having a cavity (2710) for mounting a substrate (2790) fabricated with probe sequences (2795) at known locations according to the methods disclosed in United States Patent Number 5,153,854 and PCT WO 92/10092, for example, is provided. The cavity (2710) includes inlets (2750 and 2751) for introducing selected fluids into the cavity (2710) to contact the probes (2795). Accordingly, a commercially feasible device (2700) for use in high throughput assay systems is provided. |
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| 123 | Bio-chip manufacturing method and bio-chip manufacturing apparatus using the same | JP2000156231 | 2000-05-26 | JP3865107B2 | 2007-01-10 | 健雄 田名網 |
| 124 | Improved biochip | JP2006201229 | 2006-07-24 | JP2006330000A | 2006-12-07 | MAHANT VIJAY; KURESHY FAREED |
| <P>PROBLEM TO BE SOLVED: To provide improved biochip useful for detection and/or quantification for various anti-ligands, including polypeptides, polynucleotides, carbonhydrates, pharmacologically active molecules and bacterial or eukaryotic cells and/or viruses. <P>SOLUTION: The improved biochip includes a matrix layer coupled to a substrate, wherein the matrix layer includes a plurality of ligands at a plurality of predetermined positions and the ligand binds to an anti-ligand contained in a sample fluid. A preferred matrix layer is a multi-functional matrix layer that reduce autofluorescence, incident-light-absorption, charge-effect, and/or surface unevenness of the substrate, and the obtained biochip can include an additional matrix layer. <P>COPYRIGHT: (C)2007,JPO&INPIT | ||||||
| 125 | Hydrophilic region and the hydrophobic region and the more composed of the preparation of biological molecules for the array substrate | JP2003136789 | 2003-05-15 | JP3828878B2 | 2006-10-04 | 桓 榮 崔; 桂 東 白; 壯 鎬 趙; 雲 培 金 |
| A method for manufacturing an array plate for biomolecules and a method for manufacturing a biochip using this array plate are provided. The array plate manufacturing method includes: (a) coating a surface of a substrate (1) with a hydrophobic material to form a hydrophobic layer (3); (b) etching the hydrophobic layer through an etch mask (4) placed thereon to form a hydrophilic binding site (5); (c) removing the remaining etch mask; and (d) processing the remaining region of the hydrophobic layer (3) to recover its original hydrophobic properties. The biochip manufacturing method includes processing the surface of the hydrophilic binding site (5) of an array plate manufactured using the method, and applying a solution containing biomolecules to the surface of the hydrophilic binding site. |
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| 126 | Surface is activated, the synthesis of biopolymers using an organic polymer | JP51287395 | 1994-10-28 | JP3733413B2 | 2006-01-11 | ジェイ コーシン、ピーター; エス マトソン、ロバート; ビー ランパル、ジャン |
| 127 | Biochip having a surface coated with the polysaccharide-based hydrogels | JP2004501901 | 2003-04-14 | JP2005526972A | 2005-09-08 | グリメス，マイケル，ティー．; ゲリエール，リュック; ジロ，ピエール; ディン，ジャン; ポール，クリストファー，エー．; ボチェッティ，エジスト |
| 本発明は、重合した多糖系ヒドロゲルが表面に結合されている基体を提供する。 ヒドロゲルはサンプル由来のアナライトと結合する結合性官能基で誘導体化することができる。 本発明はさらに、サンプル由来の1種以上のアナライトと選択的に結合することができる装置およびゲルの使用方法を提供する。 | ||||||
| 128 | Light-cleavable protecting group | JP2002524622 | 2001-09-11 | JP2005523232A | 2005-08-04 | バロン，アンソニー，ディー．; マクガル，グレン，エイチ． |
| 化学合成、好ましくはオリゴヌクレオチドおよびポリペプチドの固相合成における連結基として有用な新規な化合物が提供される。 この化合物は、一般的に、光不安定であり、かつ反応性基をマスクしないように光分解によって除去され得る保護基を有する。 この保護基は、一般式（Ｙ）を有し、式中（Ｙ）は、図に示されるような化学構造である。 上記の保護化合物を用いて、成分分子から支持体上に複数の化合物（各化合物は支持体の別個の予め規定された領域を占有する）を形成する方法がまた、提供される。 | ||||||
| 129 | Clinically intelligent diagnostic apparatus and method | JP2002544663 | 2001-11-27 | JP2005509127A | 2005-04-07 | ビニート グプタ; アリス アン ジャコブス; ボリス ニコリック |
| The present invention is related to a method of determining a cause of one or more medical symptoms exhibited by a subject, the method comprising: (a) obtaining a biological sample from the subject; (b) obtaining an array of different probes or different sets of probes, wherein each probe or set of probes selectively interacts with a target associated with a different known cause of the one or more medical symptoms; (c) applying the biological sample to the probes in the array under conditions that enable all of the probes to selectively interact with any targets in the biological sample; (d) detecting interactions; and (e) analyzing interactions to determine a cause of the one or more medical symptoms. | ||||||
| 130 | Storage and / or delivery method of the applied oligomer and / or polymer to the support, and the support | JP2003542607 | 2002-11-05 | JP2005508186A | 2005-03-31 | 良英 林崎 |
| 【解決手段】少なくとも１個の支持体に適用したオリゴマー及び／又はポリマーを保管及び／又は配送する方法であって、
（ａ）少なくとも１個の支持体に少なくとも１種のオリゴマー及び／又はポリマーを適用し； （ｂ）該支持体を折るか、又は巻き； （ｃ）工程（ｂ）の支持体を保管及び／又は配送する工程を含む上記方法。 折りたたみ式若しくは巻物型シート、ルーズリーフシート又はカードの形態である、少なくとも１種のオリゴマー及び／又はポリマーを適用した支持体、並びに、少なくとも１種のオリゴマー及び／又はポリマーを適用した水溶性支持体。 【効果】本発明によれば、分子性物質（オリゴマー及び／又はポリマー）が簡便なシステムで保管及び配送できる。 このシステムは、その物質を汚染及び分解させることなく保護することができる。 |
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| 131 | Improved biochip | JP2002558470 | 2001-12-11 | JP2004523749A | 2004-08-05 | クレシヤイ，フアリード; マハント，ビジヤイ |
| 改良バイオチップは支持体と連結されたマトリックス層を含み、マトリックス層は複数の所定位置に複数のリガンドを含み、リガンドは試料液に含まれる抗リガンドに結合する。 好適マトリックス層は支持体の自己蛍光、入射光吸収、電荷効果、及び／又は表面凹凸を低減する多機能マトリックス層であり、所期バイオチップは付加マトリックス層を含むことができる。 所期バイオチップはポリペプチド、ポリヌクレオチド、炭水化物、薬理活性分子、細菌もしくは真核細胞及び／又はウイルスを含む種々の抗リガンドの検出及び／又は定量に有用であり得る。 | ||||||
| 132 | Design of lithography mask and synthesis of various probe on substrate | JP2003333828 | 2003-09-25 | JP2004141152A | 2004-05-20 | HUBBELL EARL A; STRYER LUBERT; MITTMAN MICHAEL P |
| <P>PROBLEM TO BE SOLVED: To provide a computer system for forming a mask, more precisely, provide a system for forming a probe on a substrate by generating the mask and using the same, and a method therefor. <P>SOLUTION: The system and the method for synthesizing the probe on the substrate are provided. A monomer is uniformly added to a predetermined spot of the substrate by using one or more shift reticles. The shift reticles are shifted to the substrate between stages of adding the monomer. Further, characteristics of a predetermined probe can be specified in synthesizing the probe. <P>COPYRIGHT: (C)2004,JPO | ||||||
| 133 | Devices and methods for performing chemical reactions using light generating reagents | JP2002506846 | 2001-07-03 | JP2004501665A | 2004-01-22 | サン， デイビッド; ゾウ; ゾウ， シャオチュアン |
| Fluidic methods and devices for conducting parallel chemical reactions are disclosed. The methods are based on the use of in situ photogenerated reagents such as photogenerated acids, photogenerated bases, or any other suitable chemical compounds that produce active reagents upon light radiation. The present invention describes devices and methods for performing a large number of parallel chemical reactions without the use of a large number of valves, pumps and other complicated fluidic components. The present invention provides microfluidic devices that contain a plurality of microscopic vessels for carrying out discrete chemical reactions. Other applications may include the preparation of microarrays of DNA and RNA oligonucleotides, peptides, oligosacchrides, phospholipids and other biopolymers on a substrate surface for assessing gene sequence information, screening for biological and chemical activities, identifying intermolecular complex formation, and determining structural features of molecular complexes. | ||||||
| 134 | A method and apparatus for assembly and fabrication electronically uniform device | JP2001537462 | 2000-11-03 | JP2004500247A | 2004-01-08 | カール・エフ・エドマン; クリスティアン・ガートナー; マイケル・ジェイ・ヘラー; レイチェル・フォルモサ |
| Methods and apparatus are provided for the fabrication of microscale, including micron and sub-micron scale, including nanoscale, devices. Electronic transport of movable component devices is utilized through a fluidic medium to effect transport to a desired target location on a substrate or motherboard. Forces include electrophoretic force, electroosmotic force, electrostatic force and/or dielectrophoretic force. In the preferred embodiment, free field electroosmotic forces are utilized either alone, or in conjunction with, other forces. These forces may be used singly or in combination, as well as in conjunction with yet other forces, such as fluidic forces, mechanical forces or thermal convective forces. Transport may be effected through the use of driving electrodes so as to transport the component device to yet other connection electrodes. In certain embodiments, the component devices may be attached to the target device using a solder reflow step. | ||||||
| 135 | Microarray and its manufacturing | JP2001514567 | 2000-07-28 | JP2003527569A | 2003-09-16 | アンダーソン，エヌ．，レイ; アンダーソン，ノーマン，ジー．; ブラーツ，ジェイムズ，エー． |
| (57)【要約】 本発明は、生体反応分子を含むマイクロアレイ、その利用法、およびその製造方法に関する。 それぞれ特異な反応物を含む細管あるいはロッドの束を薄切りしてこのアレイを作製すると、同じアレイを大量に製造することができる。 | ||||||
| 136 | Biosensing using a surface plasmon resonance | JP2001536562 | 2000-11-13 | JP2003514224A | 2003-04-15 | グッドリッチ，グレン; ナタン，マイケル・ジェイ; ヘ，リン; ペナ，デビッド・ジェイ; ホリウェイ，ウィリアム・ディー; ムシク，マイケル・ディー; リオン，エル・アンドリュー |
| (57)【要約】 本発明は表面プラズモン共鳴（ＳＰＲ）に基づいた検出アッセイ促進のための方法および試薬を提供する。 本方法および試薬は固形支持体を使用する任意の分子認識アッセイで使用できる。 本発明はまた、イメージング様式で働くＳＰＲ装置も提供する。 | ||||||
| 137 | Micro - inorganic permeation layer for the electric device | JP2001511671 | 2000-06-09 | JP2003505046A | 2003-02-12 | ジョン・アール・ヘイブンズ; ダニエル・イー・レイモンド; チャールズ・エイチ・グリーフ; マイケル・ケイ・クリハク; マイケル・ジェイ・ヘラー |
| (57)【要約】 本発明は、分子生物学反応のためのマイクロ−電極デバイス上に無機浸透層を沈積させる方法、およびそれによって作成されるデバイスに関する。 浸透層は好ましくはゾル−ゲルである。 ゾル−ゲル浸透層は、所定の多孔度、ポアサイズ分布、ポア形態、および表面積を持つものとして作成することができる。 また、ゾル−ゲル浸透層はマイクロ−位置エレクトリックデバイスの付着層としても機能することができる。 | ||||||
| 138 | Microarray and its manufacturing method | JP2002103656 | 2002-04-05 | JP2003028870A | 2003-01-29 | ANDERSON NORMAN G; ANDERSON N LEIGH; BRAATZ JAMES A |
| PROBLEM TO BE SOLVED: To provide a microarray containing biological reaction molecules, its utilizing method, and its manufacturing method. SOLUTION: In the microarrays, it is possible to manufacture a large number of the same arrays by preparing the arrays by slicing a bundle of capillaries or rods each containing a specific reactant. By using the arrays, it is possible to perform combined assays by passing a solution containing a sample considered containing an analyte through the microarrays containing an object substance by a hydrodynamic, electrophoresis, or mechanical means under condition that the analyte is combined with the object substance. | ||||||
| 139 | Microarray and its manufacturing method | JP2002103648 | 2002-04-05 | JP2003028869A | 2003-01-29 | ANDERSON NORMAN G; ANDERSON N LEIGH; BRAATZ JAMES A |
| PROBLEM TO BE SOLVED: To provide a microarray containing biological reaction molecules, its utilizing method, and its manufacturing method. SOLUTION: It is possible to manufacture a large number of the same arrays by preparing the arrays by slicing a bundle of capillaries or rods each containing a specific reactant. For example, under condition that fluorescence or chemiluminescent signals are obtained, various biochemical and quantitative analyses are performed on each array on the basis of nucleic acid hybridization and small molecular binding to obtain the images of the signals. By electronically processing the images of the signals, clinically and experimentally useful data is obtained in the method. Therefore, it is possible to simultaneously screen all the compounds on specific chemical and biological actions through the use of the arrays. | ||||||
| 140 | Micro-array and its manufacturing method | JP2002103655 | 2002-04-05 | JP2003014759A | 2003-01-15 | ANDERSON NORMAN G; ANDERSON N LEIGH; BRAATZ JAMES A |
| PROBLEM TO BE SOLVED: To provide a micro-array containing biological reaction molecules, a method of utilizing the micro-array, and a method of manufacturing the micro- array. SOLUTION: Thin tubes or rods in which specific reaction products are respectively enclosed or adhered are prepared and arranged in the state of a parallel bundle. When the micro-array is manufacturing after confirming that the components of the bundle maintain a fixed constitution or pattern in the lengthwise direction as a whole, identical micro-arrays can be mass-produced. | ||||||
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